LeishMANIAdb
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UPF0573 protein C2orf70 homolog

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
UPF0573 protein C2orf70 homolog
Gene product:
Domain of unknown function (DUF4586) - putative
Species:
Leishmania infantum
UniProt:
A4I4W9_LEIIN
TriTrypDb:
LINF_290033400 *
Length:
407

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 16
GO:0005815 microtubule organizing center 2 16
GO:0110165 cellular anatomical entity 1 16
GO:0016020 membrane 2 1

Expansion

Sequence features

A4I4W9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4W9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 97 101 PF00656 0.567
CLV_NRD_NRD_1 12 14 PF00675 0.445
CLV_NRD_NRD_1 264 266 PF00675 0.363
CLV_NRD_NRD_1 315 317 PF00675 0.274
CLV_NRD_NRD_1 367 369 PF00675 0.308
CLV_NRD_NRD_1 404 406 PF00675 0.502
CLV_NRD_NRD_1 55 57 PF00675 0.702
CLV_PCSK_FUR_1 262 266 PF00082 0.301
CLV_PCSK_KEX2_1 129 131 PF00082 0.238
CLV_PCSK_KEX2_1 151 153 PF00082 0.367
CLV_PCSK_KEX2_1 209 211 PF00082 0.265
CLV_PCSK_KEX2_1 264 266 PF00082 0.309
CLV_PCSK_KEX2_1 315 317 PF00082 0.287
CLV_PCSK_KEX2_1 319 321 PF00082 0.283
CLV_PCSK_KEX2_1 383 385 PF00082 0.345
CLV_PCSK_KEX2_1 404 406 PF00082 0.528
CLV_PCSK_KEX2_1 54 56 PF00082 0.518
CLV_PCSK_PC1ET2_1 129 131 PF00082 0.238
CLV_PCSK_PC1ET2_1 151 153 PF00082 0.217
CLV_PCSK_PC1ET2_1 209 211 PF00082 0.279
CLV_PCSK_PC1ET2_1 315 317 PF00082 0.287
CLV_PCSK_PC1ET2_1 319 321 PF00082 0.283
CLV_PCSK_PC1ET2_1 383 385 PF00082 0.388
CLV_PCSK_SKI1_1 109 113 PF00082 0.300
CLV_PCSK_SKI1_1 129 133 PF00082 0.249
CLV_PCSK_SKI1_1 151 155 PF00082 0.346
CLV_PCSK_SKI1_1 316 320 PF00082 0.349
CLV_PCSK_SKI1_1 364 368 PF00082 0.304
DEG_SCF_FBW7_1 44 51 PF00400 0.414
DOC_CKS1_1 30 35 PF01111 0.429
DOC_CKS1_1 45 50 PF01111 0.406
DOC_CYCLIN_yCln2_LP_2 276 282 PF00134 0.553
DOC_MAPK_gen_1 13 19 PF00069 0.338
DOC_PP2B_LxvP_1 21 24 PF13499 0.369
DOC_PP2B_LxvP_1 276 279 PF13499 0.526
DOC_PP4_FxxP_1 280 283 PF00568 0.485
DOC_PP4_FxxP_1 78 81 PF00568 0.490
DOC_USP7_MATH_1 101 105 PF00917 0.481
DOC_USP7_MATH_1 176 180 PF00917 0.492
DOC_USP7_MATH_1 283 287 PF00917 0.481
DOC_USP7_MATH_1 308 312 PF00917 0.481
DOC_USP7_MATH_1 338 342 PF00917 0.452
DOC_USP7_UBL2_3 158 162 PF12436 0.445
DOC_USP7_UBL2_3 205 209 PF12436 0.466
DOC_USP7_UBL2_3 315 319 PF12436 0.459
DOC_USP7_UBL2_3 369 373 PF12436 0.497
DOC_WW_Pin1_4 26 31 PF00397 0.424
DOC_WW_Pin1_4 32 37 PF00397 0.428
DOC_WW_Pin1_4 44 49 PF00397 0.424
LIG_14-3-3_CanoR_1 130 135 PF00244 0.438
LIG_14-3-3_CanoR_1 389 394 PF00244 0.529
LIG_14-3-3_CanoR_1 8 16 PF00244 0.353
LIG_APCC_ABBA_1 353 358 PF00400 0.481
LIG_BIR_III_2 100 104 PF00653 0.481
LIG_deltaCOP1_diTrp_1 386 393 PF00928 0.561
LIG_EH_1 347 351 PF12763 0.481
LIG_eIF4E_1 235 241 PF01652 0.550
LIG_FHA_1 394 400 PF00498 0.523
LIG_FHA_1 45 51 PF00498 0.414
LIG_FHA_2 212 218 PF00498 0.402
LIG_LIR_Apic_2 234 238 PF02991 0.458
LIG_LIR_Gen_1 128 135 PF02991 0.450
LIG_LIR_Nem_3 128 134 PF02991 0.450
LIG_LIR_Nem_3 169 175 PF02991 0.553
LIG_LIR_Nem_3 184 189 PF02991 0.568
LIG_LIR_Nem_3 234 240 PF02991 0.483
LIG_LIR_Nem_3 299 305 PF02991 0.553
LIG_LIR_Nem_3 72 77 PF02991 0.469
LIG_LYPXL_yS_3 237 240 PF13949 0.540
LIG_MYND_1 44 48 PF01753 0.417
LIG_NRBOX 16 22 PF00104 0.344
LIG_Pex14_1 251 255 PF04695 0.501
LIG_Pex14_2 127 131 PF04695 0.517
LIG_Pex14_2 350 354 PF04695 0.452
LIG_PTB_Apo_2 188 195 PF02174 0.501
LIG_PTB_Apo_2 241 248 PF02174 0.461
LIG_PTB_Phospho_1 188 194 PF10480 0.540
LIG_PTB_Phospho_1 241 247 PF10480 0.461
LIG_SH2_CRK 235 239 PF00017 0.474
LIG_SH2_CRK 74 78 PF00017 0.474
LIG_SH2_NCK_1 255 259 PF00017 0.464
LIG_SH2_NCK_1 305 309 PF00017 0.510
LIG_SH2_SRC 147 150 PF00017 0.543
LIG_SH2_STAP1 247 251 PF00017 0.503
LIG_SH2_STAT5 106 109 PF00017 0.441
LIG_SH2_STAT5 126 129 PF00017 0.468
LIG_SH2_STAT5 16 19 PF00017 0.399
LIG_SH2_STAT5 289 292 PF00017 0.498
LIG_SH2_STAT5 83 86 PF00017 0.551
LIG_SH3_1 27 33 PF00018 0.549
LIG_SH3_3 25 31 PF00018 0.596
LIG_SH3_3 384 390 PF00018 0.482
LIG_SH3_3 42 48 PF00018 0.496
LIG_TRAF2_1 214 217 PF00917 0.549
LIG_TRAF2_2 119 124 PF00917 0.481
MOD_CDK_SPxxK_3 32 39 PF00069 0.432
MOD_CK1_1 243 249 PF00069 0.456
MOD_CK1_1 29 35 PF00069 0.428
MOD_CK1_1 397 403 PF00069 0.553
MOD_CK2_1 163 169 PF00069 0.517
MOD_CK2_1 171 177 PF00069 0.481
MOD_CK2_1 211 217 PF00069 0.463
MOD_CK2_1 55 61 PF00069 0.450
MOD_GlcNHglycan 298 301 PF01048 0.292
MOD_GlcNHglycan 310 313 PF01048 0.261
MOD_GlcNHglycan 336 339 PF01048 0.272
MOD_GlcNHglycan 340 343 PF01048 0.244
MOD_GSK3_1 130 137 PF00069 0.560
MOD_GSK3_1 147 154 PF00069 0.517
MOD_GSK3_1 177 184 PF00069 0.505
MOD_GSK3_1 227 234 PF00069 0.489
MOD_GSK3_1 334 341 PF00069 0.482
MOD_GSK3_1 389 396 PF00069 0.471
MOD_GSK3_1 44 51 PF00069 0.443
MOD_GSK3_1 55 62 PF00069 0.431
MOD_N-GLC_1 109 114 PF02516 0.337
MOD_N-GLC_1 338 343 PF02516 0.340
MOD_N-GLC_1 66 71 PF02516 0.451
MOD_NEK2_1 170 175 PF00069 0.574
MOD_NEK2_1 240 245 PF00069 0.555
MOD_NEK2_1 334 339 PF00069 0.452
MOD_NEK2_1 393 398 PF00069 0.558
MOD_NEK2_1 59 64 PF00069 0.740
MOD_PIKK_1 357 363 PF00454 0.574
MOD_PKA_1 151 157 PF00069 0.417
MOD_PKA_1 208 214 PF00069 0.517
MOD_PKA_1 231 237 PF00069 0.470
MOD_PKA_1 55 61 PF00069 0.430
MOD_PKA_2 151 157 PF00069 0.417
MOD_PKA_2 209 215 PF00069 0.402
MOD_PKA_2 55 61 PF00069 0.430
MOD_PKA_2 7 13 PF00069 0.369
MOD_Plk_1 109 115 PF00069 0.540
MOD_Plk_1 69 75 PF00069 0.329
MOD_Plk_4 181 187 PF00069 0.538
MOD_Plk_4 285 291 PF00069 0.596
MOD_Plk_4 324 330 PF00069 0.529
MOD_Plk_4 394 400 PF00069 0.484
MOD_Plk_4 55 61 PF00069 0.450
MOD_Plk_4 69 75 PF00069 0.327
MOD_ProDKin_1 26 32 PF00069 0.424
MOD_ProDKin_1 44 50 PF00069 0.426
MOD_SUMO_for_1 318 321 PF00179 0.481
MOD_SUMO_rev_2 146 153 PF00179 0.417
MOD_SUMO_rev_2 199 206 PF00179 0.526
MOD_SUMO_rev_2 85 93 PF00179 0.439
MOD_SUMO_rev_2 94 101 PF00179 0.481
TRG_DiLeu_BaEn_4 217 223 PF01217 0.481
TRG_ENDOCYTIC_2 16 19 PF00928 0.338
TRG_ENDOCYTIC_2 186 189 PF00928 0.580
TRG_ENDOCYTIC_2 194 197 PF00928 0.520
TRG_ENDOCYTIC_2 237 240 PF00928 0.533
TRG_ENDOCYTIC_2 74 77 PF00928 0.494
TRG_ER_diArg_1 262 265 PF00400 0.452
TRG_ER_diArg_1 403 405 PF00400 0.498
TRG_ER_diArg_1 53 56 PF00400 0.425
TRG_NLS_MonoCore_2 206 211 PF00514 0.481
TRG_NLS_MonoExtC_3 314 319 PF00514 0.464
TRG_NLS_MonoExtN_4 205 212 PF00514 0.463
TRG_NLS_MonoExtN_4 315 320 PF00514 0.474

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6K0 Leptomonas seymouri 67% 100%
A0A0S4IPI4 Bodo saltans 37% 100%
A0A1X0P929 Trypanosomatidae 50% 100%
A0A3Q8IGT8 Leishmania donovani 30% 100%
A0A3R7NAQ1 Trypanosoma rangeli 47% 100%
A0A3S7X2W5 Leishmania donovani 100% 100%
A4HGN9 Leishmania braziliensis 30% 100%
A4HHQ4 Leishmania braziliensis 82% 99%
A4I3R2 Leishmania infantum 30% 100%
C9ZKZ0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AEB8 Leishmania major 89% 100%
E9ALG8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4Q880 Leishmania major 30% 100%
V5DTV3 Trypanosoma cruzi 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS