N-terminal acetyltransferase B complex subunit MDM20 homolog

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-acetyltransferase B complex (NatB) non catalytic subunit - putative

Species:

Leishmania infantum

UniProt:

A4I580_LEIIN

TriTrypDb:

LINF_300010300

Length:

896

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, N-acetyltransferase B complex (NatB) non catalytic subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031248	protein acetyltransferase complex	3	1
GO:0031414	N-terminal protein acetyltransferase complex	4	1
GO:0031416	NatB complex	5	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902493	acetyltransferase complex	4	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4I580

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I580

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	1
GO:0006474	N-terminal protein amino acid acetylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0017196	N-terminal peptidyl-methionine acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0031365	N-terminal protein amino acid modification	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.409
CLV_C14_Caspase3-7	638	642	PF00656	0.369
CLV_NRD_NRD_1	323	325	PF00675	0.327
CLV_NRD_NRD_1	354	356	PF00675	0.326
CLV_NRD_NRD_1	396	398	PF00675	0.251
CLV_NRD_NRD_1	485	487	PF00675	0.238
CLV_NRD_NRD_1	679	681	PF00675	0.461
CLV_NRD_NRD_1	710	712	PF00675	0.654
CLV_NRD_NRD_1	833	835	PF00675	0.445
CLV_PCSK_KEX2_1	323	325	PF00082	0.297
CLV_PCSK_KEX2_1	396	398	PF00082	0.251
CLV_PCSK_KEX2_1	485	487	PF00082	0.275
CLV_PCSK_KEX2_1	679	681	PF00082	0.461
CLV_PCSK_KEX2_1	833	835	PF00082	0.314
CLV_PCSK_SKI1_1	208	212	PF00082	0.412
CLV_PCSK_SKI1_1	396	400	PF00082	0.251
CLV_PCSK_SKI1_1	418	422	PF00082	0.321
CLV_PCSK_SKI1_1	508	512	PF00082	0.276
CLV_PCSK_SKI1_1	54	58	PF00082	0.538
CLV_PCSK_SKI1_1	610	614	PF00082	0.252
CLV_PCSK_SKI1_1	66	70	PF00082	0.478
CLV_PCSK_SKI1_1	682	686	PF00082	0.383
DEG_APCC_DBOX_1	507	515	PF00400	0.476
DEG_APCC_DBOX_1	681	689	PF00400	0.432
DEG_APCC_DBOX_1	774	782	PF00400	0.478
DEG_Nend_UBRbox_2	1	3	PF02207	0.538
DEG_SCF_FBW7_1	733	739	PF00400	0.515
DEG_SCF_FBW7_1	847	854	PF00400	0.579
DOC_CKS1_1	366	371	PF01111	0.527
DOC_CKS1_1	733	738	PF01111	0.517
DOC_CYCLIN_RxL_1	679	687	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	260	266	PF00134	0.482
DOC_MAPK_FxFP_2	795	798	PF00069	0.319
DOC_MAPK_gen_1	355	363	PF00069	0.476
DOC_MAPK_gen_1	54	63	PF00069	0.438
DOC_MAPK_gen_1	610	620	PF00069	0.419
DOC_MAPK_MEF2A_6	613	620	PF00069	0.419
DOC_PP4_FxxP_1	366	369	PF00568	0.527
DOC_PP4_FxxP_1	795	798	PF00568	0.319
DOC_USP7_MATH_1	152	156	PF00917	0.468
DOC_USP7_MATH_1	296	300	PF00917	0.380
DOC_USP7_MATH_1	427	431	PF00917	0.499
DOC_USP7_MATH_1	695	699	PF00917	0.477
DOC_USP7_MATH_1	707	711	PF00917	0.461
DOC_USP7_MATH_1	736	740	PF00917	0.602
DOC_USP7_MATH_1	851	855	PF00917	0.613
DOC_USP7_MATH_1	857	861	PF00917	0.547
DOC_USP7_UBL2_3	162	166	PF12436	0.389
DOC_USP7_UBL2_3	317	321	PF12436	0.527
DOC_USP7_UBL2_3	613	617	PF12436	0.476
DOC_USP7_UBL2_3	814	818	PF12436	0.483
DOC_WW_Pin1_4	365	370	PF00397	0.527
DOC_WW_Pin1_4	408	413	PF00397	0.534
DOC_WW_Pin1_4	464	469	PF00397	0.529
DOC_WW_Pin1_4	732	737	PF00397	0.551
DOC_WW_Pin1_4	847	852	PF00397	0.600
LIG_14-3-3_CanoR_1	104	111	PF00244	0.489
LIG_14-3-3_CanoR_1	132	137	PF00244	0.491
LIG_14-3-3_CanoR_1	231	238	PF00244	0.447
LIG_14-3-3_CanoR_1	240	250	PF00244	0.481
LIG_14-3-3_CanoR_1	288	292	PF00244	0.468
LIG_14-3-3_CanoR_1	432	440	PF00244	0.493
LIG_14-3-3_CanoR_1	629	633	PF00244	0.427
LIG_14-3-3_CanoR_1	682	691	PF00244	0.356
LIG_14-3-3_CanoR_1	838	847	PF00244	0.534
LIG_APCC_ABBA_1	253	258	PF00400	0.463
LIG_BRCT_BRCA1_1	685	689	PF00533	0.415
LIG_Clathr_ClatBox_2	542	547	PF01394	0.521
LIG_deltaCOP1_diTrp_1	248	253	PF00928	0.342
LIG_deltaCOP1_diTrp_1	621	627	PF00928	0.564
LIG_eIF4E_1	801	807	PF01652	0.372
LIG_FHA_1	163	169	PF00498	0.402
LIG_FHA_1	366	372	PF00498	0.527
LIG_FHA_1	393	399	PF00498	0.493
LIG_FHA_1	449	455	PF00498	0.451
LIG_FHA_1	489	495	PF00498	0.480
LIG_FHA_1	584	590	PF00498	0.440
LIG_FHA_1	598	604	PF00498	0.478
LIG_FHA_1	641	647	PF00498	0.372
LIG_FHA_1	663	669	PF00498	0.365
LIG_FHA_1	769	775	PF00498	0.419
LIG_FHA_1	867	873	PF00498	0.462
LIG_FHA_2	184	190	PF00498	0.456
LIG_FHA_2	197	203	PF00498	0.455
LIG_FHA_2	215	221	PF00498	0.383
LIG_FHA_2	287	293	PF00498	0.481
LIG_FHA_2	464	470	PF00498	0.476
LIG_FHA_2	606	612	PF00498	0.496
LIG_FHA_2	636	642	PF00498	0.504
LIG_IRF3_LxIS_1	357	364	PF10401	0.521
LIG_LIR_Apic_2	351	357	PF02991	0.560
LIG_LIR_Apic_2	364	369	PF02991	0.462
LIG_LIR_Apic_2	793	798	PF02991	0.334
LIG_LIR_Gen_1	113	121	PF02991	0.357
LIG_LIR_Gen_1	186	192	PF02991	0.351
LIG_LIR_Gen_1	247	256	PF02991	0.339
LIG_LIR_Gen_1	358	367	PF02991	0.505
LIG_LIR_Gen_1	447	457	PF02991	0.461
LIG_LIR_Gen_1	467	477	PF02991	0.529
LIG_LIR_Gen_1	837	847	PF02991	0.523
LIG_LIR_Gen_1	93	100	PF02991	0.402
LIG_LIR_LC3C_4	665	670	PF02991	0.396
LIG_LIR_Nem_3	186	190	PF02991	0.354
LIG_LIR_Nem_3	247	253	PF02991	0.342
LIG_LIR_Nem_3	358	363	PF02991	0.505
LIG_LIR_Nem_3	447	452	PF02991	0.449
LIG_LIR_Nem_3	467	473	PF02991	0.529
LIG_LIR_Nem_3	491	495	PF02991	0.457
LIG_LIR_Nem_3	549	554	PF02991	0.462
LIG_LIR_Nem_3	837	843	PF02991	0.525
LIG_LIR_Nem_3	93	97	PF02991	0.376
LIG_NRBOX	802	808	PF00104	0.379
LIG_PCNA_yPIPBox_3	343	356	PF02747	0.521
LIG_Pex14_1	547	551	PF04695	0.521
LIG_PTB_Apo_2	47	54	PF02174	0.432
LIG_PTB_Phospho_1	47	53	PF10480	0.427
LIG_SH2_CRK	120	124	PF00017	0.422
LIG_SH2_CRK	354	358	PF00017	0.527
LIG_SH2_CRK	470	474	PF00017	0.527
LIG_SH2_NCK_1	120	124	PF00017	0.379
LIG_SH2_PTP2	187	190	PF00017	0.329
LIG_SH2_PTP2	449	452	PF00017	0.451
LIG_SH2_SRC	187	190	PF00017	0.338
LIG_SH2_SRC	360	363	PF00017	0.514
LIG_SH2_SRC	742	745	PF00017	0.457
LIG_SH2_SRC	756	759	PF00017	0.470
LIG_SH2_STAP1	197	201	PF00017	0.379
LIG_SH2_STAP1	470	474	PF00017	0.527
LIG_SH2_STAP1	495	499	PF00017	0.469
LIG_SH2_STAP1	729	733	PF00017	0.429
LIG_SH2_STAT3	552	555	PF00017	0.527
LIG_SH2_STAT3	590	593	PF00017	0.521
LIG_SH2_STAT5	114	117	PF00017	0.369
LIG_SH2_STAT5	187	190	PF00017	0.329
LIG_SH2_STAT5	241	244	PF00017	0.406
LIG_SH2_STAT5	327	330	PF00017	0.535
LIG_SH2_STAT5	349	352	PF00017	0.512
LIG_SH2_STAT5	360	363	PF00017	0.419
LIG_SH2_STAT5	449	452	PF00017	0.446
LIG_SH2_STAT5	472	475	PF00017	0.528
LIG_SH2_STAT5	569	572	PF00017	0.527
LIG_SH2_STAT5	742	745	PF00017	0.457
LIG_SH2_STAT5	756	759	PF00017	0.483
LIG_SH2_STAT5	777	780	PF00017	0.526
LIG_SH2_STAT5	801	804	PF00017	0.369
LIG_SH2_STAT5	883	886	PF00017	0.461
LIG_SH3_3	666	672	PF00018	0.397
LIG_SUMO_SIM_anti_2	186	192	PF11976	0.451
LIG_SUMO_SIM_anti_2	330	336	PF11976	0.469
LIG_SUMO_SIM_anti_2	43	49	PF11976	0.361
LIG_SUMO_SIM_anti_2	475	481	PF11976	0.521
LIG_SUMO_SIM_anti_2	665	673	PF11976	0.404
LIG_SUMO_SIM_par_1	665	673	PF11976	0.468
LIG_TRAF2_1	299	302	PF00917	0.493
LIG_TRAF2_1	407	410	PF00917	0.542
LIG_TRAF2_1	553	556	PF00917	0.566
LIG_TYR_ITIM	527	532	PF00017	0.469
LIG_UBA3_1	159	166	PF00899	0.389
LIG_UBA3_1	802	808	PF00899	0.414
LIG_WRC_WIRS_1	363	368	PF05994	0.527
MOD_CK1_1	244	250	PF00069	0.523
MOD_CK1_1	336	342	PF00069	0.527
MOD_CK1_1	785	791	PF00069	0.471
MOD_CK2_1	214	220	PF00069	0.419
MOD_CK2_1	273	279	PF00069	0.565
MOD_CK2_1	296	302	PF00069	0.384
MOD_CK2_1	371	377	PF00069	0.552
MOD_CK2_1	384	390	PF00069	0.433
MOD_CK2_1	404	410	PF00069	0.520
MOD_CK2_1	550	556	PF00069	0.521
MOD_CK2_1	696	702	PF00069	0.483
MOD_CK2_1	756	762	PF00069	0.487
MOD_CMANNOS	544	547	PF00535	0.327
MOD_CMANNOS	624	627	PF00535	0.446
MOD_GlcNHglycan	205	208	PF01048	0.406
MOD_GlcNHglycan	232	235	PF01048	0.449
MOD_GlcNHglycan	274	278	PF01048	0.559
MOD_GlcNHglycan	600	603	PF01048	0.375
MOD_GlcNHglycan	657	660	PF01048	0.382
MOD_GlcNHglycan	714	717	PF01048	0.600
MOD_GlcNHglycan	721	724	PF01048	0.577
MOD_GlcNHglycan	736	739	PF01048	0.575
MOD_GlcNHglycan	768	771	PF01048	0.520
MOD_GlcNHglycan	786	790	PF01048	0.515
MOD_GlcNHglycan	803	806	PF01048	0.406
MOD_GlcNHglycan	840	843	PF01048	0.543
MOD_GlcNHglycan	853	856	PF01048	0.600
MOD_GSK3_1	179	186	PF00069	0.407
MOD_GSK3_1	287	294	PF00069	0.449
MOD_GSK3_1	333	340	PF00069	0.496
MOD_GSK3_1	361	368	PF00069	0.502
MOD_GSK3_1	404	411	PF00069	0.527
MOD_GSK3_1	428	435	PF00069	0.473
MOD_GSK3_1	464	471	PF00069	0.521
MOD_GSK3_1	728	735	PF00069	0.509
MOD_GSK3_1	773	780	PF00069	0.459
MOD_GSK3_1	834	841	PF00069	0.552
MOD_GSK3_1	843	850	PF00069	0.495
MOD_N-GLC_1	567	572	PF02516	0.327
MOD_N-GLC_1	66	71	PF02516	0.487
MOD_N-GLC_2	83	85	PF02516	0.454
MOD_NEK2_1	110	115	PF00069	0.361
MOD_NEK2_1	161	166	PF00069	0.338
MOD_NEK2_1	203	208	PF00069	0.354
MOD_NEK2_1	214	219	PF00069	0.361
MOD_NEK2_1	333	338	PF00069	0.525
MOD_NEK2_1	361	366	PF00069	0.455
MOD_NEK2_1	434	439	PF00069	0.569
MOD_NEK2_1	567	572	PF00069	0.485
MOD_NEK2_1	664	669	PF00069	0.404
MOD_NEK2_1	684	689	PF00069	0.342
MOD_NEK2_1	728	733	PF00069	0.484
MOD_NEK2_1	843	848	PF00069	0.555
MOD_NEK2_2	251	256	PF00069	0.382
MOD_NEK2_2	883	888	PF00069	0.448
MOD_PIKK_1	241	247	PF00454	0.460
MOD_PIKK_1	605	611	PF00454	0.451
MOD_PKA_1	355	361	PF00069	0.476
MOD_PKA_2	230	236	PF00069	0.450
MOD_PKA_2	287	293	PF00069	0.474
MOD_PKA_2	520	526	PF00069	0.533
MOD_PKA_2	628	634	PF00069	0.488
MOD_PKA_2	678	684	PF00069	0.455
MOD_PKA_2	824	830	PF00069	0.457
MOD_Plk_1	273	279	PF00069	0.546
MOD_Plk_1	291	297	PF00069	0.336
MOD_Plk_1	35	41	PF00069	0.472
MOD_Plk_1	361	367	PF00069	0.437
MOD_Plk_1	468	474	PF00069	0.560
MOD_Plk_1	557	563	PF00069	0.437
MOD_Plk_1	567	573	PF00069	0.437
MOD_Plk_2-3	478	484	PF00069	0.499
MOD_Plk_2-3	550	556	PF00069	0.521
MOD_Plk_4	183	189	PF00069	0.431
MOD_Plk_4	256	262	PF00069	0.492
MOD_Plk_4	362	368	PF00069	0.437
MOD_Plk_4	371	377	PF00069	0.437
MOD_Plk_4	468	474	PF00069	0.521
MOD_Plk_4	478	484	PF00069	0.469
MOD_Plk_4	488	494	PF00069	0.328
MOD_Plk_4	557	563	PF00069	0.445
MOD_Plk_4	585	591	PF00069	0.527
MOD_Plk_4	635	641	PF00069	0.497
MOD_Plk_4	647	653	PF00069	0.433
MOD_Plk_4	664	670	PF00069	0.306
MOD_Plk_4	684	690	PF00069	0.352
MOD_Plk_4	777	783	PF00069	0.461
MOD_ProDKin_1	365	371	PF00069	0.527
MOD_ProDKin_1	408	414	PF00069	0.534
MOD_ProDKin_1	464	470	PF00069	0.529
MOD_ProDKin_1	732	738	PF00069	0.553
MOD_ProDKin_1	847	853	PF00069	0.593
MOD_SUMO_for_1	870	873	PF00179	0.466
MOD_SUMO_for_1	887	890	PF00179	0.395
MOD_SUMO_rev_2	309	319	PF00179	0.515
MOD_SUMO_rev_2	605	615	PF00179	0.476
TRG_DiLeu_BaEn_1	475	480	PF01217	0.529
TRG_DiLeu_BaEn_4	301	307	PF01217	0.511
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.493
TRG_ENDOCYTIC_2	114	117	PF00928	0.349
TRG_ENDOCYTIC_2	120	123	PF00928	0.354
TRG_ENDOCYTIC_2	187	190	PF00928	0.329
TRG_ENDOCYTIC_2	360	363	PF00928	0.527
TRG_ENDOCYTIC_2	449	452	PF00928	0.451
TRG_ENDOCYTIC_2	470	473	PF00928	0.550
TRG_ENDOCYTIC_2	529	532	PF00928	0.437
TRG_ENDOCYTIC_2	551	554	PF00928	0.454
TRG_ENDOCYTIC_2	94	97	PF00928	0.356
TRG_ER_diArg_1	396	398	PF00400	0.452
TRG_ER_diArg_1	485	487	PF00400	0.527
TRG_ER_diArg_1	678	680	PF00400	0.466
TRG_ER_diArg_1	833	835	PF00400	0.314
TRG_NLS_MonoExtN_4	709	715	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	418	423	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.184

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I184	Leptomonas seymouri	67%	98%
A0A1X0P396	Trypanosomatidae	43%	100%
A0A3S5IR93	Trypanosoma rangeli	43%	100%
A0A3S7X316	Leishmania donovani	100%	100%
A4HI03	Leishmania braziliensis	85%	100%
C9ZQK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B0H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q17DK2	Aedes aegypti	21%	95%
Q294E0	Drosophila pseudoobscura pseudoobscura	21%	93%
Q4Q7Q4	Leishmania major	96%	100%
Q7PYI4	Anopheles gambiae	22%	91%
Q9VDQ7	Drosophila melanogaster	21%	95%
V5BGT7	Trypanosoma cruzi	47%	100%