Putative phosphatase 2C

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatase 2C - putative

Species:

Leishmania infantum

UniProt:

A4I565_LEIIN

TriTrypDb:

LINF_300008800

Length:

384

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Annotations by Jardim et al.

Phosphatase, phosphatase 2C

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 7

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Show entries

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I565

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I565

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0016311	dephosphorylation	5	4
GO:0019538	protein metabolic process	3	4
GO:0035970	peptidyl-threonine dephosphorylation	6	2
GO:0036211	protein modification process	4	4

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004721	phosphoprotein phosphatase activity	3	25
GO:0004722	protein serine/threonine phosphatase activity	4	25
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	25
GO:0016788	hydrolase activity, acting on ester bonds	3	25
GO:0016791	phosphatase activity	5	25
GO:0017018	myosin phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	25
GO:0043167	ion binding	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.371
CLV_PCSK_SKI1_1	117	121	PF00082	0.347
CLV_PCSK_SKI1_1	138	142	PF00082	0.233
CLV_PCSK_SKI1_1	343	347	PF00082	0.408
CLV_PCSK_SKI1_1	371	375	PF00082	0.465
CLV_PCSK_SKI1_1	7	11	PF00082	0.280
DOC_MAPK_DCC_7	196	205	PF00069	0.371
DOC_MAPK_gen_1	116	123	PF00069	0.244
DOC_MAPK_gen_1	190	200	PF00069	0.371
DOC_MAPK_MEF2A_6	116	123	PF00069	0.275

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C7	Leptomonas seymouri	32%	97%
A0A0N1I8W9	Leptomonas seymouri	28%	88%
A0A0N1IHU6	Leptomonas seymouri	44%	94%
A0A0N1PAL8	Leptomonas seymouri	87%	100%
A0A0N1PEL9	Leptomonas seymouri	30%	100%
A0A0S4IY95	Bodo saltans	32%	100%
A0A0S4J0A6	Bodo saltans	41%	94%
A0A0S4J8Y7	Bodo saltans	33%	74%
A0A0S4JHB4	Bodo saltans	54%	100%
A0A0S4JPC3	Bodo saltans	33%	100%

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