LeishMANIAdb
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Sulfhydryl oxidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Sulfhydryl oxidase
Gene product:
quiescin sulfhydryl oxidase - putative
Species:
Leishmania infantum
UniProt:
A4I571_LEIIN
TriTrypDb:
LINF_300009400
Length:
560

Annotations

Annotations by Jardim et al.

Redox homeostasis, Sulfhydryl oxidase QSOX

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 9, no: 1
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 11
GO:0005615 extracellular space 2 1

Expansion

Sequence features

A4I571
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I571

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 1
GO:0009987 cellular process 1 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0015035 protein-disulfide reductase activity 3 11
GO:0015036 disulfide oxidoreductase activity 4 11
GO:0016491 oxidoreductase activity 2 11
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3 11
GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 4 11
GO:0016971 flavin-linked sulfhydryl oxidase activity 4 11
GO:0016972 thiol oxidase activity 5 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0003756 protein disulfide isomerase activity 3 1
GO:0016853 isomerase activity 2 1
GO:0016860 intramolecular oxidoreductase activity 3 1
GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 66 70 PF00656 0.233
CLV_MEL_PAP_1 25 31 PF00089 0.578
CLV_NRD_NRD_1 179 181 PF00675 0.646
CLV_NRD_NRD_1 265 267 PF00675 0.607
CLV_NRD_NRD_1 295 297 PF00675 0.608
CLV_NRD_NRD_1 426 428 PF00675 0.562
CLV_NRD_NRD_1 540 542 PF00675 0.404
CLV_NRD_NRD_1 550 552 PF00675 0.440
CLV_PCSK_KEX2_1 264 266 PF00082 0.609
CLV_PCSK_KEX2_1 295 297 PF00082 0.608
CLV_PCSK_KEX2_1 426 428 PF00082 0.541
CLV_PCSK_KEX2_1 441 443 PF00082 0.488
CLV_PCSK_KEX2_1 499 501 PF00082 0.803
CLV_PCSK_KEX2_1 540 542 PF00082 0.396
CLV_PCSK_KEX2_1 548 550 PF00082 0.455
CLV_PCSK_PC1ET2_1 441 443 PF00082 0.559
CLV_PCSK_PC1ET2_1 499 501 PF00082 0.747
CLV_PCSK_PC1ET2_1 548 550 PF00082 0.543
CLV_PCSK_SKI1_1 146 150 PF00082 0.598
CLV_PCSK_SKI1_1 265 269 PF00082 0.535
CLV_PCSK_SKI1_1 316 320 PF00082 0.597
CLV_PCSK_SKI1_1 33 37 PF00082 0.562
CLV_PCSK_SKI1_1 391 395 PF00082 0.512
CLV_PCSK_SKI1_1 441 445 PF00082 0.617
CLV_PCSK_SKI1_1 551 555 PF00082 0.569
DOC_CKS1_1 326 331 PF01111 0.430
DOC_CYCLIN_RxL_1 143 150 PF00134 0.373
DOC_CYCLIN_RxL_1 192 204 PF00134 0.362
DOC_MAPK_FxFP_2 126 129 PF00069 0.353
DOC_MAPK_gen_1 3 11 PF00069 0.391
DOC_MAPK_gen_1 548 556 PF00069 0.740
DOC_MAPK_MEF2A_6 3 11 PF00069 0.391
DOC_MAPK_MEF2A_6 548 556 PF00069 0.719
DOC_PP1_RVXF_1 328 335 PF00149 0.372
DOC_PP2B_PxIxI_1 60 66 PF00149 0.395
DOC_PP4_FxxP_1 126 129 PF00568 0.280
DOC_PP4_FxxP_1 20 23 PF00568 0.455
DOC_USP7_MATH_1 224 228 PF00917 0.465
DOC_USP7_MATH_1 300 304 PF00917 0.532
DOC_USP7_MATH_1 469 473 PF00917 0.284
DOC_WW_Pin1_4 325 330 PF00397 0.362
LIG_14-3-3_CanoR_1 180 190 PF00244 0.440
LIG_14-3-3_CanoR_1 28 36 PF00244 0.454
LIG_14-3-3_CanoR_1 330 335 PF00244 0.393
LIG_14-3-3_CanoR_1 426 432 PF00244 0.330
LIG_14-3-3_CanoR_1 75 79 PF00244 0.334
LIG_AP2alpha_1 36 40 PF02296 0.396
LIG_BRCT_BRCA1_1 122 126 PF00533 0.353
LIG_Clathr_ClatBox_1 515 519 PF01394 0.426
LIG_CtBP_PxDLS_1 158 162 PF00389 0.300
LIG_FHA_1 160 166 PF00498 0.378
LIG_FHA_1 234 240 PF00498 0.360
LIG_FHA_1 369 375 PF00498 0.386
LIG_FHA_1 378 384 PF00498 0.357
LIG_FHA_1 399 405 PF00498 0.386
LIG_FHA_1 488 494 PF00498 0.579
LIG_FHA_1 521 527 PF00498 0.377
LIG_FHA_2 135 141 PF00498 0.483
LIG_FHA_2 192 198 PF00498 0.461
LIG_FHA_2 457 463 PF00498 0.418
LIG_FHA_2 64 70 PF00498 0.302
LIG_FHA_2 86 92 PF00498 0.320
LIG_LIR_Apic_2 123 129 PF02991 0.353
LIG_LIR_Gen_1 234 245 PF02991 0.369
LIG_LIR_Gen_1 248 259 PF02991 0.296
LIG_LIR_Gen_1 313 321 PF02991 0.407
LIG_LIR_Gen_1 38 45 PF02991 0.392
LIG_LIR_Gen_1 381 390 PF02991 0.369
LIG_LIR_Gen_1 401 408 PF02991 0.334
LIG_LIR_Gen_1 519 529 PF02991 0.292
LIG_LIR_Nem_3 123 128 PF02991 0.362
LIG_LIR_Nem_3 234 240 PF02991 0.384
LIG_LIR_Nem_3 248 254 PF02991 0.290
LIG_LIR_Nem_3 313 317 PF02991 0.405
LIG_LIR_Nem_3 341 347 PF02991 0.331
LIG_LIR_Nem_3 38 43 PF02991 0.410
LIG_LIR_Nem_3 381 387 PF02991 0.369
LIG_LIR_Nem_3 401 406 PF02991 0.334
LIG_LIR_Nem_3 519 524 PF02991 0.292
LIG_MLH1_MIPbox_1 122 126 PF16413 0.330
LIG_Pex14_2 124 128 PF04695 0.330
LIG_Pex14_2 247 251 PF04695 0.331
LIG_Pex14_2 36 40 PF04695 0.403
LIG_PTB_Apo_2 241 248 PF02174 0.361
LIG_SH2_CRK 355 359 PF00017 0.313
LIG_SH2_CRK 512 516 PF00017 0.517
LIG_SH2_GRB2like 512 515 PF00017 0.401
LIG_SH2_SRC 67 70 PF00017 0.261
LIG_SH2_STAP1 289 293 PF00017 0.439
LIG_SH2_STAP1 389 393 PF00017 0.386
LIG_SH2_STAT5 125 128 PF00017 0.391
LIG_SH2_STAT5 205 208 PF00017 0.405
LIG_SH2_STAT5 21 24 PF00017 0.647
LIG_SH2_STAT5 474 477 PF00017 0.382
LIG_SH2_STAT5 537 540 PF00017 0.537
LIG_SH2_STAT5 67 70 PF00017 0.330
LIG_SH3_1 549 555 PF00018 0.733
LIG_SH3_2 437 442 PF14604 0.339
LIG_SH3_2 552 557 PF14604 0.760
LIG_SH3_3 116 122 PF00018 0.376
LIG_SH3_3 434 440 PF00018 0.330
LIG_SH3_3 549 555 PF00018 0.733
LIG_SUMO_SIM_anti_2 519 526 PF11976 0.368
LIG_SUMO_SIM_par_1 41 49 PF11976 0.370
LIG_TRFH_1 125 129 PF08558 0.362
LIG_TYR_ITIM 353 358 PF00017 0.313
LIG_WRC_WIRS_1 121 126 PF05994 0.353
LIG_WRC_WIRS_1 518 523 PF05994 0.384
MOD_CDK_SPK_2 325 330 PF00069 0.362
MOD_CK1_1 185 191 PF00069 0.307
MOD_CK1_1 209 215 PF00069 0.466
MOD_CK1_1 333 339 PF00069 0.380
MOD_CK1_1 517 523 PF00069 0.316
MOD_CK2_1 134 140 PF00069 0.409
MOD_CK2_1 191 197 PF00069 0.408
MOD_CK2_1 427 433 PF00069 0.435
MOD_CK2_1 456 462 PF00069 0.431
MOD_CK2_1 46 52 PF00069 0.373
MOD_GlcNHglycan 184 187 PF01048 0.648
MOD_GlcNHglycan 260 263 PF01048 0.652
MOD_GlcNHglycan 319 322 PF01048 0.588
MOD_GlcNHglycan 544 547 PF01048 0.482
MOD_GlcNHglycan 55 58 PF01048 0.535
MOD_GlcNHglycan 76 79 PF01048 0.561
MOD_GlcNHglycan 90 94 PF01048 0.397
MOD_GSK3_1 181 188 PF00069 0.377
MOD_GSK3_1 222 229 PF00069 0.474
MOD_GSK3_1 27 34 PF00069 0.579
MOD_GSK3_1 333 340 PF00069 0.326
MOD_GSK3_1 487 494 PF00069 0.515
MOD_GSK3_1 63 70 PF00069 0.393
MOD_GSK3_1 85 92 PF00069 0.362
MOD_N-GLC_1 134 139 PF02516 0.623
MOD_N-GLC_1 159 164 PF02516 0.489
MOD_N-GLC_1 377 382 PF02516 0.502
MOD_N-GLC_1 45 50 PF02516 0.549
MOD_NEK2_1 182 187 PF00069 0.398
MOD_NEK2_1 246 251 PF00069 0.337
MOD_NEK2_1 287 292 PF00069 0.436
MOD_NEK2_1 29 34 PF00069 0.462
MOD_NEK2_1 307 312 PF00069 0.227
MOD_NEK2_1 317 322 PF00069 0.365
MOD_NEK2_1 354 359 PF00069 0.297
MOD_NEK2_1 53 58 PF00069 0.364
MOD_NEK2_2 106 111 PF00069 0.325
MOD_PKA_2 191 197 PF00069 0.330
MOD_PKA_2 206 212 PF00069 0.448
MOD_PKA_2 27 33 PF00069 0.515
MOD_PKA_2 491 497 PF00069 0.532
MOD_PKA_2 74 80 PF00069 0.343
MOD_Plk_1 106 112 PF00069 0.360
MOD_Plk_1 134 140 PF00069 0.467
MOD_Plk_1 232 238 PF00069 0.424
MOD_Plk_1 45 51 PF00069 0.339
MOD_Plk_1 85 91 PF00069 0.300
MOD_Plk_1 97 103 PF00069 0.360
MOD_Plk_4 120 126 PF00069 0.362
MOD_Plk_4 246 252 PF00069 0.306
MOD_Plk_4 517 523 PF00069 0.307
MOD_Plk_4 63 69 PF00069 0.393
MOD_ProDKin_1 325 331 PF00069 0.361
MOD_SUMO_rev_2 150 159 PF00179 0.480
TRG_AP2beta_CARGO_1 381 391 PF09066 0.386
TRG_DiLeu_BaEn_2 461 467 PF01217 0.413
TRG_ENDOCYTIC_2 125 128 PF00928 0.386
TRG_ENDOCYTIC_2 344 347 PF00928 0.322
TRG_ENDOCYTIC_2 355 358 PF00928 0.258
TRG_ENDOCYTIC_2 512 515 PF00928 0.522
TRG_ER_diArg_1 264 266 PF00400 0.412
TRG_ER_diArg_1 295 297 PF00400 0.408
TRG_ER_diArg_1 426 428 PF00400 0.362
TRG_ER_diArg_1 475 478 PF00400 0.339
TRG_ER_diArg_1 539 541 PF00400 0.578
TRG_ER_diArg_1 549 551 PF00400 0.653
TRG_ER_diArg_1 556 559 PF00400 0.733
TRG_NLS_MonoCore_2 547 552 PF00514 0.747
TRG_NLS_MonoExtC_3 547 552 PF00514 0.723
TRG_Pf-PMV_PEXEL_1 163 168 PF00026 0.593
TRG_Pf-PMV_PEXEL_1 33 38 PF00026 0.568
TRG_Pf-PMV_PEXEL_1 500 504 PF00026 0.735
TRG_Pf-PMV_PEXEL_1 51 55 PF00026 0.516

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2H4 Leptomonas seymouri 46% 97%
A0A0S4ILW1 Bodo saltans 30% 72%
A0A1X0P2E7 Trypanosomatidae 39% 100%
A0A3S7X306 Leishmania donovani 100% 100%
A0A422NMK4 Trypanosoma rangeli 37% 100%
A4HHZ4 Leishmania braziliensis 67% 99%
C9ZQJ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9B0G8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q7R5 Leishmania major 90% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS