Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I566_LEIIN

TriTrypDb:

LINF_300008900

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4I566

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I566

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.719
CLV_C14_Caspase3-7	220	224	PF00656	0.678
CLV_C14_Caspase3-7	65	69	PF00656	0.477
CLV_NRD_NRD_1	242	244	PF00675	0.497
CLV_NRD_NRD_1	246	248	PF00675	0.463
CLV_PCSK_KEX2_1	242	244	PF00082	0.497
CLV_PCSK_SKI1_1	16	20	PF00082	0.403
DEG_APCC_DBOX_1	15	23	PF00400	0.499
DEG_Kelch_Keap1_1	145	150	PF01344	0.693
DEG_Nend_Nbox_1	1	3	PF02207	0.643
DEG_SCF_FBW7_1	215	222	PF00400	0.704
DEG_SCF_TRCP1_1	68	74	PF00400	0.508
DEG_SPOP_SBC_1	45	49	PF00917	0.423
DOC_CKS1_1	161	166	PF01111	0.719
DOC_CYCLIN_yClb5_NLxxxL_5	4	13	PF00134	0.529
DOC_MAPK_MEF2A_6	11	19	PF00069	0.594
DOC_MAPK_MEF2A_6	95	103	PF00069	0.320
DOC_PP2B_LxvP_1	211	214	PF13499	0.684
DOC_PP4_FxxP_1	212	215	PF00568	0.709
DOC_PP4_MxPP_1	169	172	PF00568	0.690
DOC_USP7_MATH_1	45	49	PF00917	0.439
DOC_WW_Pin1_4	160	165	PF00397	0.734
DOC_WW_Pin1_4	2	7	PF00397	0.619
DOC_WW_Pin1_4	215	220	PF00397	0.700
DOC_WW_Pin1_4	46	51	PF00397	0.424
DOC_WW_Pin1_4	71	76	PF00397	0.536
LIG_14-3-3_CanoR_1	235	239	PF00244	0.772
LIG_Actin_WH2_2	5	22	PF00022	0.595
LIG_BRCT_BRCA1_1	206	210	PF00533	0.796
LIG_DCNL_PONY_1	1	4	PF03556	0.634
LIG_deltaCOP1_diTrp_1	85	96	PF00928	0.437
LIG_FHA_1	132	138	PF00498	0.726
LIG_FHA_1	177	183	PF00498	0.781
LIG_FHA_2	126	132	PF00498	0.752
LIG_FHA_2	63	69	PF00498	0.442
LIG_LIR_Apic_2	209	215	PF02991	0.714
LIG_LIR_Gen_1	207	215	PF02991	0.794
LIG_LIR_Gen_1	86	97	PF02991	0.453
LIG_LIR_Nem_3	122	126	PF02991	0.654
LIG_LIR_Nem_3	207	213	PF02991	0.799
LIG_LIR_Nem_3	86	92	PF02991	0.501
LIG_LIR_Nem_3	93	99	PF02991	0.374
LIG_NRBOX	8	14	PF00104	0.552
LIG_NRP_CendR_1	247	250	PF00754	0.478
LIG_Pex14_2	96	100	PF04695	0.442
LIG_SH2_CRK	161	165	PF00017	0.663
LIG_SH2_STAT5	119	122	PF00017	0.689
LIG_SH3_1	167	173	PF00018	0.682
LIG_SH3_3	167	173	PF00018	0.779
LIG_SH3_3	72	78	PF00018	0.530
LIG_SUMO_SIM_par_1	33	38	PF11976	0.385
LIG_TRAF2_1	183	186	PF00917	0.788
MOD_CDK_SPK_2	160	165	PF00069	0.644
MOD_CDK_SPxxK_3	160	167	PF00069	0.644
MOD_CK1_1	129	135	PF00069	0.636
MOD_CK1_1	136	142	PF00069	0.611
MOD_CK1_1	143	149	PF00069	0.545
MOD_CK1_1	151	157	PF00069	0.532
MOD_CK1_1	204	210	PF00069	0.662
MOD_CK1_1	234	240	PF00069	0.600
MOD_CK1_1	38	44	PF00069	0.592
MOD_CK1_1	48	54	PF00069	0.546
MOD_CK1_1	58	64	PF00069	0.462
MOD_CK1_1	66	72	PF00069	0.526
MOD_CK1_1	76	82	PF00069	0.533
MOD_CK2_1	129	135	PF00069	0.673
MOD_CK2_1	144	150	PF00069	0.542
MOD_CK2_1	151	157	PF00069	0.630
MOD_GlcNHglycan	147	150	PF01048	0.675
MOD_GlcNHglycan	154	157	PF01048	0.602
MOD_GlcNHglycan	37	40	PF01048	0.537
MOD_GlcNHglycan	55	58	PF01048	0.525
MOD_GlcNHglycan	68	71	PF01048	0.651
MOD_GSK3_1	125	132	PF00069	0.610
MOD_GSK3_1	136	143	PF00069	0.574
MOD_GSK3_1	144	151	PF00069	0.499
MOD_GSK3_1	201	208	PF00069	0.666
MOD_GSK3_1	215	222	PF00069	0.649
MOD_GSK3_1	234	241	PF00069	0.777
MOD_GSK3_1	35	42	PF00069	0.664
MOD_GSK3_1	44	51	PF00069	0.616
MOD_GSK3_1	58	65	PF00069	0.505
MOD_N-GLC_1	204	209	PF02516	0.663
MOD_N-GLC_1	7	12	PF02516	0.391
MOD_N-GLC_1	90	95	PF02516	0.506
MOD_NEK2_1	238	243	PF00069	0.603
MOD_NEK2_1	44	49	PF00069	0.677
MOD_NEK2_2	90	95	PF00069	0.451
MOD_PIKK_1	140	146	PF00454	0.635
MOD_PIKK_1	199	205	PF00454	0.659
MOD_PKA_2	139	145	PF00069	0.666
MOD_PKA_2	234	240	PF00069	0.644
MOD_Plk_1	63	69	PF00069	0.594
MOD_Plk_1	7	13	PF00069	0.372
MOD_Plk_1	90	96	PF00069	0.645
MOD_ProDKin_1	160	166	PF00069	0.669
MOD_ProDKin_1	2	8	PF00069	0.501
MOD_ProDKin_1	215	221	PF00069	0.624
MOD_ProDKin_1	46	52	PF00069	0.514
MOD_ProDKin_1	71	77	PF00069	0.668
TRG_DiLeu_BaEn_2	205	211	PF01217	0.620
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.492
TRG_ENDOCYTIC_2	123	126	PF00928	0.579
TRG_ER_diArg_1	164	167	PF00400	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X330	Leishmania donovani	98%	100%
A4HHY6	Leishmania braziliensis	64%	100%
E9B0G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q7S0	Leishmania major	84%	100%