TPR_REGION domain-containing protein

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA polymerase-associated protein CTR9 - putative

Species:

Leishmania infantum

UniProt:

A4I4W8_LEIIN

TriTrypDb:

LINF_290033300

Length:

873

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1
GO:0008023	transcription elongation factor complex	3	1
GO:0016593	Cdc73/Paf1 complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I4W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4W8

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0016570	histone modification	5	12
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	12
GO:0019222	regulation of metabolic process	3	12
GO:0019538	protein metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051252	regulation of RNA metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0071704	organic substance metabolic process	2	12
GO:0080090	regulation of primary metabolic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1903506	regulation of nucleic acid-templated transcription	7	12
GO:2001141	regulation of RNA biosynthetic process	6	12
GO:0031056	regulation of histone modification	7	1
GO:0031060	regulation of histone methylation	5	1
GO:0031399	regulation of protein modification process	6	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051569	regulation of histone H3-K4 methylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0000993	RNA polymerase II complex binding	5	1
GO:0001098	basal transcription machinery binding	3	1
GO:0001099	basal RNA polymerase II transcription machinery binding	4	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0043175	RNA polymerase core enzyme binding	5	1
GO:0070063	RNA polymerase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	623	627	PF00656	0.454
CLV_C14_Caspase3-7	654	658	PF00656	0.371
CLV_C14_Caspase3-7	733	737	PF00656	0.357
CLV_C14_Caspase3-7	847	851	PF00656	0.548
CLV_NRD_NRD_1	100	102	PF00675	0.460
CLV_NRD_NRD_1	170	172	PF00675	0.431
CLV_NRD_NRD_1	383	385	PF00675	0.380
CLV_NRD_NRD_1	599	601	PF00675	0.406
CLV_NRD_NRD_1	788	790	PF00675	0.480
CLV_NRD_NRD_1	800	802	PF00675	0.460
CLV_NRD_NRD_1	815	817	PF00675	0.441
CLV_PCSK_FUR_1	747	751	PF00082	0.384
CLV_PCSK_KEX2_1	170	172	PF00082	0.381
CLV_PCSK_KEX2_1	383	385	PF00082	0.313
CLV_PCSK_KEX2_1	454	456	PF00082	0.393
CLV_PCSK_KEX2_1	599	601	PF00082	0.406
CLV_PCSK_KEX2_1	749	751	PF00082	0.411
CLV_PCSK_KEX2_1	788	790	PF00082	0.428
CLV_PCSK_KEX2_1	800	802	PF00082	0.408
CLV_PCSK_KEX2_1	99	101	PF00082	0.401
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.393
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.457
CLV_PCSK_SKI1_1	170	174	PF00082	0.415
CLV_PCSK_SKI1_1	246	250	PF00082	0.381
CLV_PCSK_SKI1_1	270	274	PF00082	0.273
CLV_PCSK_SKI1_1	330	334	PF00082	0.235
CLV_PCSK_SKI1_1	394	398	PF00082	0.460
CLV_PCSK_SKI1_1	526	530	PF00082	0.420
CLV_PCSK_SKI1_1	575	579	PF00082	0.381
CLV_PCSK_SKI1_1	583	587	PF00082	0.443
CLV_PCSK_SKI1_1	711	715	PF00082	0.526
CLV_PCSK_SKI1_1	788	792	PF00082	0.520
CLV_Separin_Metazoa	74	78	PF03568	0.433
DEG_APCC_DBOX_1	245	253	PF00400	0.331
DEG_APCC_DBOX_1	50	58	PF00400	0.358
DEG_SCF_FBW7_1	614	619	PF00400	0.424
DEG_SPOP_SBC_1	5	9	PF00917	0.489
DOC_CYCLIN_RxL_1	388	401	PF00134	0.455
DOC_CYCLIN_yCln2_LP_2	540	546	PF00134	0.335
DOC_MAPK_gen_1	459	467	PF00069	0.300
DOC_MAPK_MEF2A_6	147	156	PF00069	0.407
DOC_MAPK_MEF2A_6	459	467	PF00069	0.293
DOC_MAPK_MEF2A_6	831	839	PF00069	0.500
DOC_PP1_RVXF_1	478	484	PF00149	0.445
DOC_PP2B_LxvP_1	396	399	PF13499	0.484
DOC_PP2B_LxvP_1	540	543	PF13499	0.353
DOC_PP4_FxxP_1	474	477	PF00568	0.266
DOC_USP7_MATH_1	34	38	PF00917	0.409
DOC_USP7_MATH_1	372	376	PF00917	0.356
DOC_USP7_MATH_1	6	10	PF00917	0.429
DOC_USP7_MATH_1	79	83	PF00917	0.403
DOC_WW_Pin1_4	145	150	PF00397	0.398
DOC_WW_Pin1_4	254	259	PF00397	0.404
DOC_WW_Pin1_4	612	617	PF00397	0.413
LIG_14-3-3_CanoR_1	237	243	PF00244	0.330
LIG_14-3-3_CanoR_1	244	249	PF00244	0.322
LIG_14-3-3_CanoR_1	253	261	PF00244	0.255
LIG_14-3-3_CanoR_1	345	352	PF00244	0.407
LIG_14-3-3_CanoR_1	51	55	PF00244	0.422
LIG_14-3-3_CanoR_1	652	660	PF00244	0.418
LIG_14-3-3_CanoR_1	761	767	PF00244	0.427
LIG_Actin_WH2_2	226	241	PF00022	0.436
LIG_Actin_WH2_2	37	53	PF00022	0.445
LIG_Actin_WH2_2	694	710	PF00022	0.429
LIG_CtBP_PxDLS_1	258	262	PF00389	0.376
LIG_deltaCOP1_diTrp_1	785	791	PF00928	0.480
LIG_EH1_1	38	46	PF00400	0.423
LIG_eIF4E_1	446	452	PF01652	0.343
LIG_FHA_1	146	152	PF00498	0.474
LIG_FHA_1	216	222	PF00498	0.321
LIG_FHA_1	24	30	PF00498	0.279
LIG_FHA_1	355	361	PF00498	0.347
LIG_FHA_1	5	11	PF00498	0.582
LIG_FHA_1	620	626	PF00498	0.461
LIG_FHA_1	65	71	PF00498	0.482
LIG_FHA_1	693	699	PF00498	0.338
LIG_FHA_1	708	714	PF00498	0.459
LIG_FHA_1	730	736	PF00498	0.487
LIG_FHA_1	853	859	PF00498	0.713
LIG_FHA_2	102	108	PF00498	0.451
LIG_FHA_2	433	439	PF00498	0.434
LIG_FHA_2	731	737	PF00498	0.485
LIG_FHA_2	766	772	PF00498	0.359
LIG_FHA_2	845	851	PF00498	0.556
LIG_GBD_Chelix_1	191	199	PF00786	0.382
LIG_Integrin_RGD_1	600	602	PF01839	0.405
LIG_Integrin_RGD_1	92	94	PF01839	0.402
LIG_LIR_Apic_2	472	477	PF02991	0.410
LIG_LIR_Apic_2	867	873	PF02991	0.619
LIG_LIR_Gen_1	644	650	PF02991	0.462
LIG_LIR_Gen_1	822	832	PF02991	0.525
LIG_LIR_Nem_3	130	136	PF02991	0.281
LIG_LIR_Nem_3	184	190	PF02991	0.408
LIG_LIR_Nem_3	438	444	PF02991	0.375
LIG_LIR_Nem_3	560	566	PF02991	0.412
LIG_LIR_Nem_3	785	790	PF02991	0.402
LIG_LIR_Nem_3	822	827	PF02991	0.481
LIG_NRBOX	244	250	PF00104	0.447
LIG_NRBOX	447	453	PF00104	0.284
LIG_NRBOX	497	503	PF00104	0.348
LIG_PCNA_PIPBox_1	512	521	PF02747	0.430
LIG_PCNA_yPIPBox_3	512	526	PF02747	0.441
LIG_PCNA_yPIPBox_3	694	708	PF02747	0.421
LIG_Pex14_1	787	791	PF04695	0.397
LIG_Rb_LxCxE_1	268	287	PF01857	0.363
LIG_SH2_CRK	302	306	PF00017	0.279
LIG_SH2_GRB2like	194	197	PF00017	0.225
LIG_SH2_PTP2	194	197	PF00017	0.353
LIG_SH2_PTP2	441	444	PF00017	0.272
LIG_SH2_PTP2	464	467	PF00017	0.283
LIG_SH2_SRC	670	673	PF00017	0.273
LIG_SH2_SRC	83	86	PF00017	0.275
LIG_SH2_STAP1	129	133	PF00017	0.418
LIG_SH2_STAP1	138	142	PF00017	0.443
LIG_SH2_STAP1	302	306	PF00017	0.235
LIG_SH2_STAP1	352	356	PF00017	0.322
LIG_SH2_STAP1	660	664	PF00017	0.318
LIG_SH2_STAP1	670	674	PF00017	0.244
LIG_SH2_STAT3	251	254	PF00017	0.451
LIG_SH2_STAT5	124	127	PF00017	0.411
LIG_SH2_STAT5	136	139	PF00017	0.343
LIG_SH2_STAT5	194	197	PF00017	0.375
LIG_SH2_STAT5	229	232	PF00017	0.283
LIG_SH2_STAT5	251	254	PF00017	0.451
LIG_SH2_STAT5	441	444	PF00017	0.272
LIG_SH2_STAT5	464	467	PF00017	0.249
LIG_SH2_STAT5	645	648	PF00017	0.339
LIG_SH2_STAT5	662	665	PF00017	0.229
LIG_SH2_STAT5	751	754	PF00017	0.338
LIG_SH2_STAT5	758	761	PF00017	0.285
LIG_SH2_STAT5	83	86	PF00017	0.275
LIG_SH3_2	72	77	PF14604	0.526
LIG_SH3_3	69	75	PF00018	0.527
LIG_SH3_3	855	861	PF00018	0.622
LIG_SUMO_SIM_anti_2	672	678	PF11976	0.391
LIG_TRAF2_1	257	260	PF00917	0.393
LIG_TYR_ITIM	300	305	PF00017	0.279
LIG_TYR_ITIM	439	444	PF00017	0.280
MOD_CK1_1	145	151	PF00069	0.348
MOD_CK1_1	569	575	PF00069	0.406
MOD_CK1_1	612	618	PF00069	0.548
MOD_CK1_1	720	726	PF00069	0.294
MOD_CK1_1	9	15	PF00069	0.457
MOD_CK2_1	101	107	PF00069	0.375
MOD_CK2_1	124	130	PF00069	0.357
MOD_CK2_1	254	260	PF00069	0.361
MOD_CK2_1	521	527	PF00069	0.448
MOD_CK2_1	607	613	PF00069	0.470
MOD_CK2_1	720	726	PF00069	0.433
MOD_CK2_1	765	771	PF00069	0.490
MOD_CK2_1	79	85	PF00069	0.358
MOD_CMANNOS	497	500	PF00535	0.421
MOD_GlcNHglycan	20	23	PF01048	0.451
MOD_GlcNHglycan	286	289	PF01048	0.272
MOD_GlcNHglycan	404	407	PF01048	0.490
MOD_GlcNHglycan	411	414	PF01048	0.436
MOD_GlcNHglycan	523	526	PF01048	0.405
MOD_GlcNHglycan	568	571	PF01048	0.305
MOD_GlcNHglycan	755	758	PF01048	0.447
MOD_GlcNHglycan	782	785	PF01048	0.397
MOD_GSK3_1	350	357	PF00069	0.321
MOD_GSK3_1	372	379	PF00069	0.401
MOD_GSK3_1	398	405	PF00069	0.452
MOD_GSK3_1	4	11	PF00069	0.499
MOD_GSK3_1	57	64	PF00069	0.419
MOD_GSK3_1	612	619	PF00069	0.553
MOD_GSK3_1	644	651	PF00069	0.398
MOD_GSK3_1	707	714	PF00069	0.440
MOD_N-GLC_1	216	221	PF02516	0.376
MOD_N-GLC_1	322	327	PF02516	0.363
MOD_N-GLC_1	535	540	PF02516	0.496
MOD_NEK2_1	238	243	PF00069	0.422
MOD_NEK2_1	284	289	PF00069	0.224
MOD_NEK2_1	306	311	PF00069	0.174
MOD_NEK2_1	350	355	PF00069	0.318
MOD_NEK2_1	356	361	PF00069	0.318
MOD_NEK2_1	430	435	PF00069	0.457
MOD_NEK2_1	50	55	PF00069	0.362
MOD_NEK2_1	520	525	PF00069	0.356
MOD_NEK2_1	566	571	PF00069	0.405
MOD_NEK2_1	607	612	PF00069	0.470
MOD_NEK2_1	61	66	PF00069	0.363
MOD_NEK2_1	707	712	PF00069	0.414
MOD_NEK2_1	827	832	PF00069	0.485
MOD_NEK2_1	844	849	PF00069	0.413
MOD_NEK2_1	852	857	PF00069	0.582
MOD_NEK2_2	136	141	PF00069	0.427
MOD_PIKK_1	124	130	PF00454	0.436
MOD_PIKK_1	558	564	PF00454	0.400
MOD_PKA_2	252	258	PF00069	0.415
MOD_PKA_2	344	350	PF00069	0.430
MOD_PKA_2	50	56	PF00069	0.312
MOD_PKA_2	651	657	PF00069	0.398
MOD_PKA_2	762	768	PF00069	0.382
MOD_PKA_2	827	833	PF00069	0.503
MOD_PKB_1	99	107	PF00069	0.382
MOD_Plk_1	129	135	PF00069	0.420
MOD_Plk_1	216	222	PF00069	0.370
MOD_Plk_1	322	328	PF00069	0.363
MOD_Plk_1	437	443	PF00069	0.352
MOD_Plk_1	61	67	PF00069	0.359
MOD_Plk_4	216	222	PF00069	0.359
MOD_Plk_4	314	320	PF00069	0.291
MOD_Plk_4	437	443	PF00069	0.352
MOD_Plk_4	717	723	PF00069	0.501
MOD_Plk_4	765	771	PF00069	0.542
MOD_Plk_4	79	85	PF00069	0.382
MOD_ProDKin_1	145	151	PF00069	0.396
MOD_ProDKin_1	254	260	PF00069	0.398
MOD_ProDKin_1	612	618	PF00069	0.414
MOD_SUMO_for_1	35	38	PF00179	0.419
MOD_SUMO_rev_2	809	819	PF00179	0.592
TRG_DiLeu_BaEn_1	259	264	PF01217	0.433
TRG_DiLeu_BaEn_1	268	273	PF01217	0.288
TRG_DiLeu_BaEn_1	672	677	PF01217	0.429
TRG_DiLeu_BaEn_1	687	692	PF01217	0.474
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.310
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.203
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.313
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.367
TRG_ENDOCYTIC_2	194	197	PF00928	0.425
TRG_ENDOCYTIC_2	302	305	PF00928	0.254
TRG_ENDOCYTIC_2	441	444	PF00928	0.265
TRG_ENDOCYTIC_2	464	467	PF00928	0.257
TRG_ENDOCYTIC_2	478	481	PF00928	0.250
TRG_ENDOCYTIC_2	742	745	PF00928	0.439
TRG_ENDOCYTIC_2	824	827	PF00928	0.511
TRG_ER_diArg_1	170	172	PF00400	0.431
TRG_ER_diArg_1	383	385	PF00400	0.266
TRG_ER_diArg_1	787	789	PF00400	0.532
TRG_ER_diArg_1	99	101	PF00400	0.401
TRG_NES_CRM1_1	493	508	PF08389	0.308
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	816	820	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEV8	Leptomonas seymouri	75%	100%
A0A0S4IRK7	Bodo saltans	28%	99%
A0A1X0P9X2	Trypanosomatidae	42%	96%
A0A3Q8IEI0	Leishmania donovani	100%	100%
A0A3R7MIY5	Trypanosoma rangeli	41%	95%
A4HHQ3	Leishmania braziliensis	90%	100%
C9ZKZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	97%
E9AEB7	Leishmania major	97%	100%
E9ALG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BC46	Trypanosoma cruzi	42%	96%