Putative 4-methyl-5(Beta-hydroxyethyl)-thiazole monophosphate synthesis protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein - putative

Species:

Leishmania infantum

UniProt:

A4I5A6_LEIIN

TriTrypDb:

LINF_300012900

Length:

196

Annotations

Annotations by Jardim et al.

Coenzyme/cofactor biosynthesis, 4-methyl-5(Beta-hydroxyethyl)-thiazole monophosphate synthesis

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I5A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5A6

Function

Biological processes
Term	Name	Level	Count
GO:0006081	cellular aldehyde metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1903189	glyoxal metabolic process	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	176	180	PF00082	0.360
CLV_PCSK_SKI1_1	39	43	PF00082	0.357
CLV_PCSK_SKI1_1	85	89	PF00082	0.290
DEG_Nend_UBRbox_3	1	3	PF02207	0.204
DOC_MAPK_MEF2A_6	25	32	PF00069	0.274
DOC_PP1_SILK_1	165	170	PF00149	0.297
DOC_USP7_MATH_1	163	167	PF00917	0.331
DOC_USP7_MATH_1	8	12	PF00917	0.359
DOC_WW_Pin1_4	167	172	PF00397	0.460
LIG_Actin_WH2_2	69	87	PF00022	0.303
LIG_FHA_1	137	143	PF00498	0.371
LIG_GBD_Chelix_1	173	181	PF00786	0.398
LIG_LIR_Gen_1	62	69	PF02991	0.344
LIG_LIR_Nem_3	122	127	PF02991	0.272
LIG_LIR_Nem_3	156	162	PF02991	0.339
LIG_LIR_Nem_3	62	66	PF02991	0.280
LIG_SH2_CRK	63	67	PF00017	0.272
LIG_SH2_CRK	98	102	PF00017	0.253
LIG_SH2_STAP1	137	141	PF00017	0.248
LIG_SH2_STAP1	63	67	PF00017	0.303
LIG_SH2_STAT5	159	162	PF00017	0.303
LIG_SH3_3	63	69	PF00018	0.253
LIG_SUMO_SIM_anti_2	11	18	PF11976	0.375
LIG_SUMO_SIM_par_1	15	21	PF11976	0.265
LIG_TYR_ITIM	61	66	PF00017	0.259
MOD_CK2_1	31	37	PF00069	0.297
MOD_CK2_1	56	62	PF00069	0.434
MOD_Cter_Amidation	93	96	PF01082	0.303
MOD_GlcNHglycan	57	61	PF01048	0.302
MOD_GSK3_1	131	138	PF00069	0.431
MOD_GSK3_1	163	170	PF00069	0.395
MOD_GSK3_1	31	38	PF00069	0.295
MOD_Plk_1	56	62	PF00069	0.204
MOD_Plk_2-3	15	21	PF00069	0.270
MOD_Plk_4	163	169	PF00069	0.338
MOD_Plk_4	31	37	PF00069	0.266
MOD_ProDKin_1	167	173	PF00069	0.455
MOD_SUMO_for_1	143	146	PF00179	0.259
MOD_SUMO_rev_2	34	41	PF00179	0.412
TRG_DiLeu_BaEn_1	12	17	PF01217	0.370
TRG_ENDOCYTIC_2	124	127	PF00928	0.253
TRG_ENDOCYTIC_2	159	162	PF00928	0.436
TRG_ENDOCYTIC_2	63	66	PF00928	0.272
TRG_ENDOCYTIC_2	98	101	PF00928	0.253
TRG_NES_CRM1_1	172	184	PF08389	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JDE5	Bodo saltans	43%	98%
A0A1X0P220	Trypanosomatidae	56%	99%
A0A3Q8IHS5	Leishmania donovani	99%	100%
A0A422P4U5	Trypanosoma rangeli	49%	99%
A1Z9J4	Drosophila melanogaster	34%	90%
A4HI30	Leishmania braziliensis	79%	100%
C6K3W3	Leptomonas seymouri	69%	100%
C9ZQP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	99%
E9B0K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O06006	Bacillus subtilis (strain 168)	32%	100%
O16228	Caenorhabditis elegans	32%	100%
O28987	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	28%	100%
O59413	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	34%	100%
O88767	Rattus norvegicus	38%	100%
P47275	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	27%	100%
P55880	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	32%	100%
P90994	Caenorhabditis elegans	35%	100%
Q10356	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q46948	Escherichia coli (strain K12)	34%	100%
Q4Q7N0	Leishmania major	95%	100%
Q51732	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	34%	100%
Q58377	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	26%	96%
Q5E946	Bos taurus	38%	100%
Q5JGM7	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	32%	100%
Q5XJ36	Danio rerio	37%	100%
Q7TQ35	Mesocricetus auratus	36%	100%
Q8UW59	Gallus gallus	35%	100%
Q95LI9	Chlorocebus aethiops	38%	100%
Q99497	Homo sapiens	38%	100%
Q99LX0	Mus musculus	38%	100%
Q9V1F8	Pyrococcus abyssi (strain GE5 / Orsay)	36%	100%
Q9VA37	Drosophila melanogaster	35%	100%
V5DQT9	Trypanosoma cruzi	56%	69%