Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I524_LEIIN

TriTrypDb:

LINF_300008000

Length:

148

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I524

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I524

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	6	12	PF00089	0.510
CLV_NRD_NRD_1	62	64	PF00675	0.581
CLV_PCSK_KEX2_1	62	64	PF00082	0.613
DOC_CYCLIN_yCln2_LP_2	36	42	PF00134	0.668
DOC_PP2B_LxvP_1	36	39	PF13499	0.590
DOC_USP7_MATH_1	71	75	PF00917	0.595
DOC_WW_Pin1_4	104	109	PF00397	0.517
LIG_14-3-3_CanoR_1	30	40	PF00244	0.627
LIG_14-3-3_CanoR_1	9	16	PF00244	0.606
LIG_14-3-3_CanoR_1	93	99	PF00244	0.499
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_BRCT_BRCA1_1	129	133	PF00533	0.546
LIG_BRCT_BRCA1_1	79	83	PF00533	0.535
LIG_deltaCOP1_diTrp_1	124	133	PF00928	0.572
LIG_FHA_1	109	115	PF00498	0.549
LIG_FHA_1	74	80	PF00498	0.624
LIG_FHA_2	105	111	PF00498	0.544
LIG_FHA_2	80	86	PF00498	0.544
LIG_IRF3_LxIS_1	36	41	PF10401	0.581
LIG_LIR_Apic_2	11	16	PF02991	0.534
LIG_LIR_Gen_1	106	117	PF02991	0.544
LIG_LIR_Nem_3	106	112	PF02991	0.576
LIG_LIR_Nem_3	21	27	PF02991	0.501
LIG_LIR_Nem_3	80	86	PF02991	0.561
LIG_NRBOX	2	8	PF00104	0.585
LIG_PTB_Apo_2	78	85	PF02174	0.569
LIG_SH2_CRK	109	113	PF00017	0.592
LIG_SH2_CRK	24	28	PF00017	0.506
LIG_SH2_NCK_1	109	113	PF00017	0.544
LIG_SH2_PTP2	13	16	PF00017	0.534
LIG_SH2_STAT5	13	16	PF00017	0.534
LIG_SUMO_SIM_par_1	110	116	PF11976	0.568
LIG_TYR_ITSM	105	112	PF00017	0.536
MOD_CK1_1	113	119	PF00069	0.562
MOD_CK1_1	127	133	PF00069	0.423
MOD_CK1_1	29	35	PF00069	0.630
MOD_CK1_1	43	49	PF00069	0.574
MOD_CK2_1	54	60	PF00069	0.602
MOD_CK2_1	71	77	PF00069	0.597
MOD_Cter_Amidation	60	63	PF01082	0.573
MOD_GlcNHglycan	124	129	PF01048	0.457
MOD_GlcNHglycan	18	21	PF01048	0.459
MOD_GlcNHglycan	3	6	PF01048	0.606
MOD_GlcNHglycan	40	43	PF01048	0.602
MOD_GSK3_1	104	111	PF00069	0.598
MOD_GSK3_1	14	21	PF00069	0.552
MOD_GSK3_1	26	33	PF00069	0.712
MOD_GSK3_1	38	45	PF00069	0.717
MOD_GSK3_1	50	57	PF00069	0.559
MOD_GSK3_1	73	80	PF00069	0.534
MOD_NEK2_1	1	6	PF00069	0.605
MOD_NEK2_1	18	23	PF00069	0.474
MOD_NEK2_1	44	49	PF00069	0.629
MOD_NEK2_2	54	59	PF00069	0.558
MOD_NEK2_2	8	13	PF00069	0.612
MOD_PKA_2	29	35	PF00069	0.585
MOD_PKA_2	8	14	PF00069	0.706
MOD_PKA_2	92	98	PF00069	0.481
MOD_Plk_2-3	110	116	PF00069	0.550
MOD_Plk_2-3	73	79	PF00069	0.595
MOD_Plk_4	113	119	PF00069	0.598
MOD_Plk_4	45	51	PF00069	0.572
MOD_Plk_4	79	85	PF00069	0.638
MOD_ProDKin_1	104	110	PF00069	0.518
TRG_DiLeu_BaEn_1	136	141	PF01217	0.487
TRG_DiLeu_BaEn_2	128	134	PF01217	0.560
TRG_ENDOCYTIC_2	109	112	PF00928	0.608
TRG_ENDOCYTIC_2	24	27	PF00928	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM95	Leptomonas seymouri	54%	95%
A0A3S7X2Y5	Leishmania donovani	100%	100%
A4HHX4	Leishmania braziliensis	79%	100%
C9ZQI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B0F4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q7S9	Leishmania major	95%	100%