Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I5A1_LEIIN

TriTrypDb:

LINF_300012400

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I5A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I5A1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.460
CLV_NRD_NRD_1	257	259	PF00675	0.349
CLV_NRD_NRD_1	36	38	PF00675	0.546
CLV_PCSK_KEX2_1	166	168	PF00082	0.399
CLV_PCSK_KEX2_1	2	4	PF00082	0.460
CLV_PCSK_KEX2_1	230	232	PF00082	0.374
CLV_PCSK_KEX2_1	35	37	PF00082	0.520
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.425
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.399
CLV_PCSK_PC7_1	32	38	PF00082	0.486
CLV_PCSK_SKI1_1	3	7	PF00082	0.486
CLV_PCSK_SKI1_1	70	74	PF00082	0.366
DEG_MDM2_SWIB_1	250	257	PF02201	0.312
DEG_MDM2_SWIB_1	73	81	PF02201	0.431
DEG_Nend_UBRbox_1	1	4	PF02207	0.489
DEG_SCF_FBW7_1	203	210	PF00400	0.483
DOC_CKS1_1	204	209	PF01111	0.417
DOC_CKS1_1	262	267	PF01111	0.418
DOC_CYCLIN_RxL_1	64	76	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	274	277	PF00134	0.395
DOC_MAPK_DCC_7	174	182	PF00069	0.440
DOC_MAPK_gen_1	165	173	PF00069	0.425
DOC_MAPK_gen_1	230	236	PF00069	0.396
DOC_MAPK_MEF2A_6	174	182	PF00069	0.469
DOC_MAPK_MEF2A_6	189	197	PF00069	0.308
DOC_PP1_RVXF_1	56	63	PF00149	0.382
DOC_PP2B_LxvP_1	274	277	PF13499	0.395
DOC_USP7_MATH_1	123	127	PF00917	0.410
DOC_USP7_MATH_1	135	139	PF00917	0.287
DOC_WW_Pin1_4	203	208	PF00397	0.447
DOC_WW_Pin1_4	261	266	PF00397	0.363
DOC_WW_Pin1_4	27	32	PF00397	0.540
DOC_WW_Pin1_4	4	9	PF00397	0.447
DOC_WW_Pin1_4	42	47	PF00397	0.505
LIG_14-3-3_CanoR_1	189	194	PF00244	0.337
LIG_14-3-3_CanoR_1	2	8	PF00244	0.638
LIG_APCC_ABBAyCdc20_2	205	211	PF00400	0.473
LIG_BRCT_BRCA1_1	58	62	PF00533	0.379
LIG_BRCT_BRCA1_1	6	10	PF00533	0.521
LIG_CtBP_PxDLS_1	265	269	PF00389	0.467
LIG_FHA_1	46	52	PF00498	0.528
LIG_FHA_1	88	94	PF00498	0.410
LIG_FHA_2	262	268	PF00498	0.349
LIG_FHA_2	74	80	PF00498	0.529
LIG_LIR_Apic_2	260	265	PF02991	0.411
LIG_LIR_Gen_1	206	217	PF02991	0.353
LIG_LIR_Gen_1	76	84	PF02991	0.408
LIG_LIR_Gen_1	88	97	PF02991	0.462
LIG_LIR_Nem_3	206	212	PF02991	0.373
LIG_LIR_Nem_3	59	65	PF02991	0.413
LIG_LIR_Nem_3	7	13	PF02991	0.642
LIG_LIR_Nem_3	76	80	PF02991	0.434
LIG_PCNA_PIPBox_1	102	111	PF02747	0.409
LIG_Pex14_2	250	254	PF04695	0.315
LIG_Pex14_2	73	77	PF04695	0.439
LIG_PTB_Apo_2	235	242	PF02174	0.385
LIG_SH2_CRK	65	69	PF00017	0.309
LIG_SH2_STAP1	252	256	PF00017	0.386
LIG_SH3_3	14	20	PF00018	0.506
LIG_SH3_3	175	181	PF00018	0.391
LIG_SH3_3	201	207	PF00018	0.372
LIG_SH3_3	41	47	PF00018	0.521
LIG_SH3_3	65	71	PF00018	0.345
LIG_SUMO_SIM_anti_2	158	164	PF11976	0.491
LIG_SUMO_SIM_anti_2	194	199	PF11976	0.332
LIG_SUMO_SIM_par_1	158	164	PF11976	0.435
LIG_SxIP_EBH_1	17	28	PF03271	0.473
LIG_TRAF2_1	76	79	PF00917	0.453
LIG_UBA3_1	100	104	PF00899	0.291
LIG_UBA3_1	115	120	PF00899	0.306
MOD_CDK_SPK_2	27	32	PF00069	0.480
MOD_CDK_SPxxK_3	4	11	PF00069	0.439
MOD_CK1_1	140	146	PF00069	0.548
MOD_CK1_1	210	216	PF00069	0.367
MOD_CK1_1	26	32	PF00069	0.505
MOD_CK1_1	261	267	PF00069	0.350
MOD_CK1_1	45	51	PF00069	0.649
MOD_CK2_1	142	148	PF00069	0.426
MOD_CK2_1	261	267	PF00069	0.350
MOD_CK2_1	73	79	PF00069	0.528
MOD_Cter_Amidation	33	36	PF01082	0.541
MOD_GlcNHglycan	125	128	PF01048	0.439
MOD_GlcNHglycan	25	28	PF01048	0.594
MOD_GlcNHglycan	95	98	PF01048	0.435
MOD_GSK3_1	189	196	PF00069	0.337
MOD_GSK3_1	19	26	PF00069	0.582
MOD_GSK3_1	199	206	PF00069	0.404
MOD_GSK3_1	89	96	PF00069	0.386
MOD_N-GLC_1	123	128	PF02516	0.453
MOD_NEK2_1	161	166	PF00069	0.450
MOD_NEK2_1	221	226	PF00069	0.360
MOD_NEK2_1	73	78	PF00069	0.472
MOD_NEK2_1	89	94	PF00069	0.331
MOD_PIKK_1	137	143	PF00454	0.464
MOD_PK_1	189	195	PF00069	0.338
MOD_PKA_1	258	264	PF00069	0.351
MOD_PKA_2	188	194	PF00069	0.361
MOD_Plk_1	210	216	PF00069	0.337
MOD_Plk_1	87	93	PF00069	0.271
MOD_Plk_4	155	161	PF00069	0.403
MOD_Plk_4	193	199	PF00069	0.330
MOD_Plk_4	258	264	PF00069	0.320
MOD_ProDKin_1	203	209	PF00069	0.438
MOD_ProDKin_1	261	267	PF00069	0.374
MOD_ProDKin_1	27	33	PF00069	0.529
MOD_ProDKin_1	4	10	PF00069	0.448
MOD_ProDKin_1	42	48	PF00069	0.500
MOD_SUMO_rev_2	113	122	PF00179	0.376
MOD_SUMO_rev_2	194	203	PF00179	0.413
MOD_SUMO_rev_2	50	60	PF00179	0.436
TRG_DiLeu_BaEn_1	270	275	PF01217	0.358
TRG_DiLeu_BaEn_2	62	68	PF01217	0.310
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.390
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.462
TRG_ENDOCYTIC_2	219	222	PF00928	0.349
TRG_ENDOCYTIC_2	65	68	PF00928	0.285
TRG_ER_diArg_1	1	3	PF00400	0.467
TRG_ER_diArg_1	35	37	PF00400	0.534
TRG_ER_FFAT_1	126	138	PF00635	0.458
TRG_NLS_MonoExtC_3	164	170	PF00514	0.449
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC7	Leptomonas seymouri	70%	100%
A0A0S4JDI3	Bodo saltans	35%	80%
A0A1X0P267	Trypanosomatidae	49%	95%
A0A3Q8IE40	Leishmania donovani	100%	88%
A0A422P4V6	Trypanosoma rangeli	49%	95%
A4HI24	Leishmania braziliensis	88%	100%
C9ZQN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	94%
E9B0J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q7N5	Leishmania major	97%	100%