LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Alpha/beta hydrolase family/alpha/beta hydrolase fold - putative
Species:
Leishmania infantum
UniProt:
A4I4Z6_LEIIN
TriTrypDb:
LINF_300005100
Length:
425

Annotations

LeishMANIAdb annotations

Posesses a conserved AB hydrolase domain. Due to the distribution of hydrophilic / hydrophobic amino acids, it likely only has a perimembrane helix, not a full TM one.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 25
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4I4Z6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4Z6

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 3
GO:0008152 metabolic process 1 3
GO:0009987 cellular process 1 3
GO:0044237 cellular metabolic process 2 3
GO:0044238 primary metabolic process 2 3
GO:0044255 cellular lipid metabolic process 3 3
GO:0071704 organic substance metabolic process 2 3
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0016298 lipase activity 4 3
GO:0016787 hydrolase activity 2 5
GO:0016788 hydrolase activity, acting on ester bonds 3 3
GO:0034338 short-chain carboxylesterase activity 5 3
GO:0047372 acylglycerol lipase activity 5 3
GO:0052689 carboxylic ester hydrolase activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 251 255 PF00656 0.354
CLV_NRD_NRD_1 261 263 PF00675 0.450
CLV_NRD_NRD_1 281 283 PF00675 0.465
CLV_PCSK_KEX2_1 261 263 PF00082 0.368
CLV_PCSK_KEX2_1 281 283 PF00082 0.477
CLV_PCSK_SKI1_1 126 130 PF00082 0.507
CLV_PCSK_SKI1_1 189 193 PF00082 0.413
CLV_PCSK_SKI1_1 282 286 PF00082 0.500
CLV_PCSK_SKI1_1 298 302 PF00082 0.441
CLV_PCSK_SKI1_1 321 325 PF00082 0.479
CLV_PCSK_SKI1_1 66 70 PF00082 0.492
DEG_SCF_FBW7_1 169 176 PF00400 0.273
DOC_CDC14_PxL_1 132 140 PF14671 0.278
DOC_CDC14_PxL_1 287 295 PF14671 0.335
DOC_CDC14_PxL_1 322 330 PF14671 0.335
DOC_CKS1_1 174 179 PF01111 0.297
DOC_CKS1_1 330 335 PF01111 0.307
DOC_MAPK_DCC_7 17 26 PF00069 0.415
DOC_MAPK_gen_1 126 135 PF00069 0.313
DOC_MAPK_gen_1 23 31 PF00069 0.539
DOC_MAPK_MEF2A_6 126 135 PF00069 0.313
DOC_MAPK_MEF2A_6 17 26 PF00069 0.601
DOC_MAPK_MEF2A_6 321 330 PF00069 0.335
DOC_MAPK_MEF2A_6 377 386 PF00069 0.267
DOC_PP1_RVXF_1 21 27 PF00149 0.497
DOC_PP2B_LxvP_1 133 136 PF13499 0.261
DOC_PP2B_LxvP_1 385 388 PF13499 0.254
DOC_PP2B_PxIxI_1 210 216 PF00149 0.354
DOC_PP4_FxxP_1 330 333 PF00568 0.273
DOC_PP4_FxxP_1 349 352 PF00568 0.123
DOC_USP7_MATH_1 300 304 PF00917 0.307
DOC_USP7_MATH_1 368 372 PF00917 0.230
DOC_USP7_MATH_1 97 101 PF00917 0.341
DOC_USP7_UBL2_3 66 70 PF12436 0.225
DOC_WW_Pin1_4 169 174 PF00397 0.243
DOC_WW_Pin1_4 245 250 PF00397 0.258
DOC_WW_Pin1_4 291 296 PF00397 0.237
DOC_WW_Pin1_4 329 334 PF00397 0.288
DOC_WW_Pin1_4 338 343 PF00397 0.288
DOC_WW_Pin1_4 419 424 PF00397 0.390
LIG_14-3-3_CanoR_1 321 326 PF00244 0.327
LIG_Actin_WH2_2 28 44 PF00022 0.261
LIG_deltaCOP1_diTrp_1 344 349 PF00928 0.193
LIG_FHA_1 142 148 PF00498 0.280
LIG_FHA_1 174 180 PF00498 0.254
LIG_FHA_1 183 189 PF00498 0.213
LIG_FHA_1 404 410 PF00498 0.311
LIG_FHA_2 170 176 PF00498 0.311
LIG_FHA_2 313 319 PF00498 0.258
LIG_FHA_2 330 336 PF00498 0.200
LIG_FHA_2 406 412 PF00498 0.353
LIG_IRF3_LxIS_1 351 357 PF10401 0.199
LIG_LIR_Apic_2 327 333 PF02991 0.300
LIG_LIR_Gen_1 100 111 PF02991 0.249
LIG_LIR_Gen_1 148 155 PF02991 0.302
LIG_LIR_Gen_1 318 326 PF02991 0.287
LIG_LIR_Gen_1 334 343 PF02991 0.168
LIG_LIR_Nem_3 100 106 PF02991 0.388
LIG_LIR_Nem_3 148 153 PF02991 0.286
LIG_LIR_Nem_3 318 322 PF02991 0.286
LIG_LIR_Nem_3 334 340 PF02991 0.172
LIG_LIR_Nem_3 67 71 PF02991 0.240
LIG_MYND_1 291 295 PF01753 0.222
LIG_NRBOX 117 123 PF00104 0.196
LIG_NRP_CendR_1 424 425 PF00754 0.651
LIG_Pex14_1 345 349 PF04695 0.335
LIG_Pex14_2 155 159 PF04695 0.344
LIG_Pex14_2 32 36 PF04695 0.307
LIG_PTB_Apo_2 111 118 PF02174 0.357
LIG_PTB_Phospho_1 111 117 PF10480 0.230
LIG_REV1ctd_RIR_1 44 53 PF16727 0.428
LIG_REV1ctd_RIR_1 66 74 PF16727 0.227
LIG_SH2_CRK 103 107 PF00017 0.338
LIG_SH2_NCK_1 415 419 PF00017 0.258
LIG_SH2_SRC 146 149 PF00017 0.335
LIG_SH2_SRC 268 271 PF00017 0.325
LIG_SH2_SRC 79 82 PF00017 0.352
LIG_SH2_STAP1 415 419 PF00017 0.396
LIG_SH2_STAT5 117 120 PF00017 0.307
LIG_SH2_STAT5 146 149 PF00017 0.250
LIG_SH2_STAT5 227 230 PF00017 0.267
LIG_SH2_STAT5 395 398 PF00017 0.267
LIG_SH3_3 103 109 PF00018 0.344
LIG_SH3_3 16 22 PF00018 0.573
LIG_SH3_3 243 249 PF00018 0.295
LIG_SUMO_SIM_anti_2 241 248 PF11976 0.199
LIG_TYR_ITIM 101 106 PF00017 0.385
MOD_CDK_SPK_2 173 178 PF00069 0.297
MOD_CDK_SPK_2 419 424 PF00069 0.259
MOD_CDK_SPxK_1 419 425 PF00069 0.261
MOD_CDK_SPxxK_3 291 298 PF00069 0.228
MOD_CK2_1 169 175 PF00069 0.315
MOD_CK2_1 338 344 PF00069 0.266
MOD_CK2_1 405 411 PF00069 0.324
MOD_CMANNOS 400 403 PF00535 0.506
MOD_GlcNHglycan 141 144 PF01048 0.473
MOD_GlcNHglycan 180 183 PF01048 0.467
MOD_GlcNHglycan 302 305 PF01048 0.497
MOD_GlcNHglycan 356 359 PF01048 0.498
MOD_GlcNHglycan 5 8 PF01048 0.506
MOD_GlcNHglycan 84 87 PF01048 0.494
MOD_GSK3_1 137 144 PF00069 0.218
MOD_GSK3_1 169 176 PF00069 0.259
MOD_GSK3_1 178 185 PF00069 0.247
MOD_GSK3_1 368 375 PF00069 0.363
MOD_GSK3_1 41 48 PF00069 0.519
MOD_GSK3_1 82 89 PF00069 0.284
MOD_NEK2_1 122 127 PF00069 0.342
MOD_NEK2_1 153 158 PF00069 0.323
MOD_NEK2_1 354 359 PF00069 0.274
MOD_NEK2_1 372 377 PF00069 0.143
MOD_NEK2_1 41 46 PF00069 0.477
MOD_NEK2_1 5 10 PF00069 0.700
MOD_PKA_1 261 267 PF00069 0.158
MOD_PKA_2 261 267 PF00069 0.334
MOD_PKA_2 41 47 PF00069 0.402
MOD_Plk_4 405 411 PF00069 0.268
MOD_Plk_4 64 70 PF00069 0.330
MOD_Plk_4 87 93 PF00069 0.264
MOD_ProDKin_1 169 175 PF00069 0.243
MOD_ProDKin_1 245 251 PF00069 0.258
MOD_ProDKin_1 291 297 PF00069 0.237
MOD_ProDKin_1 329 335 PF00069 0.288
MOD_ProDKin_1 338 344 PF00069 0.288
MOD_ProDKin_1 419 425 PF00069 0.403
TRG_DiLeu_BaEn_1 175 180 PF01217 0.335
TRG_ENDOCYTIC_2 103 106 PF00928 0.342
TRG_ENDOCYTIC_2 337 340 PF00928 0.243
TRG_ER_diArg_1 261 263 PF00400 0.367
TRG_ER_diArg_1 423 425 PF00400 0.310
TRG_Pf-PMV_PEXEL_1 236 241 PF00026 0.484

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5L7 Leptomonas seymouri 33% 93%
A0A0N1HZ60 Leptomonas seymouri 35% 92%
A0A0N1I523 Leptomonas seymouri 29% 96%
A0A0N1I5Q2 Leptomonas seymouri 31% 84%
A0A0N1I7U8 Leptomonas seymouri 66% 100%
A0A0S4JMS7 Bodo saltans 38% 98%
A0A0S4JTS9 Bodo saltans 38% 99%
A0A1X0NEW5 Trypanosomatidae 42% 100%
A0A1X0NSK7 Trypanosomatidae 42% 100%
A0A1X0NUZ6 Trypanosomatidae 27% 100%
A0A3S5H6J1 Leishmania donovani 31% 90%
A0A3S7X2V6 Leishmania donovani 99% 100%
A0A422NB49 Trypanosoma rangeli 45% 100%
A0A422NQC5 Trypanosoma rangeli 37% 97%
A4H6L0 Leishmania braziliensis 34% 100%
A4HHU6 Leishmania braziliensis 79% 100%
A4HUZ4 Leishmania infantum 32% 100%
C9ZPB9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9ANM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9ANM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B0C6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
P08910 Homo sapiens 26% 100%
P45524 Escherichia coli (strain K12) 29% 100%
P73879 Synechocystis sp. (strain PCC 6803 / Kazusa) 26% 100%
Q05AK6 Danio rerio 26% 100%
Q0VC00 Bos taurus 25% 100%
Q18610 Caenorhabditis elegans 25% 100%
Q24093 Drosophila melanogaster 24% 100%
Q3T0A0 Bos taurus 26% 100%
Q40863 Picea glauca 30% 93%
Q4Q7V8 Leishmania major 91% 100%
Q4QGZ4 Leishmania major 32% 100%
Q4QGZ5 Leishmania major 31% 100%
Q4R2Y9 Macaca fascicularis 26% 100%
Q54H38 Dictyostelium discoideum 26% 100%
Q5EA42 Bos taurus 26% 100%
Q5F2F2 Mus musculus 25% 93%
Q5RK23 Rattus norvegicus 26% 100%
Q6UXT9 Homo sapiens 25% 91%
Q802V6 Danio rerio 25% 98%
Q8WU67 Homo sapiens 26% 100%
Q91ZH7 Mus musculus 27% 100%
Q96SE0 Homo sapiens 26% 100%
Q9QXM0 Mus musculus 26% 100%
Q9QZC8 Mus musculus 25% 100%
V5AZF4 Trypanosoma cruzi 42% 100%
V5BBC2 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS