Putative Zn finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein 1 - putative

Species:

Leishmania infantum

UniProt:

A4I520_LEIIN

TriTrypDb:

LINF_300007600

Length:

641

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I520

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I520

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.442
CLV_C14_Caspase3-7	324	328	PF00656	0.617
CLV_C14_Caspase3-7	585	589	PF00656	0.540
CLV_C14_Caspase3-7	78	82	PF00656	0.494
CLV_C14_Caspase3-7	97	101	PF00656	0.383
CLV_NRD_NRD_1	220	222	PF00675	0.547
CLV_NRD_NRD_1	265	267	PF00675	0.559
CLV_NRD_NRD_1	363	365	PF00675	0.438
CLV_NRD_NRD_1	624	626	PF00675	0.625
CLV_NRD_NRD_1	629	631	PF00675	0.639
CLV_PCSK_KEX2_1	220	222	PF00082	0.589
CLV_PCSK_KEX2_1	265	267	PF00082	0.709
CLV_PCSK_KEX2_1	512	514	PF00082	0.433
CLV_PCSK_KEX2_1	629	631	PF00082	0.591
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.433
CLV_PCSK_PC7_1	625	631	PF00082	0.582
CLV_PCSK_SKI1_1	103	107	PF00082	0.448
CLV_PCSK_SKI1_1	130	134	PF00082	0.427
CLV_PCSK_SKI1_1	226	230	PF00082	0.614
CLV_PCSK_SKI1_1	365	369	PF00082	0.534
CLV_PCSK_SKI1_1	46	50	PF00082	0.438
CLV_PCSK_SKI1_1	550	554	PF00082	0.404
CLV_PCSK_SKI1_1	575	579	PF00082	0.582
CLV_PCSK_SKI1_1	625	629	PF00082	0.623
CLV_PCSK_SKI1_1	636	640	PF00082	0.623
DEG_APCC_DBOX_1	102	110	PF00400	0.462
DOC_ANK_TNKS_1	331	338	PF00023	0.568
DOC_CDC14_PxL_1	515	523	PF14671	0.403
DOC_CKS1_1	577	582	PF01111	0.686
DOC_CKS1_1	92	97	PF01111	0.608
DOC_CYCLIN_RxL_1	524	536	PF00134	0.492
DOC_CYCLIN_yClb5_NLxxxL_5	303	312	PF00134	0.482
DOC_CYCLIN_yCln2_LP_2	92	98	PF00134	0.505
DOC_MAPK_DCC_7	513	523	PF00069	0.353
DOC_MAPK_gen_1	226	236	PF00069	0.605
DOC_MAPK_gen_1	512	523	PF00069	0.602
DOC_MAPK_MEF2A_6	139	146	PF00069	0.476
DOC_MAPK_MEF2A_6	516	525	PF00069	0.388
DOC_MAPK_RevD_3	616	631	PF00069	0.641
DOC_PP1_RVXF_1	121	128	PF00149	0.439
DOC_PP1_RVXF_1	141	147	PF00149	0.342
DOC_PP4_FxxP_1	380	383	PF00568	0.437
DOC_PP4_FxxP_1	577	580	PF00568	0.586
DOC_USP7_MATH_1	107	111	PF00917	0.498
DOC_USP7_MATH_1	126	130	PF00917	0.258
DOC_USP7_MATH_1	178	182	PF00917	0.746
DOC_USP7_MATH_1	281	285	PF00917	0.576
DOC_USP7_MATH_1	321	325	PF00917	0.583
DOC_USP7_MATH_1	339	343	PF00917	0.675
DOC_USP7_MATH_1	347	351	PF00917	0.569
DOC_USP7_MATH_1	433	437	PF00917	0.501
DOC_USP7_MATH_1	450	454	PF00917	0.736
DOC_USP7_MATH_1	459	463	PF00917	0.733
DOC_USP7_MATH_1	486	490	PF00917	0.451
DOC_USP7_MATH_1	573	577	PF00917	0.546
DOC_USP7_MATH_1	581	585	PF00917	0.519
DOC_USP7_MATH_1	602	606	PF00917	0.658
DOC_USP7_MATH_1	608	612	PF00917	0.696
DOC_USP7_MATH_1	79	83	PF00917	0.760
DOC_USP7_UBL2_3	139	143	PF12436	0.475
DOC_USP7_UBL2_3	632	636	PF12436	0.576
DOC_WW_Pin1_4	168	173	PF00397	0.600
DOC_WW_Pin1_4	345	350	PF00397	0.732
DOC_WW_Pin1_4	576	581	PF00397	0.600
DOC_WW_Pin1_4	610	615	PF00397	0.627
DOC_WW_Pin1_4	91	96	PF00397	0.617
LIG_14-3-3_CanoR_1	300	309	PF00244	0.556
LIG_14-3-3_CanoR_1	360	368	PF00244	0.482
LIG_14-3-3_CanoR_1	369	378	PF00244	0.477
LIG_14-3-3_CanoR_1	407	412	PF00244	0.490
LIG_BIR_II_1	1	5	PF00653	0.454
LIG_BIR_III_4	425	429	PF00653	0.434
LIG_BIR_III_4	607	611	PF00653	0.623
LIG_BRCT_BRCA1_1	123	127	PF00533	0.470
LIG_BRCT_BRCA1_1	371	375	PF00533	0.361
LIG_BRCT_BRCA1_1	400	404	PF00533	0.593
LIG_FHA_1	13	19	PF00498	0.428
LIG_FHA_1	229	235	PF00498	0.645
LIG_FHA_1	611	617	PF00498	0.591
LIG_FHA_1	71	77	PF00498	0.570
LIG_FHA_2	106	112	PF00498	0.502
LIG_FHA_2	225	231	PF00498	0.724
LIG_FHA_2	28	34	PF00498	0.476
LIG_FHA_2	583	589	PF00498	0.618
LIG_LIR_Apic_2	410	414	PF02991	0.375
LIG_LIR_Apic_2	504	509	PF02991	0.534
LIG_LIR_Apic_2	576	580	PF02991	0.674
LIG_LIR_Gen_1	116	127	PF02991	0.420
LIG_LIR_Gen_1	145	154	PF02991	0.562
LIG_LIR_Gen_1	210	219	PF02991	0.493
LIG_LIR_Gen_1	372	383	PF02991	0.412
LIG_LIR_Gen_1	462	472	PF02991	0.699
LIG_LIR_Gen_1	474	485	PF02991	0.278
LIG_LIR_Nem_3	116	122	PF02991	0.588
LIG_LIR_Nem_3	145	149	PF02991	0.560
LIG_LIR_Nem_3	210	215	PF02991	0.494
LIG_LIR_Nem_3	296	302	PF02991	0.553
LIG_LIR_Nem_3	372	378	PF02991	0.392
LIG_LIR_Nem_3	462	467	PF02991	0.717
LIG_LIR_Nem_3	474	480	PF02991	0.278
LIG_LIR_Nem_3	514	518	PF02991	0.489
LIG_MYND_3	518	522	PF01753	0.399
LIG_SH2_NCK_1	50	54	PF00017	0.551
LIG_SH2_STAP1	115	119	PF00017	0.493
LIG_SH2_STAT5	115	118	PF00017	0.441
LIG_SH3_2	621	626	PF14604	0.589
LIG_SH3_3	101	107	PF00018	0.684
LIG_SH3_3	150	156	PF00018	0.447
LIG_SH3_3	171	177	PF00018	0.697
LIG_SH3_3	212	218	PF00018	0.587
LIG_SH3_3	540	546	PF00018	0.476
LIG_SH3_3	596	602	PF00018	0.505
LIG_SH3_3	615	621	PF00018	0.550
LIG_SUMO_SIM_par_1	468	474	PF11976	0.463
LIG_SUMO_SIM_par_1	611	619	PF11976	0.538
LIG_TYR_ITIM	553	558	PF00017	0.446
LIG_UBA3_1	23	32	PF00899	0.514
LIG_UBA3_1	308	315	PF00899	0.531
LIG_WRC_WIRS_1	574	579	PF05994	0.641
MOD_CDK_SPxxK_3	168	175	PF00069	0.602
MOD_CK1_1	275	281	PF00069	0.648
MOD_CK1_1	348	354	PF00069	0.692
MOD_CK1_1	462	468	PF00069	0.640
MOD_CK1_1	497	503	PF00069	0.587
MOD_CK1_1	576	582	PF00069	0.641
MOD_CK1_1	609	615	PF00069	0.612
MOD_CK1_1	91	97	PF00069	0.668
MOD_CK2_1	105	111	PF00069	0.504
MOD_CK2_1	27	33	PF00069	0.515
MOD_CK2_1	347	353	PF00069	0.552
MOD_CK2_1	538	544	PF00069	0.658
MOD_Cter_Amidation	263	266	PF01082	0.566
MOD_GlcNHglycan	277	280	PF01048	0.632
MOD_GlcNHglycan	3	6	PF01048	0.442
MOD_GlcNHglycan	323	326	PF01048	0.584
MOD_GlcNHglycan	371	374	PF01048	0.359
MOD_GlcNHglycan	452	455	PF01048	0.734
MOD_GlcNHglycan	464	467	PF01048	0.413
MOD_GlcNHglycan	488	491	PF01048	0.273
MOD_GlcNHglycan	568	571	PF01048	0.654
MOD_GlcNHglycan	581	584	PF01048	0.544
MOD_GlcNHglycan	604	607	PF01048	0.764
MOD_GlcNHglycan	608	611	PF01048	0.744
MOD_GlcNHglycan	618	621	PF01048	0.621
MOD_GlcNHglycan	96	99	PF01048	0.626
MOD_GSK3_1	105	112	PF00069	0.397
MOD_GSK3_1	121	128	PF00069	0.436
MOD_GSK3_1	183	190	PF00069	0.703
MOD_GSK3_1	224	231	PF00069	0.671
MOD_GSK3_1	271	278	PF00069	0.691
MOD_GSK3_1	317	324	PF00069	0.571
MOD_GSK3_1	335	342	PF00069	0.693
MOD_GSK3_1	369	376	PF00069	0.437
MOD_GSK3_1	455	462	PF00069	0.706
MOD_GSK3_1	494	501	PF00069	0.593
MOD_GSK3_1	602	609	PF00069	0.712
MOD_GSK3_1	632	639	PF00069	0.665
MOD_GSK3_1	90	97	PF00069	0.668
MOD_N-GLC_1	486	491	PF02516	0.282
MOD_N-GLC_1	530	535	PF02516	0.480
MOD_N-GLC_2	118	120	PF02516	0.376
MOD_N-GLC_2	479	481	PF02516	0.256
MOD_NEK2_1	1	6	PF00069	0.482
MOD_NEK2_1	185	190	PF00069	0.571
MOD_NEK2_1	243	248	PF00069	0.646
MOD_NEK2_1	272	277	PF00069	0.741
MOD_NEK2_1	340	345	PF00069	0.532
MOD_NEK2_1	368	373	PF00069	0.491
MOD_NEK2_1	616	621	PF00069	0.666
MOD_NEK2_1	90	95	PF00069	0.620
MOD_NEK2_2	224	229	PF00069	0.497
MOD_NEK2_2	434	439	PF00069	0.433
MOD_NEK2_2	60	65	PF00069	0.504
MOD_PKA_1	625	631	PF00069	0.601
MOD_PKA_2	264	270	PF00069	0.667
MOD_PKA_2	359	365	PF00069	0.427
MOD_PKA_2	368	374	PF00069	0.374
MOD_PKA_2	51	57	PF00069	0.485
MOD_Plk_1	434	440	PF00069	0.569
MOD_Plk_1	486	492	PF00069	0.482
MOD_Plk_1	530	536	PF00069	0.495
MOD_Plk_2-3	517	523	PF00069	0.381
MOD_Plk_4	148	154	PF00069	0.572
MOD_Plk_4	155	161	PF00069	0.710
MOD_Plk_4	459	465	PF00069	0.722
MOD_Plk_4	501	507	PF00069	0.461
MOD_ProDKin_1	168	174	PF00069	0.599
MOD_ProDKin_1	345	351	PF00069	0.728
MOD_ProDKin_1	576	582	PF00069	0.601
MOD_ProDKin_1	610	616	PF00069	0.630
MOD_ProDKin_1	91	97	PF00069	0.610
MOD_SUMO_for_1	236	239	PF00179	0.626
MOD_SUMO_rev_2	359	367	PF00179	0.455
MOD_SUMO_rev_2	392	401	PF00179	0.488
MOD_SUMO_rev_2	453	459	PF00179	0.559
TRG_ENDOCYTIC_2	50	53	PF00928	0.432
TRG_ENDOCYTIC_2	555	558	PF00928	0.498
TRG_ER_diArg_1	219	221	PF00400	0.549
TRG_ER_diArg_1	265	268	PF00400	0.539
TRG_ER_diArg_1	472	475	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W2	Leptomonas seymouri	37%	88%
A0A1X0P2C9	Trypanosomatidae	34%	100%
A0A3Q8IEK7	Leishmania donovani	100%	100%
A0A3R7MIW1	Trypanosoma rangeli	34%	100%
A4HHX0	Leishmania braziliensis	72%	100%
C9ZQH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B0F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q7T3	Leishmania major	90%	99%
Q585P3	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	35%	100%
V5DD36	Trypanosoma cruzi	33%	100%