LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative phosphatase 2C

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative phosphatase 2C
Gene product:
phosphatase 2C - putative
Species:
Leishmania infantum
UniProt:
A4I565_LEIIN
TriTrypDb:
LINF_300008800
Length:
384

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Annotations by Jardim et al.

Phosphatase, phosphatase 2C

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 1
Forrest at al. (metacyclic) no yes: 1
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 1
Pissara et al. yes yes: 7
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 24
NetGPI no yes: 0, no: 24
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 2
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0110165 cellular anatomical entity 1 2
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I565
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I565

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 4
GO:0006793 phosphorus metabolic process 3 4
GO:0006796 phosphate-containing compound metabolic process 4 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0008152 metabolic process 1 4
GO:0009987 cellular process 1 4
GO:0016311 dephosphorylation 5 4
GO:0019538 protein metabolic process 3 4
GO:0035970 peptidyl-threonine dephosphorylation 6 2
GO:0036211 protein modification process 4 4
GO:0043170 macromolecule metabolic process 3 4
GO:0043412 macromolecule modification 4 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0071704 organic substance metabolic process 2 4
GO:1901564 organonitrogen compound metabolic process 3 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 25
GO:0004721 phosphoprotein phosphatase activity 3 25
GO:0004722 protein serine/threonine phosphatase activity 4 25
GO:0016787 hydrolase activity 2 25
GO:0016788 hydrolase activity, acting on ester bonds 3 25
GO:0016791 phosphatase activity 5 25
GO:0017018 myosin phosphatase activity 5 11
GO:0042578 phosphoric ester hydrolase activity 4 25
GO:0140096 catalytic activity, acting on a protein 2 25
GO:0005488 binding 1 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 115 117 PF00675 0.371
CLV_PCSK_SKI1_1 117 121 PF00082 0.347
CLV_PCSK_SKI1_1 138 142 PF00082 0.233
CLV_PCSK_SKI1_1 343 347 PF00082 0.408
CLV_PCSK_SKI1_1 371 375 PF00082 0.465
CLV_PCSK_SKI1_1 7 11 PF00082 0.280
DOC_MAPK_DCC_7 196 205 PF00069 0.371
DOC_MAPK_gen_1 116 123 PF00069 0.244
DOC_MAPK_gen_1 190 200 PF00069 0.371
DOC_MAPK_MEF2A_6 116 123 PF00069 0.275
DOC_MAPK_MEF2A_6 196 205 PF00069 0.371
DOC_PP1_RVXF_1 136 142 PF00149 0.248
DOC_PP2B_LxvP_1 3 6 PF13499 0.482
DOC_USP7_MATH_1 17 21 PF00917 0.359
DOC_USP7_MATH_1 201 205 PF00917 0.370
DOC_USP7_MATH_1 25 29 PF00917 0.289
DOC_USP7_MATH_1 62 66 PF00917 0.372
LIG_14-3-3_CanoR_1 16 22 PF00244 0.300
LIG_14-3-3_CanoR_1 33 37 PF00244 0.233
LIG_BRCT_BRCA1_1 175 179 PF00533 0.238
LIG_deltaCOP1_diTrp_1 355 361 PF00928 0.365
LIG_FHA_1 109 115 PF00498 0.247
LIG_FHA_1 118 124 PF00498 0.231
LIG_FHA_1 152 158 PF00498 0.331
LIG_FHA_1 284 290 PF00498 0.457
LIG_FHA_2 342 348 PF00498 0.414
LIG_LIR_Gen_1 109 119 PF02991 0.255
LIG_LIR_Gen_1 212 221 PF02991 0.305
LIG_LIR_Gen_1 322 330 PF02991 0.314
LIG_LIR_Gen_1 355 366 PF02991 0.383
LIG_LIR_Gen_1 372 378 PF02991 0.366
LIG_LIR_LC3C_4 267 271 PF02991 0.214
LIG_LIR_Nem_3 109 115 PF02991 0.265
LIG_LIR_Nem_3 212 216 PF02991 0.305
LIG_LIR_Nem_3 322 327 PF02991 0.314
LIG_LIR_Nem_3 355 361 PF02991 0.382
LIG_LIR_Nem_3 372 377 PF02991 0.357
LIG_LIR_Nem_3 49 55 PF02991 0.349
LIG_Pex14_2 222 226 PF04695 0.229
LIG_REV1ctd_RIR_1 358 364 PF16727 0.401
LIG_SH2_CRK 324 328 PF00017 0.293
LIG_SH2_SRC 149 152 PF00017 0.169
LIG_SH2_STAP1 305 309 PF00017 0.330
LIG_SH2_STAT3 192 195 PF00017 0.285
LIG_SH2_STAT5 149 152 PF00017 0.197
LIG_SH2_STAT5 52 55 PF00017 0.291
LIG_SH2_STAT5 67 70 PF00017 0.246
LIG_SH3_3 145 151 PF00018 0.323
LIG_SH3_3 286 292 PF00018 0.303
LIG_SUMO_SIM_anti_2 202 207 PF11976 0.197
LIG_SUMO_SIM_anti_2 244 250 PF11976 0.273
LIG_SUMO_SIM_par_1 196 202 PF11976 0.236
LIG_TYR_ITIM 50 55 PF00017 0.371
LIG_WRC_WIRS_1 280 285 PF05994 0.246
MOD_CK1_1 163 169 PF00069 0.371
MOD_CK2_1 341 347 PF00069 0.415
MOD_CK2_1 369 375 PF00069 0.413
MOD_CK2_1 57 63 PF00069 0.432
MOD_GlcNHglycan 63 67 PF01048 0.313
MOD_GSK3_1 101 108 PF00069 0.400
MOD_GSK3_1 275 282 PF00069 0.329
MOD_GSK3_1 377 384 PF00069 0.589
MOD_N-GLC_1 224 229 PF02516 0.285
MOD_N-GLC_1 264 269 PF02516 0.275
MOD_NEK2_1 119 124 PF00069 0.371
MOD_NEK2_1 173 178 PF00069 0.258
MOD_NEK2_1 283 288 PF00069 0.472
MOD_NEK2_1 311 316 PF00069 0.382
MOD_NEK2_1 377 382 PF00069 0.485
MOD_NEK2_2 180 185 PF00069 0.241
MOD_PIKK_1 25 31 PF00454 0.361
MOD_PIKK_1 334 340 PF00454 0.286
MOD_PKA_2 32 38 PF00069 0.258
MOD_Plk_1 117 123 PF00069 0.213
MOD_Plk_1 180 186 PF00069 0.250
MOD_Plk_1 201 207 PF00069 0.275
MOD_Plk_1 264 270 PF00069 0.275
MOD_Plk_1 356 362 PF00069 0.502
MOD_Plk_1 369 375 PF00069 0.376
MOD_Plk_1 62 68 PF00069 0.349
MOD_Plk_4 160 166 PF00069 0.373
MOD_Plk_4 17 23 PF00069 0.330
MOD_Plk_4 201 207 PF00069 0.387
MOD_Plk_4 284 290 PF00069 0.351
MOD_Plk_4 369 375 PF00069 0.429
MOD_SUMO_rev_2 144 148 PF00179 0.264
TRG_DiLeu_BaEn_2 208 214 PF01217 0.180
TRG_ENDOCYTIC_2 305 308 PF00928 0.306
TRG_ENDOCYTIC_2 324 327 PF00928 0.280
TRG_ENDOCYTIC_2 52 55 PF00928 0.371
TRG_NES_CRM1_1 81 97 PF08389 0.357
TRG_Pf-PMV_PEXEL_1 70 74 PF00026 0.393
TRG_Pf-PMV_PEXEL_1 77 81 PF00026 0.345

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5C7 Leptomonas seymouri 32% 97%
A0A0N1I8W9 Leptomonas seymouri 28% 88%
A0A0N1IHU6 Leptomonas seymouri 44% 94%
A0A0N1PAL8 Leptomonas seymouri 87% 100%
A0A0N1PEL9 Leptomonas seymouri 30% 100%
A0A0S4IY95 Bodo saltans 32% 100%
A0A0S4J0A6 Bodo saltans 41% 94%
A0A0S4J8Y7 Bodo saltans 33% 74%
A0A0S4JHB4 Bodo saltans 54% 100%
A0A0S4JPC3 Bodo saltans 33% 100%
A0A0S4JPM8 Bodo saltans 33% 100%
A0A1X0NRG3 Trypanosomatidae 31% 100%
A0A1X0NUB7 Trypanosomatidae 32% 80%
A0A1X0NVC4 Trypanosomatidae 33% 93%
A0A1X0P2A0 Trypanosomatidae 57% 100%
A0A1X0P568 Trypanosomatidae 40% 94%
A0A1X0P991 Trypanosomatidae 33% 100%
A0A1X0PAN4 Trypanosomatidae 31% 100%
A0A3Q8IEK6 Leishmania donovani 35% 100%
A0A3Q8IFG7 Leishmania donovani 100% 100%
A0A3Q8IGS1 Leishmania donovani 31% 68%
A0A3Q8IK65 Leishmania donovani 37% 100%
A0A3Q8IL63 Leishmania donovani 30% 98%
A0A3S7WTA2 Leishmania donovani 31% 95%
A0A3S7WZ14 Leishmania donovani 45% 95%
A0A3S7X808 Leishmania donovani 29% 85%
A0A422N8D7 Trypanosoma rangeli 28% 100%
A0A422NAJ1 Trypanosoma rangeli 31% 100%
A0A422NBV9 Trypanosoma rangeli 41% 94%
A0A422NL94 Trypanosoma rangeli 31% 88%
A0A422NML6 Trypanosoma rangeli 56% 100%
A0A422NS77 Trypanosoma rangeli 35% 93%
A0A422P293 Trypanosoma rangeli 33% 100%
A0CUB5 Paramecium tetraurelia 29% 100%
A0DSB3 Paramecium tetraurelia 30% 100%
A0DTY1 Paramecium tetraurelia 30% 100%
A3A8W2 Oryza sativa subsp. japonica 29% 100%
A3A8W6 Oryza sativa subsp. japonica 24% 66%
A3CCP9 Oryza sativa subsp. japonica 26% 77%
A4H7Y6 Leishmania braziliensis 33% 100%
A4HAW5 Leishmania braziliensis 32% 100%
A4HAW6 Leishmania braziliensis 29% 85%
A4HE10 Leishmania braziliensis 44% 100%
A4HG10 Leishmania braziliensis 34% 100%
A4HHY5 Leishmania braziliensis 92% 100%
A4HKF6 Leishmania braziliensis 30% 68%
A4HNR1 Leishmania braziliensis 36% 100%
A4HWB4 Leishmania infantum 31% 100%
A4I1B7 Leishmania infantum 45% 100%
A4I329 Leishmania infantum 35% 100%
A4I7Y4 Leishmania infantum 31% 68%
A4IA25 Leishmania infantum 30% 98%
A4IA26 Leishmania infantum 28% 85%
A4ICT4 Leishmania infantum 37% 100%
A5PJZ2 Bos taurus 32% 100%
C9ZJK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZMJ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
C9ZNW4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 90%
C9ZQJ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
D0A2L9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
D0A5L0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 94%
D0AA51 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 90%
E9ACV0 Leishmania major 34% 100%
E9AQ14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9ASH0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9AXF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9AZD9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B0G2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9B2U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 68%
E9B540 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B541 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
O04719 Arabidopsis thaliana 31% 91%
O62829 Bos taurus 34% 100%
O62830 Bos taurus 33% 79%
O75688 Homo sapiens 32% 80%
O80492 Arabidopsis thaliana 28% 90%
O80871 Arabidopsis thaliana 27% 97%
P20650 Rattus norvegicus 34% 100%
P34221 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 82%
P35182 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
P35813 Homo sapiens 34% 100%
P35814 Oryctolagus cuniculus 34% 100%
P35815 Rattus norvegicus 32% 98%
P36982 Leishmania chagasi 45% 95%
P36993 Mus musculus 32% 98%
P38089 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 98%
P40371 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 100%
P49443 Mus musculus 34% 100%
P49593 Homo sapiens 28% 85%
P49596 Caenorhabditis elegans 33% 100%
P49597 Arabidopsis thaliana 29% 88%
P49599 Arabidopsis thaliana 29% 99%
P93006 Arabidopsis thaliana 28% 100%
Q0DBU3 Oryza sativa subsp. japonica 31% 100%
Q0IIF0 Bos taurus 32% 100%
Q0J2L7 Oryza sativa subsp. japonica 33% 100%
Q0J2R1 Oryza sativa subsp. japonica 33% 100%
Q0JL75 Oryza sativa subsp. japonica 32% 100%
Q0JLP9 Oryza sativa subsp. japonica 29% 82%
Q10MN6 Oryza sativa subsp. japonica 27% 89%
Q10MX1 Oryza sativa subsp. japonica 30% 98%
Q19775 Caenorhabditis elegans 32% 82%
Q2PC20 Bos taurus 32% 100%
Q2QWE3 Oryza sativa subsp. japonica 27% 91%
Q2R637 Oryza sativa subsp. japonica 27% 89%
Q3EAF9 Arabidopsis thaliana 28% 100%
Q4PSE8 Arabidopsis thaliana 36% 86%
Q4Q225 Leishmania major 37% 100%
Q4Q2U5 Leishmania major 28% 85%
Q4Q2U6 Leishmania major 30% 100%
Q4Q5B1 Leishmania major 31% 68%
Q4Q7S1 Leishmania major 98% 100%
Q4QA19 Leishmania major 45% 100%
Q4QFG7 Leishmania major 32% 100%
Q53Q11 Oryza sativa subsp. japonica 30% 97%
Q5JKN1 Oryza sativa subsp. japonica 29% 99%
Q5N9N2 Oryza sativa subsp. japonica 31% 93%
Q5SGD2 Homo sapiens 34% 100%
Q5SMK6 Oryza sativa subsp. japonica 27% 100%
Q5Z6F5 Oryza sativa subsp. japonica 35% 100%
Q652Z7 Oryza sativa subsp. japonica 31% 100%
Q653S3 Oryza sativa subsp. japonica 28% 100%
Q65XK7 Oryza sativa subsp. japonica 27% 100%
Q67J17 Oryza sativa subsp. japonica 24% 91%
Q67UX7 Oryza sativa subsp. japonica 34% 100%
Q69QZ0 Oryza sativa subsp. japonica 29% 100%
Q69VD9 Oryza sativa subsp. japonica 28% 100%
Q6AUQ4 Oryza sativa subsp. japonica 28% 99%
Q6EN45 Oryza sativa subsp. japonica 33% 100%
Q6ING9 Xenopus laevis 29% 100%
Q6K1U4 Oryza sativa subsp. japonica 25% 74%
Q6K5I0 Oryza sativa subsp. japonica 24% 74%
Q6L4R7 Oryza sativa subsp. japonica 28% 86%
Q6L5C4 Oryza sativa subsp. japonica 32% 78%
Q6L5H6 Oryza sativa subsp. japonica 29% 99%
Q6YTI2 Oryza sativa subsp. japonica 24% 87%
Q6ZKL8 Oryza sativa subsp. japonica 25% 72%
Q7XJ53 Arabidopsis thaliana 25% 100%
Q7XR06 Oryza sativa subsp. japonica 32% 100%
Q7XU84 Oryza sativa subsp. japonica 30% 100%
Q8BGL1 Mus musculus 32% 95%
Q8BHN0 Mus musculus 34% 100%
Q8BXN7 Mus musculus 32% 100%
Q8CGA0 Mus musculus 29% 85%
Q8LAY8 Arabidopsis thaliana 37% 100%
Q8N3J5 Homo sapiens 32% 100%
Q8N819 Homo sapiens 33% 89%
Q8R0F6 Mus musculus 31% 98%
Q8RX37 Arabidopsis thaliana 28% 100%
Q8RXV3 Arabidopsis thaliana 35% 100%
Q8VZN9 Arabidopsis thaliana 34% 100%
Q93YS2 Arabidopsis thaliana 27% 73%
Q94AT1 Arabidopsis thaliana 32% 91%
Q9CAJ0 Arabidopsis thaliana 26% 75%
Q9FX08 Arabidopsis thaliana 25% 90%
Q9FYN7 Oryza sativa subsp. japonica 28% 100%
Q9H0C8 Homo sapiens 32% 98%
Q9LME4 Arabidopsis thaliana 30% 100%
Q9LMT1 Arabidopsis thaliana 30% 100%
Q9LNF4 Arabidopsis thaliana 27% 100%
Q9LNP9 Arabidopsis thaliana 28% 75%
Q9LUU7 Arabidopsis thaliana 29% 91%
Q9M1V8 Arabidopsis thaliana 27% 91%
Q9M9C6 Arabidopsis thaliana 29% 88%
Q9M9W9 Arabidopsis thaliana 31% 100%
Q9S9Z7 Arabidopsis thaliana 32% 100%
Q9SD02 Arabidopsis thaliana 28% 100%
Q9SLA1 Arabidopsis thaliana 29% 98%
Q9WVR7 Rattus norvegicus 29% 85%
Q9XEE8 Arabidopsis thaliana 29% 98%
Q9Z1Z6 Rattus norvegicus 31% 98%
V5AZJ4 Trypanosoma cruzi 29% 97%
V5BA03 Trypanosoma cruzi 33% 100%
V5BCX6 Trypanosoma cruzi 32% 100%
V5BH00 Trypanosoma cruzi 57% 100%
V5BSS7 Trypanosoma cruzi 41% 94%
V5DCR6 Trypanosoma cruzi 35% 93%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS