FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3' -5'-cyclic nucleotide phosphodiesterase - putative

Species:

Leishmania infantum

UniProt:

A4I4X6_LEIIN

TriTrypDb:

LINF_290034600

Length:

1081

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I4X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4X6

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	7
GO:0009987	cellular process	1	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0065007	biological regulation	1	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	7
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	7
GO:0005488	binding	1	7
GO:0008081	phosphoric diester hydrolase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.571
CLV_MEL_PAP_1	568	574	PF00089	0.462
CLV_NRD_NRD_1	1004	1006	PF00675	0.596
CLV_NRD_NRD_1	184	186	PF00675	0.608
CLV_NRD_NRD_1	229	231	PF00675	0.647
CLV_NRD_NRD_1	442	444	PF00675	0.552
CLV_NRD_NRD_1	69	71	PF00675	0.443
CLV_NRD_NRD_1	891	893	PF00675	0.627
CLV_NRD_NRD_1	968	970	PF00675	0.575
CLV_PCSK_KEX2_1	1003	1005	PF00082	0.600
CLV_PCSK_KEX2_1	184	186	PF00082	0.608
CLV_PCSK_KEX2_1	229	231	PF00082	0.480
CLV_PCSK_KEX2_1	26	28	PF00082	0.411
CLV_PCSK_KEX2_1	442	444	PF00082	0.624
CLV_PCSK_KEX2_1	640	642	PF00082	0.411
CLV_PCSK_KEX2_1	968	970	PF00082	0.617
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.411
CLV_PCSK_PC1ET2_1	640	642	PF00082	0.411
CLV_PCSK_SKI1_1	1005	1009	PF00082	0.588
CLV_PCSK_SKI1_1	26	30	PF00082	0.436
CLV_PCSK_SKI1_1	261	265	PF00082	0.707
CLV_PCSK_SKI1_1	376	380	PF00082	0.599
CLV_PCSK_SKI1_1	485	489	PF00082	0.522
CLV_PCSK_SKI1_1	866	870	PF00082	0.798
CLV_PCSK_SKI1_1	906	910	PF00082	0.582
CLV_PCSK_SKI1_1	954	958	PF00082	0.554
CLV_Separin_Metazoa	416	420	PF03568	0.623
CLV_Separin_Metazoa	951	955	PF03568	0.582
DEG_APCC_DBOX_1	452	460	PF00400	0.589
DEG_APCC_DBOX_1	484	492	PF00400	0.565
DEG_APCC_KENBOX_2	33	37	PF00400	0.411
DOC_CDC14_PxL_1	543	551	PF14671	0.549
DOC_CKS1_1	691	696	PF01111	0.513
DOC_CYCLIN_RxL_1	792	803	PF00134	0.436
DOC_MAPK_DCC_7	541	551	PF00069	0.480
DOC_MAPK_gen_1	917	926	PF00069	0.583
DOC_MAPK_HePTP_8	568	580	PF00069	0.545
DOC_MAPK_MEF2A_6	485	492	PF00069	0.612
DOC_MAPK_MEF2A_6	571	580	PF00069	0.544
DOC_MAPK_MEF2A_6	752	760	PF00069	0.513
DOC_PP1_RVXF_1	639	646	PF00149	0.411
DOC_PP4_FxxP_1	820	823	PF00568	0.411
DOC_PP4_FxxP_1	859	862	PF00568	0.540
DOC_USP7_MATH_1	161	165	PF00917	0.548
DOC_USP7_MATH_1	196	200	PF00917	0.559
DOC_USP7_MATH_1	248	252	PF00917	0.559
DOC_USP7_MATH_1	361	365	PF00917	0.562
DOC_USP7_MATH_1	500	504	PF00917	0.773
DOC_USP7_MATH_1	655	659	PF00917	0.513
DOC_USP7_MATH_1	801	805	PF00917	0.513
DOC_USP7_MATH_1	876	880	PF00917	0.619
DOC_USP7_MATH_1	932	936	PF00917	0.608
DOC_USP7_MATH_1	943	947	PF00917	0.568
DOC_WW_Pin1_4	1055	1060	PF00397	0.739
DOC_WW_Pin1_4	690	695	PF00397	0.513
DOC_WW_Pin1_4	797	802	PF00397	0.411
DOC_WW_Pin1_4	834	839	PF00397	0.411
DOC_WW_Pin1_4	939	944	PF00397	0.664
DOC_WW_Pin1_4	97	102	PF00397	0.656
LIG_14-3-3_CanoR_1	27	31	PF00244	0.411
LIG_14-3-3_CanoR_1	586	590	PF00244	0.580
LIG_14-3-3_CanoR_1	726	731	PF00244	0.513
LIG_14-3-3_CanoR_1	805	810	PF00244	0.513
LIG_14-3-3_CanoR_1	840	846	PF00244	0.490
LIG_14-3-3_CanoR_1	866	871	PF00244	0.686
LIG_14-3-3_CanoR_1	989	997	PF00244	0.711
LIG_Actin_WH2_2	232	248	PF00022	0.566
LIG_APCC_ABBA_1	580	585	PF00400	0.580
LIG_BH_BH3_1	986	1002	PF00452	0.492
LIG_BIR_II_1	1	5	PF00653	0.628
LIG_BRCT_BRCA1_1	657	661	PF00533	0.513
LIG_BRCT_BRCA1_2	657	663	PF00533	0.436
LIG_CaM_NSCaTE_8	480	487	PF13499	0.678
LIG_deltaCOP1_diTrp_1	550	554	PF00928	0.487
LIG_DLG_GKlike_1	805	813	PF00625	0.513
LIG_FHA_1	1073	1079	PF00498	0.711
LIG_FHA_1	262	268	PF00498	0.701
LIG_FHA_1	315	321	PF00498	0.614
LIG_FHA_1	397	403	PF00498	0.522
LIG_FHA_1	691	697	PF00498	0.443
LIG_FHA_1	704	710	PF00498	0.307
LIG_FHA_1	741	747	PF00498	0.377
LIG_FHA_1	907	913	PF00498	0.600
LIG_FHA_1	94	100	PF00498	0.559
LIG_FHA_1	942	948	PF00498	0.781
LIG_FHA_1	975	981	PF00498	0.658
LIG_FHA_2	30	36	PF00498	0.479
LIG_FHA_2	353	359	PF00498	0.609
LIG_FHA_2	402	408	PF00498	0.615
LIG_FHA_2	523	529	PF00498	0.625
LIG_FHA_2	554	560	PF00498	0.474
LIG_FHA_2	634	640	PF00498	0.408
LIG_FHA_2	86	92	PF00498	0.772
LIG_GBD_Chelix_1	986	994	PF00786	0.716
LIG_Integrin_isoDGR_2	512	514	PF01839	0.572
LIG_LIR_Apic_2	519	524	PF02991	0.556
LIG_LIR_Apic_2	732	737	PF02991	0.513
LIG_LIR_Apic_2	818	823	PF02991	0.411
LIG_LIR_Apic_2	856	862	PF02991	0.651
LIG_LIR_Gen_1	216	224	PF02991	0.612
LIG_LIR_Gen_1	553	560	PF02991	0.579
LIG_LIR_Gen_1	686	696	PF02991	0.411
LIG_LIR_Nem_3	216	220	PF02991	0.616
LIG_LIR_Nem_3	529	535	PF02991	0.617
LIG_LIR_Nem_3	553	557	PF02991	0.579
LIG_LIR_Nem_3	667	673	PF02991	0.375
LIG_LIR_Nem_3	686	691	PF02991	0.353
LIG_LIR_Nem_3	710	714	PF02991	0.513
LIG_LYPXL_yS_3	532	535	PF13949	0.539
LIG_MYND_3	546	550	PF01753	0.537
LIG_NRBOX	133	139	PF00104	0.525
LIG_NRBOX	755	761	PF00104	0.323
LIG_OCRL_FandH_1	722	734	PF00620	0.513
LIG_PCNA_yPIPBox_3	125	138	PF02747	0.544
LIG_Pex14_2	816	820	PF04695	0.411
LIG_PTAP_UEV_1	56	61	PF05743	0.436
LIG_Rb_pABgroove_1	819	827	PF01858	0.402
LIG_REV1ctd_RIR_1	28	37	PF16727	0.411
LIG_SH2_CRK	622	626	PF00017	0.402
LIG_SH2_CRK	673	677	PF00017	0.436
LIG_SH2_GRB2like	608	611	PF00017	0.411
LIG_SH2_SRC	470	473	PF00017	0.681
LIG_SH2_STAP1	281	285	PF00017	0.700
LIG_SH2_STAP1	744	748	PF00017	0.513
LIG_SH2_STAT5	1035	1038	PF00017	0.786
LIG_SH2_STAT5	849	852	PF00017	0.603
LIG_SH3_1	795	801	PF00018	0.411
LIG_SH3_2	57	62	PF14604	0.436
LIG_SH3_3	1041	1047	PF00018	0.741
LIG_SH3_3	2	8	PF00018	0.585
LIG_SH3_3	54	60	PF00018	0.394
LIG_SH3_3	795	801	PF00018	0.353
LIG_SH3_3	95	101	PF00018	0.550
LIG_SUMO_SIM_anti_2	132	139	PF11976	0.516
LIG_SUMO_SIM_anti_2	923	928	PF11976	0.588
LIG_TRAF2_1	112	115	PF00917	0.577
LIG_TRAF2_1	238	241	PF00917	0.668
LIG_TRAF2_1	413	416	PF00917	0.607
LIG_TRAF2_1	469	472	PF00917	0.680
LIG_TRAF2_1	852	855	PF00917	0.639
LIG_TRAF2_1	979	982	PF00917	0.613
LIG_TYR_ITIM	530	535	PF00017	0.611
LIG_UBA3_1	134	141	PF00899	0.518
LIG_UBA3_1	631	640	PF00899	0.411
MOD_CDC14_SPxK_1	837	840	PF00782	0.513
MOD_CDK_SPxK_1	834	840	PF00069	0.513
MOD_CK1_1	1058	1064	PF00069	0.719
MOD_CK1_1	108	114	PF00069	0.580
MOD_CK1_1	47	53	PF00069	0.511
MOD_CK1_1	503	509	PF00069	0.758
MOD_CK1_1	800	806	PF00069	0.513
MOD_CK1_1	834	840	PF00069	0.474
MOD_CK1_1	942	948	PF00069	0.691
MOD_CK1_1	988	994	PF00069	0.614
MOD_CK2_1	1066	1072	PF00069	0.699
MOD_CK2_1	108	114	PF00069	0.585
MOD_CK2_1	235	241	PF00069	0.678
MOD_CK2_1	266	272	PF00069	0.644
MOD_CK2_1	29	35	PF00069	0.479
MOD_CK2_1	352	358	PF00069	0.600
MOD_CK2_1	401	407	PF00069	0.612
MOD_CK2_1	522	528	PF00069	0.628
MOD_CK2_1	553	559	PF00069	0.433
MOD_CK2_1	633	639	PF00069	0.411
MOD_CK2_1	726	732	PF00069	0.513
MOD_CK2_1	75	81	PF00069	0.566
MOD_CK2_1	876	882	PF00069	0.783
MOD_CK2_1	943	949	PF00069	0.660
MOD_CMANNOS	477	480	PF00535	0.684
MOD_Cter_Amidation	182	185	PF01082	0.508
MOD_GlcNHglycan	1068	1071	PF01048	0.587
MOD_GlcNHglycan	1075	1078	PF01048	0.604
MOD_GlcNHglycan	110	113	PF01048	0.569
MOD_GlcNHglycan	156	159	PF01048	0.630
MOD_GlcNHglycan	16	19	PF01048	0.411
MOD_GlcNHglycan	163	166	PF01048	0.589
MOD_GlcNHglycan	363	366	PF01048	0.630
MOD_GlcNHglycan	49	52	PF01048	0.411
MOD_GlcNHglycan	502	505	PF01048	0.705
MOD_GlcNHglycan	805	808	PF01048	0.416
MOD_GSK3_1	1030	1037	PF00069	0.738
MOD_GSK3_1	249	256	PF00069	0.549
MOD_GSK3_1	26	33	PF00069	0.405
MOD_GSK3_1	287	294	PF00069	0.679
MOD_GSK3_1	331	338	PF00069	0.479
MOD_GSK3_1	397	404	PF00069	0.604
MOD_GSK3_1	43	50	PF00069	0.485
MOD_GSK3_1	499	506	PF00069	0.781
MOD_GSK3_1	662	669	PF00069	0.341
MOD_GSK3_1	699	706	PF00069	0.299
MOD_GSK3_1	740	747	PF00069	0.403
MOD_GSK3_1	797	804	PF00069	0.513
MOD_GSK3_1	866	873	PF00069	0.808
MOD_GSK3_1	928	935	PF00069	0.651
MOD_GSK3_1	93	100	PF00069	0.641
MOD_GSK3_1	939	946	PF00069	0.608
MOD_N-GLC_1	130	135	PF02516	0.537
MOD_NEK2_1	249	254	PF00069	0.614
MOD_NEK2_1	360	365	PF00069	0.641
MOD_NEK2_1	43	48	PF00069	0.411
MOD_NEK2_1	463	468	PF00069	0.701
MOD_NEK2_1	595	600	PF00069	0.482
MOD_NEK2_1	624	629	PF00069	0.397
MOD_NEK2_1	666	671	PF00069	0.389
MOD_NEK2_1	696	701	PF00069	0.411
MOD_NEK2_1	853	858	PF00069	0.568
MOD_PIKK_1	401	407	PF00454	0.690
MOD_PIKK_1	75	81	PF00454	0.645
MOD_PIKK_1	85	91	PF00454	0.565
MOD_PIKK_1	866	872	PF00454	0.690
MOD_PIKK_1	932	938	PF00454	0.629
MOD_PKA_1	26	32	PF00069	0.411
MOD_PKA_2	26	32	PF00069	0.411
MOD_PKA_2	331	337	PF00069	0.472
MOD_PKA_2	513	519	PF00069	0.570
MOD_PKA_2	585	591	PF00069	0.578
MOD_PKA_2	699	705	PF00069	0.383
MOD_PKA_2	75	81	PF00069	0.561
MOD_PKA_2	982	988	PF00069	0.691
MOD_PKB_1	904	912	PF00069	0.582
MOD_Plk_1	130	136	PF00069	0.541
MOD_Plk_1	291	297	PF00069	0.707
MOD_Plk_1	379	385	PF00069	0.451
MOD_Plk_1	421	427	PF00069	0.461
MOD_Plk_1	666	672	PF00069	0.405
MOD_Plk_1	744	750	PF00069	0.377
MOD_Plk_1	898	904	PF00069	0.558
MOD_Plk_2-3	130	136	PF00069	0.565
MOD_Plk_2-3	216	222	PF00069	0.615
MOD_Plk_2-3	352	358	PF00069	0.600
MOD_Plk_2-3	553	559	PF00069	0.580
MOD_Plk_2-3	740	746	PF00069	0.513
MOD_Plk_4	130	136	PF00069	0.541
MOD_Plk_4	522	528	PF00069	0.628
MOD_Plk_4	666	672	PF00069	0.389
MOD_Plk_4	719	725	PF00069	0.411
MOD_Plk_4	726	732	PF00069	0.411
MOD_Plk_4	754	760	PF00069	0.424
MOD_ProDKin_1	1055	1061	PF00069	0.731
MOD_ProDKin_1	690	696	PF00069	0.513
MOD_ProDKin_1	797	803	PF00069	0.411
MOD_ProDKin_1	834	840	PF00069	0.411
MOD_ProDKin_1	939	945	PF00069	0.661
MOD_ProDKin_1	97	103	PF00069	0.646
MOD_SUMO_for_1	1065	1068	PF00179	0.717
MOD_SUMO_for_1	175	178	PF00179	0.599
MOD_SUMO_for_1	213	216	PF00179	0.710
MOD_SUMO_for_1	224	227	PF00179	0.495
MOD_SUMO_for_1	390	393	PF00179	0.686
MOD_SUMO_rev_2	102	111	PF00179	0.687
MOD_SUMO_rev_2	171	181	PF00179	0.564
MOD_SUMO_rev_2	735	743	PF00179	0.513
TRG_DiLeu_BaEn_1	130	135	PF01217	0.527
TRG_DiLeu_BaEn_1	433	438	PF01217	0.641
TRG_DiLeu_BaEn_1	565	570	PF01217	0.590
TRG_DiLeu_BaEn_1	710	715	PF01217	0.513
TRG_DiLeu_BaEn_4	240	246	PF01217	0.573
TRG_DiLeu_BaEn_4	304	310	PF01217	0.543
TRG_ENDOCYTIC_2	532	535	PF00928	0.617
TRG_ENDOCYTIC_2	622	625	PF00928	0.378
TRG_ENDOCYTIC_2	673	676	PF00928	0.436
TRG_ER_diArg_1	1003	1005	PF00400	0.621
TRG_ER_diArg_1	184	186	PF00400	0.608
TRG_ER_diArg_1	425	428	PF00400	0.473
TRG_ER_diArg_1	441	443	PF00400	0.444
TRG_ER_diArg_1	968	970	PF00400	0.617
TRG_NES_CRM1_1	813	826	PF08389	0.402
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.686
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	736	740	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	917	921	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I536	Leptomonas seymouri	42%	90%
A0A3S7X2S6	Leishmania donovani	99%	100%
A4HHS5	Leishmania braziliensis	74%	100%
E9AED0	Leishmania major	90%	100%
E9ALF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%