Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.
Structural Proteins, leucine-rich repeat
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 9 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 4 |
| NetGPI | no | yes: 0, no: 4 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005929 | cilium | 4 | 5 |
| GO:0042995 | cell projection | 2 | 5 |
| GO:0043226 | organelle | 2 | 5 |
| GO:0043227 | membrane-bounded organelle | 3 | 5 |
| GO:0110165 | cellular anatomical entity | 1 | 5 |
| GO:0120025 | plasma membrane bounded cell projection | 3 | 5 |
| GO:0005739 | mitochondrion | 5 | 1 |
| GO:0005741 | mitochondrial outer membrane | 5 | 1 |
| GO:0016020 | membrane | 2 | 3 |
| GO:0019867 | outer membrane | 3 | 1 |
| GO:0031090 | organelle membrane | 3 | 1 |
| GO:0031966 | mitochondrial membrane | 4 | 1 |
| GO:0031968 | organelle outer membrane | 4 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 1 |
| GO:0098588 | bounding membrane of organelle | 4 | 1 |
Related structures:
AlphaFold database: A4I510
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 38 | 42 | PF00656 | 0.627 |
| CLV_PCSK_SKI1_1 | 110 | 114 | PF00082 | 0.222 |
| CLV_PCSK_SKI1_1 | 139 | 143 | PF00082 | 0.355 |
| CLV_PCSK_SKI1_1 | 164 | 168 | PF00082 | 0.384 |
| CLV_PCSK_SKI1_1 | 4 | 8 | PF00082 | 0.381 |
| CLV_PCSK_SKI1_1 | 92 | 96 | PF00082 | 0.427 |
| DOC_MAPK_MEF2A_6 | 4 | 13 | PF00069 | 0.550 |
| DOC_MAPK_MEF2A_6 | 63 | 71 | PF00069 | 0.627 |
| DOC_USP7_MATH_1 | 144 | 148 | PF00917 | 0.690 |
| DOC_USP7_UBL2_3 | 88 | 92 | PF12436 | 0.627 |
| LIG_14-3-3_CanoR_1 | 121 | 127 | PF00244 | 0.592 |
| LIG_14-3-3_CanoR_1 | 146 | 155 | PF00244 | 0.682 |
| LIG_14-3-3_CanoR_1 | 182 | 186 | PF00244 | 0.731 |
| LIG_14-3-3_CanoR_1 | 4 | 13 | PF00244 | 0.581 |
| LIG_14-3-3_CterR_2 | 213 | 216 | PF00244 | 0.540 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.627 |
| LIG_BRCT_BRCA1_1 | 9 | 13 | PF00533 | 0.627 |
| LIG_DLG_GKlike_1 | 63 | 71 | PF00625 | 0.627 |
| LIG_FHA_1 | 140 | 146 | PF00498 | 0.684 |
| LIG_FHA_1 | 34 | 40 | PF00498 | 0.627 |
| LIG_FHA_2 | 127 | 133 | PF00498 | 0.581 |
| LIG_FHA_2 | 3 | 9 | PF00498 | 0.627 |
| LIG_FHA_2 | 93 | 99 | PF00498 | 0.627 |
| LIG_LIR_Apic_2 | 156 | 161 | PF02991 | 0.680 |
| LIG_LIR_Gen_1 | 10 | 19 | PF02991 | 0.627 |
| LIG_LIR_Gen_1 | 76 | 86 | PF02991 | 0.581 |
| LIG_LIR_Nem_3 | 10 | 16 | PF02991 | 0.627 |
| LIG_LIR_Nem_3 | 76 | 82 | PF02991 | 0.508 |
| LIG_SH2_CRK | 158 | 162 | PF00017 | 0.687 |
| LIG_SH2_CRK | 194 | 198 | PF00017 | 0.518 |
| LIG_SH2_NCK_1 | 172 | 176 | PF00017 | 0.627 |
| LIG_SH2_SRC | 122 | 125 | PF00017 | 0.662 |
| LIG_SH2_STAP1 | 124 | 128 | PF00017 | 0.627 |
| LIG_SH2_STAT5 | 122 | 125 | PF00017 | 0.662 |
| LIG_SUMO_SIM_par_1 | 202 | 207 | PF11976 | 0.390 |
| LIG_SUMO_SIM_par_1 | 35 | 41 | PF11976 | 0.627 |
| LIG_TYR_ITIM | 192 | 197 | PF00017 | 0.518 |
| MOD_CK1_1 | 147 | 153 | PF00069 | 0.638 |
| MOD_CK1_1 | 30 | 36 | PF00069 | 0.627 |
| MOD_CK1_1 | 59 | 65 | PF00069 | 0.670 |
| MOD_CK2_1 | 2 | 8 | PF00069 | 0.627 |
| MOD_CK2_1 | 59 | 65 | PF00069 | 0.670 |
| MOD_GlcNHglycan | 59 | 62 | PF01048 | 0.426 |
| MOD_GSK3_1 | 122 | 129 | PF00069 | 0.545 |
| MOD_GSK3_1 | 144 | 151 | PF00069 | 0.658 |
| MOD_GSK3_1 | 33 | 40 | PF00069 | 0.587 |
| MOD_GSK3_1 | 59 | 66 | PF00069 | 0.576 |
| MOD_N-GLC_1 | 67 | 72 | PF02516 | 0.427 |
| MOD_NEK2_1 | 126 | 131 | PF00069 | 0.596 |
| MOD_NEK2_1 | 56 | 61 | PF00069 | 0.579 |
| MOD_NEK2_1 | 67 | 72 | PF00069 | 0.422 |
| MOD_NEK2_1 | 86 | 91 | PF00069 | 0.439 |
| MOD_NEK2_2 | 181 | 186 | PF00069 | 0.726 |
| MOD_PKA_2 | 145 | 151 | PF00069 | 0.670 |
| MOD_PKA_2 | 181 | 187 | PF00069 | 0.732 |
| MOD_Plk_1 | 67 | 73 | PF00069 | 0.627 |
| MOD_Plk_1 | 7 | 13 | PF00069 | 0.627 |
| MOD_Plk_4 | 187 | 193 | PF00069 | 0.581 |
| MOD_Plk_4 | 204 | 210 | PF00069 | 0.518 |
| MOD_SUMO_rev_2 | 173 | 180 | PF00179 | 0.635 |
| TRG_ENDOCYTIC_2 | 172 | 175 | PF00928 | 0.622 |
| TRG_ENDOCYTIC_2 | 194 | 197 | PF00928 | 0.370 |
| TRG_ER_diArg_1 | 210 | 213 | PF00400 | 0.509 |
| TRG_Pf-PMV_PEXEL_1 | 139 | 143 | PF00026 | 0.427 |
| TRG_Pf-PMV_PEXEL_1 | 164 | 168 | PF00026 | 0.452 |
| TRG_Pf-PMV_PEXEL_1 | 169 | 173 | PF00026 | 0.438 |
| TRG_Pf-PMV_PEXEL_1 | 4 | 8 | PF00026 | 0.427 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A3S7X2X2 | Leishmania donovani | 99% | 100% |
| E9B0E0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 94% | 100% |
| Q4Q7T8 | Leishmania major | 94% | 100% |