Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I592_LEIIN

TriTrypDb:

LINF_300011500

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I592

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I592

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.533
CLV_NRD_NRD_1	164	166	PF00675	0.556
CLV_NRD_NRD_1	193	195	PF00675	0.442
CLV_NRD_NRD_1	77	79	PF00675	0.372
CLV_PCSK_KEX2_1	103	105	PF00082	0.555
CLV_PCSK_KEX2_1	164	166	PF00082	0.538
CLV_PCSK_KEX2_1	193	195	PF00082	0.521
CLV_PCSK_KEX2_1	77	79	PF00082	0.372
CLV_PCSK_SKI1_1	115	119	PF00082	0.682
CLV_PCSK_SKI1_1	34	38	PF00082	0.392
DEG_Nend_Nbox_1	1	3	PF02207	0.518
DOC_MAPK_gen_1	164	171	PF00069	0.523
DOC_MAPK_JIP1_4	165	171	PF00069	0.457
DOC_PP2B_LxvP_1	160	163	PF13499	0.467
DOC_PP2B_PxIxI_1	183	189	PF00149	0.401
DOC_USP7_MATH_1	121	125	PF00917	0.721
DOC_WW_Pin1_4	14	19	PF00397	0.487
LIG_14-3-3_CanoR_1	3	8	PF00244	0.546
LIG_14-3-3_CanoR_1	34	43	PF00244	0.388
LIG_14-3-3_CanoR_1	60	66	PF00244	0.348
LIG_AP2alpha_2	196	198	PF02296	0.455
LIG_BRCT_BRCA1_1	15	19	PF00533	0.530
LIG_FHA_1	15	21	PF00498	0.518
LIG_FHA_2	137	143	PF00498	0.630
LIG_FHA_2	187	193	PF00498	0.414
LIG_LIR_Nem_3	51	56	PF02991	0.490
LIG_NRBOX	96	102	PF00104	0.508
LIG_Pex14_2	59	63	PF04695	0.327
LIG_REV1ctd_RIR_1	115	123	PF16727	0.615
LIG_REV1ctd_RIR_1	50	58	PF16727	0.409
LIG_SH2_CRK	80	84	PF00017	0.467
LIG_SH2_STAP1	75	79	PF00017	0.355
LIG_SH2_STAT5	85	88	PF00017	0.406
LIG_SH3_3	150	156	PF00018	0.496
LIG_SH3_3	160	166	PF00018	0.492
LIG_SH3_3	55	61	PF00018	0.410
MOD_CK1_1	124	130	PF00069	0.620
MOD_CK2_1	136	142	PF00069	0.579
MOD_CK2_1	186	192	PF00069	0.411
MOD_Cter_Amidation	101	104	PF01082	0.539
MOD_GlcNHglycan	126	129	PF01048	0.697
MOD_GlcNHglycan	65	68	PF01048	0.427
MOD_GSK3_1	120	127	PF00069	0.692
MOD_GSK3_1	143	150	PF00069	0.522
MOD_GSK3_1	3	10	PF00069	0.559
MOD_GSK3_1	61	68	PF00069	0.362
MOD_N-GLC_1	124	129	PF02516	0.566
MOD_N-GLC_1	14	19	PF02516	0.542
MOD_N-GLC_1	34	39	PF02516	0.256
MOD_NEK2_1	13	18	PF00069	0.496
MOD_NEK2_1	63	68	PF00069	0.342
MOD_PK_1	3	9	PF00069	0.521
MOD_PKA_2	121	127	PF00069	0.503
MOD_Plk_1	124	130	PF00069	0.570
MOD_Plk_1	144	150	PF00069	0.483
MOD_Plk_4	3	9	PF00069	0.500
MOD_ProDKin_1	14	20	PF00069	0.475
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.472
TRG_ENDOCYTIC_2	80	83	PF00928	0.360
TRG_ENDOCYTIC_2	85	88	PF00928	0.340
TRG_ER_diArg_1	163	165	PF00400	0.540
TRG_ER_diArg_1	77	79	PF00400	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F0	Leptomonas seymouri	77%	100%
A0A0S4JPS5	Bodo saltans	36%	100%
A0A1X0P291	Trypanosomatidae	55%	100%
A0A3S7X362	Leishmania donovani	99%	100%
A0A422NIE5	Trypanosoma rangeli	55%	100%
A4HI15	Leishmania braziliensis	88%	100%
C9ZQM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9B0I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q7Q9	Leishmania major	96%	100%