Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5A5_LEIIN

TriTrypDb:

LINF_300012800

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5A5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5A5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.479
CLV_NRD_NRD_1	4	6	PF00675	0.589
CLV_NRD_NRD_1	94	96	PF00675	0.538
CLV_PCSK_FUR_1	92	96	PF00082	0.485
CLV_PCSK_KEX2_1	4	6	PF00082	0.612
CLV_PCSK_KEX2_1	55	57	PF00082	0.636
CLV_PCSK_KEX2_1	91	93	PF00082	0.645
CLV_PCSK_KEX2_1	94	96	PF00082	0.626
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.592
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.644
CLV_PCSK_SKI1_1	127	131	PF00082	0.644
CLV_PCSK_SKI1_1	4	8	PF00082	0.484
CLV_PCSK_SKI1_1	98	102	PF00082	0.542
DEG_Nend_Nbox_1	1	3	PF02207	0.664
DOC_CDC14_PxL_1	157	165	PF14671	0.486
DOC_PP1_RVXF_1	12	19	PF00149	0.654
DOC_USP7_MATH_1	116	120	PF00917	0.514
DOC_USP7_MATH_1	190	194	PF00917	0.570
DOC_USP7_MATH_1	231	235	PF00917	0.544
DOC_USP7_MATH_1	31	35	PF00917	0.720
DOC_USP7_MATH_1	76	80	PF00917	0.672
DOC_WW_Pin1_4	140	145	PF00397	0.629
DOC_WW_Pin1_4	55	60	PF00397	0.606
DOC_WW_Pin1_4	64	69	PF00397	0.576
LIG_14-3-3_CanoR_1	127	133	PF00244	0.449
LIG_FHA_1	113	119	PF00498	0.659
LIG_FHA_1	194	200	PF00498	0.407
LIG_FHA_1	99	105	PF00498	0.474
LIG_LIR_Gen_1	146	155	PF02991	0.516
LIG_LIR_Nem_3	146	150	PF02991	0.525
LIG_NRBOX	103	109	PF00104	0.537
LIG_PTB_Apo_2	35	42	PF02174	0.398
LIG_SH2_CRK	205	209	PF00017	0.377
LIG_SH2_NCK_1	205	209	PF00017	0.362
LIG_SH2_PTP2	263	266	PF00017	0.471
LIG_SH2_SRC	123	126	PF00017	0.597
LIG_SH2_STAT5	123	126	PF00017	0.508
LIG_SH2_STAT5	263	266	PF00017	0.471
LIG_SH3_3	175	181	PF00018	0.436
LIG_SH3_3	184	190	PF00018	0.482
LIG_SH3_3	65	71	PF00018	0.675
LIG_TRAF2_1	100	103	PF00917	0.564
LIG_TRAF2_1	143	146	PF00917	0.640
MOD_CDK_SPK_2	55	60	PF00069	0.706
MOD_CK1_1	111	117	PF00069	0.524
MOD_CK1_1	166	172	PF00069	0.487
MOD_CK1_1	193	199	PF00069	0.424
MOD_CK1_1	64	70	PF00069	0.687
MOD_CK2_1	131	137	PF00069	0.452
MOD_CK2_1	140	146	PF00069	0.459
MOD_CK2_1	150	156	PF00069	0.440
MOD_CMANNOS	15	18	PF00535	0.585
MOD_GlcNHglycan	119	122	PF01048	0.642
MOD_GlcNHglycan	134	137	PF01048	0.414
MOD_GlcNHglycan	165	168	PF01048	0.574
MOD_GlcNHglycan	227	230	PF01048	0.387
MOD_GlcNHglycan	63	67	PF01048	0.647
MOD_GSK3_1	108	115	PF00069	0.582
MOD_GSK3_1	128	135	PF00069	0.613
MOD_GSK3_1	166	173	PF00069	0.496
MOD_GSK3_1	176	183	PF00069	0.348
MOD_GSK3_1	219	226	PF00069	0.433
MOD_GSK3_1	62	69	PF00069	0.672
MOD_GSK3_1	74	81	PF00069	0.655
MOD_N-GLC_1	108	113	PF02516	0.492
MOD_N-GLC_1	269	274	PF02516	0.327
MOD_NEK2_1	108	113	PF00069	0.492
MOD_NEK2_1	150	155	PF00069	0.617
MOD_NEK2_1	163	168	PF00069	0.493
MOD_NEK2_1	212	217	PF00069	0.510
MOD_NEK2_1	61	66	PF00069	0.597
MOD_NEK2_2	47	52	PF00069	0.666
MOD_PIKK_1	8	14	PF00454	0.514
MOD_PK_1	22	28	PF00069	0.740
MOD_PKA_2	112	118	PF00069	0.517
MOD_PKA_2	163	169	PF00069	0.598
MOD_Plk_1	269	275	PF00069	0.335
MOD_Plk_1	47	53	PF00069	0.680
MOD_Plk_4	128	134	PF00069	0.671
MOD_Plk_4	170	176	PF00069	0.439
MOD_Plk_4	22	28	PF00069	0.627
MOD_Plk_4	269	275	PF00069	0.423
MOD_ProDKin_1	140	146	PF00069	0.633
MOD_ProDKin_1	55	61	PF00069	0.606
MOD_ProDKin_1	64	70	PF00069	0.575
MOD_SUMO_rev_2	77	83	PF00179	0.511
TRG_DiLeu_BaEn_1	103	108	PF01217	0.561
TRG_ER_diArg_1	3	5	PF00400	0.648
TRG_ER_diArg_1	92	95	PF00400	0.611
TRG_NLS_MonoExtC_3	90	95	PF00514	0.488
TRG_NLS_MonoExtN_4	89	95	PF00514	0.487
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFH4	Leptomonas seymouri	50%	100%
A0A0S4JGE4	Bodo saltans	31%	81%
A0A1X0P245	Trypanosomatidae	33%	89%
A0A3S7X369	Leishmania donovani	100%	100%
A0A422P4T3	Trypanosoma rangeli	35%	99%
A4HI29	Leishmania braziliensis	85%	100%
C9ZQN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	97%
E9B0K1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q7N1	Leishmania major	96%	100%
V5BUA0	Trypanosoma cruzi	36%	99%