LeishMANIAdb
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Alkyldihydroxyacetonephosphate synthase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Alkyldihydroxyacetonephosphate synthase
Gene product:
alkyldihydroxyacetonephosphate synthase
Species:
Leishmania infantum
UniProt:
A4I507_LEIIN
TriTrypDb:
LINF_300006300
Length:
621

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, Alkyldihydroxyacetonephosphate synthase ADS1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I507
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I507

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 1
GO:0006662 glycerol ether metabolic process 4 1
GO:0008152 metabolic process 1 1
GO:0008610 lipid biosynthetic process 4 1
GO:0008611 ether lipid biosynthetic process 5 1
GO:0009058 biosynthetic process 2 1
GO:0009987 cellular process 1 1
GO:0018904 ether metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0046485 ether lipid metabolic process 4 1
GO:0046504 glycerol ether biosynthetic process 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0097384 cellular lipid biosynthetic process 4 1
GO:1901503 ether biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0008609 alkylglycerone-phosphate synthase activity 4 8
GO:0016740 transferase activity 2 8
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3 8
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0050660 flavin adenine dinucleotide binding 4 12
GO:0071949 FAD binding 5 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 128 130 PF00675 0.373
CLV_NRD_NRD_1 193 195 PF00675 0.275
CLV_NRD_NRD_1 391 393 PF00675 0.372
CLV_PCSK_KEX2_1 193 195 PF00082 0.305
CLV_PCSK_KEX2_1 391 393 PF00082 0.330
CLV_PCSK_KEX2_1 527 529 PF00082 0.297
CLV_PCSK_PC1ET2_1 527 529 PF00082 0.297
CLV_PCSK_SKI1_1 206 210 PF00082 0.410
CLV_PCSK_SKI1_1 269 273 PF00082 0.261
CLV_PCSK_SKI1_1 341 345 PF00082 0.256
CLV_PCSK_SKI1_1 379 383 PF00082 0.276
CLV_PCSK_SKI1_1 46 50 PF00082 0.374
CLV_PCSK_SKI1_1 472 476 PF00082 0.259
CLV_PCSK_SKI1_1 520 524 PF00082 0.271
CLV_PCSK_SKI1_1 527 531 PF00082 0.259
DEG_APCC_DBOX_1 391 399 PF00400 0.414
DEG_SCF_FBW7_1 276 283 PF00400 0.378
DEG_SPOP_SBC_1 361 365 PF00917 0.369
DOC_CKS1_1 270 275 PF01111 0.259
DOC_CKS1_1 277 282 PF01111 0.362
DOC_CYCLIN_RxL_1 46 53 PF00134 0.454
DOC_CYCLIN_RxL_1 599 609 PF00134 0.491
DOC_CYCLIN_yClb1_LxF_4 49 55 PF00134 0.451
DOC_CYCLIN_yClb5_NLxxxL_5 49 55 PF00134 0.463
DOC_MAPK_gen_1 183 190 PF00069 0.265
DOC_MAPK_gen_1 193 201 PF00069 0.251
DOC_MAPK_gen_1 391 398 PF00069 0.297
DOC_MAPK_gen_1 46 54 PF00069 0.348
DOC_MAPK_gen_1 599 608 PF00069 0.430
DOC_MAPK_MEF2A_6 158 166 PF00069 0.261
DOC_MAPK_MEF2A_6 183 192 PF00069 0.265
DOC_MAPK_MEF2A_6 391 400 PF00069 0.241
DOC_MAPK_MEF2A_6 514 523 PF00069 0.366
DOC_PP1_RVXF_1 15 21 PF00149 0.393
DOC_PP1_RVXF_1 404 410 PF00149 0.369
DOC_PP1_RVXF_1 602 609 PF00149 0.488
DOC_USP7_MATH_1 248 252 PF00917 0.261
DOC_USP7_MATH_1 280 284 PF00917 0.400
DOC_USP7_MATH_1 552 556 PF00917 0.369
DOC_USP7_MATH_1 616 620 PF00917 0.467
DOC_USP7_MATH_2 589 595 PF00917 0.574
DOC_USP7_UBL2_3 572 576 PF12436 0.381
DOC_WW_Pin1_4 269 274 PF00397 0.259
DOC_WW_Pin1_4 276 281 PF00397 0.360
DOC_WW_Pin1_4 400 405 PF00397 0.375
DOC_WW_Pin1_4 584 589 PF00397 0.426
DOC_WW_Pin1_4 69 74 PF00397 0.425
LIG_14-3-3_CanoR_1 185 191 PF00244 0.318
LIG_14-3-3_CanoR_1 206 211 PF00244 0.381
LIG_14-3-3_CanoR_1 357 361 PF00244 0.271
LIG_14-3-3_CanoR_1 372 381 PF00244 0.261
LIG_14-3-3_CanoR_1 386 391 PF00244 0.320
LIG_14-3-3_CanoR_1 392 396 PF00244 0.175
LIG_14-3-3_CanoR_1 528 534 PF00244 0.343
LIG_Actin_WH2_2 375 393 PF00022 0.291
LIG_AP2alpha_2 179 181 PF02296 0.376
LIG_APCC_ABBA_1 348 353 PF00400 0.261
LIG_EVH1_1 585 589 PF00568 0.456
LIG_FHA_1 171 177 PF00498 0.261
LIG_FHA_1 210 216 PF00498 0.373
LIG_FHA_1 272 278 PF00498 0.340
LIG_FHA_1 283 289 PF00498 0.438
LIG_FHA_1 306 312 PF00498 0.311
LIG_FHA_1 345 351 PF00498 0.283
LIG_FHA_1 412 418 PF00498 0.328
LIG_FHA_1 458 464 PF00498 0.264
LIG_FHA_1 535 541 PF00498 0.283
LIG_FHA_2 311 317 PF00498 0.475
LIG_FHA_2 431 437 PF00498 0.369
LIG_FHA_2 8 14 PF00498 0.543
LIG_LIR_Apic_2 321 326 PF02991 0.261
LIG_LIR_Apic_2 436 442 PF02991 0.237
LIG_LIR_Apic_2 555 560 PF02991 0.381
LIG_LIR_Gen_1 236 246 PF02991 0.288
LIG_LIR_Gen_1 329 340 PF02991 0.346
LIG_LIR_Gen_1 452 462 PF02991 0.318
LIG_LIR_Gen_1 53 63 PF02991 0.420
LIG_LIR_Gen_1 605 616 PF02991 0.373
LIG_LIR_Nem_3 13 18 PF02991 0.353
LIG_LIR_Nem_3 236 242 PF02991 0.288
LIG_LIR_Nem_3 255 261 PF02991 0.261
LIG_LIR_Nem_3 298 304 PF02991 0.280
LIG_LIR_Nem_3 329 335 PF02991 0.229
LIG_LIR_Nem_3 452 457 PF02991 0.318
LIG_LIR_Nem_3 53 59 PF02991 0.455
LIG_MYND_1 69 73 PF01753 0.541
LIG_PDZ_Class_1 616 621 PF00595 0.505
LIG_Pex14_1 454 458 PF04695 0.261
LIG_Pex14_1 553 557 PF04695 0.261
LIG_Pex14_2 224 228 PF04695 0.408
LIG_Pex14_2 328 332 PF04695 0.277
LIG_SH2_CRK 15 19 PF00017 0.400
LIG_SH2_CRK 239 243 PF00017 0.295
LIG_SH2_CRK 421 425 PF00017 0.383
LIG_SH2_CRK 439 443 PF00017 0.117
LIG_SH2_CRK 557 561 PF00017 0.310
LIG_SH2_NCK_1 439 443 PF00017 0.261
LIG_SH2_NCK_1 548 552 PF00017 0.277
LIG_SH2_SRC 548 551 PF00017 0.277
LIG_SH2_SRC 56 59 PF00017 0.407
LIG_SH2_STAP1 336 340 PF00017 0.390
LIG_SH2_STAP1 464 468 PF00017 0.277
LIG_SH2_STAT5 323 326 PF00017 0.318
LIG_SH2_STAT5 336 339 PF00017 0.318
LIG_SH2_STAT5 443 446 PF00017 0.247
LIG_SH2_STAT5 506 509 PF00017 0.247
LIG_SH3_1 583 589 PF00018 0.422
LIG_SH3_3 159 165 PF00018 0.277
LIG_SH3_3 211 217 PF00018 0.277
LIG_SH3_3 267 273 PF00018 0.277
LIG_SH3_3 583 589 PF00018 0.401
LIG_SH3_3 67 73 PF00018 0.463
LIG_SUMO_SIM_anti_2 394 399 PF11976 0.302
LIG_SUMO_SIM_par_1 186 191 PF11976 0.261
LIG_SUMO_SIM_par_1 197 202 PF11976 0.261
LIG_TYR_ITIM 546 551 PF00017 0.277
LIG_UBA3_1 152 158 PF00899 0.273
LIG_UBA3_1 521 527 PF00899 0.346
LIG_WRC_WIRS_1 207 212 PF05994 0.346
LIG_WRC_WIRS_1 325 330 PF05994 0.261
LIG_WRC_WIRS_1 378 383 PF05994 0.398
LIG_WRC_WIRS_1 506 511 PF05994 0.261
LIG_WW_3 587 591 PF00397 0.552
MOD_CDC14_SPxK_1 587 590 PF00782 0.541
MOD_CDK_SPxK_1 400 406 PF00069 0.272
MOD_CDK_SPxK_1 584 590 PF00069 0.523
MOD_CK2_1 310 316 PF00069 0.477
MOD_CK2_1 377 383 PF00069 0.338
MOD_CK2_1 7 13 PF00069 0.564
MOD_CMANNOS 20 23 PF00535 0.312
MOD_GlcNHglycan 250 253 PF01048 0.261
MOD_GlcNHglycan 332 335 PF01048 0.277
MOD_GlcNHglycan 510 513 PF01048 0.376
MOD_GlcNHglycan 58 62 PF01048 0.465
MOD_GlcNHglycan 593 596 PF01048 0.542
MOD_GlcNHglycan 96 100 PF01048 0.453
MOD_GSK3_1 202 209 PF00069 0.333
MOD_GSK3_1 233 240 PF00069 0.256
MOD_GSK3_1 248 255 PF00069 0.195
MOD_GSK3_1 276 283 PF00069 0.369
MOD_GSK3_1 330 337 PF00069 0.274
MOD_GSK3_1 356 363 PF00069 0.271
MOD_GSK3_1 373 380 PF00069 0.304
MOD_GSK3_1 458 465 PF00069 0.295
MOD_GSK3_1 534 541 PF00069 0.295
MOD_N-GLC_1 170 175 PF02516 0.277
MOD_N-GLC_1 538 543 PF02516 0.262
MOD_N-GLC_1 591 596 PF02516 0.540
MOD_N-GLC_2 577 579 PF02516 0.253
MOD_NEK2_1 101 106 PF00069 0.436
MOD_NEK2_1 238 243 PF00069 0.342
MOD_NEK2_1 356 361 PF00069 0.344
MOD_NEK2_1 362 367 PF00069 0.300
MOD_NEK2_1 373 378 PF00069 0.175
MOD_NEK2_1 447 452 PF00069 0.271
MOD_NEK2_1 458 463 PF00069 0.211
MOD_NEK2_1 505 510 PF00069 0.250
MOD_NEK2_1 534 539 PF00069 0.295
MOD_PIKK_1 101 107 PF00454 0.425
MOD_PIKK_1 462 468 PF00454 0.381
MOD_PIKK_1 7 13 PF00454 0.447
MOD_PK_1 197 203 PF00069 0.273
MOD_PKA_1 391 397 PF00069 0.328
MOD_PKA_1 527 533 PF00069 0.328
MOD_PKA_2 202 208 PF00069 0.361
MOD_PKA_2 248 254 PF00069 0.259
MOD_PKA_2 356 362 PF00069 0.261
MOD_PKA_2 391 397 PF00069 0.330
MOD_PKA_2 527 533 PF00069 0.346
MOD_PKB_1 384 392 PF00069 0.194
MOD_Plk_1 305 311 PF00069 0.334
MOD_Plk_1 458 464 PF00069 0.261
MOD_Plk_1 95 101 PF00069 0.452
MOD_Plk_4 233 239 PF00069 0.326
MOD_Plk_4 365 371 PF00069 0.297
MOD_Plk_4 377 383 PF00069 0.238
MOD_Plk_4 458 464 PF00069 0.275
MOD_ProDKin_1 269 275 PF00069 0.259
MOD_ProDKin_1 276 282 PF00069 0.361
MOD_ProDKin_1 400 406 PF00069 0.375
MOD_ProDKin_1 584 590 PF00069 0.433
MOD_ProDKin_1 69 75 PF00069 0.415
MOD_SUMO_for_1 309 312 PF00179 0.313
MOD_SUMO_rev_2 104 112 PF00179 0.454
MOD_SUMO_rev_2 312 319 PF00179 0.354
MOD_SUMO_rev_2 515 522 PF00179 0.278
TRG_ENDOCYTIC_2 122 125 PF00928 0.292
TRG_ENDOCYTIC_2 15 18 PF00928 0.367
TRG_ENDOCYTIC_2 239 242 PF00928 0.290
TRG_ENDOCYTIC_2 258 261 PF00928 0.261
TRG_ENDOCYTIC_2 421 424 PF00928 0.383
TRG_ENDOCYTIC_2 506 509 PF00928 0.261
TRG_ENDOCYTIC_2 548 551 PF00928 0.277
TRG_ENDOCYTIC_2 56 59 PF00928 0.458
TRG_ER_diArg_1 126 129 PF00400 0.307
TRG_ER_diArg_1 183 186 PF00400 0.288
TRG_ER_diArg_1 192 194 PF00400 0.223
TRG_ER_diArg_1 390 392 PF00400 0.330
TRG_NLS_MonoExtC_3 525 531 PF00514 0.328
TRG_Pf-PMV_PEXEL_1 317 321 PF00026 0.414
TRG_Pf-PMV_PEXEL_1 49 53 PF00026 0.456
TRG_Pf-PMV_PEXEL_1 604 609 PF00026 0.493
TRG_PTS1 618 621 PF00515 0.407

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6Q0 Leptomonas seymouri 23% 100%
A0A0N1PE88 Leptomonas seymouri 23% 100%
A0A0N1PEY1 Leptomonas seymouri 81% 100%
A0A0S4JD99 Bodo saltans 25% 100%
A0A0S4JV88 Bodo saltans 63% 98%
A0A1X0P026 Trypanosomatidae 22% 100%
A0A1X0P2J0 Trypanosomatidae 60% 100%
A0A3Q8IDH3 Leishmania donovani 24% 100%
A0A3Q8IDH5 Leishmania donovani 23% 100%
A0A3Q8IEJ5 Leishmania donovani 23% 100%
A0A3Q8IRN9 Leishmania donovani 99% 100%
A0A422N649 Trypanosoma rangeli 64% 100%
A4HFX9 Leishmania braziliensis 23% 98%
A4HHV7 Leishmania braziliensis 88% 100%
A4I0D2 Leishmania infantum 23% 100%
A4I309 Leishmania infantum 22% 91%
A4I481 Leishmania infantum 24% 100%
A4VGK4 Pseudomonas stutzeri (strain A1501) 23% 100%
C9ZQF7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
D4MUV9 Anaerostipes hadrus 24% 100%
E9ADI2 Leishmania major 22% 90%
E9ADN0 Leishmania major 23% 100%
E9AM50 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AZA6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 94%
E9B0D7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
F1QXM5 Danio rerio 24% 100%
H6LBS1 Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1) 23% 100%
O00116 Homo sapiens 31% 94%
O23240 Arabidopsis thaliana 24% 100%
O29853 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 23% 100%
O45218 Caenorhabditis elegans 30% 100%
O96759 Dictyostelium discoideum 38% 100%
O97157 Trypanosoma brucei brucei 60% 100%
P32891 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 100%
P39976 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 100%
P94535 Bacillus subtilis (strain 168) 25% 100%
P97275 Cavia porcellus 31% 94%
Q12627 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 24% 100%
Q46911 Escherichia coli (strain K12) 25% 100%
Q7TNG8 Mus musculus 24% 100%
Q7YWB6 Leishmania major 96% 100%
Q86WU2 Homo sapiens 23% 100%
Q8C0I1 Mus musculus 31% 96%
Q8X7S0 Escherichia coli O157:H7 25% 100%
Q94AX4 Arabidopsis thaliana 24% 100%
Q9EQR2 Rattus norvegicus 31% 96%
Q9V778 Drosophila melanogaster 31% 98%
V5BCB2 Trypanosoma cruzi 64% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS