Intergrin alpha chain protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ciliary BBSome complex subunit 2 - N-terminal/Ciliary BBSome complex subunit 2 - middle region/Ciliary BBSome complex subunit 2 - C-terminal - putative

Species:

Leishmania infantum

UniProt:

A4I587_LEIIN

TriTrypDb:

LINF_300011000

Length:

831

Annotations

Annotations by Jardim et al.

Structural Proteins, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005856	cytoskeleton	5	11
GO:0032991	protein-containing complex	1	12
GO:0034464	BBSome	2	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0030666	endocytic vesicle membrane	5	1
GO:0030669	clathrin-coated endocytic vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0031514	motile cilium	5	1
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4I587

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I587

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0044782	cilium organization	5	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12
GO:1905515	non-motile cilium assembly	7	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.609
CLV_C14_Caspase3-7	3	7	PF00656	0.416
CLV_C14_Caspase3-7	725	729	PF00656	0.475
CLV_NRD_NRD_1	403	405	PF00675	0.327
CLV_NRD_NRD_1	440	442	PF00675	0.296
CLV_PCSK_KEX2_1	440	442	PF00082	0.299
CLV_PCSK_KEX2_1	482	484	PF00082	0.356
CLV_PCSK_KEX2_1	772	774	PF00082	0.258
CLV_PCSK_KEX2_1	84	86	PF00082	0.302
CLV_PCSK_KEX2_1	88	90	PF00082	0.302
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.356
CLV_PCSK_PC1ET2_1	772	774	PF00082	0.258
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.302
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.302
CLV_PCSK_SKI1_1	158	162	PF00082	0.302
CLV_PCSK_SKI1_1	594	598	PF00082	0.298
CLV_PCSK_SKI1_1	70	74	PF00082	0.348
CLV_PCSK_SKI1_1	706	710	PF00082	0.337
CLV_PCSK_SKI1_1	734	738	PF00082	0.262
CLV_PCSK_SKI1_1	781	785	PF00082	0.270
CLV_PCSK_SKI1_1	811	815	PF00082	0.298
CLV_PCSK_SKI1_1	85	89	PF00082	0.221
DEG_APCC_KENBOX_2	814	818	PF00400	0.537
DEG_SPOP_SBC_1	180	184	PF00917	0.480
DOC_CYCLIN_RxL_1	393	403	PF00134	0.511
DOC_CYCLIN_RxL_1	591	600	PF00134	0.537
DOC_CYCLIN_RxL_1	731	741	PF00134	0.537
DOC_MAPK_gen_1	312	320	PF00069	0.556
DOC_MAPK_gen_1	482	488	PF00069	0.562
DOC_MAPK_MEF2A_6	379	387	PF00069	0.556
DOC_MAPK_MEF2A_6	468	476	PF00069	0.480
DOC_MAPK_MEF2A_6	594	601	PF00069	0.540
DOC_MAPK_MEF2A_6	695	702	PF00069	0.556
DOC_MAPK_NFAT4_5	594	602	PF00069	0.537
DOC_MAPK_NFAT4_5	695	703	PF00069	0.556
DOC_PP4_FxxP_1	522	525	PF00568	0.525
DOC_PP4_FxxP_1	610	613	PF00568	0.487
DOC_USP7_MATH_1	145	149	PF00917	0.464
DOC_USP7_MATH_1	225	229	PF00917	0.531
DOC_USP7_MATH_1	285	289	PF00917	0.556
DOC_USP7_MATH_1	44	48	PF00917	0.677
DOC_USP7_MATH_1	512	516	PF00917	0.507
DOC_USP7_MATH_1	63	67	PF00917	0.403
DOC_USP7_MATH_1	649	653	PF00917	0.556
DOC_USP7_MATH_1	83	87	PF00917	0.320
DOC_USP7_MATH_1	92	96	PF00917	0.430
DOC_USP7_UBL2_3	781	785	PF12436	0.462
DOC_USP7_UBL2_3	84	88	PF12436	0.502
LIG_14-3-3_CanoR_1	209	214	PF00244	0.457
LIG_14-3-3_CanoR_1	314	319	PF00244	0.475
LIG_14-3-3_CanoR_1	607	611	PF00244	0.500
LIG_Actin_WH2_2	23	39	PF00022	0.466
LIG_Actin_WH2_2	592	609	PF00022	0.556
LIG_Actin_WH2_2	691	708	PF00022	0.521
LIG_APCC_ABBAyCdc20_2	594	600	PF00400	0.458
LIG_BIR_II_1	1	5	PF00653	0.502
LIG_BIR_III_3	1	5	PF00653	0.449
LIG_BRCT_BRCA1_1	242	246	PF00533	0.462
LIG_BRCT_BRCA1_1	320	324	PF00533	0.451
LIG_BRCT_BRCA1_1	358	362	PF00533	0.528
LIG_BRCT_BRCA1_1	60	64	PF00533	0.502
LIG_CaM_NSCaTE_8	130	137	PF13499	0.403
LIG_Clathr_ClatBox_1	596	600	PF01394	0.537
LIG_deltaCOP1_diTrp_1	603	610	PF00928	0.537
LIG_FHA_1	135	141	PF00498	0.451
LIG_FHA_1	145	151	PF00498	0.384
LIG_FHA_1	465	471	PF00498	0.462
LIG_FHA_1	48	54	PF00498	0.562
LIG_FHA_1	550	556	PF00498	0.547
LIG_FHA_1	623	629	PF00498	0.556
LIG_FHA_1	656	662	PF00498	0.486
LIG_FHA_1	97	103	PF00498	0.524
LIG_FHA_2	1	7	PF00498	0.675
LIG_FHA_2	13	19	PF00498	0.392
LIG_FHA_2	181	187	PF00498	0.605
LIG_FHA_2	257	263	PF00498	0.495
LIG_FHA_2	401	407	PF00498	0.485
LIG_FHA_2	430	436	PF00498	0.559
LIG_FHA_2	447	453	PF00498	0.471
LIG_Integrin_isoDGR_2	341	343	PF01839	0.291
LIG_Integrin_RGD_1	483	485	PF01839	0.337
LIG_LIR_Apic_2	521	525	PF02991	0.513
LIG_LIR_Apic_2	579	585	PF02991	0.493
LIG_LIR_Apic_2	609	613	PF02991	0.490
LIG_LIR_Gen_1	137	146	PF02991	0.507
LIG_LIR_Gen_1	321	332	PF02991	0.451
LIG_LIR_Gen_1	713	722	PF02991	0.473
LIG_LIR_Gen_1	755	762	PF02991	0.537
LIG_LIR_Nem_3	137	141	PF02991	0.507
LIG_LIR_Nem_3	208	213	PF02991	0.423
LIG_LIR_Nem_3	321	327	PF02991	0.451
LIG_LIR_Nem_3	713	718	PF02991	0.473
LIG_LIR_Nem_3	755	759	PF02991	0.521
LIG_SH2_CRK	138	142	PF00017	0.502
LIG_SH2_CRK	292	296	PF00017	0.556
LIG_SH2_CRK	561	565	PF00017	0.522
LIG_SH2_CRK	582	586	PF00017	0.525
LIG_SH2_CRK	756	760	PF00017	0.451
LIG_SH2_SRC	546	549	PF00017	0.495
LIG_SH2_STAP1	138	142	PF00017	0.502
LIG_SH2_STAP1	292	296	PF00017	0.556
LIG_SH2_STAP1	366	370	PF00017	0.537
LIG_SH2_STAP1	756	760	PF00017	0.462
LIG_SH2_STAT5	294	297	PF00017	0.462
LIG_SH3_2	24	29	PF14604	0.260
LIG_SH3_3	174	180	PF00018	0.529
LIG_SH3_3	21	27	PF00018	0.369
LIG_SH3_3	473	479	PF00018	0.500
LIG_SH3_3	50	56	PF00018	0.647
LIG_SH3_3	550	556	PF00018	0.490
LIG_SUMO_SIM_anti_2	614	620	PF11976	0.500
LIG_SUMO_SIM_anti_2	821	828	PF11976	0.538
LIG_SUMO_SIM_par_1	614	620	PF11976	0.429
LIG_SUMO_SIM_par_1	657	664	PF11976	0.500
LIG_SUMO_SIM_par_1	697	703	PF11976	0.543
LIG_TRAF2_1	433	436	PF00917	0.511
LIG_TYR_ITIM	160	165	PF00017	0.502
LIG_UBA3_1	559	566	PF00899	0.403
LIG_UBA3_1	745	754	PF00899	0.511
LIG_WRC_WIRS_1	519	524	PF05994	0.528
MOD_CK1_1	181	187	PF00069	0.654
MOD_CK1_1	47	53	PF00069	0.671
MOD_CK1_1	58	64	PF00069	0.326
MOD_CK2_1	12	18	PF00069	0.437
MOD_CK2_1	180	186	PF00069	0.605
MOD_CK2_1	256	262	PF00069	0.474
MOD_CK2_1	429	435	PF00069	0.513
MOD_CK2_1	446	452	PF00069	0.503
MOD_CK2_1	818	824	PF00069	0.526
MOD_CK2_1	825	831	PF00069	0.615
MOD_GlcNHglycan	183	186	PF01048	0.662
MOD_GlcNHglycan	231	234	PF01048	0.580
MOD_GlcNHglycan	287	290	PF01048	0.311
MOD_GlcNHglycan	320	323	PF01048	0.264
MOD_GlcNHglycan	367	370	PF01048	0.300
MOD_GlcNHglycan	37	40	PF01048	0.534
MOD_GlcNHglycan	43	47	PF01048	0.579
MOD_GlcNHglycan	452	455	PF01048	0.335
MOD_GlcNHglycan	461	464	PF01048	0.339
MOD_GlcNHglycan	513	517	PF01048	0.258
MOD_GlcNHglycan	532	535	PF01048	0.364
MOD_GlcNHglycan	57	60	PF01048	0.242
MOD_GlcNHglycan	651	654	PF01048	0.332
MOD_GlcNHglycan	66	69	PF01048	0.264
MOD_GlcNHglycan	85	88	PF01048	0.141
MOD_GSK3_1	104	111	PF00069	0.412
MOD_GSK3_1	225	232	PF00069	0.481
MOD_GSK3_1	314	321	PF00069	0.537
MOD_GSK3_1	387	394	PF00069	0.456
MOD_GSK3_1	446	453	PF00069	0.508
MOD_GSK3_1	514	521	PF00069	0.476
MOD_GSK3_1	728	735	PF00069	0.501
MOD_GSK3_1	748	755	PF00069	0.537
MOD_GSK3_1	92	99	PF00069	0.462
MOD_LATS_1	10	16	PF00433	0.486
MOD_LATS_1	635	641	PF00433	0.537
MOD_N-GLC_1	195	200	PF02516	0.458
MOD_N-GLC_1	297	302	PF02516	0.262
MOD_N-GLC_1	530	535	PF02516	0.300
MOD_N-GLC_1	75	80	PF02516	0.307
MOD_N-GLC_2	586	588	PF02516	0.286
MOD_N-GLC_2	788	790	PF02516	0.356
MOD_NEK2_1	126	131	PF00069	0.361
MOD_NEK2_1	35	40	PF00069	0.531
MOD_NEK2_1	362	367	PF00069	0.475
MOD_NEK2_1	400	405	PF00069	0.508
MOD_NEK2_1	518	523	PF00069	0.530
MOD_NEK2_1	530	535	PF00069	0.460
MOD_NEK2_1	542	547	PF00069	0.462
MOD_NEK2_1	606	611	PF00069	0.478
MOD_NEK2_1	64	69	PF00069	0.502
MOD_NEK2_1	752	757	PF00069	0.515
MOD_NEK2_1	806	811	PF00069	0.500
MOD_NEK2_2	195	200	PF00069	0.458
MOD_NEK2_2	256	261	PF00069	0.537
MOD_PK_1	314	320	PF00069	0.556
MOD_PK_1	356	362	PF00069	0.411
MOD_PKA_2	362	368	PF00069	0.491
MOD_PKA_2	606	612	PF00069	0.507
MOD_PKB_1	312	320	PF00069	0.543
MOD_Plk_1	104	110	PF00069	0.421
MOD_Plk_1	195	201	PF00069	0.421
MOD_Plk_1	446	452	PF00069	0.462
MOD_Plk_1	549	555	PF00069	0.510
MOD_Plk_4	104	110	PF00069	0.401
MOD_Plk_4	145	151	PF00069	0.408
MOD_Plk_4	173	179	PF00069	0.619
MOD_Plk_4	195	201	PF00069	0.436
MOD_Plk_4	235	241	PF00069	0.420
MOD_Plk_4	356	362	PF00069	0.430
MOD_Plk_4	514	520	PF00069	0.469
MOD_Plk_4	728	734	PF00069	0.535
MOD_Plk_4	818	824	PF00069	0.488
MOD_SUMO_rev_2	778	783	PF00179	0.516
TRG_DiLeu_BaEn_1	614	619	PF01217	0.545
TRG_DiLeu_BaEn_1	741	746	PF01217	0.462
TRG_DiLeu_LyEn_5	741	746	PF01217	0.475
TRG_ENDOCYTIC_2	138	141	PF00928	0.502
TRG_ENDOCYTIC_2	162	165	PF00928	0.421
TRG_ENDOCYTIC_2	210	213	PF00928	0.435
TRG_ENDOCYTIC_2	292	295	PF00928	0.556
TRG_ENDOCYTIC_2	756	759	PF00928	0.451
TRG_ENDOCYTIC_2	777	780	PF00928	0.475
TRG_ER_diArg_1	311	314	PF00400	0.544
TRG_NES_CRM1_1	600	615	PF08389	0.537
TRG_Pf-PMV_PEXEL_1	744	748	PF00026	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK5	Leptomonas seymouri	72%	100%
A0A0S4JJZ6	Bodo saltans	35%	100%
A0A1X0P2D4	Trypanosomatidae	42%	100%
A0A3Q8IE31	Leishmania donovani	100%	100%
A0A422NII3	Trypanosoma rangeli	42%	100%
A4HI10	Leishmania braziliensis	88%	100%
C9ZQL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B0I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q19640	Caenorhabditis elegans	25%	100%
Q4Q7P7	Leishmania major	96%	100%
Q98SP7	Danio rerio	30%	100%
Q99MH9	Rattus norvegicus	32%	100%
Q9BXC9	Homo sapiens	32%	100%
Q9CWF6	Mus musculus	32%	100%
V5D873	Trypanosoma cruzi	40%	100%