LeishMANIAdb
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Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine nucleotide-binding protein subunit beta-like protein
Gene product:
WD-40 repeat protein
Species:
Leishmania infantum
UniProt:
A4I569_LEIIN
TriTrypDb:
LINF_300009200
Length:
479

Annotations

Annotations by Jardim et al.

Membrane associated proteins, WD-40 repeat

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 11
GO:0005840 ribosome 5 12
GO:0032991 protein-containing complex 1 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 11
GO:0043228 non-membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 11
GO:0043232 intracellular non-membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:1990904 ribonucleoprotein complex 2 12
GO:0005654 nucleoplasm 2 1
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex 4 1
GO:0005849 mRNA cleavage factor complex 3 1
GO:0140513 nuclear protein-containing complex 2 1

Expansion

Sequence features

A4I569
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I569

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006396 RNA processing 6 12
GO:0006397 mRNA processing 7 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0016071 mRNA metabolic process 6 12
GO:0031123 RNA 3'-end processing 7 12
GO:0031124 mRNA 3'-end processing 8 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0006378 mRNA polyadenylation 7 1
GO:0043631 RNA polyadenylation 6 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 383 387 PF00656 0.461
CLV_NRD_NRD_1 147 149 PF00675 0.355
CLV_NRD_NRD_1 188 190 PF00675 0.554
CLV_NRD_NRD_1 350 352 PF00675 0.551
CLV_NRD_NRD_1 43 45 PF00675 0.651
CLV_NRD_NRD_1 57 59 PF00675 0.481
CLV_NRD_NRD_1 8 10 PF00675 0.706
CLV_PCSK_KEX2_1 147 149 PF00082 0.355
CLV_PCSK_KEX2_1 188 190 PF00082 0.554
CLV_PCSK_KEX2_1 358 360 PF00082 0.525
CLV_PCSK_KEX2_1 42 44 PF00082 0.664
CLV_PCSK_KEX2_1 57 59 PF00082 0.486
CLV_PCSK_KEX2_1 7 9 PF00082 0.716
CLV_PCSK_PC1ET2_1 358 360 PF00082 0.525
CLV_PCSK_PC7_1 3 9 PF00082 0.694
CLV_PCSK_SKI1_1 147 151 PF00082 0.333
CLV_PCSK_SKI1_1 334 338 PF00082 0.324
CLV_PCSK_SKI1_1 358 362 PF00082 0.507
CLV_PCSK_SKI1_1 74 78 PF00082 0.420
DEG_APCC_DBOX_1 133 141 PF00400 0.372
DEG_APCC_DBOX_1 73 81 PF00400 0.454
DEG_Nend_UBRbox_2 1 3 PF02207 0.730
DOC_ANK_TNKS_1 327 334 PF00023 0.530
DOC_CKS1_1 133 138 PF01111 0.503
DOC_MAPK_gen_1 188 194 PF00069 0.506
DOC_PP1_RVXF_1 180 187 PF00149 0.336
DOC_PP1_RVXF_1 221 228 PF00149 0.339
DOC_PP1_RVXF_1 367 373 PF00149 0.343
DOC_PP1_RVXF_1 62 69 PF00149 0.454
DOC_PP4_FxxP_1 30 33 PF00568 0.710
DOC_PP4_FxxP_1 68 71 PF00568 0.521
DOC_USP7_MATH_1 258 262 PF00917 0.653
DOC_USP7_MATH_1 293 297 PF00917 0.458
DOC_USP7_MATH_1 374 378 PF00917 0.463
DOC_USP7_MATH_1 385 389 PF00917 0.309
DOC_USP7_UBL2_3 421 425 PF12436 0.590
DOC_WW_Pin1_4 132 137 PF00397 0.525
DOC_WW_Pin1_4 140 145 PF00397 0.474
DOC_WW_Pin1_4 432 437 PF00397 0.466
DOC_WW_Pin1_4 67 72 PF00397 0.473
DOC_WW_Pin1_4 82 87 PF00397 0.388
LIG_14-3-3_CanoR_1 148 158 PF00244 0.328
LIG_14-3-3_CanoR_1 351 355 PF00244 0.568
LIG_14-3-3_CanoR_1 43 51 PF00244 0.683
LIG_BRCT_BRCA1_1 26 30 PF00533 0.725
LIG_BRCT_BRCA1_1 376 380 PF00533 0.497
LIG_CSL_BTD_1 433 436 PF09270 0.476
LIG_deltaCOP1_diTrp_1 224 234 PF00928 0.353
LIG_eIF4E_1 96 102 PF01652 0.477
LIG_FHA_1 115 121 PF00498 0.221
LIG_FHA_1 246 252 PF00498 0.391
LIG_FHA_1 342 348 PF00498 0.495
LIG_FHA_1 362 368 PF00498 0.322
LIG_FHA_1 400 406 PF00498 0.673
LIG_FHA_1 76 82 PF00498 0.436
LIG_FHA_1 96 102 PF00498 0.233
LIG_FHA_2 351 357 PF00498 0.552
LIG_FHA_2 373 379 PF00498 0.505
LIG_FHA_2 381 387 PF00498 0.460
LIG_LIR_Apic_2 27 33 PF02991 0.706
LIG_LIR_Apic_2 67 71 PF02991 0.528
LIG_LIR_Gen_1 157 166 PF02991 0.323
LIG_LIR_Gen_1 207 215 PF02991 0.341
LIG_LIR_Nem_3 157 161 PF02991 0.304
LIG_LIR_Nem_3 224 230 PF02991 0.444
LIG_LIR_Nem_3 282 288 PF02991 0.433
LIG_LIR_Nem_3 388 394 PF02991 0.377
LIG_PDZ_Class_2 474 479 PF00595 0.568
LIG_Pex14_1 205 209 PF04695 0.353
LIG_Pex14_2 26 30 PF04695 0.569
LIG_Pex14_2 45 49 PF04695 0.701
LIG_PTB_Apo_2 205 212 PF02174 0.496
LIG_SH2_CRK 288 292 PF00017 0.477
LIG_SH2_STAP1 138 142 PF00017 0.449
LIG_SH2_STAP1 87 91 PF00017 0.539
LIG_SH2_STAP1 97 101 PF00017 0.362
LIG_SH2_STAT3 138 141 PF00017 0.471
LIG_SH2_STAT5 97 100 PF00017 0.466
LIG_SH3_2 38 43 PF14604 0.702
LIG_SH3_3 35 41 PF00018 0.682
LIG_TRAF2_1 458 461 PF00917 0.490
LIG_TYR_ITIM 389 394 PF00017 0.366
MOD_CDK_SPxxK_3 140 147 PF00069 0.468
MOD_CDK_SPxxK_3 67 74 PF00069 0.444
MOD_CK1_1 296 302 PF00069 0.367
MOD_CK1_1 310 316 PF00069 0.338
MOD_CK2_1 350 356 PF00069 0.551
MOD_CK2_1 441 447 PF00069 0.412
MOD_Cter_Amidation 145 148 PF01082 0.374
MOD_Cter_Amidation 186 189 PF01082 0.507
MOD_GlcNHglycan 144 147 PF01048 0.502
MOD_GlcNHglycan 194 197 PF01048 0.328
MOD_GlcNHglycan 240 244 PF01048 0.356
MOD_GlcNHglycan 26 29 PF01048 0.712
MOD_GlcNHglycan 337 340 PF01048 0.289
MOD_GlcNHglycan 443 446 PF01048 0.315
MOD_GSK3_1 100 107 PF00069 0.281
MOD_GSK3_1 110 117 PF00069 0.312
MOD_GSK3_1 210 217 PF00069 0.427
MOD_GSK3_1 254 261 PF00069 0.603
MOD_GSK3_1 318 325 PF00069 0.354
MOD_GSK3_1 337 344 PF00069 0.199
MOD_GSK3_1 81 88 PF00069 0.598
MOD_N-GLC_1 109 114 PF02516 0.451
MOD_N-GLC_1 120 125 PF02516 0.320
MOD_NEK2_1 149 154 PF00069 0.297
MOD_NEK2_1 204 209 PF00069 0.333
MOD_NEK2_1 291 296 PF00069 0.276
MOD_NEK2_1 379 384 PF00069 0.324
MOD_NEK2_1 441 446 PF00069 0.311
MOD_PIKK_1 114 120 PF00454 0.354
MOD_PIKK_1 293 299 PF00454 0.276
MOD_PIKK_1 318 324 PF00454 0.376
MOD_PIKK_1 350 356 PF00454 0.551
MOD_PKA_1 358 364 PF00069 0.538
MOD_PKA_2 310 316 PF00069 0.419
MOD_PKA_2 350 356 PF00069 0.554
MOD_PKA_2 358 364 PF00069 0.546
MOD_PKB_1 42 50 PF00069 0.705
MOD_Plk_1 120 126 PF00069 0.379
MOD_Plk_1 223 229 PF00069 0.346
MOD_Plk_4 385 391 PF00069 0.356
MOD_ProDKin_1 132 138 PF00069 0.519
MOD_ProDKin_1 140 146 PF00069 0.475
MOD_ProDKin_1 432 438 PF00069 0.323
MOD_ProDKin_1 67 73 PF00069 0.475
MOD_ProDKin_1 82 88 PF00069 0.385
MOD_SUMO_for_1 271 274 PF00179 0.397
MOD_SUMO_rev_2 165 173 PF00179 0.403
MOD_SUMO_rev_2 226 234 PF00179 0.433
MOD_SUMO_rev_2 269 273 PF00179 0.391
TRG_DiLeu_BaLyEn_6 145 150 PF01217 0.350
TRG_ENDOCYTIC_2 288 291 PF00928 0.340
TRG_ENDOCYTIC_2 391 394 PF00928 0.372
TRG_ER_diArg_1 147 149 PF00400 0.367
TRG_ER_diArg_1 41 44 PF00400 0.610
TRG_ER_diArg_1 56 58 PF00400 0.504
TRG_ER_diArg_1 6 9 PF00400 0.687
TRG_Pf-PMV_PEXEL_1 58 63 PF00026 0.653

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHN2 Leptomonas seymouri 23% 92%
A0A0N1PBX5 Leptomonas seymouri 90% 100%
A0A0S4J5T5 Bodo saltans 27% 89%
A0A0S4JFE0 Bodo saltans 56% 100%
A0A0S4KJ87 Bodo saltans 25% 80%
A0A1X0P2X5 Trypanosomatidae 64% 100%
A0A3Q8IE21 Leishmania donovani 98% 98%
A0A3Q8IGC4 Leishmania donovani 24% 92%
A0A3R7N6M9 Trypanosoma rangeli 23% 92%
A0A3R7NRU0 Trypanosoma rangeli 63% 100%
A4HHZ2 Leishmania braziliensis 93% 100%
A4I135 Leishmania infantum 24% 100%
B5X212 Salmo salar 22% 100%
B8AP31 Oryza sativa subsp. indica 24% 100%
C9ZQJ5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 100%
C9ZW72 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 78%
E9AX72 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9B0G6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
G0SC29 Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) 23% 93%
O60907 Homo sapiens 21% 83%
O76071 Homo sapiens 23% 100%
P0CS46 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 27% 67%
P0CS47 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 27% 67%
P42841 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 100%
P49177 Arabidopsis thaliana 25% 100%
P49178 Zea mays 23% 100%
Q28DW0 Xenopus tropicalis 24% 100%
Q28I85 Xenopus tropicalis 23% 100%
Q2TZG4 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 31% 79%
Q32PJ6 Bos taurus 22% 100%
Q40687 Oryza sativa subsp. japonica 24% 100%
Q4I7X1 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 27% 78%
Q4Q7R7 Leishmania major 99% 99%
Q4QAA4 Leishmania major 24% 100%
Q4R8H1 Macaca fascicularis 21% 84%
Q4V8C4 Rattus norvegicus 22% 100%
Q4X1Y0 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 29% 94%
Q54KL5 Dictyostelium discoideum 23% 100%
Q55DA2 Dictyostelium discoideum 21% 100%
Q58D20 Bos taurus 24% 99%
Q59WJ4 Candida albicans (strain SC5314 / ATCC MYA-2876) 29% 88%
Q5AZX0 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 28% 84%
Q5DFU0 Schistosoma japonicum 24% 100%
Q5M7T1 Rattus norvegicus 22% 100%
Q5RD06 Pongo abelii 22% 100%
Q5RE95 Pongo abelii 22% 100%
Q5RFF8 Pongo abelii 24% 99%
Q6BVZ3 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 28% 95%
Q6CGP9 Yarrowia lipolytica (strain CLIB 122 / E 150) 27% 90%
Q6CP71 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 31% 100%
Q6FJS0 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 29% 100%
Q6NLV4 Arabidopsis thaliana 33% 74%
Q75AV4 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 27% 100%
Q7RY68 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 29% 73%
Q7T0P4 Xenopus laevis 23% 100%
Q86VZ2 Homo sapiens 22% 100%
Q8VEJ4 Mus musculus 24% 99%
Q95RJ9 Drosophila melanogaster 25% 68%
Q99KN2 Mus musculus 23% 100%
Q9D7H2 Mus musculus 22% 100%
Q9FLX9 Arabidopsis thaliana 22% 100%
Q9FN19 Arabidopsis thaliana 22% 78%
Q9NVX2 Homo sapiens 24% 99%
Q9QXE7 Mus musculus 22% 91%
Q9UTN4 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 94%
Q9V3J8 Drosophila melanogaster 25% 100%
V5BEB2 Trypanosoma cruzi 24% 89%
V5DD51 Trypanosoma cruzi 64% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS