Aspartate--tRNA ligase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aspartyl-tRNA synthetase - putative

Species:

Leishmania infantum

UniProt:

A4I574_LEIIN

TriTrypDb:

LINF_300009700

Length:

550

Annotations

Annotations by Jardim et al.

tRNA synthetase, aspartyl-tRNA synthetase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005829	cytosol	2	1
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	12
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Previous1Next

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I574

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I574

PDB structure(s): 6od8_A , 6od8_B

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006399	tRNA metabolic process	7	12
GO:0006418	tRNA aminoacylation for protein translation	6	12
GO:0006422	aspartyl-tRNA aminoacylation	7	12
GO:0006520	amino acid metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12

Previous1 2 3Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	12
GO:0004812	aminoacyl-tRNA ligase activity	4	12
GO:0004815	aspartate-tRNA ligase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	12

Previous1 2 3Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.457
CLV_C14_Caspase3-7	503	507	PF00656	0.447
CLV_MEL_PAP_1	83	89	PF00089	0.311
CLV_NRD_NRD_1	181	183	PF00675	0.388
CLV_NRD_NRD_1	22	24	PF00675	0.452
CLV_NRD_NRD_1	90	92	PF00675	0.223
CLV_PCSK_SKI1_1	224	228	PF00082	0.223
CLV_PCSK_SKI1_1	298	302	PF00082	0.306
CLV_PCSK_SKI1_1	339	343	PF00082	0.348
CLV_PCSK_SKI1_1	38	42	PF00082	0.470

Previous1 2 3 4 5…16Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZP3	Leptomonas seymouri	86%	100%
A0A0N1I7V4	Leptomonas seymouri	22%	75%
A0A0N1PBD9	Leptomonas seymouri	20%	94%
A0A0S4IKL4	Bodo saltans	70%	100%
A0A0S4IMX7	Bodo saltans	45%	100%
A0A0S4INT6	Bodo saltans	48%	97%
A0A0S4ISB0	Bodo saltans	46%	88%
A0A0S4JS96	Bodo saltans	21%	94%
A0A1X0NQW4	Trypanosomatidae	21%	92%
A0A1X0NXR0	Trypanosomatidae	39%	94%

Previous1 2 3 4 5…46Next