Putative actin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-like protein - putative

Species:

Leishmania infantum

UniProt:

A4I4Z1_LEIIN

TriTrypDb:

LINF_290035200

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005869	dynactin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A4I4Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4Z1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.409
CLV_NRD_NRD_1	23	25	PF00675	0.632
CLV_NRD_NRD_1	34	36	PF00675	0.553
CLV_PCSK_KEX2_1	272	274	PF00082	0.254
CLV_PCSK_KEX2_1	34	36	PF00082	0.529
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.169
CLV_PCSK_PC7_1	268	274	PF00082	0.169
CLV_PCSK_SKI1_1	277	281	PF00082	0.312
DEG_APCC_DBOX_1	272	280	PF00400	0.369
DEG_COP1_1	180	188	PF00400	0.453
DEG_Nend_UBRbox_2	1	3	PF02207	0.389
DEG_SPOP_SBC_1	237	241	PF00917	0.499
DOC_CYCLIN_RxL_1	268	280	PF00134	0.490
DOC_MAPK_DCC_7	181	190	PF00069	0.455
DOC_MAPK_gen_1	21	31	PF00069	0.529
DOC_MAPK_HePTP_8	178	190	PF00069	0.455
DOC_MAPK_MEF2A_6	181	190	PF00069	0.455
DOC_MAPK_MEF2A_6	24	31	PF00069	0.522
DOC_MAPK_MEF2A_6	61	70	PF00069	0.513
DOC_PP2B_LxvP_1	188	191	PF13499	0.451
DOC_USP7_MATH_1	191	195	PF00917	0.494
DOC_USP7_UBL2_3	21	25	PF12436	0.501
LIG_14-3-3_CanoR_1	142	147	PF00244	0.467
LIG_14-3-3_CanoR_1	208	215	PF00244	0.543
LIG_14-3-3_CanoR_1	24	28	PF00244	0.577
LIG_APCC_ABBA_1	195	200	PF00400	0.455
LIG_BRCT_BRCA1_1	232	236	PF00533	0.547
LIG_FHA_1	111	117	PF00498	0.424
LIG_FHA_1	146	152	PF00498	0.440
LIG_FHA_1	165	171	PF00498	0.554
LIG_FHA_1	216	222	PF00498	0.440
LIG_FHA_1	238	244	PF00498	0.510
LIG_FHA_1	24	30	PF00498	0.480
LIG_FHA_1	65	71	PF00498	0.419
LIG_FHA_2	187	193	PF00498	0.407
LIG_FHA_2	200	206	PF00498	0.419
LIG_Integrin_RGD_1	160	162	PF01839	0.224
LIG_LIR_Gen_1	239	250	PF02991	0.469
LIG_LIR_Gen_1	83	92	PF02991	0.477
LIG_LIR_Nem_3	13	19	PF02991	0.345
LIG_LIR_Nem_3	239	245	PF02991	0.458
LIG_LIR_Nem_3	304	309	PF02991	0.532
LIG_LIR_Nem_3	83	89	PF02991	0.458
LIG_NRBOX	154	160	PF00104	0.512
LIG_NRBOX	67	73	PF00104	0.496
LIG_SH2_CRK	16	20	PF00017	0.388
LIG_SH2_STAP1	101	105	PF00017	0.499
LIG_SH2_STAT5	101	104	PF00017	0.483
LIG_SH2_STAT5	41	44	PF00017	0.429
LIG_SH2_STAT5	5	8	PF00017	0.445
LIG_SUMO_SIM_anti_2	26	31	PF11976	0.526
LIG_SUMO_SIM_anti_2	63	70	PF11976	0.443
LIG_SUMO_SIM_par_1	67	74	PF11976	0.452
LIG_TRAF2_1	62	65	PF00917	0.499
LIG_TYR_ITIM	14	19	PF00017	0.377
LIG_UBA3_1	289	297	PF00899	0.433
LIG_WRC_WIRS_1	72	77	PF05994	0.424
MOD_CK1_1	145	151	PF00069	0.497
MOD_CK1_1	216	222	PF00069	0.512
MOD_CK1_1	77	83	PF00069	0.469
MOD_CK2_1	174	180	PF00069	0.512
MOD_CK2_1	199	205	PF00069	0.499
MOD_CK2_1	217	223	PF00069	0.497
MOD_CK2_1	301	307	PF00069	0.468
MOD_CK2_1	84	90	PF00069	0.499
MOD_GlcNHglycan	103	106	PF01048	0.246
MOD_GlcNHglycan	112	116	PF01048	0.222
MOD_GlcNHglycan	210	213	PF01048	0.232
MOD_GlcNHglycan	284	287	PF01048	0.230
MOD_GlcNHglycan	56	59	PF01048	0.251
MOD_GSK3_1	134	141	PF00069	0.511
MOD_GSK3_1	213	220	PF00069	0.456
MOD_GSK3_1	80	87	PF00069	0.456
MOD_LATS_1	275	281	PF00433	0.512
MOD_N-GLC_2	36	38	PF02516	0.525
MOD_NEK2_1	1	6	PF00069	0.315
MOD_NEK2_1	213	218	PF00069	0.473
MOD_NEK2_1	71	76	PF00069	0.446
MOD_NEK2_1	84	89	PF00069	0.454
MOD_NEK2_1	99	104	PF00069	0.390
MOD_NEK2_2	10	15	PF00069	0.314
MOD_NEK2_2	191	196	PF00069	0.512
MOD_PIKK_1	288	294	PF00454	0.426
MOD_PIKK_1	74	80	PF00454	0.455
MOD_PK_1	142	148	PF00069	0.512
MOD_PKA_2	141	147	PF00069	0.500
MOD_PKA_2	207	213	PF00069	0.439
MOD_PKA_2	23	29	PF00069	0.479
MOD_Plk_1	1	7	PF00069	0.310
MOD_Plk_1	164	170	PF00069	0.506
MOD_Plk_1	186	192	PF00069	0.512
MOD_Plk_1	237	243	PF00069	0.480
MOD_Plk_1	64	70	PF00069	0.453
MOD_Plk_4	1	7	PF00069	0.389
MOD_Plk_4	174	180	PF00069	0.507
MOD_Plk_4	191	197	PF00069	0.512
MOD_Plk_4	238	244	PF00069	0.446
MOD_Plk_4	246	252	PF00069	0.464
MOD_Plk_4	64	70	PF00069	0.422
MOD_Plk_4	80	86	PF00069	0.386
TRG_DiLeu_BaEn_1	154	159	PF01217	0.512
TRG_DiLeu_BaEn_1	180	185	PF01217	0.550
TRG_DiLeu_BaEn_1	64	69	PF01217	0.512
TRG_DiLeu_BaEn_3	64	70	PF01217	0.499
TRG_DiLeu_LyEn_5	154	159	PF01217	0.455
TRG_ENDOCYTIC_2	16	19	PF00928	0.388
TRG_ENDOCYTIC_2	86	89	PF00928	0.534
TRG_NES_CRM1_1	292	305	PF08389	0.433
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.236
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.202

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y8	Leptomonas seymouri	78%	100%
A0A0S4KG45	Bodo saltans	27%	89%
A0A1X0NIU0	Trypanosomatidae	22%	82%
A0A1X0NRG7	Trypanosomatidae	24%	83%
A0A1X0P9A3	Trypanosomatidae	36%	99%
A0A3S5IR27	Trypanosoma rangeli	38%	95%
A0A3S7X2U7	Leishmania donovani	99%	100%
A4HHT1	Leishmania braziliensis	85%	100%
C9ZKK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	99%
E9ALF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P02581	Glycine max	26%	86%
P07828	Dictyostelium discoideum	24%	85%
Q03341	Echinococcus granulosus	23%	86%
Q4FXC8	Leishmania major	96%	100%
Q4QR76	Rattus norvegicus	24%	77%
Q9QY83	Mus musculus	23%	77%
Q9Y614	Homo sapiens	24%	78%
V5C0Q2	Trypanosoma cruzi	23%	83%
V5DTX0	Trypanosoma cruzi	36%	99%