Nucleic acid binding, rRNA adenine N(6)-methyltransferase
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 9 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005730 | nucleolus | 5 | 1 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043228 | non-membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043232 | intracellular non-membrane-bounded organelle | 4 | 1 |
| GO:0110165 | cellular anatomical entity | 1 | 2 |
| GO:0016020 | membrane | 2 | 1 |
Related structures:
AlphaFold database: A4I515
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000154 | rRNA modification | 6 | 1 |
| GO:0001510 | RNA methylation | 4 | 1 |
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 1 |
| GO:0006364 | rRNA processing | 8 | 1 |
| GO:0006396 | RNA processing | 6 | 1 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 1 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 1 |
| GO:0008152 | metabolic process | 1 | 1 |
| GO:0009451 | RNA modification | 5 | 1 |
| GO:0009987 | cellular process | 1 | 1 |
| GO:0016070 | RNA metabolic process | 5 | 1 |
| GO:0016072 | rRNA metabolic process | 7 | 1 |
| GO:0031167 | rRNA methylation | 5 | 1 |
| GO:0032259 | methylation | 2 | 1 |
| GO:0034470 | ncRNA processing | 7 | 1 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 1 |
| GO:0034660 | ncRNA metabolic process | 6 | 1 |
| GO:0043170 | macromolecule metabolic process | 3 | 1 |
| GO:0043412 | macromolecule modification | 4 | 1 |
| GO:0043414 | macromolecule methylation | 3 | 1 |
| GO:0044237 | cellular metabolic process | 2 | 1 |
| GO:0044238 | primary metabolic process | 2 | 1 |
| GO:0044260 | obsolete cellular macromolecule metabolic process | 3 | 1 |
| GO:0046483 | heterocycle metabolic process | 3 | 1 |
| GO:0071704 | organic substance metabolic process | 2 | 1 |
| GO:0090304 | nucleic acid metabolic process | 4 | 1 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity | 6 | 12 |
| GO:0003676 | nucleic acid binding | 3 | 12 |
| GO:0003723 | RNA binding | 4 | 12 |
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0005488 | binding | 1 | 12 |
| GO:0008168 | methyltransferase activity | 4 | 12 |
| GO:0008170 | N-methyltransferase activity | 5 | 12 |
| GO:0008173 | RNA methyltransferase activity | 4 | 12 |
| GO:0008649 | rRNA methyltransferase activity | 5 | 12 |
| GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity | 5 | 12 |
| GO:0016433 | rRNA (adenine) methyltransferase activity | 6 | 12 |
| GO:0016740 | transferase activity | 2 | 12 |
| GO:0016741 | transferase activity, transferring one-carbon groups | 3 | 12 |
| GO:0097159 | organic cyclic compound binding | 2 | 12 |
| GO:0140098 | catalytic activity, acting on RNA | 3 | 12 |
| GO:0140102 | catalytic activity, acting on a rRNA | 4 | 12 |
| GO:0140640 | catalytic activity, acting on a nucleic acid | 2 | 12 |
| GO:1901363 | heterocyclic compound binding | 2 | 12 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 22 | 24 | PF00675 | 0.624 |
| CLV_NRD_NRD_1 | 272 | 274 | PF00675 | 0.229 |
| CLV_NRD_NRD_1 | 298 | 300 | PF00675 | 0.517 |
| CLV_NRD_NRD_1 | 43 | 45 | PF00675 | 0.624 |
| CLV_PCSK_KEX2_1 | 137 | 139 | PF00082 | 0.250 |
| CLV_PCSK_KEX2_1 | 349 | 351 | PF00082 | 0.335 |
| CLV_PCSK_KEX2_1 | 43 | 45 | PF00082 | 0.707 |
| CLV_PCSK_KEX2_1 | 54 | 56 | PF00082 | 0.554 |
| CLV_PCSK_PC1ET2_1 | 137 | 139 | PF00082 | 0.250 |
| CLV_PCSK_PC1ET2_1 | 349 | 351 | PF00082 | 0.335 |
| CLV_PCSK_PC1ET2_1 | 54 | 56 | PF00082 | 0.625 |
| CLV_PCSK_SKI1_1 | 181 | 185 | PF00082 | 0.254 |
| CLV_PCSK_SKI1_1 | 23 | 27 | PF00082 | 0.569 |
| CLV_PCSK_SKI1_1 | 268 | 272 | PF00082 | 0.229 |
| CLV_PCSK_SKI1_1 | 30 | 34 | PF00082 | 0.585 |
| CLV_PCSK_SKI1_1 | 315 | 319 | PF00082 | 0.718 |
| CLV_PCSK_SKI1_1 | 335 | 339 | PF00082 | 0.276 |
| DEG_APCC_DBOX_1 | 334 | 342 | PF00400 | 0.417 |
| DEG_SPOP_SBC_1 | 316 | 320 | PF00917 | 0.630 |
| DOC_CKS1_1 | 140 | 145 | PF01111 | 0.454 |
| DOC_CKS1_1 | 183 | 188 | PF01111 | 0.520 |
| DOC_CYCLIN_RxL_1 | 265 | 272 | PF00134 | 0.472 |
| DOC_CYCLIN_RxL_1 | 332 | 340 | PF00134 | 0.408 |
| DOC_CYCLIN_yCln2_LP_2 | 80 | 86 | PF00134 | 0.429 |
| DOC_MAPK_gen_1 | 252 | 260 | PF00069 | 0.365 |
| DOC_MAPK_gen_1 | 3 | 12 | PF00069 | 0.552 |
| DOC_MAPK_MEF2A_6 | 252 | 260 | PF00069 | 0.430 |
| DOC_MAPK_MEF2A_6 | 96 | 104 | PF00069 | 0.429 |
| DOC_MAPK_RevD_3 | 286 | 300 | PF00069 | 0.458 |
| DOC_PP1_RVXF_1 | 119 | 126 | PF00149 | 0.429 |
| DOC_PP1_RVXF_1 | 21 | 28 | PF00149 | 0.552 |
| DOC_PP4_FxxP_1 | 236 | 239 | PF00568 | 0.429 |
| DOC_USP7_MATH_1 | 143 | 147 | PF00917 | 0.479 |
| DOC_USP7_MATH_1 | 173 | 177 | PF00917 | 0.429 |
| DOC_USP7_MATH_1 | 223 | 227 | PF00917 | 0.440 |
| DOC_USP7_MATH_1 | 316 | 320 | PF00917 | 0.655 |
| DOC_USP7_UBL2_3 | 26 | 30 | PF12436 | 0.603 |
| DOC_USP7_UBL2_3 | 92 | 96 | PF12436 | 0.429 |
| DOC_WW_Pin1_4 | 139 | 144 | PF00397 | 0.429 |
| DOC_WW_Pin1_4 | 182 | 187 | PF00397 | 0.520 |
| DOC_WW_Pin1_4 | 35 | 40 | PF00397 | 0.666 |
| LIG_14-3-3_CanoR_1 | 214 | 218 | PF00244 | 0.429 |
| LIG_14-3-3_CanoR_1 | 224 | 231 | PF00244 | 0.429 |
| LIG_BRCT_BRCA1_1 | 278 | 282 | PF00533 | 0.429 |
| LIG_FHA_1 | 106 | 112 | PF00498 | 0.429 |
| LIG_FHA_1 | 27 | 33 | PF00498 | 0.652 |
| LIG_FHA_1 | 96 | 102 | PF00498 | 0.431 |
| LIG_FHA_2 | 44 | 50 | PF00498 | 0.527 |
| LIG_LIR_Apic_2 | 235 | 239 | PF02991 | 0.429 |
| LIG_LIR_Gen_1 | 209 | 217 | PF02991 | 0.439 |
| LIG_LIR_Nem_3 | 157 | 163 | PF02991 | 0.433 |
| LIG_LIR_Nem_3 | 209 | 215 | PF02991 | 0.439 |
| LIG_LIR_Nem_3 | 261 | 266 | PF02991 | 0.437 |
| LIG_LIR_Nem_3 | 293 | 298 | PF02991 | 0.361 |
| LIG_LIR_Nem_3 | 332 | 337 | PF02991 | 0.386 |
| LIG_Pex14_2 | 195 | 199 | PF04695 | 0.429 |
| LIG_Pex14_2 | 71 | 75 | PF04695 | 0.449 |
| LIG_PTB_Apo_2 | 166 | 173 | PF02174 | 0.429 |
| LIG_PTB_Apo_2 | 69 | 76 | PF02174 | 0.290 |
| LIG_PTB_Phospho_1 | 166 | 172 | PF10480 | 0.429 |
| LIG_Rb_pABgroove_1 | 286 | 294 | PF01858 | 0.394 |
| LIG_SH2_CRK | 212 | 216 | PF00017 | 0.429 |
| LIG_SH2_SRC | 172 | 175 | PF00017 | 0.429 |
| LIG_SH2_STAP1 | 292 | 296 | PF00017 | 0.427 |
| LIG_SH2_STAT5 | 162 | 165 | PF00017 | 0.425 |
| LIG_SH2_STAT5 | 212 | 215 | PF00017 | 0.433 |
| LIG_SH2_STAT5 | 295 | 298 | PF00017 | 0.364 |
| LIG_SH3_1 | 248 | 254 | PF00018 | 0.429 |
| LIG_SH3_3 | 248 | 254 | PF00018 | 0.429 |
| LIG_UBA3_1 | 228 | 233 | PF00899 | 0.421 |
| LIG_UBA3_1 | 359 | 368 | PF00899 | 0.424 |
| MOD_CDK_SPxxK_3 | 182 | 189 | PF00069 | 0.520 |
| MOD_CK1_1 | 216 | 222 | PF00069 | 0.440 |
| MOD_CK1_1 | 232 | 238 | PF00069 | 0.435 |
| MOD_CK1_1 | 319 | 325 | PF00069 | 0.656 |
| MOD_CK1_1 | 327 | 333 | PF00069 | 0.521 |
| MOD_CK2_1 | 43 | 49 | PF00069 | 0.527 |
| MOD_GlcNHglycan | 13 | 16 | PF01048 | 0.564 |
| MOD_GlcNHglycan | 175 | 178 | PF01048 | 0.229 |
| MOD_GlcNHglycan | 311 | 314 | PF01048 | 0.740 |
| MOD_GlcNHglycan | 321 | 324 | PF01048 | 0.624 |
| MOD_GlcNHglycan | 57 | 60 | PF01048 | 0.608 |
| MOD_GlcNHglycan | 66 | 69 | PF01048 | 0.478 |
| MOD_GSK3_1 | 105 | 112 | PF00069 | 0.429 |
| MOD_GSK3_1 | 139 | 146 | PF00069 | 0.464 |
| MOD_GSK3_1 | 26 | 33 | PF00069 | 0.576 |
| MOD_GSK3_1 | 277 | 284 | PF00069 | 0.429 |
| MOD_GSK3_1 | 315 | 322 | PF00069 | 0.646 |
| MOD_GSK3_1 | 55 | 62 | PF00069 | 0.608 |
| MOD_N-GLC_1 | 109 | 114 | PF02516 | 0.234 |
| MOD_NEK2_1 | 115 | 120 | PF00069 | 0.460 |
| MOD_NEK2_1 | 229 | 234 | PF00069 | 0.439 |
| MOD_NEK2_1 | 269 | 274 | PF00069 | 0.481 |
| MOD_NEK2_1 | 317 | 322 | PF00069 | 0.619 |
| MOD_NEK2_1 | 337 | 342 | PF00069 | 0.261 |
| MOD_NEK2_1 | 34 | 39 | PF00069 | 0.613 |
| MOD_PIKK_1 | 216 | 222 | PF00454 | 0.440 |
| MOD_PIKK_1 | 62 | 68 | PF00454 | 0.544 |
| MOD_PK_1 | 277 | 283 | PF00069 | 0.429 |
| MOD_PKA_1 | 276 | 282 | PF00069 | 0.429 |
| MOD_PKA_1 | 43 | 49 | PF00069 | 0.634 |
| MOD_PKA_1 | 54 | 60 | PF00069 | 0.647 |
| MOD_PKA_2 | 213 | 219 | PF00069 | 0.429 |
| MOD_PKA_2 | 223 | 229 | PF00069 | 0.429 |
| MOD_PKA_2 | 43 | 49 | PF00069 | 0.728 |
| MOD_PKA_2 | 54 | 60 | PF00069 | 0.516 |
| MOD_Plk_1 | 242 | 248 | PF00069 | 0.429 |
| MOD_Plk_4 | 242 | 248 | PF00069 | 0.429 |
| MOD_Plk_4 | 277 | 283 | PF00069 | 0.429 |
| MOD_Plk_4 | 337 | 343 | PF00069 | 0.299 |
| MOD_Plk_4 | 358 | 364 | PF00069 | 0.422 |
| MOD_ProDKin_1 | 139 | 145 | PF00069 | 0.429 |
| MOD_ProDKin_1 | 182 | 188 | PF00069 | 0.520 |
| MOD_ProDKin_1 | 35 | 41 | PF00069 | 0.664 |
| MOD_SUMO_for_1 | 240 | 243 | PF00179 | 0.429 |
| MOD_SUMO_rev_2 | 244 | 254 | PF00179 | 0.429 |
| TRG_DiLeu_BaEn_1 | 262 | 267 | PF01217 | 0.429 |
| TRG_ENDOCYTIC_2 | 212 | 215 | PF00928 | 0.433 |
| TRG_ENDOCYTIC_2 | 298 | 301 | PF00928 | 0.399 |
| TRG_ER_diArg_1 | 350 | 353 | PF00400 | 0.375 |
| TRG_NLS_MonoExtC_3 | 272 | 277 | PF00514 | 0.429 |
| TRG_Pf-PMV_PEXEL_1 | 335 | 339 | PF00026 | 0.361 |
| TRG_Pf-PMV_PEXEL_1 | 352 | 356 | PF00026 | 0.304 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1IB33 | Leptomonas seymouri | 88% | 100% |
| A0A0S4JJ91 | Bodo saltans | 68% | 100% |
| A0A1X0P2H9 | Trypanosomatidae | 73% | 100% |
| A0A3S7X2X5 | Leishmania donovani | 100% | 100% |
| A0A422N140 | Trypanosoma rangeli | 72% | 100% |
| A2RCH2 | Streptococcus pyogenes serotype M5 (strain Manfredo) | 29% | 100% |
| A3CQN5 | Streptococcus sanguinis (strain SK36) | 33% | 100% |
| A4HHW5 | Leishmania braziliensis | 89% | 98% |
| B1AJP2 | Ureaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736) | 32% | 100% |
| B1HS82 | Lysinibacillus sphaericus (strain C3-41) | 30% | 100% |
| B1KRY8 | Clostridium botulinum (strain Loch Maree / Type A3) | 32% | 100% |
| B2AH89 | Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1) | 31% | 100% |
| B2SX63 | Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) | 30% | 100% |
| B4RBS4 | Phenylobacterium zucineum (strain HLK1) | 34% | 100% |
| B4U0U9 | Streptococcus equi subsp. zooepidemicus (strain MGCS10565) | 29% | 100% |
| B5ZCB6 | Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western) | 30% | 100% |
| C0M8P2 | Streptococcus equi subsp. equi (strain 4047) | 29% | 100% |
| C0MF36 | Streptococcus equi subsp. zooepidemicus (strain H70) | 29% | 100% |
| C1AXY5 | Rhodococcus opacus (strain B4) | 28% | 100% |
| C1CMT3 | Streptococcus pneumoniae (strain P1031) | 31% | 100% |
| C3KXY4 | Clostridium botulinum (strain 657 / Type Ba4) | 32% | 100% |
| C9ZQH0 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 72% | 98% |
| E9B0E5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 97% | 100% |
| G0SEH7 | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) | 45% | 97% |
| O22268 | Arabidopsis thaliana | 45% | 100% |
| P41819 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 42% | 100% |
| P78697 | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) | 46% | 100% |
| Q03IR2 | Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9) | 28% | 100% |
| Q09522 | Caenorhabditis elegans | 46% | 100% |
| Q0KEA7 | Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) | 31% | 100% |
| Q1J8J4 | Streptococcus pyogenes serotype M4 (strain MGAS10750) | 29% | 100% |
| Q1JDL6 | Streptococcus pyogenes serotype M12 (strain MGAS2096) | 29% | 100% |
| Q1JIN6 | Streptococcus pyogenes serotype M2 (strain MGAS10270) | 29% | 100% |
| Q1JNI8 | Streptococcus pyogenes serotype M12 (strain MGAS9429) | 29% | 100% |
| Q1WV73 | Ligilactobacillus salivarius (strain UCC118) | 32% | 100% |
| Q223E6 | Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) | 29% | 100% |
| Q2KHT8 | Bos taurus | 52% | 100% |
| Q38V22 | Latilactobacillus sakei subsp. sakei (strain 23K) | 30% | 100% |
| Q475Q1 | Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) | 32% | 100% |
| Q48VC6 | Streptococcus pyogenes serotype M28 (strain MGAS6180) | 29% | 100% |
| Q4Q7U7 | Leishmania major | 96% | 100% |
| Q4QMZ9 | Haemophilus influenzae (strain 86-028NP) | 28% | 100% |
| Q54QK7 | Dictyostelium discoideum | 50% | 100% |
| Q5XDX4 | Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) | 29% | 100% |
| Q65PH9 | Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) | 31% | 100% |
| Q6BSY5 | Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) | 44% | 100% |
| Q6C7H6 | Yarrowia lipolytica (strain CLIB 122 / E 150) | 46% | 100% |
| Q6FKY3 | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) | 45% | 100% |
| Q74C12 | Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) | 31% | 100% |
| Q75C90 | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) | 44% | 100% |
| Q7VM33 | Haemophilus ducreyi (strain 35000HP / ATCC 700724) | 32% | 100% |
| Q8P2N8 | Streptococcus pyogenes serotype M18 (strain MGAS8232) | 29% | 100% |
| Q95KJ0 | Macaca fascicularis | 51% | 100% |
| Q9A1I0 | Streptococcus pyogenes serotype M1 | 29% | 100% |
| Q9CHN8 | Lactococcus lactis subsp. lactis (strain IL1403) | 30% | 100% |
| Q9CLL5 | Pasteurella multocida (strain Pm70) | 28% | 100% |
| Q9D0D4 | Mus musculus | 51% | 100% |
| Q9FK02 | Arabidopsis thaliana | 40% | 98% |
| Q9PPN8 | Ureaplasma parvum serovar 3 (strain ATCC 700970) | 32% | 100% |
| Q9UNQ2 | Homo sapiens | 51% | 100% |
| Q9VAQ5 | Drosophila melanogaster | 50% | 100% |
| V5BCC0 | Trypanosoma cruzi | 72% | 100% |