LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I577_LEIIN
TriTrypDb:
LINF_300010000
Length:
716

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I577
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I577

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 235 239 PF00656 0.738
CLV_NRD_NRD_1 12 14 PF00675 0.704
CLV_NRD_NRD_1 284 286 PF00675 0.608
CLV_NRD_NRD_1 484 486 PF00675 0.637
CLV_NRD_NRD_1 585 587 PF00675 0.470
CLV_NRD_NRD_1 623 625 PF00675 0.566
CLV_NRD_NRD_1 670 672 PF00675 0.523
CLV_NRD_NRD_1 673 675 PF00675 0.534
CLV_NRD_NRD_1 93 95 PF00675 0.805
CLV_PCSK_FUR_1 668 672 PF00082 0.524
CLV_PCSK_KEX2_1 12 14 PF00082 0.629
CLV_PCSK_KEX2_1 284 286 PF00082 0.608
CLV_PCSK_KEX2_1 484 486 PF00082 0.637
CLV_PCSK_KEX2_1 527 529 PF00082 0.698
CLV_PCSK_KEX2_1 584 586 PF00082 0.509
CLV_PCSK_KEX2_1 614 616 PF00082 0.594
CLV_PCSK_KEX2_1 625 627 PF00082 0.507
CLV_PCSK_KEX2_1 670 672 PF00082 0.523
CLV_PCSK_KEX2_1 677 679 PF00082 0.543
CLV_PCSK_KEX2_1 688 690 PF00082 0.520
CLV_PCSK_KEX2_1 697 699 PF00082 0.313
CLV_PCSK_KEX2_1 93 95 PF00082 0.805
CLV_PCSK_PC1ET2_1 527 529 PF00082 0.659
CLV_PCSK_PC1ET2_1 584 586 PF00082 0.549
CLV_PCSK_PC1ET2_1 614 616 PF00082 0.594
CLV_PCSK_PC1ET2_1 625 627 PF00082 0.507
CLV_PCSK_PC1ET2_1 677 679 PF00082 0.543
CLV_PCSK_PC1ET2_1 688 690 PF00082 0.520
CLV_PCSK_PC1ET2_1 697 699 PF00082 0.313
CLV_PCSK_SKI1_1 175 179 PF00082 0.597
CLV_PCSK_SKI1_1 484 488 PF00082 0.487
CLV_PCSK_SKI1_1 569 573 PF00082 0.644
CLV_PCSK_SKI1_1 586 590 PF00082 0.419
CLV_PCSK_SKI1_1 697 701 PF00082 0.545
DEG_APCC_DBOX_1 19 27 PF00400 0.702
DEG_SPOP_SBC_1 100 104 PF00917 0.702
DOC_CYCLIN_RxL_1 481 491 PF00134 0.505
DOC_CYCLIN_RxL_1 552 562 PF00134 0.651
DOC_MAPK_gen_1 272 279 PF00069 0.679
DOC_MAPK_gen_1 584 595 PF00069 0.543
DOC_MAPK_gen_1 597 605 PF00069 0.416
DOC_MAPK_gen_1 688 695 PF00069 0.623
DOC_PP4_FxxP_1 505 508 PF00568 0.672
DOC_PP4_FxxP_1 87 90 PF00568 0.606
DOC_USP7_MATH_1 119 123 PF00917 0.802
DOC_USP7_MATH_1 127 131 PF00917 0.697
DOC_USP7_MATH_1 177 181 PF00917 0.784
DOC_USP7_MATH_1 297 301 PF00917 0.707
DOC_USP7_MATH_1 407 411 PF00917 0.715
DOC_USP7_MATH_1 413 417 PF00917 0.796
DOC_USP7_MATH_1 445 449 PF00917 0.585
DOC_USP7_MATH_1 538 542 PF00917 0.767
DOC_USP7_MATH_1 567 571 PF00917 0.595
DOC_WW_Pin1_4 130 135 PF00397 0.767
DOC_WW_Pin1_4 164 169 PF00397 0.700
DOC_WW_Pin1_4 187 192 PF00397 0.740
DOC_WW_Pin1_4 218 223 PF00397 0.677
DOC_WW_Pin1_4 298 303 PF00397 0.752
DOC_WW_Pin1_4 311 316 PF00397 0.657
DOC_WW_Pin1_4 323 328 PF00397 0.711
DOC_WW_Pin1_4 373 378 PF00397 0.653
DOC_WW_Pin1_4 68 73 PF00397 0.727
DOC_WW_Pin1_4 708 713 PF00397 0.718
DOC_WW_Pin1_4 74 79 PF00397 0.718
DOC_WW_Pin1_4 86 91 PF00397 0.476
LIG_14-3-3_CanoR_1 179 183 PF00244 0.604
LIG_14-3-3_CanoR_1 196 204 PF00244 0.741
LIG_14-3-3_CanoR_1 272 278 PF00244 0.648
LIG_14-3-3_CanoR_1 334 344 PF00244 0.686
LIG_14-3-3_CanoR_1 585 589 PF00244 0.571
LIG_14-3-3_CanoR_1 698 706 PF00244 0.696
LIG_14-3-3_CterR_2 714 716 PF00244 0.845
LIG_Actin_WH2_2 675 690 PF00022 0.632
LIG_BIR_II_1 1 5 PF00653 0.757
LIG_BRCT_BRCA1_1 101 105 PF00533 0.683
LIG_BRCT_BRCA1_1 81 85 PF00533 0.811
LIG_DLG_GKlike_1 318 326 PF00625 0.657
LIG_FHA_1 102 108 PF00498 0.702
LIG_FHA_1 340 346 PF00498 0.661
LIG_FHA_1 399 405 PF00498 0.806
LIG_FHA_1 431 437 PF00498 0.691
LIG_FHA_1 554 560 PF00498 0.640
LIG_FHA_1 688 694 PF00498 0.560
LIG_FHA_1 698 704 PF00498 0.536
LIG_FHA_2 276 282 PF00498 0.696
LIG_FHA_2 384 390 PF00498 0.728
LIG_FHA_2 456 462 PF00498 0.725
LIG_FHA_2 538 544 PF00498 0.603
LIG_LIR_Apic_2 503 508 PF02991 0.777
LIG_LIR_Gen_1 659 665 PF02991 0.518
LIG_LIR_Nem_3 348 352 PF02991 0.633
LIG_LIR_Nem_3 480 486 PF02991 0.475
LIG_LIR_Nem_3 659 664 PF02991 0.518
LIG_LYPXL_yS_3 349 352 PF13949 0.633
LIG_MYND_1 222 226 PF01753 0.574
LIG_SH2_CRK 483 487 PF00017 0.530
LIG_SH2_NCK_1 24 28 PF00017 0.619
LIG_SH2_SRC 232 235 PF00017 0.614
LIG_SH2_STAP1 630 634 PF00017 0.590
LIG_SH2_STAT5 495 498 PF00017 0.559
LIG_SH3_1 704 710 PF00018 0.672
LIG_SH3_2 191 196 PF14604 0.815
LIG_SH3_2 709 714 PF14604 0.706
LIG_SH3_3 145 151 PF00018 0.694
LIG_SH3_3 188 194 PF00018 0.814
LIG_SH3_3 296 302 PF00018 0.582
LIG_SH3_3 704 710 PF00018 0.672
LIG_SH3_CIN85_PxpxPR_1 506 511 PF14604 0.763
LIG_SUMO_SIM_anti_2 659 667 PF11976 0.515
LIG_SUMO_SIM_par_1 485 491 PF11976 0.509
LIG_TRAF2_1 367 370 PF00917 0.635
LIG_TRAF2_1 386 389 PF00917 0.801
LIG_TRAF2_1 510 513 PF00917 0.651
LIG_TRAF2_1 643 646 PF00917 0.661
LIG_UBA3_1 486 494 PF00899 0.649
LIG_WW_3 711 715 PF00397 0.713
MOD_CDC14_SPxK_1 172 175 PF00782 0.801
MOD_CDC14_SPxK_1 711 714 PF00782 0.712
MOD_CDK_SPK_2 218 223 PF00069 0.626
MOD_CDK_SPxK_1 169 175 PF00069 0.796
MOD_CDK_SPxK_1 708 714 PF00069 0.703
MOD_CDK_SPxxK_3 311 318 PF00069 0.816
MOD_CDK_SPxxK_3 86 93 PF00069 0.579
MOD_CK1_1 112 118 PF00069 0.699
MOD_CK1_1 130 136 PF00069 0.642
MOD_CK1_1 164 170 PF00069 0.784
MOD_CK1_1 181 187 PF00069 0.557
MOD_CK1_1 2 8 PF00069 0.731
MOD_CK1_1 237 243 PF00069 0.798
MOD_CK1_1 321 327 PF00069 0.704
MOD_CK1_1 398 404 PF00069 0.756
MOD_CK1_1 414 420 PF00069 0.705
MOD_CK1_1 439 445 PF00069 0.592
MOD_CK2_1 119 125 PF00069 0.699
MOD_CK2_1 203 209 PF00069 0.733
MOD_CK2_1 298 304 PF00069 0.659
MOD_CK2_1 382 388 PF00069 0.728
MOD_CK2_1 393 399 PF00069 0.497
MOD_CK2_1 455 461 PF00069 0.584
MOD_CK2_1 537 543 PF00069 0.634
MOD_Cter_Amidation 582 585 PF01082 0.637
MOD_GlcNHglycan 1 4 PF01048 0.691
MOD_GlcNHglycan 112 115 PF01048 0.759
MOD_GlcNHglycan 121 124 PF01048 0.676
MOD_GlcNHglycan 163 166 PF01048 0.632
MOD_GlcNHglycan 184 187 PF01048 0.748
MOD_GlcNHglycan 205 208 PF01048 0.772
MOD_GlcNHglycan 290 293 PF01048 0.570
MOD_GlcNHglycan 323 326 PF01048 0.720
MOD_GlcNHglycan 36 39 PF01048 0.828
MOD_GlcNHglycan 411 414 PF01048 0.821
MOD_GlcNHglycan 419 422 PF01048 0.805
MOD_GlcNHglycan 438 441 PF01048 0.764
MOD_GlcNHglycan 463 466 PF01048 0.671
MOD_GlcNHglycan 471 474 PF01048 0.587
MOD_GlcNHglycan 52 55 PF01048 0.506
MOD_GlcNHglycan 549 552 PF01048 0.574
MOD_GlcNHglycan 627 633 PF01048 0.584
MOD_GSK3_1 115 122 PF00069 0.707
MOD_GSK3_1 177 184 PF00069 0.784
MOD_GSK3_1 208 215 PF00069 0.746
MOD_GSK3_1 335 342 PF00069 0.640
MOD_GSK3_1 373 380 PF00069 0.662
MOD_GSK3_1 383 390 PF00069 0.612
MOD_GSK3_1 394 401 PF00069 0.545
MOD_GSK3_1 405 412 PF00069 0.801
MOD_GSK3_1 413 420 PF00069 0.603
MOD_GSK3_1 445 452 PF00069 0.690
MOD_GSK3_1 453 460 PF00069 0.643
MOD_GSK3_1 652 659 PF00069 0.517
MOD_N-GLC_1 110 115 PF02516 0.698
MOD_N-GLC_1 430 435 PF02516 0.692
MOD_NEK2_1 1 6 PF00069 0.675
MOD_NEK2_1 161 166 PF00069 0.722
MOD_NEK2_1 178 183 PF00069 0.696
MOD_NEK2_1 449 454 PF00069 0.641
MOD_NEK2_2 567 572 PF00069 0.646
MOD_PIKK_1 2 8 PF00454 0.731
MOD_PIKK_1 365 371 PF00454 0.718
MOD_PIKK_1 697 703 PF00454 0.562
MOD_PKA_1 527 533 PF00069 0.714
MOD_PKA_1 584 590 PF00069 0.571
MOD_PKA_1 697 703 PF00069 0.562
MOD_PKA_2 178 184 PF00069 0.807
MOD_PKA_2 195 201 PF00069 0.548
MOD_PKA_2 333 339 PF00069 0.744
MOD_PKA_2 527 533 PF00069 0.714
MOD_PKA_2 547 553 PF00069 0.335
MOD_PKA_2 584 590 PF00069 0.571
MOD_PKA_2 697 703 PF00069 0.664
MOD_Plk_1 387 393 PF00069 0.768
MOD_Plk_1 553 559 PF00069 0.651
MOD_Plk_2-3 388 394 PF00069 0.808
MOD_Plk_4 178 184 PF00069 0.593
MOD_Plk_4 657 663 PF00069 0.513
MOD_ProDKin_1 130 136 PF00069 0.766
MOD_ProDKin_1 164 170 PF00069 0.699
MOD_ProDKin_1 187 193 PF00069 0.739
MOD_ProDKin_1 218 224 PF00069 0.676
MOD_ProDKin_1 298 304 PF00069 0.749
MOD_ProDKin_1 311 317 PF00069 0.655
MOD_ProDKin_1 323 329 PF00069 0.711
MOD_ProDKin_1 373 379 PF00069 0.658
MOD_ProDKin_1 68 74 PF00069 0.723
MOD_ProDKin_1 708 714 PF00069 0.725
MOD_ProDKin_1 86 92 PF00069 0.474
MOD_SUMO_rev_2 230 237 PF00179 0.709
TRG_DiLeu_BaLyEn_6 482 487 PF01217 0.633
TRG_DiLeu_BaLyEn_6 599 604 PF01217 0.517
TRG_ENDOCYTIC_2 349 352 PF00928 0.640
TRG_ENDOCYTIC_2 483 486 PF00928 0.507
TRG_ER_diArg_1 12 14 PF00400 0.704
TRG_ER_diArg_1 283 285 PF00400 0.602
TRG_ER_diArg_1 359 362 PF00400 0.679
TRG_ER_diArg_1 483 485 PF00400 0.640
TRG_ER_diArg_1 545 548 PF00400 0.585
TRG_ER_diArg_1 623 626 PF00400 0.648
TRG_ER_diArg_1 670 672 PF00400 0.523
TRG_ER_diArg_1 92 94 PF00400 0.799
TRG_NES_CRM1_1 652 667 PF08389 0.516
TRG_Pf-PMV_PEXEL_1 12 16 PF00026 0.618
TRG_Pf-PMV_PEXEL_1 155 159 PF00026 0.647
TRG_Pf-PMV_PEXEL_1 362 366 PF00026 0.485
TRG_Pf-PMV_PEXEL_1 485 490 PF00026 0.539
TRG_Pf-PMV_PEXEL_1 507 512 PF00026 0.741
TRG_Pf-PMV_PEXEL_1 516 520 PF00026 0.577
TRG_Pf-PMV_PEXEL_1 586 590 PF00026 0.513
TRG_Pf-PMV_PEXEL_1 591 596 PF00026 0.510
TRG_Pf-PMV_PEXEL_1 602 606 PF00026 0.551
TRG_Pf-PMV_PEXEL_1 614 618 PF00026 0.529

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDA1 Leptomonas seymouri 44% 100%
A0A3S7X301 Leishmania donovani 100% 100%
A4HI00 Leishmania braziliensis 75% 99%
E9B0H4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 97%
Q4Q7Q7 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS