Beta_helix domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Periplasmic copper-binding protein (NosD)/Right handed beta helix region containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I4X9_LEIIN

TriTrypDb:

LINF_290034900

Length:

278

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I4X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4X9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.448
CLV_NRD_NRD_1	184	186	PF00675	0.328
CLV_NRD_NRD_1	199	201	PF00675	0.302
CLV_NRD_NRD_1	93	95	PF00675	0.274
CLV_PCSK_SKI1_1	88	92	PF00082	0.217
DOC_MAPK_gen_1	200	206	PF00069	0.313
DOC_USP7_MATH_1	270	274	PF00917	0.530
DOC_USP7_MATH_1	57	61	PF00917	0.622
LIG_APCC_ABBA_1	179	184	PF00400	0.417
LIG_FHA_1	117	123	PF00498	0.414
LIG_FHA_1	176	182	PF00498	0.440
LIG_FHA_1	262	268	PF00498	0.488
LIG_FHA_1	3	9	PF00498	0.437
LIG_FHA_1	40	46	PF00498	0.417
LIG_FHA_1	71	77	PF00498	0.336
LIG_LIR_Nem_3	143	147	PF02991	0.435
LIG_LIR_Nem_3	176	182	PF02991	0.314
LIG_LIR_Nem_3	218	224	PF02991	0.525
LIG_LRP6_Inhibitor_1	169	175	PF00058	0.286
LIG_REV1ctd_RIR_1	225	235	PF16727	0.377
LIG_SH2_STAP1	183	187	PF00017	0.441
LIG_SH2_STAT5	138	141	PF00017	0.329
LIG_SH2_STAT5	205	208	PF00017	0.289
LIG_SH3_3	4	10	PF00018	0.544
LIG_SH3_3	40	46	PF00018	0.491
LIG_SUMO_SIM_par_1	72	77	PF11976	0.442
MOD_CK1_1	238	244	PF00069	0.396
MOD_CK1_1	60	66	PF00069	0.658
MOD_CK2_1	140	146	PF00069	0.308
MOD_GlcNHglycan	187	190	PF01048	0.434
MOD_GlcNHglycan	237	240	PF01048	0.443
MOD_GlcNHglycan	261	264	PF01048	0.452
MOD_GlcNHglycan	76	79	PF01048	0.449
MOD_GSK3_1	238	245	PF00069	0.402
MOD_GSK3_1	66	73	PF00069	0.466
MOD_GSK3_1	74	81	PF00069	0.395
MOD_N-GLC_1	47	52	PF02516	0.426
MOD_N-GLC_1	78	83	PF02516	0.395
MOD_NEK2_1	140	145	PF00069	0.356
MOD_NEK2_1	227	232	PF00069	0.403
MOD_NEK2_1	242	247	PF00069	0.291
MOD_NEK2_1	39	44	PF00069	0.509
MOD_NEK2_1	47	52	PF00069	0.468
MOD_NEK2_2	118	123	PF00069	0.308
MOD_NEK2_2	270	275	PF00069	0.487
MOD_PKA_1	185	191	PF00069	0.302
MOD_PKA_2	233	239	PF00069	0.324
MOD_PKB_1	173	181	PF00069	0.400
MOD_Plk_1	175	181	PF00069	0.400
MOD_Plk_1	215	221	PF00069	0.302
MOD_Plk_1	39	45	PF00069	0.380
MOD_Plk_1	47	53	PF00069	0.333
MOD_Plk_1	78	84	PF00069	0.308
MOD_Plk_2-3	192	198	PF00069	0.289
MOD_Plk_4	2	8	PF00069	0.476
MOD_Plk_4	28	34	PF00069	0.435
MOD_Plk_4	66	72	PF00069	0.498
TRG_DiLeu_BaEn_4	40	46	PF01217	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL58	Leptomonas seymouri	55%	99%
A0A0S4KFM6	Bodo saltans	38%	100%
A0A1X0P907	Trypanosomatidae	48%	100%
A0A3Q8IDZ0	Leishmania donovani	100%	100%
A0A422NEU4	Trypanosoma rangeli	47%	100%
A4HHS8	Leishmania braziliensis	81%	100%
C9ZKL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AED3	Leishmania major	96%	100%
E9ALF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5C239	Trypanosoma cruzi	49%	100%