Mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial carrier protein - putative

Species:

Leishmania infantum

UniProt:

A4I517_LEIIN

TriTrypDb:

LINF_300007300

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4I517

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I517

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.505
CLV_NRD_NRD_1	166	168	PF00675	0.216
CLV_NRD_NRD_1	274	276	PF00675	0.338
CLV_NRD_NRD_1	347	349	PF00675	0.487
CLV_PCSK_KEX2_1	132	134	PF00082	0.503
CLV_PCSK_KEX2_1	166	168	PF00082	0.250
CLV_PCSK_KEX2_1	273	275	PF00082	0.338
CLV_PCSK_KEX2_1	83	85	PF00082	0.311
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.311
CLV_PCSK_SKI1_1	191	195	PF00082	0.339
CLV_PCSK_SKI1_1	266	270	PF00082	0.396
CLV_PCSK_SKI1_1	289	293	PF00082	0.298
CLV_PCSK_SKI1_1	89	93	PF00082	0.298
DEG_APCC_DBOX_1	247	255	PF00400	0.544
DOC_MAPK_gen_1	180	189	PF00069	0.456
DOC_MAPK_MEF2A_6	180	189	PF00069	0.468
DOC_MAPK_MEF2A_6	221	228	PF00069	0.297
DOC_MAPK_NFAT4_5	221	229	PF00069	0.276
DOC_PP1_RVXF_1	198	205	PF00149	0.308
DOC_PP1_RVXF_1	87	93	PF00149	0.582
DOC_PP2B_LxvP_1	55	58	PF13499	0.421
DOC_USP7_MATH_1	243	247	PF00917	0.541
DOC_USP7_MATH_1	72	76	PF00917	0.541
DOC_WW_Pin1_4	16	21	PF00397	0.680
LIG_14-3-3_CanoR_1	156	162	PF00244	0.443
LIG_14-3-3_CanoR_1	191	196	PF00244	0.278
LIG_14-3-3_CanoR_1	28	38	PF00244	0.539
LIG_14-3-3_CanoR_1	309	317	PF00244	0.507
LIG_14-3-3_CanoR_1	7	15	PF00244	0.645
LIG_14-3-3_CanoR_1	77	87	PF00244	0.537
LIG_14-3-3_CanoR_1	98	103	PF00244	0.515
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_BRCT_BRCA1_1	200	204	PF00533	0.335
LIG_DLG_GKlike_1	98	105	PF00625	0.381
LIG_EVH1_2	342	346	PF00568	0.617
LIG_FHA_1	113	119	PF00498	0.311
LIG_FHA_1	139	145	PF00498	0.364
LIG_FHA_1	192	198	PF00498	0.441
LIG_FHA_1	310	316	PF00498	0.510
LIG_FHA_1	324	330	PF00498	0.633
LIG_FHA_1	54	60	PF00498	0.482
LIG_LIR_Apic_2	18	24	PF02991	0.645
LIG_LIR_Apic_2	312	317	PF02991	0.531
LIG_LIR_Gen_1	114	123	PF02991	0.285
LIG_LIR_Gen_1	149	159	PF02991	0.381
LIG_LIR_Nem_3	101	105	PF02991	0.305
LIG_LIR_Nem_3	114	119	PF02991	0.213
LIG_LIR_Nem_3	149	155	PF02991	0.381
LIG_LIR_Nem_3	217	223	PF02991	0.290
LIG_LIR_Nem_3	267	272	PF02991	0.515
LIG_LIR_Nem_3	279	285	PF02991	0.481
LIG_LIR_Nem_3	308	314	PF02991	0.539
LIG_LIR_Nem_3	63	68	PF02991	0.548
LIG_PCNA_yPIPBox_3	200	214	PF02747	0.372
LIG_Pex14_2	204	208	PF04695	0.273
LIG_Pex14_2	223	227	PF04695	0.130
LIG_Pex14_2	88	92	PF04695	0.496
LIG_Rb_pABgroove_1	276	284	PF01858	0.532
LIG_REV1ctd_RIR_1	283	289	PF16727	0.485
LIG_REV1ctd_RIR_1	85	93	PF16727	0.516
LIG_SH2_CRK	109	113	PF00017	0.335
LIG_SH2_CRK	152	156	PF00017	0.439
LIG_SH2_CRK	21	25	PF00017	0.722
LIG_SH2_CRK	216	220	PF00017	0.316
LIG_SH2_CRK	265	269	PF00017	0.592
LIG_SH2_NCK_1	145	149	PF00017	0.202
LIG_SH2_SRC	314	317	PF00017	0.596
LIG_SH2_STAP1	311	315	PF00017	0.514
LIG_SH2_STAT3	242	245	PF00017	0.546
LIG_SH2_STAT5	229	232	PF00017	0.259
LIG_SH2_STAT5	31	34	PF00017	0.515
LIG_SH2_STAT5	311	314	PF00017	0.545
LIG_SH2_STAT5	337	340	PF00017	0.632
LIG_SH2_STAT5	66	69	PF00017	0.527
LIG_SH3_2	162	167	PF14604	0.381
LIG_SH3_3	159	165	PF00018	0.522
LIG_SH3_3	329	335	PF00018	0.621
LIG_SUMO_SIM_anti_2	194	199	PF11976	0.395
LIG_TYR_ITIM	214	219	PF00017	0.323
LIG_WRC_WIRS_1	113	118	PF05994	0.335
LIG_WRC_WIRS_1	232	237	PF05994	0.375
LIG_WW_1	341	344	PF00397	0.613
MOD_CK1_1	2	8	PF00069	0.596
MOD_CK1_1	328	334	PF00069	0.650
MOD_GlcNHglycan	168	171	PF01048	0.280
MOD_GlcNHglycan	292	295	PF01048	0.333
MOD_GSK3_1	305	312	PF00069	0.483
MOD_GSK3_1	317	324	PF00069	0.623
MOD_N-GLC_1	254	259	PF02516	0.336
MOD_NEK2_1	111	116	PF00069	0.307
MOD_NEK2_1	144	149	PF00069	0.335
MOD_NEK2_1	198	203	PF00069	0.406
MOD_NEK2_1	3	8	PF00069	0.628
MOD_NEK2_2	243	248	PF00069	0.480
MOD_PIKK_1	31	37	PF00454	0.570
MOD_PIKK_1	323	329	PF00454	0.639
MOD_PKA_1	166	172	PF00069	0.381
MOD_PKA_2	155	161	PF00069	0.465
MOD_PKA_2	166	172	PF00069	0.457
MOD_PKA_2	9	15	PF00069	0.647
MOD_Plk_1	73	79	PF00069	0.568
MOD_Plk_4	231	237	PF00069	0.305
MOD_ProDKin_1	16	22	PF00069	0.681
TRG_ENDOCYTIC_2	109	112	PF00928	0.319
TRG_ENDOCYTIC_2	152	155	PF00928	0.432
TRG_ENDOCYTIC_2	190	193	PF00928	0.259
TRG_ENDOCYTIC_2	211	214	PF00928	0.234
TRG_ENDOCYTIC_2	216	219	PF00928	0.308
TRG_ENDOCYTIC_2	220	223	PF00928	0.295
TRG_ENDOCYTIC_2	229	232	PF00928	0.192
TRG_ENDOCYTIC_2	265	268	PF00928	0.593
TRG_ENDOCYTIC_2	282	285	PF00928	0.471
TRG_ER_diArg_1	165	167	PF00400	0.572
TRG_ER_diArg_1	272	275	PF00400	0.474
TRG_ER_diArg_1	97	100	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	266	271	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD65	Leptomonas seymouri	68%	99%
A0A1X0P2B3	Trypanosomatidae	54%	98%
A0A3S7X2Y8	Leishmania donovani	99%	100%
A4HHW7	Leishmania braziliensis	82%	100%
C9ZQH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B0E7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P04710	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q4Q7T6	Leishmania major	93%	100%
V5DD32	Trypanosoma cruzi	55%	100%