Putative nitrate reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nitrate reductase - putative

Species:

Leishmania infantum

UniProt:

A4I589_LEIIN

TriTrypDb:

LINF_300011200

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I589

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I589

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	10
GO:0008940	nitrate reductase activity	4	8
GO:0009703	nitrate reductase (NADH) activity	6	8
GO:0016491	oxidoreductase activity	2	11
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	3	8
GO:0020037	heme binding	4	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	4	8
GO:0046872	metal ion binding	4	10
GO:0046906	tetrapyrrole binding	3	10
GO:0050463	nitrate reductase [NAD(P)H] activity	5	8
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	5	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.452
CLV_C14_Caspase3-7	514	518	PF00656	0.439
CLV_NRD_NRD_1	127	129	PF00675	0.482
CLV_NRD_NRD_1	147	149	PF00675	0.219
CLV_NRD_NRD_1	260	262	PF00675	0.576
CLV_NRD_NRD_1	443	445	PF00675	0.397
CLV_NRD_NRD_1	81	83	PF00675	0.748
CLV_PCSK_KEX2_1	127	129	PF00082	0.433
CLV_PCSK_KEX2_1	259	261	PF00082	0.639
CLV_PCSK_KEX2_1	443	445	PF00082	0.490
CLV_PCSK_SKI1_1	123	127	PF00082	0.476
CLV_PCSK_SKI1_1	132	136	PF00082	0.437
CLV_PCSK_SKI1_1	196	200	PF00082	0.397
CLV_PCSK_SKI1_1	244	248	PF00082	0.418
CLV_PCSK_SKI1_1	302	306	PF00082	0.458
CLV_PCSK_SKI1_1	461	465	PF00082	0.418
CLV_PCSK_SKI1_1	82	86	PF00082	0.654
DEG_SCF_FBW7_1	50	56	PF00400	0.742
DEG_SPOP_SBC_1	6	10	PF00917	0.616
DOC_CKS1_1	333	338	PF01111	0.501
DOC_CKS1_1	430	435	PF01111	0.491
DOC_CKS1_1	50	55	PF01111	0.741
DOC_MAPK_gen_1	212	221	PF00069	0.515
DOC_MAPK_MEF2A_6	457	466	PF00069	0.499
DOC_PP2B_LxvP_1	72	75	PF13499	0.808
DOC_PP4_FxxP_1	306	309	PF00568	0.439
DOC_PP4_FxxP_1	333	336	PF00568	0.516
DOC_PP4_FxxP_1	371	374	PF00568	0.521
DOC_USP7_MATH_1	160	164	PF00917	0.664
DOC_USP7_UBL2_3	243	247	PF12436	0.396
DOC_WW_Pin1_4	161	166	PF00397	0.722
DOC_WW_Pin1_4	168	173	PF00397	0.797
DOC_WW_Pin1_4	206	211	PF00397	0.480
DOC_WW_Pin1_4	259	264	PF00397	0.642
DOC_WW_Pin1_4	332	337	PF00397	0.367
DOC_WW_Pin1_4	429	434	PF00397	0.491
DOC_WW_Pin1_4	46	51	PF00397	0.845
DOC_WW_Pin1_4	467	472	PF00397	0.495
LIG_14-3-3_CanoR_1	294	304	PF00244	0.425
LIG_14-3-3_CanoR_1	448	455	PF00244	0.516
LIG_14-3-3_CanoR_1	490	496	PF00244	0.537
LIG_14-3-3_CanoR_1	7	13	PF00244	0.792
LIG_14-3-3_CanoR_1	82	88	PF00244	0.615
LIG_BRCT_BRCA1_1	356	360	PF00533	0.433
LIG_BRCT_BRCA1_1	422	426	PF00533	0.316
LIG_FHA_1	111	117	PF00498	0.442
LIG_FHA_1	171	177	PF00498	0.792
LIG_FHA_1	185	191	PF00498	0.628
LIG_FHA_1	285	291	PF00498	0.532
LIG_FHA_1	296	302	PF00498	0.405
LIG_FHA_1	402	408	PF00498	0.514
LIG_FHA_1	457	463	PF00498	0.448
LIG_FHA_1	99	105	PF00498	0.526
LIG_FHA_2	430	436	PF00498	0.530
LIG_FHA_2	512	518	PF00498	0.530
LIG_FHA_2	53	59	PF00498	0.819
LIG_FHA_2	84	90	PF00498	0.495
LIG_Integrin_isoDGR_2	226	228	PF01839	0.530
LIG_Integrin_isoDGR_2	353	355	PF01839	0.452
LIG_LIR_Apic_2	305	309	PF02991	0.443
LIG_LIR_Apic_2	330	336	PF02991	0.462
LIG_LIR_Apic_2	368	374	PF02991	0.405
LIG_LIR_Gen_1	232	242	PF02991	0.428
LIG_LIR_Nem_3	232	237	PF02991	0.385
LIG_LIR_Nem_3	300	306	PF02991	0.543
LIG_LIR_Nem_3	331	337	PF02991	0.417
LIG_LIR_Nem_3	357	363	PF02991	0.441
LIG_MLH1_MIPbox_1	356	360	PF16413	0.433
LIG_OCRL_FandH_1	233	245	PF00620	0.413
LIG_Pex14_2	333	337	PF04695	0.530
LIG_REV1ctd_RIR_1	358	368	PF16727	0.433
LIG_SH2_CRK	323	327	PF00017	0.481
LIG_SH2_GRB2like	323	326	PF00017	0.530
LIG_SH2_STAP1	449	453	PF00017	0.530
LIG_SH2_STAT5	250	253	PF00017	0.406
LIG_SH2_STAT5	303	306	PF00017	0.490
LIG_SH2_STAT5	334	337	PF00017	0.405
LIG_SH2_STAT5	359	362	PF00017	0.458
LIG_SH3_1	260	266	PF00018	0.467
LIG_SH3_3	251	257	PF00018	0.512
LIG_SH3_3	260	266	PF00018	0.623
LIG_SH3_3	276	282	PF00018	0.607
LIG_SH3_3	371	377	PF00018	0.385
LIG_SH3_3	427	433	PF00018	0.491
LIG_SH3_3	47	53	PF00018	0.840
LIG_SH3_3	506	512	PF00018	0.510
LIG_SUMO_SIM_anti_2	101	107	PF11976	0.431
LIG_SUMO_SIM_par_1	101	107	PF11976	0.530
LIG_SUMO_SIM_par_1	461	467	PF11976	0.518
LIG_TRAF2_1	14	17	PF00917	0.841
LIG_TRAF2_1	167	170	PF00917	0.832
LIG_TRAF2_1	391	394	PF00917	0.590
LIG_TRAF2_1	65	68	PF00917	0.855
LIG_TRFH_1	249	253	PF08558	0.530
LIG_WRC_WIRS_1	112	117	PF05994	0.458
LIG_WRC_WIRS_1	303	308	PF05994	0.530
MOD_CDC14_SPxK_1	262	265	PF00782	0.627
MOD_CDK_SPxK_1	206	212	PF00069	0.480
MOD_CDK_SPxK_1	259	265	PF00069	0.663
MOD_CDK_SPxK_1	332	338	PF00069	0.484
MOD_CK1_1	140	146	PF00069	0.537
MOD_CK1_1	161	167	PF00069	0.664
MOD_CK1_1	297	303	PF00069	0.543
MOD_CK1_1	411	417	PF00069	0.530
MOD_CK1_1	422	428	PF00069	0.518
MOD_CK1_1	429	435	PF00069	0.447
MOD_CK1_1	447	453	PF00069	0.497
MOD_CK1_1	467	473	PF00069	0.543
MOD_CK1_1	480	486	PF00069	0.316
MOD_CK1_1	8	14	PF00069	0.642
MOD_CK2_1	52	58	PF00069	0.766
MOD_CK2_1	62	68	PF00069	0.839
MOD_CK2_1	83	89	PF00069	0.597
MOD_GlcNHglycan	10	13	PF01048	0.794
MOD_GlcNHglycan	123	126	PF01048	0.509
MOD_GlcNHglycan	142	145	PF01048	0.253
MOD_GlcNHglycan	273	276	PF01048	0.673
MOD_GlcNHglycan	356	359	PF01048	0.492
MOD_GlcNHglycan	64	67	PF01048	0.783
MOD_GSK3_1	111	118	PF00069	0.419
MOD_GSK3_1	184	191	PF00069	0.618
MOD_GSK3_1	22	29	PF00069	0.817
MOD_GSK3_1	328	335	PF00069	0.492
MOD_GSK3_1	336	343	PF00069	0.415
MOD_GSK3_1	416	423	PF00069	0.408
MOD_GSK3_1	44	51	PF00069	0.807
MOD_GSK3_1	444	451	PF00069	0.242
MOD_GSK3_1	472	479	PF00069	0.476
MOD_GSK3_1	492	499	PF00069	0.402
MOD_LATS_1	319	325	PF00433	0.484
MOD_LATS_1	5	11	PF00433	0.717
MOD_N-GLC_1	295	300	PF02516	0.548
MOD_NEK2_1	115	120	PF00069	0.406
MOD_NEK2_1	304	309	PF00069	0.475
MOD_NEK2_1	33	38	PF00069	0.775
MOD_NEK2_1	426	431	PF00069	0.385
MOD_NEK2_1	44	49	PF00069	0.817
MOD_NEK2_1	464	469	PF00069	0.456
MOD_NEK2_2	137	142	PF00069	0.530
MOD_PIKK_1	281	287	PF00454	0.537
MOD_PIKK_1	416	422	PF00454	0.530
MOD_PIKK_1	529	535	PF00454	0.555
MOD_PKA_2	354	360	PF00069	0.490
MOD_PKA_2	447	453	PF00069	0.473
MOD_PKA_2	489	495	PF00069	0.530
MOD_PKA_2	6	12	PF00069	0.801
MOD_Plk_1	110	116	PF00069	0.387
MOD_Plk_1	328	334	PF00069	0.355
MOD_Plk_1	472	478	PF00069	0.530
MOD_Plk_4	111	117	PF00069	0.521
MOD_Plk_4	217	223	PF00069	0.532
MOD_Plk_4	230	236	PF00069	0.260
MOD_Plk_4	422	428	PF00069	0.413
MOD_ProDKin_1	161	167	PF00069	0.724
MOD_ProDKin_1	168	174	PF00069	0.794
MOD_ProDKin_1	206	212	PF00069	0.480
MOD_ProDKin_1	259	265	PF00069	0.635
MOD_ProDKin_1	332	338	PF00069	0.367
MOD_ProDKin_1	429	435	PF00069	0.491
MOD_ProDKin_1	46	52	PF00069	0.848
MOD_ProDKin_1	467	473	PF00069	0.495
TRG_DiLeu_BaEn_1	89	94	PF01217	0.530
TRG_DiLeu_BaEn_4	67	73	PF01217	0.714
TRG_ENDOCYTIC_2	303	306	PF00928	0.537
TRG_ENDOCYTIC_2	323	326	PF00928	0.199
TRG_ENDOCYTIC_2	334	337	PF00928	0.405
TRG_ER_diArg_1	126	128	PF00400	0.433
TRG_ER_diArg_1	179	182	PF00400	0.555
TRG_ER_diArg_1	259	261	PF00400	0.668
TRG_ER_diArg_1	442	444	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	288	293	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN6	Leptomonas seymouri	44%	85%
A0A1X0P389	Trypanosomatidae	34%	100%
A0A3Q8IJ69	Leishmania donovani	99%	100%
A0A422NIH2	Trypanosoma rangeli	33%	100%
A4HI12	Leishmania braziliensis	71%	100%
C9ZQM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B0I6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q7P5	Leishmania major	89%	100%
V5B7R2	Trypanosoma cruzi	35%	100%