SP-RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MIZ/SP-RING zinc finger containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I4W6_LEIIN

TriTrypDb:

LINF_290033000

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4W6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.670
CLV_NRD_NRD_1	183	185	PF00675	0.429
CLV_NRD_NRD_1	20	22	PF00675	0.523
CLV_NRD_NRD_1	354	356	PF00675	0.680
CLV_NRD_NRD_1	390	392	PF00675	0.651
CLV_NRD_NRD_1	95	97	PF00675	0.395
CLV_PCSK_FUR_1	183	187	PF00082	0.547
CLV_PCSK_FUR_1	352	356	PF00082	0.638
CLV_PCSK_KEX2_1	183	185	PF00082	0.452
CLV_PCSK_KEX2_1	20	22	PF00082	0.533
CLV_PCSK_KEX2_1	354	356	PF00082	0.645
CLV_PCSK_KEX2_1	389	391	PF00082	0.597
CLV_PCSK_KEX2_1	95	97	PF00082	0.413
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.553
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.619
CLV_PCSK_SKI1_1	346	350	PF00082	0.420
DOC_ANK_TNKS_1	378	385	PF00023	0.564
DOC_CKS1_1	137	142	PF01111	0.526
DOC_CKS1_1	155	160	PF01111	0.508
DOC_CKS1_1	216	221	PF01111	0.590
DOC_CKS1_1	237	242	PF01111	0.509
DOC_CKS1_1	371	376	PF01111	0.789
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.615
DOC_MAPK_gen_1	255	264	PF00069	0.513
DOC_MAPK_gen_1	388	394	PF00069	0.615
DOC_MAPK_HePTP_8	290	302	PF00069	0.441
DOC_MAPK_MEF2A_6	293	302	PF00069	0.438
DOC_PP2B_LxvP_1	66	69	PF13499	0.697
DOC_PP4_FxxP_1	137	140	PF00568	0.531
DOC_USP7_MATH_1	289	293	PF00917	0.492
DOC_USP7_MATH_1	309	313	PF00917	0.574
DOC_USP7_MATH_1	319	323	PF00917	0.508
DOC_USP7_MATH_1	359	363	PF00917	0.782
DOC_USP7_MATH_1	372	376	PF00917	0.658
DOC_USP7_MATH_1	50	54	PF00917	0.521
DOC_USP7_MATH_1	78	82	PF00917	0.534
DOC_WW_Pin1_4	136	141	PF00397	0.465
DOC_WW_Pin1_4	154	159	PF00397	0.495
DOC_WW_Pin1_4	215	220	PF00397	0.579
DOC_WW_Pin1_4	236	241	PF00397	0.496
DOC_WW_Pin1_4	370	375	PF00397	0.733
LIG_14-3-3_CanoR_1	102	108	PF00244	0.540
LIG_14-3-3_CanoR_1	20	28	PF00244	0.520
LIG_14-3-3_CanoR_1	277	283	PF00244	0.578
LIG_14-3-3_CanoR_1	346	351	PF00244	0.553
LIG_14-3-3_CanoR_1	354	364	PF00244	0.761
LIG_14-3-3_CanoR_1	40	46	PF00244	0.224
LIG_AP2alpha_2	221	223	PF02296	0.578
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BIR_III_2	328	332	PF00653	0.574
LIG_BIR_III_4	381	385	PF00653	0.563
LIG_Clathr_ClatBox_1	264	268	PF01394	0.478
LIG_FHA_1	118	124	PF00498	0.555
LIG_FHA_1	129	135	PF00498	0.517
LIG_FHA_1	137	143	PF00498	0.525
LIG_FHA_1	150	156	PF00498	0.655
LIG_FHA_1	204	210	PF00498	0.459
LIG_FHA_1	23	29	PF00498	0.561
LIG_FHA_1	232	238	PF00498	0.542
LIG_FHA_1	279	285	PF00498	0.568
LIG_FHA_1	292	298	PF00498	0.570
LIG_FHA_1	302	308	PF00498	0.565
LIG_FHA_1	345	351	PF00498	0.523
LIG_FHA_1	40	46	PF00498	0.537
LIG_FHA_2	104	110	PF00498	0.600
LIG_FHA_2	148	154	PF00498	0.624
LIG_FHA_2	216	222	PF00498	0.531
LIG_FHA_2	225	231	PF00498	0.676
LIG_LIR_Gen_1	104	113	PF02991	0.599
LIG_LIR_Gen_1	278	287	PF02991	0.629
LIG_LIR_Gen_1	63	72	PF02991	0.705
LIG_LIR_Nem_3	104	110	PF02991	0.587
LIG_LIR_Nem_3	278	282	PF02991	0.608
LIG_LIR_Nem_3	30	35	PF02991	0.563
LIG_LIR_Nem_3	63	68	PF02991	0.731
LIG_NRBOX	190	196	PF00104	0.526
LIG_SH2_CRK	13	17	PF00017	0.510
LIG_SH2_CRK	32	36	PF00017	0.301
LIG_SH2_NCK_1	107	111	PF00017	0.606
LIG_SH2_NCK_1	313	317	PF00017	0.601
LIG_SH2_SRC	107	110	PF00017	0.597
LIG_SH2_STAP1	313	317	PF00017	0.601
LIG_SH2_STAT3	126	129	PF00017	0.514
LIG_SH2_STAT3	190	193	PF00017	0.514
LIG_SH2_STAT5	105	108	PF00017	0.636
LIG_SH2_STAT5	190	193	PF00017	0.524
LIG_SH2_STAT5	65	68	PF00017	0.741
LIG_SH3_2	371	376	PF14604	0.749
LIG_SH3_3	216	222	PF00018	0.582
LIG_SH3_3	234	240	PF00018	0.530
LIG_SH3_3	281	287	PF00018	0.623
LIG_SH3_3	368	374	PF00018	0.755
LIG_SH3_3	66	72	PF00018	0.625
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.525
LIG_SUMO_SIM_par_1	208	215	PF11976	0.543
LIG_TRAF2_1	358	361	PF00917	0.706
LIG_WRC_WIRS_1	267	272	PF05994	0.428
MOD_CDK_SPxK_1	236	242	PF00069	0.497
MOD_CDK_SPxK_1	370	376	PF00069	0.744
MOD_CK1_1	228	234	PF00069	0.593
MOD_CK1_1	278	284	PF00069	0.622
MOD_CK1_1	322	328	PF00069	0.690
MOD_CK1_1	70	76	PF00069	0.520
MOD_CK2_1	208	214	PF00069	0.429
MOD_CK2_1	224	230	PF00069	0.658
MOD_CK2_1	355	361	PF00069	0.766
MOD_Cter_Amidation	352	355	PF01082	0.628
MOD_GlcNHglycan	1	4	PF01048	0.732
MOD_GlcNHglycan	123	126	PF01048	0.552
MOD_GlcNHglycan	357	360	PF01048	0.719
MOD_GlcNHglycan	361	364	PF01048	0.749
MOD_GlcNHglycan	72	75	PF01048	0.576
MOD_GSK3_1	117	124	PF00069	0.601
MOD_GSK3_1	147	154	PF00069	0.601
MOD_GSK3_1	208	215	PF00069	0.457
MOD_GSK3_1	224	231	PF00069	0.577
MOD_GSK3_1	232	239	PF00069	0.564
MOD_GSK3_1	271	278	PF00069	0.539
MOD_GSK3_1	319	326	PF00069	0.666
MOD_GSK3_1	340	347	PF00069	0.504
MOD_GSK3_1	355	362	PF00069	0.622
MOD_N-GLC_1	212	217	PF02516	0.566
MOD_NEK2_1	101	106	PF00069	0.498
MOD_NEK2_1	160	165	PF00069	0.599
MOD_NEK2_1	212	217	PF00069	0.495
MOD_NEK2_1	38	43	PF00069	0.545
MOD_NEK2_2	117	122	PF00069	0.618
MOD_NEK2_2	291	296	PF00069	0.519
MOD_PIKK_1	203	209	PF00454	0.532
MOD_PIKK_1	243	249	PF00454	0.530
MOD_PIKK_1	271	277	PF00454	0.441
MOD_PIKK_1	78	84	PF00454	0.523
MOD_PKA_2	101	107	PF00069	0.596
MOD_PKA_2	22	28	PF00069	0.599
MOD_PKA_2	39	45	PF00069	0.382
MOD_Plk_1	212	218	PF00069	0.505
MOD_Plk_1	228	234	PF00069	0.645
MOD_Plk_1	359	365	PF00069	0.806
MOD_Plk_4	245	251	PF00069	0.461
MOD_Plk_4	266	272	PF00069	0.402
MOD_Plk_4	346	352	PF00069	0.528
MOD_Plk_4	61	67	PF00069	0.522
MOD_Plk_4	84	90	PF00069	0.381
MOD_ProDKin_1	136	142	PF00069	0.460
MOD_ProDKin_1	154	160	PF00069	0.490
MOD_ProDKin_1	215	221	PF00069	0.578
MOD_ProDKin_1	236	242	PF00069	0.497
MOD_ProDKin_1	370	376	PF00069	0.736
TRG_ENDOCYTIC_2	107	110	PF00928	0.595
TRG_ENDOCYTIC_2	13	16	PF00928	0.596
TRG_ENDOCYTIC_2	32	35	PF00928	0.428
TRG_ENDOCYTIC_2	65	68	PF00928	0.741
TRG_ER_diArg_1	183	186	PF00400	0.447
TRG_ER_diArg_1	19	21	PF00400	0.547
TRG_ER_diArg_1	351	354	PF00400	0.591
TRG_ER_diArg_1	390	392	PF00400	0.644
TRG_ER_diArg_1	95	97	PF00400	0.413
TRG_NLS_MonoCore_2	387	392	PF00514	0.669
TRG_NLS_MonoExtC_3	387	393	PF00514	0.664
TRG_NLS_MonoExtN_4	183	188	PF00514	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I530	Leptomonas seymouri	56%	99%
A0A1X0P9D0	Trypanosomatidae	25%	100%
A0A3R7LU18	Trypanosoma rangeli	30%	100%
A0A3S7X2U8	Leishmania donovani	99%	100%
A4HHQ1	Leishmania braziliensis	78%	100%
C9ZKZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AEB4	Leishmania major	93%	100%
E9ALH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5C220	Trypanosoma cruzi	28%	100%