Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rubisco LSMT substrate-binding - putative

Species:

Leishmania infantum

UniProt:

A4I511_LEIIN

TriTrypDb:

LINF_300006700

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I511

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I511

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	11
GO:0032259	methylation	2	11
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018026	peptidyl-lysine monomethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008168	methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.520
CLV_C14_Caspase3-7	81	85	PF00656	0.466
CLV_MEL_PAP_1	593	599	PF00089	0.344
CLV_NRD_NRD_1	266	268	PF00675	0.479
CLV_NRD_NRD_1	28	30	PF00675	0.504
CLV_NRD_NRD_1	392	394	PF00675	0.407
CLV_NRD_NRD_1	487	489	PF00675	0.360
CLV_NRD_NRD_1	493	495	PF00675	0.347
CLV_NRD_NRD_1	535	537	PF00675	0.326
CLV_PCSK_KEX2_1	266	268	PF00082	0.479
CLV_PCSK_KEX2_1	27	29	PF00082	0.360
CLV_PCSK_KEX2_1	303	305	PF00082	0.411
CLV_PCSK_KEX2_1	487	489	PF00082	0.362
CLV_PCSK_KEX2_1	493	495	PF00082	0.350
CLV_PCSK_KEX2_1	535	537	PF00082	0.326
CLV_PCSK_KEX2_1	600	602	PF00082	0.273
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.360
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.411
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.288
CLV_PCSK_PC7_1	262	268	PF00082	0.382
CLV_PCSK_PC7_1	596	602	PF00082	0.269
CLV_PCSK_SKI1_1	130	134	PF00082	0.378
CLV_PCSK_SKI1_1	156	160	PF00082	0.660
CLV_PCSK_SKI1_1	166	170	PF00082	0.618
CLV_PCSK_SKI1_1	177	181	PF00082	0.508
CLV_PCSK_SKI1_1	237	241	PF00082	0.468
CLV_PCSK_SKI1_1	266	270	PF00082	0.409
CLV_PCSK_SKI1_1	488	492	PF00082	0.405
CLV_PCSK_SKI1_1	494	498	PF00082	0.372
DEG_APCC_DBOX_1	202	210	PF00400	0.386
DEG_APCC_DBOX_1	595	603	PF00400	0.469
DEG_APCC_DBOX_1	67	75	PF00400	0.447
DOC_CYCLIN_RxL_1	262	270	PF00134	0.470
DOC_CYCLIN_yCln2_LP_2	448	454	PF00134	0.445
DOC_MAPK_gen_1	493	499	PF00069	0.464
DOC_MAPK_MEF2A_6	587	595	PF00069	0.494
DOC_MAPK_RevD_3	289	304	PF00069	0.393
DOC_PP1_RVXF_1	104	110	PF00149	0.433
DOC_PP1_RVXF_1	175	181	PF00149	0.474
DOC_PP1_RVXF_1	27	34	PF00149	0.382
DOC_PP1_RVXF_1	603	610	PF00149	0.335
DOC_PP2B_LxvP_1	207	210	PF13499	0.376
DOC_PP2B_LxvP_1	452	455	PF13499	0.578
DOC_PP2B_LxvP_1	497	500	PF13499	0.479
DOC_USP7_MATH_1	122	126	PF00917	0.539
DOC_USP7_MATH_1	143	147	PF00917	0.527
DOC_USP7_MATH_1	154	158	PF00917	0.657
DOC_USP7_MATH_1	199	203	PF00917	0.465
DOC_USP7_MATH_1	232	236	PF00917	0.453
DOC_USP7_MATH_1	302	306	PF00917	0.554
DOC_USP7_MATH_1	335	339	PF00917	0.456
DOC_USP7_MATH_1	340	344	PF00917	0.380
DOC_USP7_MATH_1	550	554	PF00917	0.531
DOC_WW_Pin1_4	541	546	PF00397	0.564
LIG_14-3-3_CanoR_1	166	171	PF00244	0.556
LIG_14-3-3_CanoR_1	266	276	PF00244	0.480
LIG_14-3-3_CanoR_1	57	63	PF00244	0.550
LIG_14-3-3_CterR_2	612	614	PF00244	0.426
LIG_Actin_WH2_2	586	602	PF00022	0.521
LIG_AP2alpha_2	97	99	PF02296	0.431
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BRCT_BRCA1_1	211	215	PF00533	0.390
LIG_BRCT_BRCA1_1	342	346	PF00533	0.428
LIG_BRCT_BRCA1_1	359	363	PF00533	0.212
LIG_Clathr_ClatBox_1	71	75	PF01394	0.448
LIG_deltaCOP1_diTrp_1	172	180	PF00928	0.405
LIG_EH1_1	214	222	PF00400	0.258
LIG_FHA_1	136	142	PF00498	0.403
LIG_FHA_1	276	282	PF00498	0.414
LIG_FHA_1	386	392	PF00498	0.489
LIG_FHA_1	401	407	PF00498	0.486
LIG_FHA_1	6	12	PF00498	0.621
LIG_FHA_2	167	173	PF00498	0.595
LIG_FHA_2	409	415	PF00498	0.440
LIG_FHA_2	567	573	PF00498	0.484
LIG_FHA_2	574	580	PF00498	0.456
LIG_FHA_2	59	65	PF00498	0.550
LIG_FHA_2	76	82	PF00498	0.461
LIG_LIR_Apic_2	58	63	PF02991	0.494
LIG_LIR_Gen_1	527	537	PF02991	0.460
LIG_LIR_Gen_1	78	88	PF02991	0.376
LIG_LIR_Nem_3	263	268	PF02991	0.358
LIG_LIR_Nem_3	418	423	PF02991	0.328
LIG_LIR_Nem_3	78	83	PF02991	0.362
LIG_LYPXL_yS_3	276	279	PF13949	0.330
LIG_NRBOX	235	241	PF00104	0.385
LIG_NRBOX	514	520	PF00104	0.486
LIG_SH2_CRK	223	227	PF00017	0.367
LIG_SH2_CRK	423	427	PF00017	0.321
LIG_SH2_CRK	435	439	PF00017	0.336
LIG_SH2_NCK_1	136	140	PF00017	0.453
LIG_SH2_STAP1	253	257	PF00017	0.346
LIG_SH2_STAP1	495	499	PF00017	0.379
LIG_SH2_STAT5	223	226	PF00017	0.389
LIG_SH2_STAT5	30	33	PF00017	0.406
LIG_SH3_1	536	542	PF00018	0.508
LIG_SH3_3	274	280	PF00018	0.333
LIG_SH3_3	452	458	PF00018	0.428
LIG_SH3_3	536	542	PF00018	0.508
LIG_SH3_3	92	98	PF00018	0.459
LIG_SUMO_SIM_par_1	70	75	PF11976	0.425
LIG_TRAF2_1	241	244	PF00917	0.476
LIG_TRFH_1	437	441	PF08558	0.438
LIG_TYR_ITIM	221	226	PF00017	0.405
MOD_CK1_1	190	196	PF00069	0.503
MOD_CK1_1	202	208	PF00069	0.467
MOD_CK1_1	465	471	PF00069	0.755
MOD_CK1_1	544	550	PF00069	0.462
MOD_CK1_1	565	571	PF00069	0.540
MOD_CK2_1	145	151	PF00069	0.668
MOD_CK2_1	566	572	PF00069	0.494
MOD_CK2_1	573	579	PF00069	0.459
MOD_CK2_1	58	64	PF00069	0.500
MOD_CK2_1	75	81	PF00069	0.264
MOD_Cter_Amidation	533	536	PF01082	0.222
MOD_GlcNHglycan	1	4	PF01048	0.746
MOD_GlcNHglycan	151	155	PF01048	0.650
MOD_GlcNHglycan	156	159	PF01048	0.639
MOD_GlcNHglycan	332	335	PF01048	0.484
MOD_GlcNHglycan	341	345	PF01048	0.454
MOD_GlcNHglycan	406	409	PF01048	0.341
MOD_GlcNHglycan	469	473	PF01048	0.712
MOD_GSK3_1	1	8	PF00069	0.648
MOD_GSK3_1	143	150	PF00069	0.624
MOD_GSK3_1	168	175	PF00069	0.509
MOD_GSK3_1	353	360	PF00069	0.454
MOD_GSK3_1	400	407	PF00069	0.234
MOD_GSK3_1	468	475	PF00069	0.714
MOD_GSK3_1	550	557	PF00069	0.476
MOD_GSK3_1	562	569	PF00069	0.466
MOD_LATS_1	164	170	PF00433	0.536
MOD_N-GLC_1	18	23	PF02516	0.454
MOD_N-GLC_1	385	390	PF02516	0.368
MOD_NEK2_1	1	6	PF00069	0.732
MOD_NEK2_1	216	221	PF00069	0.321
MOD_NEK2_1	314	319	PF00069	0.461
MOD_NEK2_1	404	409	PF00069	0.350
MOD_NEK2_1	419	424	PF00069	0.344
MOD_NEK2_2	137	142	PF00069	0.477
MOD_PIKK_1	302	308	PF00454	0.458
MOD_PKA_2	202	208	PF00069	0.440
MOD_Plk_1	260	266	PF00069	0.448
MOD_Plk_1	480	486	PF00069	0.481
MOD_Plk_1	573	579	PF00069	0.534
MOD_Plk_2-3	573	579	PF00069	0.524
MOD_Plk_2-3	75	81	PF00069	0.462
MOD_Plk_4	202	208	PF00069	0.428
MOD_Plk_4	216	222	PF00069	0.284
MOD_Plk_4	314	320	PF00069	0.388
MOD_Plk_4	550	556	PF00069	0.546
MOD_ProDKin_1	541	547	PF00069	0.564
TRG_DiLeu_BaEn_1	243	248	PF01217	0.374
TRG_DiLeu_BaEn_2	44	50	PF01217	0.530
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.480
TRG_ENDOCYTIC_2	223	226	PF00928	0.389
TRG_ENDOCYTIC_2	253	256	PF00928	0.425
TRG_ENDOCYTIC_2	276	279	PF00928	0.330
TRG_ENDOCYTIC_2	423	426	PF00928	0.324
TRG_ENDOCYTIC_2	435	438	PF00928	0.328
TRG_ENDOCYTIC_2	537	540	PF00928	0.532
TRG_ER_diArg_1	265	267	PF00400	0.474
TRG_ER_diArg_1	28	30	PF00400	0.383
TRG_ER_diArg_1	487	489	PF00400	0.455
TRG_ER_diArg_1	492	494	PF00400	0.444
TRG_ER_diArg_1	535	537	PF00400	0.527
TRG_ER_diArg_1	67	70	PF00400	0.419
TRG_NES_CRM1_1	287	299	PF08389	0.375
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8B9	Leptomonas seymouri	61%	97%
A0A0S4JJX6	Bodo saltans	33%	89%
A0A1X0P2C3	Trypanosomatidae	42%	100%
A0A3Q8IFL1	Leishmania donovani	100%	100%
A0A422N122	Trypanosoma rangeli	44%	100%
A4HHW1	Leishmania braziliensis	81%	100%
C9ZQG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B0E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q7U0	Leishmania major	93%	100%
V5AWY0	Trypanosoma cruzi	44%	100%