Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family/X-Pro dipeptidyl-peptidase (S15 family) - putative

Species:

Leishmania infantum

UniProt:

A4I567_LEIIN

TriTrypDb:

LINF_300009000

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I567

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I567

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.373
CLV_C14_Caspase3-7	16	20	PF00656	0.371
CLV_C14_Caspase3-7	231	235	PF00656	0.412
CLV_C14_Caspase3-7	3	7	PF00656	0.604
CLV_C14_Caspase3-7	484	488	PF00656	0.555
CLV_NRD_NRD_1	218	220	PF00675	0.377
CLV_NRD_NRD_1	79	81	PF00675	0.355
CLV_PCSK_KEX2_1	220	222	PF00082	0.436
CLV_PCSK_KEX2_1	224	226	PF00082	0.390
CLV_PCSK_KEX2_1	79	81	PF00082	0.355
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.436
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.390
CLV_PCSK_SKI1_1	221	225	PF00082	0.383
CLV_PCSK_SKI1_1	237	241	PF00082	0.384
CLV_PCSK_SKI1_1	266	270	PF00082	0.474
CLV_PCSK_SKI1_1	295	299	PF00082	0.454
DEG_APCC_DBOX_1	132	140	PF00400	0.312
DEG_Nend_Nbox_1	1	3	PF02207	0.587
DEG_SCF_FBW7_1	441	448	PF00400	0.640
DEG_SPOP_SBC_1	378	382	PF00917	0.671
DEG_SPOP_SBC_1	389	393	PF00917	0.691
DOC_CKS1_1	276	281	PF01111	0.496
DOC_CYCLIN_RxL_1	310	323	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	353	356	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	399	405	PF00134	0.622
DOC_MAPK_DCC_7	201	211	PF00069	0.353
DOC_MAPK_DCC_7	240	249	PF00069	0.410
DOC_MAPK_gen_1	201	211	PF00069	0.409
DOC_MAPK_MEF2A_6	204	211	PF00069	0.353
DOC_MAPK_MEF2A_6	240	249	PF00069	0.410
DOC_MAPK_MEF2A_6	286	294	PF00069	0.444
DOC_MAPK_MEF2A_6	295	302	PF00069	0.402
DOC_MAPK_NFAT4_5	295	303	PF00069	0.400
DOC_PP1_RVXF_1	62	69	PF00149	0.420
DOC_PP2B_LxvP_1	353	356	PF13499	0.614
DOC_PP2B_LxvP_1	399	402	PF13499	0.592
DOC_PP2B_LxvP_1	405	408	PF13499	0.586
DOC_PP2B_PxIxI_1	206	212	PF00149	0.353
DOC_PP4_FxxP_1	256	259	PF00568	0.431
DOC_PP4_FxxP_1	269	272	PF00568	0.462
DOC_USP7_MATH_1	183	187	PF00917	0.409
DOC_USP7_MATH_1	376	380	PF00917	0.699
DOC_USP7_MATH_1	385	389	PF00917	0.600
DOC_USP7_MATH_1	445	449	PF00917	0.637
DOC_USP7_MATH_1	454	458	PF00917	0.692
DOC_USP7_MATH_1	482	486	PF00917	0.562
DOC_USP7_UBL2_3	220	224	PF12436	0.371
DOC_WW_Pin1_4	179	184	PF00397	0.312
DOC_WW_Pin1_4	255	260	PF00397	0.523
DOC_WW_Pin1_4	275	280	PF00397	0.308
DOC_WW_Pin1_4	322	327	PF00397	0.609
DOC_WW_Pin1_4	381	386	PF00397	0.611
DOC_WW_Pin1_4	407	412	PF00397	0.622
DOC_WW_Pin1_4	423	428	PF00397	0.581
DOC_WW_Pin1_4	441	446	PF00397	0.646
DOC_WW_Pin1_4	477	482	PF00397	0.556
LIG_14-3-3_CanoR_1	27	35	PF00244	0.501
LIG_14-3-3_CanoR_1	453	463	PF00244	0.642
LIG_14-3-3_CanoR_1	67	73	PF00244	0.375
LIG_AP2alpha_2	172	174	PF02296	0.349
LIG_BIR_III_2	267	271	PF00653	0.479
LIG_BRCT_BRCA1_1	126	130	PF00533	0.312
LIG_BRCT_BRCA1_1	391	395	PF00533	0.659
LIG_Clathr_ClatBox_1	110	114	PF01394	0.312
LIG_CtBP_PxDLS_1	440	444	PF00389	0.551
LIG_eIF4E_1	131	137	PF01652	0.409
LIG_FHA_1	200	206	PF00498	0.476
LIG_FHA_1	30	36	PF00498	0.446
LIG_FHA_1	364	370	PF00498	0.632
LIG_FHA_1	458	464	PF00498	0.595
LIG_FHA_1	484	490	PF00498	0.572
LIG_FHA_2	258	264	PF00498	0.401
LIG_FHA_2	391	397	PF00498	0.655
LIG_LIR_Apic_2	253	259	PF02991	0.444
LIG_LIR_Apic_2	267	272	PF02991	0.454
LIG_LIR_Gen_1	106	115	PF02991	0.404
LIG_LIR_Gen_1	122	131	PF02991	0.244
LIG_LIR_Gen_1	141	150	PF02991	0.312
LIG_LIR_Gen_1	181	191	PF02991	0.312
LIG_LIR_Nem_3	106	111	PF02991	0.428
LIG_LIR_Nem_3	122	128	PF02991	0.244
LIG_LIR_Nem_3	141	145	PF02991	0.312
LIG_LIR_Nem_3	181	187	PF02991	0.312
LIG_LIR_Nem_3	71	76	PF02991	0.398
LIG_MYND_1	441	445	PF01753	0.554
LIG_Pex14_1	72	76	PF04695	0.438
LIG_Pex14_2	111	115	PF04695	0.373
LIG_Pex14_2	68	72	PF04695	0.387
LIG_PTAP_UEV_1	341	346	PF05743	0.503
LIG_SH2_PTP2	125	128	PF00017	0.373
LIG_SH2_STAT3	131	134	PF00017	0.312
LIG_SH2_STAT5	125	128	PF00017	0.360
LIG_SH2_STAT5	301	304	PF00017	0.362
LIG_SH2_STAT5	86	89	PF00017	0.325
LIG_SH3_3	339	345	PF00018	0.679
LIG_SH3_3	405	411	PF00018	0.670
LIG_SH3_3	472	478	PF00018	0.555
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.409
LIG_SUMO_SIM_par_1	135	141	PF11976	0.409
LIG_WW_3	27	31	PF00397	0.404
MOD_CDK_SPxK_1	441	447	PF00069	0.561
MOD_CDK_SPxxK_3	407	414	PF00069	0.657
MOD_CDK_SPxxK_3	423	430	PF00069	0.558
MOD_CK1_1	118	124	PF00069	0.312
MOD_CK1_1	13	19	PF00069	0.486
MOD_CK1_1	340	346	PF00069	0.726
MOD_CK1_1	370	376	PF00069	0.606
MOD_CK1_1	379	385	PF00069	0.652
MOD_CK1_1	388	394	PF00069	0.716
MOD_CK1_1	422	428	PF00069	0.602
MOD_CK1_1	449	455	PF00069	0.639
MOD_CK1_1	457	463	PF00069	0.738
MOD_CK1_1	471	477	PF00069	0.539
MOD_CK2_1	118	124	PF00069	0.312
MOD_CK2_1	257	263	PF00069	0.394
MOD_CK2_1	28	34	PF00069	0.487
MOD_GlcNHglycan	117	120	PF01048	0.319
MOD_GlcNHglycan	12	15	PF01048	0.430
MOD_GlcNHglycan	2	5	PF01048	0.543
MOD_GlcNHglycan	342	345	PF01048	0.716
MOD_GlcNHglycan	374	377	PF01048	0.661
MOD_GlcNHglycan	387	390	PF01048	0.604
MOD_GlcNHglycan	449	452	PF01048	0.581
MOD_GlcNHglycan	456	459	PF01048	0.548
MOD_GlcNHglycan	470	473	PF01048	0.512
MOD_GSK3_1	179	186	PF00069	0.373
MOD_GSK3_1	363	370	PF00069	0.650
MOD_GSK3_1	372	379	PF00069	0.678
MOD_GSK3_1	380	387	PF00069	0.691
MOD_GSK3_1	390	397	PF00069	0.516
MOD_GSK3_1	403	410	PF00069	0.495
MOD_GSK3_1	419	426	PF00069	0.599
MOD_GSK3_1	431	438	PF00069	0.783
MOD_GSK3_1	441	448	PF00069	0.556
MOD_GSK3_1	467	474	PF00069	0.630
MOD_GSK3_1	68	75	PF00069	0.270
MOD_GSK3_1	9	16	PF00069	0.517
MOD_N-GLC_1	490	495	PF02516	0.551
MOD_NEK2_1	115	120	PF00069	0.317
MOD_NEK2_1	17	22	PF00069	0.416
MOD_NEK2_1	320	325	PF00069	0.554
MOD_NEK2_1	368	373	PF00069	0.636
MOD_NEK2_1	395	400	PF00069	0.606
MOD_NEK2_1	435	440	PF00069	0.564
MOD_NEK2_1	446	451	PF00069	0.517
MOD_NEK2_1	68	73	PF00069	0.386
MOD_NEK2_1	9	14	PF00069	0.576
MOD_NEK2_2	183	188	PF00069	0.373
MOD_PKA_2	29	35	PF00069	0.502
MOD_PKA_2	340	346	PF00069	0.597
MOD_PKA_2	422	428	PF00069	0.581
MOD_PKA_2	446	452	PF00069	0.671
MOD_Plk_1	395	401	PF00069	0.645
MOD_Plk_4	13	19	PF00069	0.486
MOD_Plk_4	68	74	PF00069	0.359
MOD_ProDKin_1	179	185	PF00069	0.312
MOD_ProDKin_1	255	261	PF00069	0.517
MOD_ProDKin_1	275	281	PF00069	0.307
MOD_ProDKin_1	322	328	PF00069	0.611
MOD_ProDKin_1	381	387	PF00069	0.612
MOD_ProDKin_1	407	413	PF00069	0.617
MOD_ProDKin_1	423	429	PF00069	0.581
MOD_ProDKin_1	441	447	PF00069	0.649
MOD_ProDKin_1	477	483	PF00069	0.557
TRG_DiLeu_BaEn_1	132	137	PF01217	0.409
TRG_DiLeu_BaEn_1	99	104	PF01217	0.349
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.312
TRG_ENDOCYTIC_2	125	128	PF00928	0.373
TRG_ENDOCYTIC_2	95	98	PF00928	0.312
TRG_ER_diArg_1	218	221	PF00400	0.380
TRG_ER_diArg_1	79	81	PF00400	0.357
TRG_NES_CRM1_1	134	149	PF08389	0.373
TRG_NES_CRM1_1	288	304	PF08389	0.426
TRG_NES_CRM1_1	99	114	PF08389	0.312
TRG_NLS_MonoExtN_4	217	223	PF00514	0.378
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRJ3	Leptomonas seymouri	68%	100%
A0A1X0P2B9	Trypanosomatidae	54%	100%
A0A3S5H7M3	Leishmania donovani	99%	100%
A4HHZ0	Leishmania braziliensis	86%	100%
E9B0G4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q7R9	Leishmania major	93%	100%