Putative mitotic cyclin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitotic cyclin - putative

Species:

Leishmania infantum

UniProt:

A4I503_LEIIN

TriTrypDb:

LINF_300005800

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	7	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4I503

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I503

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	1
GO:0001932	regulation of protein phosphorylation	7	1
GO:0009987	cellular process	1	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0022402	cell cycle process	2	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031399	regulation of protein modification process	6	1
GO:0042325	regulation of phosphorylation	7	1
GO:0043549	regulation of kinase activity	5	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0045859	regulation of protein kinase activity	6	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051338	regulation of transferase activity	4	1
GO:0051726	regulation of cell cycle	4	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0071900	regulation of protein serine/threonine kinase activity	7	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903047	mitotic cell cycle process	3	1
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	1

Molecular functions
Term	Name	Level	Count
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	1
GO:0019207	kinase regulator activity	3	1
GO:0019887	protein kinase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.317
CLV_NRD_NRD_1	140	142	PF00675	0.536
CLV_NRD_NRD_1	283	285	PF00675	0.603
CLV_NRD_NRD_1	359	361	PF00675	0.378
CLV_NRD_NRD_1	417	419	PF00675	0.481
CLV_NRD_NRD_1	72	74	PF00675	0.518
CLV_PCSK_KEX2_1	283	285	PF00082	0.598
CLV_PCSK_KEX2_1	359	361	PF00082	0.415
CLV_PCSK_KEX2_1	417	419	PF00082	0.481
CLV_PCSK_KEX2_1	72	74	PF00082	0.582
CLV_PCSK_SKI1_1	283	287	PF00082	0.582
CLV_PCSK_SKI1_1	359	363	PF00082	0.407
CLV_PCSK_SKI1_1	388	392	PF00082	0.475
CLV_PCSK_SKI1_1	42	46	PF00082	0.551
CLV_PCSK_SKI1_1	51	55	PF00082	0.494
CLV_PCSK_SKI1_1	73	77	PF00082	0.533
DEG_APCC_DBOX_1	264	272	PF00400	0.462
DEG_APCC_DBOX_1	358	366	PF00400	0.567
DOC_CYCLIN_yCln2_LP_2	19	25	PF00134	0.491
DOC_MAPK_gen_1	51	61	PF00069	0.347
DOC_MAPK_MEF2A_6	218	225	PF00069	0.412
DOC_MAPK_MEF2A_6	89	97	PF00069	0.323
DOC_PP2B_LxvP_1	400	403	PF13499	0.586
DOC_USP7_MATH_1	203	207	PF00917	0.439
DOC_USP7_UBL2_3	47	51	PF12436	0.374
DOC_WW_Pin1_4	349	354	PF00397	0.577
LIG_14-3-3_CanoR_1	218	224	PF00244	0.455
LIG_14-3-3_CanoR_1	265	275	PF00244	0.434
LIG_14-3-3_CanoR_1	333	338	PF00244	0.469
LIG_14-3-3_CanoR_1	89	94	PF00244	0.376
LIG_14-3-3_CterR_2	417	420	PF00244	0.613
LIG_Actin_WH2_2	126	143	PF00022	0.315
LIG_Actin_WH2_2	75	91	PF00022	0.315
LIG_BIR_II_1	1	5	PF00653	0.479
LIG_BRCT_BRCA1_1	16	20	PF00533	0.489
LIG_eIF4E_1	181	187	PF01652	0.408
LIG_EVH1_1	400	404	PF00568	0.637
LIG_EVH1_2	403	407	PF00568	0.633
LIG_FHA_1	172	178	PF00498	0.334
LIG_FHA_1	267	273	PF00498	0.441
LIG_FHA_1	320	326	PF00498	0.402
LIG_FHA_1	372	378	PF00498	0.612
LIG_FHA_1	74	80	PF00498	0.303
LIG_FHA_1	90	96	PF00498	0.293
LIG_FHA_2	295	301	PF00498	0.446
LIG_FHA_2	325	331	PF00498	0.351
LIG_FHA_2	391	397	PF00498	0.661
LIG_FHA_2	404	410	PF00498	0.638
LIG_IRF3_LxIS_1	365	372	PF10401	0.606
LIG_LIR_Apic_2	36	41	PF02991	0.512
LIG_LIR_Gen_1	219	225	PF02991	0.428
LIG_LIR_Gen_1	250	261	PF02991	0.339
LIG_LIR_Gen_1	303	310	PF02991	0.392
LIG_LIR_Gen_1	312	321	PF02991	0.384
LIG_LIR_Gen_1	330	338	PF02991	0.250
LIG_LIR_Gen_1	43	53	PF02991	0.361
LIG_LIR_Nem_3	165	170	PF02991	0.329
LIG_LIR_Nem_3	219	223	PF02991	0.430
LIG_LIR_Nem_3	250	256	PF02991	0.333
LIG_LIR_Nem_3	303	307	PF02991	0.389
LIG_LIR_Nem_3	312	317	PF02991	0.390
LIG_LIR_Nem_3	330	334	PF02991	0.283
LIG_PCNA_PIPBox_1	232	241	PF02747	0.468
LIG_Pex14_2	256	260	PF04695	0.402
LIG_PTB_Apo_2	175	182	PF02174	0.331
LIG_PTB_Phospho_1	175	181	PF10480	0.331
LIG_SH2_CRK	335	339	PF00017	0.469
LIG_SH2_PTP2	304	307	PF00017	0.413
LIG_SH2_SRC	170	173	PF00017	0.420
LIG_SH2_SRC	38	41	PF00017	0.478
LIG_SH2_STAT5	103	106	PF00017	0.374
LIG_SH2_STAT5	170	173	PF00017	0.408
LIG_SH2_STAT5	181	184	PF00017	0.280
LIG_SH2_STAT5	304	307	PF00017	0.409
LIG_SH2_STAT5	337	340	PF00017	0.443
LIG_SH2_STAT5	413	416	PF00017	0.618
LIG_SH3_1	398	404	PF00018	0.589
LIG_SH3_3	398	404	PF00018	0.648
LIG_SUMO_SIM_anti_2	2	10	PF11976	0.479
LIG_SUMO_SIM_anti_2	206	211	PF11976	0.405
LIG_SUMO_SIM_anti_2	219	227	PF11976	0.391
LIG_SUMO_SIM_anti_2	57	63	PF11976	0.345
LIG_SUMO_SIM_par_1	142	148	PF11976	0.356
LIG_SUMO_SIM_par_1	203	208	PF11976	0.398
LIG_TRAF2_1	158	161	PF00917	0.387
LIG_UBA3_1	44	51	PF00899	0.356
LIG_WRC_WIRS_1	163	168	PF05994	0.287
MOD_CDC14_SPxK_1	352	355	PF00782	0.676
MOD_CDK_SPxK_1	349	355	PF00069	0.580
MOD_CK1_1	12	18	PF00069	0.496
MOD_CK1_1	227	233	PF00069	0.436
MOD_CK1_1	247	253	PF00069	0.230
MOD_CK1_1	289	295	PF00069	0.437
MOD_CK1_1	309	315	PF00069	0.215
MOD_CK1_1	336	342	PF00069	0.394
MOD_CK1_1	57	63	PF00069	0.399
MOD_CK2_1	192	198	PF00069	0.429
MOD_CK2_1	294	300	PF00069	0.455
MOD_CK2_1	324	330	PF00069	0.351
MOD_CK2_1	390	396	PF00069	0.653
MOD_GlcNHglycan	239	242	PF01048	0.634
MOD_GlcNHglycan	311	314	PF01048	0.610
MOD_GlcNHglycan	370	374	PF01048	0.416
MOD_GSK3_1	244	251	PF00069	0.494
MOD_GSK3_1	288	295	PF00069	0.442
MOD_GSK3_1	403	410	PF00069	0.646
MOD_GSK3_1	6	13	PF00069	0.464
MOD_NEK2_1	192	197	PF00069	0.453
MOD_NEK2_1	239	244	PF00069	0.415
MOD_NEK2_1	245	250	PF00069	0.468
MOD_NEK2_1	255	260	PF00069	0.333
MOD_NEK2_1	286	291	PF00069	0.377
MOD_NEK2_1	369	374	PF00069	0.588
MOD_NEK2_1	382	387	PF00069	0.537
MOD_NEK2_1	407	412	PF00069	0.641
MOD_NEK2_1	62	67	PF00069	0.304
MOD_NEK2_1	88	93	PF00069	0.311
MOD_NEK2_1	99	104	PF00069	0.295
MOD_NEK2_2	162	167	PF00069	0.291
MOD_PIKK_1	192	198	PF00454	0.503
MOD_PIKK_1	289	295	PF00454	0.477
MOD_PIKK_1	319	325	PF00454	0.404
MOD_PIKK_1	371	377	PF00454	0.614
MOD_PKA_2	300	306	PF00069	0.390
MOD_PKA_2	407	413	PF00069	0.610
MOD_PKA_2	88	94	PF00069	0.386
MOD_Plk_1	57	63	PF00069	0.416
MOD_Plk_4	162	168	PF00069	0.320
MOD_Plk_4	172	178	PF00069	0.343
MOD_Plk_4	219	225	PF00069	0.449
MOD_Plk_4	248	254	PF00069	0.426
MOD_Plk_4	300	306	PF00069	0.403
MOD_Plk_4	333	339	PF00069	0.443
MOD_Plk_4	40	46	PF00069	0.468
MOD_Plk_4	62	68	PF00069	0.299
MOD_Plk_4	99	105	PF00069	0.416
MOD_ProDKin_1	349	355	PF00069	0.580
MOD_SUMO_for_1	128	131	PF00179	0.315
MOD_SUMO_for_1	34	37	PF00179	0.549
MOD_SUMO_rev_2	36	44	PF00179	0.479
TRG_DiLeu_BaEn_1	357	362	PF01217	0.619
TRG_DiLeu_LyEn_5	357	362	PF01217	0.619
TRG_ENDOCYTIC_2	181	184	PF00928	0.334
TRG_ENDOCYTIC_2	304	307	PF00928	0.413
TRG_ENDOCYTIC_2	335	338	PF00928	0.469
TRG_ER_diArg_1	283	285	PF00400	0.410
TRG_ER_diArg_1	359	361	PF00400	0.578
TRG_ER_diArg_1	417	419	PF00400	0.681
TRG_ER_diArg_1	72	74	PF00400	0.360
TRG_NES_CRM1_1	136	148	PF08389	0.334
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P2	Leptomonas seymouri	80%	100%
A0A0S4JZZ8	Bodo saltans	46%	99%
A0A1X0P2F8	Trypanosomatidae	46%	100%
A0A3Q8IHJ8	Leishmania donovani	99%	100%
A4HHV3	Leishmania braziliensis	91%	100%
C9ZQF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	93%
E9B0D3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q7U8	Leishmania major	96%	100%