Disabled homolog 1-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4X7_LEIIN

TriTrypDb:

LINF_290034700

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4X7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.546
CLV_NRD_NRD_1	5	7	PF00675	0.604
CLV_PCSK_SKI1_1	23	27	PF00082	0.745
DEG_Nend_UBRbox_2	1	3	PF02207	0.634
DOC_PP2B_LxvP_1	51	54	PF13499	0.590
DOC_PP4_FxxP_1	79	82	PF00568	0.623
DOC_PP4_MxPP_1	97	100	PF00568	0.589
DOC_USP7_MATH_1	114	118	PF00917	0.596
DOC_USP7_MATH_1	12	16	PF00917	0.564
DOC_USP7_MATH_1	181	185	PF00917	0.555
DOC_USP7_MATH_1	216	220	PF00917	0.602
DOC_USP7_MATH_1	238	242	PF00917	0.531
DOC_USP7_MATH_1	254	258	PF00917	0.543
DOC_USP7_MATH_1	275	279	PF00917	0.601
DOC_USP7_MATH_1	286	290	PF00917	0.614
DOC_USP7_MATH_1	52	56	PF00917	0.535
DOC_WW_Pin1_4	108	113	PF00397	0.776
DOC_WW_Pin1_4	142	147	PF00397	0.557
DOC_WW_Pin1_4	165	170	PF00397	0.600
DOC_WW_Pin1_4	185	190	PF00397	0.607
DOC_WW_Pin1_4	218	223	PF00397	0.595
DOC_WW_Pin1_4	269	274	PF00397	0.605
DOC_WW_Pin1_4	86	91	PF00397	0.643
LIG_BIR_III_2	34	38	PF00653	0.564
LIG_BRCT_BRCA1_1	191	195	PF00533	0.634
LIG_CSL_BTD_1	92	95	PF09270	0.571
LIG_EVH1_1	79	83	PF00568	0.583
LIG_FHA_1	186	192	PF00498	0.609
LIG_FHA_2	219	225	PF00498	0.572
LIG_LIR_Apic_2	132	136	PF02991	0.474
LIG_LYPXL_yS_3	64	67	PF13949	0.532
LIG_SH2_CRK	128	132	PF00017	0.571
LIG_SH2_CRK	133	137	PF00017	0.680
LIG_SH2_NCK_1	253	257	PF00017	0.612
LIG_SH2_STAP1	171	175	PF00017	0.617
LIG_SH2_STAT3	115	118	PF00017	0.604
LIG_SH2_STAT3	60	63	PF00017	0.515
LIG_SH2_STAT5	115	118	PF00017	0.769
LIG_SH2_STAT5	171	174	PF00017	0.655
LIG_SH3_3	175	181	PF00018	0.619
LIG_SH3_3	203	209	PF00018	0.629
LIG_SH3_3	212	218	PF00018	0.527
LIG_SH3_3	226	232	PF00018	0.609
LIG_SH3_3	77	83	PF00018	0.732
LIG_SH3_3	95	101	PF00018	0.476
LIG_SH3_4	161	168	PF00018	0.572
LIG_TYR_ITIM	126	131	PF00017	0.448
MOD_CDK_SPK_2	269	274	PF00069	0.605
MOD_CK1_1	200	206	PF00069	0.611
MOD_CK2_1	181	187	PF00069	0.546
MOD_CK2_1	218	224	PF00069	0.571
MOD_GlcNHglycan	158	161	PF01048	0.710
MOD_GlcNHglycan	183	186	PF01048	0.746
MOD_GlcNHglycan	199	202	PF01048	0.541
MOD_GlcNHglycan	256	259	PF01048	0.585
MOD_GlcNHglycan	305	308	PF01048	0.551
MOD_GSK3_1	165	172	PF00069	0.602
MOD_GSK3_1	181	188	PF00069	0.644
MOD_GSK3_1	196	203	PF00069	0.519
MOD_GSK3_1	248	255	PF00069	0.577
MOD_GSK3_1	275	282	PF00069	0.588
MOD_GSK3_1	82	89	PF00069	0.674
MOD_N-GLC_1	106	111	PF02516	0.634
MOD_N-GLC_1	201	206	PF02516	0.572
MOD_NEK2_1	131	136	PF00069	0.473
MOD_NEK2_1	139	144	PF00069	0.602
MOD_NEK2_1	150	155	PF00069	0.547
MOD_NEK2_1	196	201	PF00069	0.599
MOD_NEK2_1	223	228	PF00069	0.526
MOD_PIKK_1	114	120	PF00454	0.606
MOD_PIKK_1	248	254	PF00454	0.553
MOD_PIKK_1	286	292	PF00454	0.656
MOD_Plk_1	106	112	PF00069	0.624
MOD_Plk_1	223	229	PF00069	0.633
MOD_Plk_1	267	273	PF00069	0.596
MOD_ProDKin_1	108	114	PF00069	0.622
MOD_ProDKin_1	142	148	PF00069	0.560
MOD_ProDKin_1	165	171	PF00069	0.602
MOD_ProDKin_1	185	191	PF00069	0.607
MOD_ProDKin_1	218	224	PF00069	0.597
MOD_ProDKin_1	269	275	PF00069	0.607
MOD_ProDKin_1	86	92	PF00069	0.664
MOD_SUMO_rev_2	2	8	PF00179	0.590
TRG_ENDOCYTIC_2	128	131	PF00928	0.500
TRG_ENDOCYTIC_2	64	67	PF00928	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA0	Leptomonas seymouri	51%	99%
A0A3S7X2X0	Leishmania donovani	100%	100%
A4HHS6	Leishmania braziliensis	69%	100%
E9AED1	Leishmania major	91%	100%
E9ALF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%