RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4X8_LEIIN

TriTrypDb:

LINF_290034800

Length:

992

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I4X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4X8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.626
CLV_MEL_PAP_1	687	693	PF00089	0.408
CLV_NRD_NRD_1	102	104	PF00675	0.362
CLV_NRD_NRD_1	16	18	PF00675	0.385
CLV_NRD_NRD_1	209	211	PF00675	0.382
CLV_NRD_NRD_1	325	327	PF00675	0.405
CLV_NRD_NRD_1	7	9	PF00675	0.474
CLV_NRD_NRD_1	739	741	PF00675	0.441
CLV_NRD_NRD_1	953	955	PF00675	0.404
CLV_PCSK_KEX2_1	102	104	PF00082	0.362
CLV_PCSK_KEX2_1	16	18	PF00082	0.385
CLV_PCSK_KEX2_1	209	211	PF00082	0.434
CLV_PCSK_KEX2_1	325	327	PF00082	0.405
CLV_PCSK_KEX2_1	519	521	PF00082	0.354
CLV_PCSK_KEX2_1	7	9	PF00082	0.474
CLV_PCSK_KEX2_1	739	741	PF00082	0.449
CLV_PCSK_KEX2_1	755	757	PF00082	0.458
CLV_PCSK_KEX2_1	953	955	PF00082	0.404
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.354
CLV_PCSK_PC1ET2_1	755	757	PF00082	0.427
CLV_PCSK_SKI1_1	106	110	PF00082	0.403
CLV_PCSK_SKI1_1	180	184	PF00082	0.414
CLV_PCSK_SKI1_1	236	240	PF00082	0.425
CLV_PCSK_SKI1_1	275	279	PF00082	0.407
CLV_PCSK_SKI1_1	298	302	PF00082	0.417
CLV_PCSK_SKI1_1	513	517	PF00082	0.311
CLV_PCSK_SKI1_1	522	526	PF00082	0.327
CLV_PCSK_SKI1_1	545	549	PF00082	0.297
CLV_PCSK_SKI1_1	557	561	PF00082	0.408
CLV_PCSK_SKI1_1	574	578	PF00082	0.276
CLV_PCSK_SKI1_1	7	11	PF00082	0.474
CLV_PCSK_SKI1_1	920	924	PF00082	0.454
CLV_PCSK_SKI1_1	975	979	PF00082	0.493
CLV_Separin_Metazoa	380	384	PF03568	0.601
CLV_Separin_Metazoa	914	918	PF03568	0.589
DEG_APCC_DBOX_1	235	243	PF00400	0.639
DEG_APCC_DBOX_1	573	581	PF00400	0.628
DEG_APCC_DBOX_1	672	680	PF00400	0.630
DEG_APCC_DBOX_1	79	87	PF00400	0.568
DEG_MDM2_SWIB_1	183	191	PF02201	0.597
DEG_Nend_Nbox_1	1	3	PF02207	0.751
DOC_ANK_TNKS_1	772	779	PF00023	0.690
DOC_CYCLIN_RxL_1	243	256	PF00134	0.564
DOC_CYCLIN_RxL_1	272	282	PF00134	0.643
DOC_CYCLIN_yCln2_LP_2	271	274	PF00134	0.644
DOC_CYCLIN_yCln2_LP_2	848	854	PF00134	0.523
DOC_MAPK_gen_1	102	111	PF00069	0.575
DOC_MAPK_gen_1	16	24	PF00069	0.602
DOC_MAPK_gen_1	243	252	PF00069	0.620
DOC_MAPK_gen_1	5	14	PF00069	0.675
DOC_MAPK_gen_1	519	529	PF00069	0.541
DOC_MAPK_gen_1	862	871	PF00069	0.387
DOC_MAPK_gen_1	917	926	PF00069	0.614
DOC_MAPK_MEF2A_6	520	529	PF00069	0.637
DOC_MAPK_MEF2A_6	862	871	PF00069	0.361
DOC_PP2B_LxvP_1	271	274	PF13499	0.568
DOC_PP2B_LxvP_1	686	689	PF13499	0.683
DOC_PP2B_LxvP_1	762	765	PF13499	0.634
DOC_PP2B_LxvP_1	769	772	PF13499	0.628
DOC_PP4_FxxP_1	648	651	PF00568	0.678
DOC_USP7_MATH_1	110	114	PF00917	0.601
DOC_USP7_MATH_1	155	159	PF00917	0.594
DOC_USP7_MATH_1	176	180	PF00917	0.587
DOC_USP7_MATH_1	205	209	PF00917	0.634
DOC_USP7_MATH_1	262	266	PF00917	0.668
DOC_USP7_MATH_1	40	44	PF00917	0.757
DOC_USP7_MATH_1	441	445	PF00917	0.639
DOC_USP7_MATH_1	457	461	PF00917	0.522
DOC_USP7_MATH_1	537	541	PF00917	0.646
DOC_USP7_MATH_1	582	586	PF00917	0.616
DOC_USP7_MATH_1	748	752	PF00917	0.611
DOC_USP7_MATH_1	818	822	PF00917	0.583
DOC_USP7_MATH_1	852	856	PF00917	0.403
DOC_USP7_MATH_1	918	922	PF00917	0.659
DOC_USP7_MATH_1	95	99	PF00917	0.619
DOC_USP7_MATH_1	982	986	PF00917	0.683
DOC_USP7_MATH_2	765	771	PF00917	0.670
DOC_WW_Pin1_4	689	694	PF00397	0.713
DOC_WW_Pin1_4	90	95	PF00397	0.613
LIG_14-3-3_CanoR_1	141	150	PF00244	0.596
LIG_14-3-3_CanoR_1	16	25	PF00244	0.694
LIG_14-3-3_CanoR_1	167	172	PF00244	0.546
LIG_14-3-3_CanoR_1	180	190	PF00244	0.605
LIG_14-3-3_CanoR_1	27	37	PF00244	0.756
LIG_14-3-3_CanoR_1	275	281	PF00244	0.567
LIG_14-3-3_CanoR_1	318	323	PF00244	0.577
LIG_14-3-3_CanoR_1	545	551	PF00244	0.592
LIG_14-3-3_CanoR_1	62	71	PF00244	0.557
LIG_14-3-3_CanoR_1	673	679	PF00244	0.611
LIG_14-3-3_CanoR_1	739	744	PF00244	0.612
LIG_14-3-3_CanoR_1	756	766	PF00244	0.606
LIG_14-3-3_CanoR_1	917	923	PF00244	0.612
LIG_14-3-3_CanoR_1	96	104	PF00244	0.586
LIG_APCC_ABBA_1	129	134	PF00400	0.624
LIG_BIR_III_2	533	537	PF00653	0.620
LIG_BIR_III_2	961	965	PF00653	0.711
LIG_BRCT_BRCA1_1	17	21	PF00533	0.665
LIG_BRCT_BRCA1_1	443	447	PF00533	0.566
LIG_BRCT_BRCA1_1	584	588	PF00533	0.498
LIG_BRCT_BRCA1_1	813	817	PF00533	0.626
LIG_BRCT_BRCA1_1	843	847	PF00533	0.444
LIG_CaM_NSCaTE_8	556	563	PF13499	0.622
LIG_deltaCOP1_diTrp_1	406	415	PF00928	0.593
LIG_EH1_1	375	383	PF00400	0.582
LIG_EH1_1	900	908	PF00400	0.607
LIG_EVH1_2	717	721	PF00568	0.630
LIG_FHA_1	161	167	PF00498	0.562
LIG_FHA_1	432	438	PF00498	0.592
LIG_FHA_1	509	515	PF00498	0.573
LIG_FHA_1	570	576	PF00498	0.575
LIG_FHA_1	777	783	PF00498	0.592
LIG_FHA_1	788	794	PF00498	0.543
LIG_FHA_2	280	286	PF00498	0.630
LIG_FHA_2	352	358	PF00498	0.655
LIG_FHA_2	496	502	PF00498	0.523
LIG_FHA_2	611	617	PF00498	0.619
LIG_FHA_2	82	88	PF00498	0.624
LIG_GBD_Chelix_1	465	473	PF00786	0.388
LIG_GBD_Chelix_1	542	550	PF00786	0.408
LIG_LIR_Apic_2	646	651	PF02991	0.671
LIG_LIR_Apic_2	65	71	PF02991	0.587
LIG_LIR_Gen_1	18	28	PF02991	0.682
LIG_LIR_Gen_1	184	195	PF02991	0.641
LIG_LIR_Gen_1	703	711	PF02991	0.493
LIG_LIR_Gen_1	942	951	PF02991	0.602
LIG_LIR_Nem_3	18	24	PF02991	0.667
LIG_LIR_Nem_3	184	190	PF02991	0.655
LIG_LIR_Nem_3	304	310	PF02991	0.506
LIG_LIR_Nem_3	424	430	PF02991	0.603
LIG_LIR_Nem_3	444	450	PF02991	0.477
LIG_LIR_Nem_3	623	628	PF02991	0.612
LIG_LIR_Nem_3	703	707	PF02991	0.522
LIG_LIR_Nem_3	844	850	PF02991	0.485
LIG_LIR_Nem_3	855	861	PF02991	0.457
LIG_LIR_Nem_3	883	889	PF02991	0.478
LIG_LIR_Nem_3	929	934	PF02991	0.603
LIG_LIR_Nem_3	942	947	PF02991	0.425
LIG_NRBOX	292	298	PF00104	0.657
LIG_NRBOX	511	517	PF00104	0.597
LIG_NRBOX	682	688	PF00104	0.664
LIG_Pex14_2	183	187	PF04695	0.667
LIG_Pex14_2	662	666	PF04695	0.623
LIG_PTAP_UEV_1	36	41	PF05743	0.641
LIG_Rb_pABgroove_1	248	256	PF01858	0.651
LIG_REV1ctd_RIR_1	883	892	PF16727	0.561
LIG_RPA_C_Fungi	735	747	PF08784	0.539
LIG_SH2_CRK	809	813	PF00017	0.478
LIG_SH2_GRB2like	766	769	PF00017	0.532
LIG_SH2_NCK_1	454	458	PF00017	0.601
LIG_SH2_PTP2	68	71	PF00017	0.569
LIG_SH2_PTP2	877	880	PF00017	0.485
LIG_SH2_SRC	68	71	PF00017	0.569
LIG_SH2_STAP1	704	708	PF00017	0.470
LIG_SH2_STAP1	859	863	PF00017	0.547
LIG_SH2_STAP1	889	893	PF00017	0.510
LIG_SH2_STAT3	592	595	PF00017	0.479
LIG_SH2_STAT5	375	378	PF00017	0.398
LIG_SH2_STAT5	430	433	PF00017	0.515
LIG_SH2_STAT5	68	71	PF00017	0.569
LIG_SH2_STAT5	727	730	PF00017	0.398
LIG_SH2_STAT5	833	836	PF00017	0.335
LIG_SH2_STAT5	877	880	PF00017	0.446
LIG_SH3_1	325	331	PF00018	0.533
LIG_SH3_1	690	696	PF00018	0.464
LIG_SH3_3	325	331	PF00018	0.548
LIG_SH3_3	34	40	PF00018	0.727
LIG_SH3_3	426	432	PF00018	0.499
LIG_SH3_3	636	642	PF00018	0.578
LIG_SH3_3	647	653	PF00018	0.571
LIG_SH3_3	690	696	PF00018	0.630
LIG_SH3_3	870	876	PF00018	0.357
LIG_SH3_3	930	936	PF00018	0.613
LIG_SH3_4	263	270	PF00018	0.432
LIG_SUMO_SIM_anti_2	268	273	PF11976	0.574
LIG_SUMO_SIM_anti_2	484	490	PF11976	0.450
LIG_SUMO_SIM_par_1	167	173	PF11976	0.506
LIG_TRAF2_1	354	357	PF00917	0.395
LIG_TRAF2_1	377	380	PF00917	0.511
LIG_TRAF2_1	498	501	PF00917	0.394
LIG_TRAF2_1	911	914	PF00917	0.584
LIG_TRFH_1	847	851	PF08558	0.401
LIG_TYR_ITIM	702	707	PF00017	0.534
LIG_TYR_ITIM	764	769	PF00017	0.546
LIG_WW_3	272	276	PF00397	0.530
LIG_WW_3	493	497	PF00397	0.499
MOD_CDC14_SPxK_1	93	96	PF00782	0.512
MOD_CDK_SPxK_1	90	96	PF00069	0.514
MOD_CK1_1	170	176	PF00069	0.512
MOD_CK1_1	231	237	PF00069	0.589
MOD_CK1_1	265	271	PF00069	0.568
MOD_CK1_1	43	49	PF00069	0.674
MOD_CK1_1	570	576	PF00069	0.550
MOD_CK1_1	620	626	PF00069	0.474
MOD_CK1_1	677	683	PF00069	0.525
MOD_CK1_1	692	698	PF00069	0.482
MOD_CK1_1	734	740	PF00069	0.542
MOD_CK1_1	751	757	PF00069	0.600
MOD_CK1_1	800	806	PF00069	0.533
MOD_CK1_1	840	846	PF00069	0.376
MOD_CK2_1	155	161	PF00069	0.529
MOD_CK2_1	191	197	PF00069	0.542
MOD_CK2_1	231	237	PF00069	0.455
MOD_CK2_1	279	285	PF00069	0.524
MOD_CK2_1	351	357	PF00069	0.540
MOD_CK2_1	495	501	PF00069	0.445
MOD_CK2_1	610	616	PF00069	0.518
MOD_CK2_1	81	87	PF00069	0.531
MOD_CK2_1	908	914	PF00069	0.618
MOD_GlcNHglycan	18	21	PF01048	0.678
MOD_GlcNHglycan	183	186	PF01048	0.521
MOD_GlcNHglycan	230	233	PF01048	0.431
MOD_GlcNHglycan	331	334	PF01048	0.540
MOD_GlcNHglycan	369	372	PF01048	0.472
MOD_GlcNHglycan	37	40	PF01048	0.674
MOD_GlcNHglycan	385	388	PF01048	0.427
MOD_GlcNHglycan	458	462	PF01048	0.398
MOD_GlcNHglycan	475	478	PF01048	0.482
MOD_GlcNHglycan	539	542	PF01048	0.474
MOD_GlcNHglycan	552	555	PF01048	0.411
MOD_GlcNHglycan	584	587	PF01048	0.424
MOD_GlcNHglycan	697	700	PF01048	0.502
MOD_GlcNHglycan	750	753	PF01048	0.520
MOD_GlcNHglycan	769	772	PF01048	0.324
MOD_GlcNHglycan	785	788	PF01048	0.476
MOD_GlcNHglycan	800	803	PF01048	0.494
MOD_GlcNHglycan	813	816	PF01048	0.406
MOD_GlcNHglycan	818	821	PF01048	0.259
MOD_GlcNHglycan	829	832	PF01048	0.366
MOD_GlcNHglycan	843	846	PF01048	0.338
MOD_GlcNHglycan	852	855	PF01048	0.477
MOD_GlcNHglycan	894	897	PF01048	0.587
MOD_GlcNHglycan	910	913	PF01048	0.504
MOD_GlcNHglycan	97	100	PF01048	0.508
MOD_GSK3_1	141	148	PF00069	0.523
MOD_GSK3_1	279	286	PF00069	0.509
MOD_GSK3_1	314	321	PF00069	0.419
MOD_GSK3_1	407	414	PF00069	0.385
MOD_GSK3_1	457	464	PF00069	0.520
MOD_GSK3_1	537	544	PF00069	0.514
MOD_GSK3_1	546	553	PF00069	0.524
MOD_GSK3_1	674	681	PF00069	0.498
MOD_GSK3_1	731	738	PF00069	0.394
MOD_GSK3_1	778	785	PF00069	0.539
MOD_GSK3_1	837	844	PF00069	0.373
MOD_GSK3_1	850	857	PF00069	0.361
MOD_N-GLC_1	407	412	PF02516	0.492
MOD_N-GLC_1	461	466	PF02516	0.469
MOD_N-GLC_1	767	772	PF02516	0.566
MOD_NEK2_1	1	6	PF00069	0.564
MOD_NEK2_1	10	15	PF00069	0.531
MOD_NEK2_1	313	318	PF00069	0.401
MOD_NEK2_1	344	349	PF00069	0.456
MOD_NEK2_1	381	386	PF00069	0.485
MOD_NEK2_1	407	412	PF00069	0.440
MOD_NEK2_1	413	418	PF00069	0.428
MOD_NEK2_1	473	478	PF00069	0.456
MOD_NEK2_1	503	508	PF00069	0.507
MOD_NEK2_1	546	551	PF00069	0.557
MOD_NEK2_1	610	615	PF00069	0.502
MOD_NEK2_1	678	683	PF00069	0.481
MOD_NEK2_1	710	715	PF00069	0.486
MOD_NEK2_1	721	726	PF00069	0.463
MOD_NEK2_1	816	821	PF00069	0.432
MOD_NEK2_1	827	832	PF00069	0.404
MOD_NEK2_1	880	885	PF00069	0.397
MOD_NEK2_1	949	954	PF00069	0.542
MOD_NEK2_2	508	513	PF00069	0.386
MOD_NEK2_2	778	783	PF00069	0.584
MOD_NEK2_2	918	923	PF00069	0.587
MOD_PIKK_1	141	147	PF00454	0.493
MOD_PIKK_1	263	269	PF00454	0.518
MOD_PIKK_1	352	358	PF00454	0.464
MOD_PK_1	167	173	PF00069	0.421
MOD_PK_1	739	745	PF00069	0.512
MOD_PKA_1	16	22	PF00069	0.509
MOD_PKA_1	739	745	PF00069	0.549
MOD_PKA_2	15	21	PF00069	0.702
MOD_PKA_2	28	34	PF00069	0.619
MOD_PKA_2	367	373	PF00069	0.516
MOD_PKA_2	399	405	PF00069	0.527
MOD_PKA_2	495	501	PF00069	0.500
MOD_PKA_2	617	623	PF00069	0.529
MOD_PKA_2	739	745	PF00069	0.486
MOD_PKA_2	782	788	PF00069	0.573
MOD_PKA_2	79	85	PF00069	0.440
MOD_PKA_2	95	101	PF00069	0.390
MOD_Plk_1	461	467	PF00069	0.494
MOD_Plk_1	570	576	PF00069	0.555
MOD_Plk_1	620	626	PF00069	0.568
MOD_Plk_1	973	979	PF00069	0.635
MOD_Plk_2-3	289	295	PF00069	0.533
MOD_Plk_4	125	131	PF00069	0.370
MOD_Plk_4	318	324	PF00069	0.472
MOD_Plk_4	345	351	PF00069	0.478
MOD_Plk_4	620	626	PF00069	0.495
MOD_Plk_4	643	649	PF00069	0.478
MOD_Plk_4	674	680	PF00069	0.428
MOD_Plk_4	723	729	PF00069	0.487
MOD_Plk_4	739	745	PF00069	0.507
MOD_Plk_4	854	860	PF00069	0.567
MOD_Plk_4	881	887	PF00069	0.380
MOD_ProDKin_1	689	695	PF00069	0.646
MOD_ProDKin_1	90	96	PF00069	0.514
MOD_SUMO_rev_2	193	201	PF00179	0.572
TRG_DiLeu_BaEn_1	433	438	PF01217	0.485
TRG_DiLeu_BaEn_1	484	489	PF01217	0.509
TRG_DiLeu_BaEn_1	703	708	PF01217	0.409
TRG_DiLeu_BaEn_1	902	907	PF01217	0.492
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.512
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.571
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.553
TRG_DiLeu_BaLyEn_6	876	881	PF01217	0.369
TRG_DiLeu_LyEn_5	433	438	PF01217	0.485
TRG_ENDOCYTIC_2	310	313	PF00928	0.418
TRG_ENDOCYTIC_2	375	378	PF00928	0.483
TRG_ENDOCYTIC_2	704	707	PF00928	0.367
TRG_ENDOCYTIC_2	766	769	PF00928	0.509
TRG_ENDOCYTIC_2	877	880	PF00928	0.477
TRG_ENDOCYTIC_2	944	947	PF00928	0.538
TRG_ER_diArg_1	102	104	PF00400	0.482
TRG_ER_diArg_1	324	326	PF00400	0.494
TRG_ER_diArg_1	739	741	PF00400	0.583
TRG_ER_diArg_1	863	866	PF00400	0.512
TRG_ER_FFAT_2	726	738	PF00635	0.443
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	626	630	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	920	925	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY92	Leptomonas seymouri	49%	98%
A0A1X0P9B3	Trypanosomatidae	24%	99%
A0A3S7X2T5	Leishmania donovani	99%	100%
A0A422NEU9	Trypanosoma rangeli	26%	99%
A4HHS7	Leishmania braziliensis	78%	100%
C9ZKL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	97%
E9AED2	Leishmania major	93%	100%
E9ALF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%