Cnd3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nuclear condensing complex subunits - C-term domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I4X3_LEIIN

TriTrypDb:

LINF_290034300

Length:

1040

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000796	condensin complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0044815	DNA packaging complex	2	11
GO:0000793	condensed chromosome	6	1
GO:0005654	nucleoplasm	2	1
GO:0005694	chromosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I4X3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4X3

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0007076	mitotic chromosome condensation	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022402	cell cycle process	2	11
GO:0030261	chromosome condensation	6	11
GO:0051276	chromosome organization	5	11
GO:0051301	cell division	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:1903047	mitotic cell cycle process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.409
CLV_C14_Caspase3-7	477	481	PF00656	0.390
CLV_C14_Caspase3-7	964	968	PF00656	0.504
CLV_C14_Caspase3-7	982	986	PF00656	0.302
CLV_NRD_NRD_1	1034	1036	PF00675	0.587
CLV_NRD_NRD_1	198	200	PF00675	0.322
CLV_NRD_NRD_1	208	210	PF00675	0.368
CLV_NRD_NRD_1	324	326	PF00675	0.378
CLV_NRD_NRD_1	503	505	PF00675	0.410
CLV_NRD_NRD_1	515	517	PF00675	0.393
CLV_NRD_NRD_1	75	77	PF00675	0.428
CLV_NRD_NRD_1	844	846	PF00675	0.303
CLV_PCSK_KEX2_1	1018	1020	PF00082	0.594
CLV_PCSK_KEX2_1	1036	1038	PF00082	0.493
CLV_PCSK_KEX2_1	326	328	PF00082	0.479
CLV_PCSK_KEX2_1	515	517	PF00082	0.431
CLV_PCSK_KEX2_1	651	653	PF00082	0.322
CLV_PCSK_KEX2_1	688	690	PF00082	0.304
CLV_PCSK_KEX2_1	75	77	PF00082	0.350
CLV_PCSK_KEX2_1	771	773	PF00082	0.336
CLV_PCSK_KEX2_1	983	985	PF00082	0.480
CLV_PCSK_PC1ET2_1	1018	1020	PF00082	0.602
CLV_PCSK_PC1ET2_1	1036	1038	PF00082	0.600
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.479
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.444
CLV_PCSK_PC1ET2_1	651	653	PF00082	0.322
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.296
CLV_PCSK_PC1ET2_1	771	773	PF00082	0.336
CLV_PCSK_PC1ET2_1	983	985	PF00082	0.470
CLV_PCSK_SKI1_1	200	204	PF00082	0.335
CLV_PCSK_SKI1_1	210	214	PF00082	0.337
CLV_PCSK_SKI1_1	245	249	PF00082	0.410
CLV_PCSK_SKI1_1	254	258	PF00082	0.360
CLV_PCSK_SKI1_1	392	396	PF00082	0.454
CLV_PCSK_SKI1_1	407	411	PF00082	0.230
CLV_PCSK_SKI1_1	458	462	PF00082	0.347
CLV_PCSK_SKI1_1	473	477	PF00082	0.326
CLV_PCSK_SKI1_1	484	488	PF00082	0.369
CLV_PCSK_SKI1_1	516	520	PF00082	0.426
CLV_PCSK_SKI1_1	542	546	PF00082	0.322
CLV_PCSK_SKI1_1	64	68	PF00082	0.397
CLV_PCSK_SKI1_1	688	692	PF00082	0.280
CLV_PCSK_SKI1_1	785	789	PF00082	0.313
CLV_PCSK_SKI1_1	984	988	PF00082	0.434
DEG_APCC_DBOX_1	429	437	PF00400	0.363
DEG_APCC_DBOX_1	545	553	PF00400	0.432
DOC_CYCLIN_RxL_1	404	414	PF00134	0.321
DOC_CYCLIN_RxL_1	514	524	PF00134	0.334
DOC_CYCLIN_yCln2_LP_2	366	369	PF00134	0.479
DOC_MAPK_gen_1	35	43	PF00069	0.446
DOC_MAPK_gen_1	539	549	PF00069	0.369
DOC_MAPK_gen_1	688	696	PF00069	0.436
DOC_MAPK_HePTP_8	871	883	PF00069	0.536
DOC_MAPK_MEF2A_6	53	62	PF00069	0.397
DOC_MAPK_MEF2A_6	542	551	PF00069	0.365
DOC_MAPK_MEF2A_6	874	883	PF00069	0.536
DOC_PP1_RVXF_1	390	397	PF00149	0.449
DOC_PP1_RVXF_1	433	440	PF00149	0.319
DOC_PP1_RVXF_1	795	802	PF00149	0.530
DOC_PP2B_LxvP_1	366	369	PF13499	0.421
DOC_PP2B_LxvP_1	486	489	PF13499	0.347
DOC_USP7_MATH_1	119	123	PF00917	0.485
DOC_USP7_MATH_1	166	170	PF00917	0.465
DOC_USP7_MATH_1	172	176	PF00917	0.455
DOC_USP7_MATH_1	459	463	PF00917	0.399
DOC_USP7_MATH_1	478	482	PF00917	0.314
DOC_USP7_MATH_1	526	530	PF00917	0.413
DOC_USP7_MATH_1	587	591	PF00917	0.498
DOC_USP7_MATH_1	623	627	PF00917	0.564
DOC_USP7_MATH_1	741	745	PF00917	0.536
DOC_USP7_MATH_1	793	797	PF00917	0.522
DOC_USP7_MATH_1	8	12	PF00917	0.649
DOC_USP7_MATH_1	852	856	PF00917	0.511
DOC_USP7_MATH_2	312	318	PF00917	0.397
DOC_USP7_MATH_2	445	451	PF00917	0.493
DOC_USP7_UBL2_3	35	39	PF12436	0.463
DOC_USP7_UBL2_3	684	688	PF12436	0.496
DOC_WW_Pin1_4	1003	1008	PF00397	0.688
DOC_WW_Pin1_4	308	313	PF00397	0.366
DOC_WW_Pin1_4	464	469	PF00397	0.410
LIG_14-3-3_CanoR_1	1021	1028	PF00244	0.648
LIG_14-3-3_CanoR_1	315	322	PF00244	0.436
LIG_14-3-3_CanoR_1	327	337	PF00244	0.412
LIG_14-3-3_CanoR_1	407	413	PF00244	0.307
LIG_14-3-3_CanoR_1	430	434	PF00244	0.357
LIG_14-3-3_CanoR_1	458	464	PF00244	0.427
LIG_14-3-3_CanoR_1	491	495	PF00244	0.513
LIG_14-3-3_CanoR_1	689	695	PF00244	0.544
LIG_14-3-3_CanoR_1	804	811	PF00244	0.512
LIG_14-3-3_CanoR_1	854	858	PF00244	0.475
LIG_14-3-3_CanoR_1	868	872	PF00244	0.479
LIG_14-3-3_CanoR_1	874	882	PF00244	0.471
LIG_Actin_WH2_2	113	131	PF00022	0.340
LIG_Actin_WH2_2	429	444	PF00022	0.366
LIG_Actin_WH2_2	48	66	PF00022	0.311
LIG_APCC_ABBA_1	413	418	PF00400	0.352
LIG_BIR_III_2	388	392	PF00653	0.555
LIG_BIR_III_2	562	566	PF00653	0.496
LIG_BIR_III_4	252	256	PF00653	0.531
LIG_BRCT_BRCA1_1	1022	1026	PF00533	0.705
LIG_BRCT_BRCA1_1	492	496	PF00533	0.553
LIG_BRCT_BRCA1_1	709	713	PF00533	0.401
LIG_BRCT_BRCA1_2	709	715	PF00533	0.401
LIG_CaM_IQ_9	170	186	PF13499	0.363
LIG_deltaCOP1_diTrp_1	234	242	PF00928	0.322
LIG_EH1_1	1025	1033	PF00400	0.640
LIG_EH1_1	728	736	PF00400	0.536
LIG_FHA_1	181	187	PF00498	0.340
LIG_FHA_1	340	346	PF00498	0.345
LIG_FHA_1	362	368	PF00498	0.449
LIG_FHA_1	470	476	PF00498	0.398
LIG_FHA_1	586	592	PF00498	0.427
LIG_FHA_1	808	814	PF00498	0.539
LIG_FHA_1	824	830	PF00498	0.496
LIG_FHA_2	13	19	PF00498	0.458
LIG_FHA_2	192	198	PF00498	0.392
LIG_FHA_2	356	362	PF00498	0.486
LIG_FHA_2	465	471	PF00498	0.456
LIG_Integrin_RGD_1	560	562	PF01839	0.255
LIG_LIR_Gen_1	122	131	PF02991	0.321
LIG_LIR_Gen_1	14	23	PF02991	0.370
LIG_LIR_Gen_1	234	243	PF02991	0.292
LIG_LIR_Gen_1	311	321	PF02991	0.341
LIG_LIR_Gen_1	450	460	PF02991	0.407
LIG_LIR_Gen_1	493	502	PF02991	0.468
LIG_LIR_Gen_1	527	537	PF02991	0.402
LIG_LIR_Gen_1	710	717	PF02991	0.491
LIG_LIR_LC3C_4	878	882	PF02991	0.418
LIG_LIR_Nem_3	122	127	PF02991	0.307
LIG_LIR_Nem_3	14	19	PF02991	0.436
LIG_LIR_Nem_3	214	220	PF02991	0.532
LIG_LIR_Nem_3	234	239	PF02991	0.217
LIG_LIR_Nem_3	311	316	PF02991	0.343
LIG_LIR_Nem_3	393	399	PF02991	0.466
LIG_LIR_Nem_3	411	416	PF02991	0.256
LIG_LIR_Nem_3	450	455	PF02991	0.415
LIG_LIR_Nem_3	480	486	PF02991	0.361
LIG_LIR_Nem_3	493	499	PF02991	0.366
LIG_LIR_Nem_3	527	533	PF02991	0.410
LIG_LIR_Nem_3	604	608	PF02991	0.442
LIG_LIR_Nem_3	710	716	PF02991	0.491
LIG_LIR_Nem_3	760	765	PF02991	0.522
LIG_LIR_Nem_3	782	787	PF02991	0.536
LIG_LIR_Nem_3	989	995	PF02991	0.542
LIG_MYND_1	308	312	PF01753	0.476
LIG_NRBOX	185	191	PF00104	0.343
LIG_NRBOX	405	411	PF00104	0.301
LIG_PCNA_PIPBox_1	548	557	PF02747	0.310
LIG_PCNA_TLS_4	210	217	PF02747	0.369
LIG_PCNA_yPIPBox_3	542	555	PF02747	0.307
LIG_Pex14_2	757	761	PF04695	0.441
LIG_Pex14_2	88	92	PF04695	0.405
LIG_REV1ctd_RIR_1	759	767	PF16727	0.536
LIG_SH2_CRK	569	573	PF00017	0.536
LIG_SH2_CRK	78	82	PF00017	0.367
LIG_SH2_NCK_1	313	317	PF00017	0.445
LIG_SH2_NCK_1	384	388	PF00017	0.448
LIG_SH2_PTP2	305	308	PF00017	0.445
LIG_SH2_SRC	144	147	PF00017	0.380
LIG_SH2_SRC	250	253	PF00017	0.459
LIG_SH2_SRC	382	385	PF00017	0.410
LIG_SH2_STAP1	416	420	PF00017	0.489
LIG_SH2_STAP1	809	813	PF00017	0.530
LIG_SH2_STAT5	216	219	PF00017	0.333
LIG_SH2_STAT5	246	249	PF00017	0.354
LIG_SH2_STAT5	305	308	PF00017	0.445
LIG_SH2_STAT5	421	424	PF00017	0.413
LIG_SH2_STAT5	530	533	PF00017	0.514
LIG_SH2_STAT5	697	700	PF00017	0.505
LIG_SH2_STAT5	738	741	PF00017	0.470
LIG_SH2_STAT5	809	812	PF00017	0.506
LIG_SH2_STAT5	904	907	PF00017	0.387
LIG_SH3_3	1001	1007	PF00018	0.624
LIG_SH3_3	253	259	PF00018	0.418
LIG_Sin3_3	343	350	PF02671	0.415
LIG_SUMO_SIM_anti_2	57	63	PF11976	0.389
LIG_SUMO_SIM_anti_2	810	816	PF11976	0.504
LIG_SUMO_SIM_anti_2	878	887	PF11976	0.461
LIG_SUMO_SIM_par_1	408	414	PF11976	0.435
LIG_SUMO_SIM_par_1	606	613	PF11976	0.473
LIG_SUMO_SIM_par_1	878	887	PF11976	0.529
LIG_TRAF2_1	15	18	PF00917	0.382
LIG_TRAF2_1	467	470	PF00917	0.440
LIG_TRAF2_1	836	839	PF00917	0.554
LIG_TRAF2_1	979	982	PF00917	0.418
LIG_TRFH_1	696	700	PF08558	0.401
LIG_TRFH_1	906	910	PF08558	0.452
LIG_TYR_ITIM	931	936	PF00017	0.335
LIG_UBA3_1	202	210	PF00899	0.422
LIG_UBA3_1	433	442	PF00899	0.319
LIG_UBA3_1	482	487	PF00899	0.364
LIG_UBA3_1	60	64	PF00899	0.360
LIG_WRC_WIRS_1	121	126	PF05994	0.383
LIG_WRC_WIRS_1	13	18	PF05994	0.312
LIG_WRC_WIRS_1	602	607	PF05994	0.442
LIG_WRC_WIRS_1	758	763	PF05994	0.482
MOD_CDK_SPxxK_3	308	315	PF00069	0.365
MOD_CK1_1	12	18	PF00069	0.477
MOD_CK1_1	134	140	PF00069	0.505
MOD_CK1_1	269	275	PF00069	0.367
MOD_CK1_1	355	361	PF00069	0.509
MOD_CK1_1	601	607	PF00069	0.462
MOD_CK1_1	847	853	PF00069	0.460
MOD_CK1_1	856	862	PF00069	0.460
MOD_CK1_1	867	873	PF00069	0.438
MOD_CK1_1	91	97	PF00069	0.491
MOD_CK1_1	965	971	PF00069	0.497
MOD_CK2_1	1014	1020	PF00069	0.598
MOD_CK2_1	119	125	PF00069	0.401
MOD_CK2_1	12	18	PF00069	0.477
MOD_CK2_1	308	314	PF00069	0.365
MOD_CK2_1	355	361	PF00069	0.504
MOD_CK2_1	464	470	PF00069	0.460
MOD_CK2_1	526	532	PF00069	0.434
MOD_CK2_1	660	666	PF00069	0.459
MOD_CK2_1	741	747	PF00069	0.496
MOD_CK2_1	867	873	PF00069	0.442
MOD_CK2_1	958	964	PF00069	0.716
MOD_Cter_Amidation	175	178	PF01082	0.390
MOD_Cter_Amidation	502	505	PF01082	0.416
MOD_GlcNHglycan	105	108	PF01048	0.348
MOD_GlcNHglycan	174	177	PF01048	0.436
MOD_GlcNHglycan	28	31	PF01048	0.401
MOD_GlcNHglycan	316	319	PF01048	0.466
MOD_GlcNHglycan	373	376	PF01048	0.418
MOD_GlcNHglycan	46	49	PF01048	0.393
MOD_GlcNHglycan	476	479	PF01048	0.445
MOD_GlcNHglycan	709	712	PF01048	0.332
MOD_GlcNHglycan	858	861	PF01048	0.280
MOD_GlcNHglycan	964	967	PF01048	0.621
MOD_GSK3_1	127	134	PF00069	0.340
MOD_GSK3_1	425	432	PF00069	0.404
MOD_GSK3_1	469	476	PF00069	0.390
MOD_GSK3_1	478	485	PF00069	0.354
MOD_GSK3_1	741	748	PF00069	0.526
MOD_GSK3_1	757	764	PF00069	0.399
MOD_GSK3_1	8	15	PF00069	0.545
MOD_GSK3_1	803	810	PF00069	0.555
MOD_GSK3_1	852	859	PF00069	0.559
MOD_GSK3_1	953	960	PF00069	0.741
MOD_N-GLC_1	134	139	PF02516	0.420
MOD_N-GLC_1	269	274	PF02516	0.425
MOD_N-GLC_1	426	431	PF02516	0.364
MOD_N-GLC_1	847	852	PF02516	0.277
MOD_N-GLC_2	54	56	PF02516	0.241
MOD_NEK2_1	101	106	PF00069	0.528
MOD_NEK2_1	1014	1019	PF00069	0.525
MOD_NEK2_1	266	271	PF00069	0.354
MOD_NEK2_1	297	302	PF00069	0.411
MOD_NEK2_1	377	382	PF00069	0.346
MOD_NEK2_1	482	487	PF00069	0.365
MOD_NEK2_1	555	560	PF00069	0.333
MOD_NEK2_1	690	695	PF00069	0.496
MOD_NEK2_1	757	762	PF00069	0.472
MOD_NEK2_1	888	893	PF00069	0.424
MOD_NEK2_1	922	927	PF00069	0.428
MOD_NEK2_2	478	483	PF00069	0.412
MOD_OFUCOSY	714	719	PF10250	0.255
MOD_PIKK_1	180	186	PF00454	0.343
MOD_PIKK_1	361	367	PF00454	0.525
MOD_PIKK_1	555	561	PF00454	0.297
MOD_PIKK_1	610	616	PF00454	0.461
MOD_PIKK_1	64	70	PF00454	0.557
MOD_PIKK_1	873	879	PF00454	0.557
MOD_PK_1	395	401	PF00069	0.460
MOD_PK_1	745	751	PF00069	0.401
MOD_PKA_1	745	751	PF00069	0.536
MOD_PKA_2	1020	1026	PF00069	0.643
MOD_PKA_2	314	320	PF00069	0.452
MOD_PKA_2	352	358	PF00069	0.432
MOD_PKA_2	429	435	PF00069	0.369
MOD_PKA_2	490	496	PF00069	0.509
MOD_PKA_2	503	509	PF00069	0.335
MOD_PKA_2	803	809	PF00069	0.521
MOD_PKA_2	823	829	PF00069	0.536
MOD_PKA_2	844	850	PF00069	0.475
MOD_PKA_2	853	859	PF00069	0.384
MOD_PKA_2	867	873	PF00069	0.408
MOD_PKA_2	88	94	PF00069	0.432
MOD_Plk_1	269	275	PF00069	0.428
MOD_Plk_1	361	367	PF00069	0.456
MOD_Plk_1	526	532	PF00069	0.475
MOD_Plk_1	623	629	PF00069	0.461
MOD_Plk_4	1027	1033	PF00069	0.610
MOD_Plk_4	269	275	PF00069	0.420
MOD_Plk_4	281	287	PF00069	0.267
MOD_Plk_4	377	383	PF00069	0.331
MOD_Plk_4	408	414	PF00069	0.382
MOD_Plk_4	429	435	PF00069	0.369
MOD_Plk_4	447	453	PF00069	0.391
MOD_Plk_4	478	484	PF00069	0.360
MOD_Plk_4	601	607	PF00069	0.455
MOD_Plk_4	757	763	PF00069	0.484
MOD_Plk_4	809	815	PF00069	0.505
MOD_ProDKin_1	1003	1009	PF00069	0.691
MOD_ProDKin_1	308	314	PF00069	0.365
MOD_ProDKin_1	464	470	PF00069	0.406
MOD_SUMO_for_1	1010	1013	PF00179	0.631
MOD_SUMO_for_1	533	536	PF00179	0.398
MOD_SUMO_rev_2	284	293	PF00179	0.523
MOD_SUMO_rev_2	388	394	PF00179	0.432
MOD_SUMO_rev_2	535	544	PF00179	0.354
TRG_DiLeu_BaEn_1	146	151	PF01217	0.469
TRG_DiLeu_BaEn_2	908	914	PF01217	0.499
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.445
TRG_DiLeu_BaLyEn_6	604	609	PF01217	0.455
TRG_DiLeu_BaLyEn_6	686	691	PF01217	0.536
TRG_DiLeu_BaLyEn_6	794	799	PF01217	0.556
TRG_ENDOCYTIC_2	313	316	PF00928	0.361
TRG_ENDOCYTIC_2	530	533	PF00928	0.397
TRG_ENDOCYTIC_2	569	572	PF00928	0.536
TRG_ENDOCYTIC_2	78	81	PF00928	0.370
TRG_ENDOCYTIC_2	933	936	PF00928	0.520
TRG_ER_diArg_1	1034	1037	PF00400	0.578
TRG_ER_diArg_1	74	76	PF00400	0.484
TRG_NES_CRM1_1	403	418	PF08389	0.315
TRG_NLS_Bipartite_1	1018	1040	PF00514	0.626
TRG_NLS_Bipartite_1	504	519	PF00514	0.494
TRG_NLS_MonoExtC_3	1034	1039	PF00514	0.790
TRG_NLS_MonoExtN_4	1034	1040	PF00514	0.637
TRG_NLS_MonoExtN_4	35	41	PF00514	0.392
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	576	581	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU9	Leptomonas seymouri	74%	100%
A0A0S4KHM0	Bodo saltans	38%	88%
A0A1X0P9B4	Trypanosomatidae	51%	95%
A0A3Q8IFD1	Leishmania donovani	100%	100%
A0A3R7LU33	Trypanosoma rangeli	51%	98%
A4HHR3	Leishmania braziliensis	87%	100%
C9ZKY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	98%
E9AEC7	Leishmania major	95%	100%
E9ALF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%