Kinesin-like protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin - putative

Species:

Leishmania infantum

UniProt:

A4I562_LEIIN

TriTrypDb:

LINF_300008500

Length:

610

Annotations

Annotations by Jardim et al.

Structural Proteins, Kinesin-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	11
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I562

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I562

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0006810	transport	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003774	cytoskeletal motor activity	1	11
GO:0003777	microtubule motor activity	2	11
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005524	ATP binding	5	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0016787	hydrolase activity	2	6
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0008574	plus-end-directed microtubule motor activity	3	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.380
CLV_C14_Caspase3-7	563	567	PF00656	0.731
CLV_NRD_NRD_1	207	209	PF00675	0.317
CLV_NRD_NRD_1	49	51	PF00675	0.345
CLV_NRD_NRD_1	493	495	PF00675	0.568
CLV_NRD_NRD_1	606	608	PF00675	0.607
CLV_PCSK_KEX2_1	360	362	PF00082	0.437
CLV_PCSK_KEX2_1	493	495	PF00082	0.505
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.437
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.505
CLV_PCSK_SKI1_1	106	110	PF00082	0.356
CLV_PCSK_SKI1_1	190	194	PF00082	0.383
CLV_PCSK_SKI1_1	256	260	PF00082	0.386
CLV_PCSK_SKI1_1	286	290	PF00082	0.425
CLV_PCSK_SKI1_1	293	297	PF00082	0.380
CLV_PCSK_SKI1_1	44	48	PF00082	0.389
CLV_PCSK_SKI1_1	484	488	PF00082	0.527
CLV_PCSK_SKI1_1	60	64	PF00082	0.216
DEG_APCC_DBOX_1	255	263	PF00400	0.386
DEG_APCC_DBOX_1	481	489	PF00400	0.464
DOC_CYCLIN_RxL_1	283	290	PF00134	0.425
DOC_MAPK_gen_1	161	167	PF00069	0.324
DOC_MAPK_gen_1	233	242	PF00069	0.333
DOC_MAPK_gen_1	469	477	PF00069	0.500
DOC_MAPK_gen_1	482	489	PF00069	0.447
DOC_MAPK_gen_1	578	586	PF00069	0.588
DOC_MAPK_MEF2A_6	161	169	PF00069	0.355
DOC_MAPK_MEF2A_6	482	489	PF00069	0.486
DOC_MAPK_NFAT4_5	482	490	PF00069	0.556
DOC_USP7_MATH_1	212	216	PF00917	0.397
DOC_USP7_UBL2_3	356	360	PF12436	0.443
DOC_USP7_UBL2_3	51	55	PF12436	0.358
DOC_USP7_UBL2_3	9	13	PF12436	0.567
DOC_WW_Pin1_4	330	335	PF00397	0.314
DOC_WW_Pin1_4	437	442	PF00397	0.670
DOC_WW_Pin1_4	545	550	PF00397	0.647
DOC_WW_Pin1_4	551	556	PF00397	0.617
LIG_14-3-3_CanoR_1	286	292	PF00244	0.400
LIG_14-3-3_CanoR_1	3	12	PF00244	0.702
LIG_14-3-3_CanoR_1	400	408	PF00244	0.563
LIG_14-3-3_CanoR_1	44	49	PF00244	0.335
LIG_14-3-3_CanoR_1	68	77	PF00244	0.420
LIG_Actin_WH2_2	422	437	PF00022	0.621
LIG_Actin_WH2_2	460	478	PF00022	0.526
LIG_APCC_ABBA_1	147	152	PF00400	0.314
LIG_BIR_II_1	1	5	PF00653	0.699
LIG_FHA_1	105	111	PF00498	0.333
LIG_FHA_1	12	18	PF00498	0.479
LIG_FHA_1	153	159	PF00498	0.314
LIG_FHA_1	181	187	PF00498	0.224
LIG_FHA_1	226	232	PF00498	0.386
LIG_FHA_1	248	254	PF00498	0.423
LIG_FHA_1	311	317	PF00498	0.314
LIG_FHA_1	324	330	PF00498	0.314
LIG_FHA_1	532	538	PF00498	0.520
LIG_FHA_2	134	140	PF00498	0.378
LIG_FHA_2	269	275	PF00498	0.324
LIG_FHA_2	383	389	PF00498	0.559
LIG_FHA_2	70	76	PF00498	0.391
LIG_Integrin_RGD_1	174	176	PF01839	0.310
LIG_LIR_Gen_1	127	137	PF02991	0.348
LIG_LIR_Gen_1	143	154	PF02991	0.215
LIG_LIR_Gen_1	32	38	PF02991	0.437
LIG_LIR_Gen_1	75	85	PF02991	0.353
LIG_LIR_Nem_3	127	132	PF02991	0.301
LIG_LIR_Nem_3	143	149	PF02991	0.314
LIG_LIR_Nem_3	32	36	PF02991	0.437
LIG_LIR_Nem_3	366	370	PF02991	0.453
LIG_LIR_Nem_3	75	80	PF02991	0.353
LIG_NRBOX	153	159	PF00104	0.314
LIG_PCNA_yPIPBox_3	151	164	PF02747	0.314
LIG_PCNA_yPIPBox_3	419	429	PF02747	0.577
LIG_PCNA_yPIPBox_3	459	468	PF02747	0.618
LIG_Pex14_2	63	67	PF04695	0.314
LIG_PTB_Apo_2	32	39	PF02174	0.367
LIG_PTB_Apo_2	61	68	PF02174	0.356
LIG_PTB_Phospho_1	32	38	PF10480	0.367
LIG_SH2_CRK	18	22	PF00017	0.412
LIG_SH2_CRK	367	371	PF00017	0.466
LIG_SH2_GRB2like	77	80	PF00017	0.244
LIG_SH2_PTP2	146	149	PF00017	0.314
LIG_SH2_SRC	428	431	PF00017	0.573
LIG_SH2_STAP1	140	144	PF00017	0.333
LIG_SH2_STAP1	397	401	PF00017	0.462
LIG_SH2_STAP1	77	81	PF00017	0.333
LIG_SH2_STAT5	146	149	PF00017	0.321
LIG_SH2_STAT5	18	21	PF00017	0.434
LIG_SH2_STAT5	201	204	PF00017	0.317
LIG_SH2_STAT5	371	374	PF00017	0.447
LIG_SH2_STAT5	428	431	PF00017	0.573
LIG_SH2_STAT5	536	539	PF00017	0.554
LIG_SH2_STAT5	61	64	PF00017	0.412
LIG_SH3_1	20	26	PF00018	0.356
LIG_SH3_3	18	24	PF00018	0.331
LIG_SH3_3	546	552	PF00018	0.744
LIG_SH3_3	63	69	PF00018	0.356
LIG_SUMO_SIM_par_1	176	184	PF11976	0.314
LIG_SUMO_SIM_par_1	249	254	PF11976	0.386
LIG_TRAF2_1	385	388	PF00917	0.634
LIG_TRAF2_1	389	392	PF00917	0.601
LIG_TYR_ITIM	144	149	PF00017	0.314
LIG_TYR_ITIM	365	370	PF00017	0.453
LIG_UBA3_1	153	162	PF00899	0.333
LIG_UBA3_1	226	233	PF00899	0.380
LIG_UBA3_1	288	293	PF00899	0.314
LIG_UBA3_1	374	381	PF00899	0.495
LIG_WRC_WIRS_1	503	508	PF05994	0.554
MOD_CK1_1	104	110	PF00069	0.307
MOD_CK1_1	181	187	PF00069	0.390
MOD_CK1_1	220	226	PF00069	0.307
MOD_CK1_1	287	293	PF00069	0.400
MOD_CK1_1	310	316	PF00069	0.314
MOD_CK1_1	548	554	PF00069	0.660
MOD_CK1_1	7	13	PF00069	0.670
MOD_CK2_1	121	127	PF00069	0.372
MOD_CK2_1	268	274	PF00069	0.324
MOD_CK2_1	382	388	PF00069	0.593
MOD_GlcNHglycan	103	106	PF01048	0.307
MOD_GlcNHglycan	343	346	PF01048	0.346
MOD_GlcNHglycan	401	404	PF01048	0.526
MOD_GlcNHglycan	442	445	PF01048	0.698
MOD_GlcNHglycan	453	456	PF01048	0.448
MOD_GlcNHglycan	51	54	PF01048	0.293
MOD_GlcNHglycan	537	540	PF01048	0.597
MOD_GlcNHglycan	568	571	PF01048	0.625
MOD_GlcNHglycan	9	12	PF01048	0.624
MOD_GSK3_1	1	8	PF00069	0.724
MOD_GSK3_1	104	111	PF00069	0.309
MOD_GSK3_1	138	145	PF00069	0.352
MOD_GSK3_1	212	219	PF00069	0.328
MOD_GSK3_1	243	250	PF00069	0.345
MOD_GSK3_1	262	269	PF00069	0.302
MOD_GSK3_1	332	339	PF00069	0.343
MOD_GSK3_1	49	56	PF00069	0.320
MOD_GSK3_1	531	538	PF00069	0.512
MOD_N-GLC_1	216	221	PF02516	0.314
MOD_N-GLC_1	284	289	PF02516	0.314
MOD_N-GLC_1	324	329	PF02516	0.319
MOD_N-GLC_1	330	335	PF02516	0.306
MOD_N-GLC_1	34	39	PF02516	0.345
MOD_N-GLC_1	69	74	PF02516	0.397
MOD_NEK2_1	1	6	PF00069	0.715
MOD_NEK2_1	121	126	PF00069	0.410
MOD_NEK2_1	211	216	PF00069	0.312
MOD_NEK2_1	307	312	PF00069	0.323
MOD_NEK2_1	316	321	PF00069	0.314
MOD_NEK2_1	543	548	PF00069	0.727
MOD_PIKK_1	1	7	PF00454	0.645
MOD_PIKK_1	350	356	PF00454	0.425
MOD_PIKK_1	515	521	PF00454	0.557
MOD_PIKK_1	69	75	PF00454	0.356
MOD_PKA_2	266	272	PF00069	0.305
MOD_PKA_2	307	313	PF00069	0.313
MOD_PKA_2	350	356	PF00069	0.425
MOD_PKA_2	399	405	PF00069	0.551
MOD_PKA_2	49	55	PF00069	0.329
MOD_Plk_1	279	285	PF00069	0.333
MOD_Plk_1	324	330	PF00069	0.328
MOD_Plk_1	339	345	PF00069	0.273
MOD_Plk_1	34	40	PF00069	0.342
MOD_Plk_1	382	388	PF00069	0.568
MOD_Plk_2-3	274	280	PF00069	0.333
MOD_Plk_2-3	336	342	PF00069	0.333
MOD_Plk_4	142	148	PF00069	0.314
MOD_Plk_4	222	228	PF00069	0.306
MOD_Plk_4	316	322	PF00069	0.333
MOD_Plk_4	324	330	PF00069	0.333
MOD_ProDKin_1	330	336	PF00069	0.314
MOD_ProDKin_1	437	443	PF00069	0.673
MOD_ProDKin_1	545	551	PF00069	0.649
MOD_SUMO_rev_2	156	163	PF00179	0.244
MOD_SUMO_rev_2	189	198	PF00179	0.426
MOD_SUMO_rev_2	269	278	PF00179	0.333
MOD_SUMO_rev_2	363	370	PF00179	0.448
MOD_SUMO_rev_2	402	411	PF00179	0.581
MOD_SUMO_rev_2	466	475	PF00179	0.453
MOD_SUMO_rev_2	52	62	PF00179	0.244
TRG_DiLeu_BaEn_1	406	411	PF01217	0.528
TRG_DiLeu_BaEn_1	580	585	PF01217	0.535
TRG_DiLeu_BaEn_4	406	412	PF01217	0.587
TRG_ENDOCYTIC_2	146	149	PF00928	0.314
TRG_ENDOCYTIC_2	150	153	PF00928	0.128
TRG_ENDOCYTIC_2	18	21	PF00928	0.434
TRG_ENDOCYTIC_2	318	321	PF00928	0.333
TRG_ENDOCYTIC_2	367	370	PF00928	0.462
TRG_ENDOCYTIC_2	371	374	PF00928	0.458
TRG_ENDOCYTIC_2	77	80	PF00928	0.297
TRG_ER_diArg_1	20	23	PF00400	0.317
TRG_ER_diArg_1	482	485	PF00400	0.557
TRG_NES_CRM1_1	399	414	PF08389	0.560
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.665
TRG_Pf-PMV_PEXEL_1	465	470	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	575	580	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	596	601	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	27%	70%
A0A0N1HY56	Leptomonas seymouri	28%	89%
A0A0N1I0Y5	Leptomonas seymouri	74%	99%
A0A0N1IH46	Leptomonas seymouri	27%	87%
A0A0S4IP41	Bodo saltans	33%	66%
A0A0S4IP49	Bodo saltans	26%	76%
A0A0S4IR67	Bodo saltans	27%	78%
A0A0S4JEF6	Bodo saltans	52%	91%
A0A0S4JJ54	Bodo saltans	26%	87%
A0A0S4JXY6	Bodo saltans	25%	71%
A0A1X0NP27	Trypanosomatidae	28%	82%
A0A1X0NQ03	Trypanosomatidae	25%	74%
A0A1X0NY69	Trypanosomatidae	28%	80%
A0A1X0P2B6	Trypanosomatidae	58%	99%
A0A1X0P9E3	Trypanosomatidae	29%	100%
A0A1X0P9H3	Trypanosomatidae	30%	71%
A0A1X0P9T0	Trypanosomatidae	31%	100%
A0A3Q8IBS7	Leishmania donovani	100%	100%
A0A3Q8IG88	Leishmania donovani	24%	87%
A0A3R7KSK0	Trypanosoma rangeli	28%	82%
A0A3R7LER1	Trypanosoma rangeli	28%	67%
A0A3R7MDH9	Trypanosoma rangeli	26%	86%
A0A3R7R330	Trypanosoma rangeli	31%	100%
A0A3S5IRH3	Trypanosoma rangeli	55%	100%
A0A3S7WU64	Leishmania donovani	27%	100%
A0A422MZ05	Trypanosoma rangeli	26%	90%
A0A422P055	Trypanosoma rangeli	27%	85%
A2ZRG4	Oryza sativa subsp. japonica	32%	73%
A4H4I4	Leishmania braziliensis	25%	100%
A4H4R6	Leishmania braziliensis	24%	69%
A4HAQ7	Leishmania braziliensis	25%	100%
A4HCA1	Leishmania braziliensis	25%	68%
A4HHY2	Leishmania braziliensis	76%	99%
A4HSA6	Leishmania infantum	35%	100%
A4HX45	Leishmania infantum	27%	100%
A4IBA7	Leishmania infantum	24%	87%
B9G2X9	Oryza sativa subsp. japonica	30%	100%
C9ZI82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	69%
C9ZK93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	82%
C9ZL08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZQI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	97%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	81%
E9AEA0	Leishmania major	30%	100%
E9AF32	Leishmania major	25%	87%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B687	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	88%
F4I1T9	Arabidopsis thaliana	29%	71%
Q1MTQ1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	97%
Q2R2P7	Oryza sativa subsp. japonica	33%	95%
Q4Q7S4	Leishmania major	91%	100%
Q4QJ61	Leishmania major	26%	91%
Q75HV1	Oryza sativa subsp. japonica	31%	73%
Q86ZC1	Botryotinia fuckeliana	34%	69%
Q8GW44	Arabidopsis thaliana	34%	100%
Q8NI77	Homo sapiens	29%	68%
Q91WD7	Mus musculus	30%	69%
Q965T6	Caenorhabditis elegans	36%	94%
Q96FN5	Homo sapiens	31%	94%
Q9FZ06	Arabidopsis thaliana	34%	66%
Q9SCJ4	Arabidopsis thaliana	30%	75%
Q9UTL2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9WV04	Mus musculus	30%	77%
V5BHY4	Trypanosoma cruzi	29%	82%
V5BK25	Trypanosoma cruzi	27%	85%
V5BNJ8	Trypanosoma cruzi	27%	100%
V5DMS2	Trypanosoma cruzi	27%	100%
V5DTU1	Trypanosoma cruzi	32%	100%