LeishMANIAdb
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Putative serine/threonine-protein kinase Nek3

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative serine/threonine-protein kinase Nek3
Gene product:
serine/threonine-protein kinase Nek - putative
Species:
Leishmania infantum
UniProt:
A4I4X5_LEIIN
TriTrypDb:
LINF_290034500
Length:
522

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 6
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 18
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 20
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 56
NetGPI no yes: 0, no: 57
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 7
GO:0005634 nucleus 5 2
GO:0005654 nucleoplasm 2 1
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 6
GO:0005815 microtubule organizing center 2 1
GO:0005829 cytosol 2 1
GO:0005956 protein kinase CK2 complex 3 1
GO:0032991 protein-containing complex 1 2
GO:0036064 ciliary basal body 3 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 2
GO:0140535 intracellular protein-containing complex 2 2
GO:1902494 catalytic complex 2 2
GO:1902554 serine/threonine protein kinase complex 6 2
GO:1902911 protein kinase complex 5 2
GO:1990234 transferase complex 3 2
GO:0031974 membrane-enclosed lumen 2 2
GO:0031981 nuclear lumen 5 2
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0043233 organelle lumen 3 2
GO:0070013 intracellular organelle lumen 4 2
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0005930 axoneme 2 1
GO:0005952 cAMP-dependent protein kinase complex 3 1

Expansion

Sequence features

A4I4X5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4X5

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 58
GO:0006793 phosphorus metabolic process 3 58
GO:0006796 phosphate-containing compound metabolic process 4 58
GO:0006807 nitrogen compound metabolic process 2 58
GO:0008152 metabolic process 1 58
GO:0009987 cellular process 1 58
GO:0016310 phosphorylation 5 58
GO:0019538 protein metabolic process 3 58
GO:0036211 protein modification process 4 58
GO:0043170 macromolecule metabolic process 3 58
GO:0043412 macromolecule modification 4 58
GO:0044237 cellular metabolic process 2 58
GO:0044238 primary metabolic process 2 58
GO:0071704 organic substance metabolic process 2 58
GO:1901564 organonitrogen compound metabolic process 3 58
GO:0018105 peptidyl-serine phosphorylation 6 5
GO:0018107 peptidyl-threonine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 5
GO:0018209 peptidyl-serine modification 6 5
GO:0018210 peptidyl-threonine modification 6 1
GO:0050789 regulation of biological process 2 6
GO:0050794 regulation of cellular process 3 6
GO:0051726 regulation of cell cycle 4 1
GO:0065007 biological regulation 1 6
GO:0007165 signal transduction 2 5
GO:0035556 intracellular signal transduction 3 4
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0022402 cell cycle process 2 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:1903047 mitotic cell cycle process 3 1
GO:0009266 response to temperature stimulus 3 1
GO:0009628 response to abiotic stimulus 2 1
GO:0050896 response to stimulus 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 58
GO:0003824 catalytic activity 1 58
GO:0004672 protein kinase activity 3 58
GO:0004674 protein serine/threonine kinase activity 4 48
GO:0005488 binding 1 58
GO:0005524 ATP binding 5 58
GO:0016301 kinase activity 4 58
GO:0016740 transferase activity 2 58
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 58
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 58
GO:0017076 purine nucleotide binding 4 58
GO:0030554 adenyl nucleotide binding 5 58
GO:0032553 ribonucleotide binding 3 58
GO:0032555 purine ribonucleotide binding 4 58
GO:0032559 adenyl ribonucleotide binding 5 58
GO:0035639 purine ribonucleoside triphosphate binding 4 58
GO:0036094 small molecule binding 2 58
GO:0043167 ion binding 2 58
GO:0043168 anion binding 3 58
GO:0097159 organic cyclic compound binding 2 58
GO:0097367 carbohydrate derivative binding 2 58
GO:0140096 catalytic activity, acting on a protein 2 58
GO:1901265 nucleoside phosphate binding 3 58
GO:1901363 heterocyclic compound binding 2 58
GO:0004707 MAP kinase activity 5 9
GO:0043169 cation binding 3 5
GO:0046872 metal ion binding 4 5
GO:0004690 cyclic nucleotide-dependent protein kinase activity 5 1
GO:0004691 cAMP-dependent protein kinase activity 6 1
GO:0004140 dephospho-CoA kinase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 503 507 PF00656 0.344
CLV_NRD_NRD_1 215 217 PF00675 0.211
CLV_NRD_NRD_1 260 262 PF00675 0.304
CLV_NRD_NRD_1 443 445 PF00675 0.463
CLV_PCSK_KEX2_1 215 217 PF00082 0.205
CLV_PCSK_KEX2_1 260 262 PF00082 0.404
CLV_PCSK_KEX2_1 442 444 PF00082 0.426
CLV_PCSK_PC7_1 256 262 PF00082 0.293
CLV_PCSK_SKI1_1 142 146 PF00082 0.338
CLV_PCSK_SKI1_1 251 255 PF00082 0.305
CLV_PCSK_SKI1_1 385 389 PF00082 0.585
CLV_PCSK_SKI1_1 516 520 PF00082 0.403
DEG_SPOP_SBC_1 397 401 PF00917 0.534
DOC_CKS1_1 179 184 PF01111 0.221
DOC_CYCLIN_RxL_1 431 439 PF00134 0.426
DOC_CYCLIN_yCln2_LP_2 214 220 PF00134 0.222
DOC_CYCLIN_yCln2_LP_2 272 278 PF00134 0.427
DOC_MAPK_gen_1 142 151 PF00069 0.316
DOC_MAPK_gen_1 58 65 PF00069 0.266
DOC_PP2B_LxvP_1 272 275 PF13499 0.373
DOC_PP4_FxxP_1 295 298 PF00568 0.382
DOC_PP4_FxxP_1 81 84 PF00568 0.283
DOC_USP7_MATH_1 309 313 PF00917 0.468
DOC_USP7_MATH_1 383 387 PF00917 0.791
DOC_USP7_MATH_1 402 406 PF00917 0.596
DOC_USP7_MATH_1 478 482 PF00917 0.413
DOC_USP7_MATH_1 49 53 PF00917 0.338
DOC_USP7_MATH_1 85 89 PF00917 0.191
DOC_USP7_UBL2_3 154 158 PF12436 0.233
DOC_USP7_UBL2_3 385 389 PF12436 0.552
DOC_WW_Pin1_4 178 183 PF00397 0.290
DOC_WW_Pin1_4 358 363 PF00397 0.648
LIG_14-3-3_CanoR_1 323 329 PF00244 0.479
LIG_14-3-3_CanoR_1 442 448 PF00244 0.711
LIG_14-3-3_CanoR_1 492 500 PF00244 0.523
LIG_APCC_ABBA_1 268 273 PF00400 0.448
LIG_APCC_ABBA_1 335 340 PF00400 0.433
LIG_APCC_ABBAyCdc20_2 444 450 PF00400 0.442
LIG_BIR_II_1 1 5 PF00653 0.410
LIG_BRCT_BRCA1_1 146 150 PF00533 0.190
LIG_deltaCOP1_diTrp_1 200 208 PF00928 0.209
LIG_EH1_1 161 169 PF00400 0.293
LIG_FHA_1 115 121 PF00498 0.312
LIG_FHA_1 144 150 PF00498 0.253
LIG_FHA_1 24 30 PF00498 0.251
LIG_FHA_1 369 375 PF00498 0.659
LIG_FHA_1 38 44 PF00498 0.283
LIG_FHA_1 407 413 PF00498 0.546
LIG_FHA_1 424 430 PF00498 0.592
LIG_FHA_2 261 267 PF00498 0.235
LIG_FHA_2 430 436 PF00498 0.464
LIG_FHA_2 98 104 PF00498 0.249
LIG_LIR_Apic_2 181 187 PF02991 0.330
LIG_LIR_Apic_2 303 309 PF02991 0.420
LIG_LIR_Apic_2 79 84 PF02991 0.283
LIG_LIR_Gen_1 14 21 PF02991 0.378
LIG_LIR_Gen_1 336 345 PF02991 0.395
LIG_LIR_Gen_1 94 101 PF02991 0.347
LIG_LIR_Nem_3 14 18 PF02991 0.394
LIG_LIR_Nem_3 27 33 PF02991 0.461
LIG_LIR_Nem_3 336 341 PF02991 0.413
LIG_LIR_Nem_3 513 518 PF02991 0.433
LIG_LIR_Nem_3 94 98 PF02991 0.379
LIG_NRP_CendR_1 519 522 PF00754 0.390
LIG_Pex14_2 77 81 PF04695 0.195
LIG_SH2_CRK 30 34 PF00017 0.344
LIG_SH2_STAP1 302 306 PF00017 0.409
LIG_SH2_STAT5 184 187 PF00017 0.299
LIG_SH2_STAT5 302 305 PF00017 0.455
LIG_SH2_STAT5 41 44 PF00017 0.205
LIG_SH2_STAT5 95 98 PF00017 0.419
LIG_SH3_3 273 279 PF00018 0.390
LIG_SH3_3 310 316 PF00018 0.608
LIG_SH3_3 375 381 PF00018 0.599
LIG_SH3_3 66 72 PF00018 0.213
LIG_SUMO_SIM_anti_2 62 67 PF11976 0.263
LIG_SUMO_SIM_anti_2 88 94 PF11976 0.244
LIG_SUMO_SIM_par_1 456 464 PF11976 0.465
LIG_TRAF2_1 263 266 PF00917 0.216
LIG_TRAF2_1 52 55 PF00917 0.238
LIG_TRAF2_1 59 62 PF00917 0.263
LIG_WRC_WIRS_1 428 433 PF05994 0.407
MOD_CK1_1 23 29 PF00069 0.246
MOD_CK1_1 277 283 PF00069 0.337
MOD_CK1_1 363 369 PF00069 0.669
MOD_CK1_1 427 433 PF00069 0.451
MOD_CK1_1 453 459 PF00069 0.724
MOD_CK1_1 471 477 PF00069 0.414
MOD_CK2_1 230 236 PF00069 0.218
MOD_CK2_1 260 266 PF00069 0.355
MOD_CK2_1 293 299 PF00069 0.452
MOD_CK2_1 429 435 PF00069 0.560
MOD_CK2_1 466 472 PF00069 0.524
MOD_CK2_1 49 55 PF00069 0.248
MOD_GlcNHglycan 1 4 PF01048 0.496
MOD_GlcNHglycan 22 25 PF01048 0.276
MOD_GlcNHglycan 295 298 PF01048 0.391
MOD_GlcNHglycan 318 321 PF01048 0.615
MOD_GlcNHglycan 332 335 PF01048 0.607
MOD_GlcNHglycan 365 368 PF01048 0.616
MOD_GlcNHglycan 375 378 PF01048 0.577
MOD_GlcNHglycan 384 388 PF01048 0.650
MOD_GSK3_1 129 136 PF00069 0.190
MOD_GSK3_1 174 181 PF00069 0.313
MOD_GSK3_1 196 203 PF00069 0.229
MOD_GSK3_1 20 27 PF00069 0.366
MOD_GSK3_1 256 263 PF00069 0.261
MOD_GSK3_1 280 287 PF00069 0.361
MOD_GSK3_1 33 40 PF00069 0.267
MOD_GSK3_1 368 375 PF00069 0.526
MOD_GSK3_1 383 390 PF00069 0.637
MOD_GSK3_1 393 400 PF00069 0.594
MOD_GSK3_1 402 409 PF00069 0.599
MOD_GSK3_1 423 430 PF00069 0.459
MOD_N-GLC_1 33 38 PF02516 0.378
MOD_N-GLC_1 49 54 PF02516 0.283
MOD_NEK2_1 144 149 PF00069 0.332
MOD_NEK2_1 150 155 PF00069 0.363
MOD_NEK2_1 300 305 PF00069 0.473
MOD_NEK2_1 341 346 PF00069 0.473
MOD_NEK2_1 372 377 PF00069 0.519
MOD_NEK2_1 424 429 PF00069 0.492
MOD_NEK2_1 77 82 PF00069 0.269
MOD_NEK2_2 368 373 PF00069 0.489
MOD_PIKK_1 280 286 PF00454 0.344
MOD_PKA_1 260 266 PF00069 0.293
MOD_PKA_1 388 394 PF00069 0.706
MOD_PKA_1 44 50 PF00069 0.281
MOD_PKA_1 442 448 PF00069 0.509
MOD_PKA_2 260 266 PF00069 0.258
MOD_PKA_2 322 328 PF00069 0.479
MOD_PKA_2 442 448 PF00069 0.485
MOD_PKA_2 491 497 PF00069 0.415
MOD_PKA_2 77 83 PF00069 0.201
MOD_Plk_1 37 43 PF00069 0.215
MOD_Plk_1 85 91 PF00069 0.226
MOD_Plk_2-3 97 103 PF00069 0.278
MOD_Plk_4 163 169 PF00069 0.190
MOD_Plk_4 174 180 PF00069 0.262
MOD_Plk_4 424 430 PF00069 0.457
MOD_Plk_4 443 449 PF00069 0.405
MOD_Plk_4 478 484 PF00069 0.371
MOD_Plk_4 77 83 PF00069 0.218
MOD_ProDKin_1 178 184 PF00069 0.290
MOD_ProDKin_1 358 364 PF00069 0.630
MOD_SUMO_for_1 173 176 PF00179 0.244
MOD_SUMO_for_1 381 384 PF00179 0.521
MOD_SUMO_for_1 59 62 PF00179 0.197
MOD_SUMO_rev_2 446 454 PF00179 0.439
MOD_SUMO_rev_2 513 518 PF00179 0.420
TRG_DiLeu_BaLyEn_6 287 292 PF01217 0.382
TRG_ENDOCYTIC_2 15 18 PF00928 0.354
TRG_ENDOCYTIC_2 30 33 PF00928 0.449
TRG_ENDOCYTIC_2 515 518 PF00928 0.431
TRG_ENDOCYTIC_2 95 98 PF00928 0.349
TRG_ER_diArg_1 107 110 PF00400 0.279
TRG_ER_diArg_1 214 216 PF00400 0.209
TRG_ER_diArg_1 260 262 PF00400 0.348
TRG_ER_diArg_1 288 291 PF00400 0.352
TRG_ER_diArg_1 442 444 PF00400 0.442
TRG_Pf-PMV_PEXEL_1 138 143 PF00026 0.374
TRG_Pf-PMV_PEXEL_1 290 294 PF00026 0.367
TRG_Pf-PMV_PEXEL_1 434 439 PF00026 0.450
TRG_PTS2 1 21 PF00400 0.349

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEV2 Leptomonas seymouri 64% 96%
A0A0S4JIJ6 Bodo saltans 25% 92%
A0A1X0P963 Trypanosomatidae 47% 100%
A0A3Q8IAQ1 Leishmania donovani 32% 100%
A0A3Q8IC87 Leishmania donovani 29% 100%
A0A3Q8IIG1 Leishmania donovani 33% 100%
A0A3Q8INQ4 Leishmania donovani 26% 100%
A0A3S5H5G0 Leishmania donovani 26% 100%
A0A3S5H789 Leishmania donovani 23% 100%
A0A3S5H7M0 Leishmania donovani 100% 100%
A0A3S7WTN9 Leishmania donovani 30% 100%
A0A3S7WWE7 Leishmania donovani 23% 100%
A0A3S7WYP4 Leishmania donovani 27% 100%
A0A3S7X2W3 Leishmania donovani 28% 100%
A0A3S7X2Z6 Leishmania donovani 27% 100%
A0A3S7X9R4 Leishmania donovani 30% 100%
A4H459 Leishmania braziliensis 26% 100%
A4H8C4 Leishmania braziliensis 32% 100%
A4HBL4 Leishmania braziliensis 23% 100%
A4HCE6 Leishmania braziliensis 33% 100%
A4HED7 Leishmania braziliensis 26% 100%
A4HH03 Leishmania braziliensis 32% 100%
A4HHN1 Leishmania braziliensis 28% 100%
A4HHR5 Leishmania braziliensis 77% 100%
A4HHY4 Leishmania braziliensis 26% 100%
A4HMJ3 Leishmania braziliensis 27% 100%
A4HN71 Leishmania braziliensis 31% 100%
A4HSE2 Leishmania infantum 26% 100%
A4HWP5 Leishmania infantum 30% 100%
A4HYX6 Leishmania infantum 23% 100%
A4HZA2 Leishmania infantum 24% 100%
A4HZV1 Leishmania infantum 29% 100%
A4HZW8 Leishmania infantum 32% 100%
A4I140 Leishmania infantum 27% 100%
A4I1T4 Leishmania infantum 26% 100%
A4I435 Leishmania infantum 33% 100%
A4I4U6 Leishmania infantum 28% 100%
A4I564 Leishmania infantum 27% 100%
A4IBT4 Leishmania infantum 30% 100%
A4IBT9 Leishmania infantum 30% 100%
C9ZKX6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9AEC9 Leishmania major 95% 100%
E9AEZ4 Leishmania major 27% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9ALF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9ALJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AQF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AUS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AUY2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AX78 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B0G1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
O80396 Arabidopsis thaliana 26% 100%
Q4Q7M5 Leishmania major 28% 100%
Q4Q7S2 Leishmania major 27% 100%
Q4Q7W2 Leishmania major 33% 100%
Q4Q9K2 Leishmania major 26% 100%
Q4QA98 Leishmania major 28% 100%
Q4QBQ2 Leishmania major 31% 100%
Q4QBR6 Leishmania major 29% 100%
Q4QCK0 Leishmania major 25% 100%
Q4QF23 Leishmania major 30% 100%
Q4QJJ0 Leishmania major 25% 100%
Q9GNR4 Leishmania major 30% 100%
Q9Y077 Leishmania major 28% 100%
V5C234 Trypanosoma cruzi 46% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS