A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)
Autophagy, Vacuolar sorting-associated 4 VPS4
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | yes | yes: 4 |
Forrest at al. (procyclic) | yes | yes: 4 |
Silverman et al. | no | yes: 0 |
Pissara et al. | yes | yes: 12 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 5 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 0, no: 11 |
NetGPI | no | yes: 0, no: 11 |
Term | Name | Level | Count |
---|---|---|---|
GO:0016020 | membrane | 2 | 11 |
GO:0110165 | cellular anatomical entity | 1 | 12 |
GO:0000815 | ESCRT III complex | 3 | 1 |
GO:0005737 | cytoplasm | 2 | 1 |
GO:0032838 | plasma membrane bounded cell projection cytoplasm | 4 | 1 |
GO:0032991 | protein-containing complex | 1 | 1 |
GO:0036452 | ESCRT complex | 2 | 1 |
GO:0097014 | ciliary plasm | 5 | 1 |
GO:0098796 | membrane protein complex | 2 | 1 |
GO:0099568 | cytoplasmic region | 3 | 1 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pescher et al. (upgregulation) | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Lahav et al. - mRNA
- Protein
|
Related structures:
AlphaFold database: A4I4W4
Term | Name | Level | Count |
---|---|---|---|
GO:0006810 | transport | 3 | 1 |
GO:0006996 | organelle organization | 4 | 1 |
GO:0007033 | vacuole organization | 5 | 1 |
GO:0009894 | regulation of catabolic process | 4 | 1 |
GO:0009987 | cellular process | 1 | 1 |
GO:0010506 | regulation of autophagy | 6 | 1 |
GO:0016043 | cellular component organization | 3 | 1 |
GO:0016192 | vesicle-mediated transport | 4 | 1 |
GO:0016197 | endosomal transport | 4 | 1 |
GO:0019222 | regulation of metabolic process | 3 | 1 |
GO:0031323 | regulation of cellular metabolic process | 4 | 1 |
GO:0031329 | regulation of cellular catabolic process | 5 | 1 |
GO:0046907 | intracellular transport | 3 | 1 |
GO:0050789 | regulation of biological process | 2 | 1 |
GO:0050794 | regulation of cellular process | 3 | 1 |
GO:0051179 | localization | 1 | 1 |
GO:0051234 | establishment of localization | 2 | 1 |
GO:0051641 | cellular localization | 2 | 1 |
GO:0051649 | establishment of localization in cell | 3 | 1 |
GO:0065007 | biological regulation | 1 | 1 |
GO:0071840 | cellular component organization or biogenesis | 2 | 1 |
Term | Name | Level | Count |
---|---|---|---|
GO:0000166 | nucleotide binding | 3 | 12 |
GO:0003824 | catalytic activity | 1 | 12 |
GO:0005488 | binding | 1 | 12 |
GO:0005524 | ATP binding | 5 | 12 |
GO:0016462 | pyrophosphatase activity | 5 | 12 |
GO:0016787 | hydrolase activity | 2 | 12 |
GO:0016817 | hydrolase activity, acting on acid anhydrides | 3 | 12 |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 4 | 12 |
GO:0016887 | ATP hydrolysis activity | 7 | 12 |
GO:0017076 | purine nucleotide binding | 4 | 12 |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 6 | 12 |
GO:0030554 | adenyl nucleotide binding | 5 | 12 |
GO:0032553 | ribonucleotide binding | 3 | 12 |
GO:0032555 | purine ribonucleotide binding | 4 | 12 |
GO:0032559 | adenyl ribonucleotide binding | 5 | 12 |
GO:0035639 | purine ribonucleoside triphosphate binding | 4 | 12 |
GO:0036094 | small molecule binding | 2 | 12 |
GO:0043167 | ion binding | 2 | 12 |
GO:0043168 | anion binding | 3 | 12 |
GO:0097159 | organic cyclic compound binding | 2 | 12 |
GO:0097367 | carbohydrate derivative binding | 2 | 12 |
GO:1901265 | nucleoside phosphate binding | 3 | 12 |
GO:1901363 | heterocyclic compound binding | 2 | 12 |
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_C14_Caspase3-7 | 185 | 189 | PF00656 | 0.329 |
CLV_C14_Caspase3-7 | 234 | 238 | PF00656 | 0.295 |
CLV_C14_Caspase3-7 | 246 | 250 | PF00656 | 0.295 |
CLV_NRD_NRD_1 | 159 | 161 | PF00675 | 0.431 |
CLV_NRD_NRD_1 | 252 | 254 | PF00675 | 0.306 |
CLV_NRD_NRD_1 | 290 | 292 | PF00675 | 0.343 |
CLV_NRD_NRD_1 | 294 | 296 | PF00675 | 0.343 |
CLV_NRD_NRD_1 | 331 | 333 | PF00675 | 0.360 |
CLV_PCSK_KEX2_1 | 159 | 161 | PF00082 | 0.577 |
CLV_PCSK_KEX2_1 | 252 | 254 | PF00082 | 0.295 |
CLV_PCSK_KEX2_1 | 289 | 291 | PF00082 | 0.341 |
CLV_PCSK_KEX2_1 | 294 | 296 | PF00082 | 0.345 |
CLV_PCSK_KEX2_1 | 331 | 333 | PF00082 | 0.440 |
CLV_PCSK_KEX2_1 | 363 | 365 | PF00082 | 0.407 |
CLV_PCSK_KEX2_1 | 52 | 54 | PF00082 | 0.354 |
CLV_PCSK_PC1ET2_1 | 159 | 161 | PF00082 | 0.577 |
CLV_PCSK_PC1ET2_1 | 363 | 365 | PF00082 | 0.407 |
CLV_PCSK_PC1ET2_1 | 52 | 54 | PF00082 | 0.354 |
CLV_PCSK_PC7_1 | 290 | 296 | PF00082 | 0.295 |
CLV_PCSK_SKI1_1 | 100 | 104 | PF00082 | 0.565 |
CLV_PCSK_SKI1_1 | 139 | 143 | PF00082 | 0.402 |
CLV_PCSK_SKI1_1 | 15 | 19 | PF00082 | 0.335 |
CLV_PCSK_SKI1_1 | 164 | 168 | PF00082 | 0.295 |
CLV_PCSK_SKI1_1 | 212 | 216 | PF00082 | 0.295 |
CLV_PCSK_SKI1_1 | 252 | 256 | PF00082 | 0.295 |
CLV_PCSK_SKI1_1 | 346 | 350 | PF00082 | 0.407 |
CLV_PCSK_SKI1_1 | 375 | 379 | PF00082 | 0.591 |
CLV_PCSK_SKI1_1 | 433 | 437 | PF00082 | 0.460 |
CLV_PCSK_SKI1_1 | 71 | 75 | PF00082 | 0.607 |
DOC_CYCLIN_RxL_1 | 209 | 216 | PF00134 | 0.295 |
DOC_CYCLIN_yCln2_LP_2 | 404 | 410 | PF00134 | 0.310 |
DOC_MAPK_gen_1 | 159 | 168 | PF00069 | 0.488 |
DOC_MAPK_gen_1 | 289 | 300 | PF00069 | 0.341 |
DOC_MAPK_HePTP_8 | 288 | 300 | PF00069 | 0.295 |
DOC_MAPK_MEF2A_6 | 143 | 150 | PF00069 | 0.367 |
DOC_MAPK_MEF2A_6 | 223 | 232 | PF00069 | 0.295 |
DOC_MAPK_MEF2A_6 | 291 | 300 | PF00069 | 0.295 |
DOC_PP1_RVXF_1 | 431 | 438 | PF00149 | 0.360 |
DOC_PP2B_LxvP_1 | 404 | 407 | PF13499 | 0.310 |
DOC_USP7_MATH_1 | 96 | 100 | PF00917 | 0.578 |
DOC_USP7_UBL2_3 | 139 | 143 | PF12436 | 0.389 |
DOC_USP7_UBL2_3 | 223 | 227 | PF12436 | 0.329 |
DOC_USP7_UBL2_3 | 44 | 48 | PF12436 | 0.310 |
DOC_WW_Pin1_4 | 314 | 319 | PF00397 | 0.428 |
DOC_WW_Pin1_4 | 382 | 387 | PF00397 | 0.295 |
LIG_14-3-3_CanoR_1 | 111 | 117 | PF00244 | 0.606 |
LIG_14-3-3_CanoR_1 | 252 | 262 | PF00244 | 0.295 |
LIG_Actin_WH2_2 | 128 | 145 | PF00022 | 0.381 |
LIG_APCC_ABBAyCdc20_2 | 124 | 130 | PF00400 | 0.403 |
LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.467 |
LIG_BIR_III_2 | 390 | 394 | PF00653 | 0.440 |
LIG_BRCT_BRCA1_1 | 1 | 5 | PF00533 | 0.467 |
LIG_BRCT_BRCA1_1 | 228 | 232 | PF00533 | 0.389 |
LIG_FHA_1 | 254 | 260 | PF00498 | 0.310 |
LIG_FHA_1 | 33 | 39 | PF00498 | 0.468 |
LIG_FHA_1 | 353 | 359 | PF00498 | 0.477 |
LIG_FHA_1 | 372 | 378 | PF00498 | 0.362 |
LIG_FHA_2 | 16 | 22 | PF00498 | 0.395 |
LIG_FHA_2 | 183 | 189 | PF00498 | 0.295 |
LIG_FHA_2 | 318 | 324 | PF00498 | 0.430 |
LIG_FHA_2 | 398 | 404 | PF00498 | 0.319 |
LIG_FHA_2 | 409 | 415 | PF00498 | 0.364 |
LIG_FHA_2 | 49 | 55 | PF00498 | 0.295 |
LIG_LIR_Gen_1 | 188 | 199 | PF02991 | 0.295 |
LIG_LIR_Nem_3 | 188 | 194 | PF02991 | 0.295 |
LIG_LIR_Nem_3 | 26 | 32 | PF02991 | 0.336 |
LIG_LIR_Nem_3 | 323 | 329 | PF02991 | 0.347 |
LIG_LIR_Nem_3 | 360 | 365 | PF02991 | 0.392 |
LIG_Pex14_2 | 152 | 156 | PF04695 | 0.409 |
LIG_Pex14_2 | 437 | 441 | PF04695 | 0.310 |
LIG_SH2_CRK | 169 | 173 | PF00017 | 0.295 |
LIG_SH2_GRB2like | 45 | 48 | PF00017 | 0.329 |
LIG_SH2_NCK_1 | 25 | 29 | PF00017 | 0.337 |
LIG_SH2_PTP2 | 297 | 300 | PF00017 | 0.295 |
LIG_SH2_STAP1 | 25 | 29 | PF00017 | 0.341 |
LIG_SH2_STAT5 | 178 | 181 | PF00017 | 0.336 |
LIG_SH2_STAT5 | 297 | 300 | PF00017 | 0.298 |
LIG_SH3_1 | 380 | 386 | PF00018 | 0.295 |
LIG_SH3_2 | 370 | 375 | PF14604 | 0.471 |
LIG_SH3_3 | 143 | 149 | PF00018 | 0.374 |
LIG_SH3_3 | 362 | 368 | PF00018 | 0.404 |
LIG_SH3_3 | 380 | 386 | PF00018 | 0.295 |
LIG_SUMO_SIM_anti_2 | 268 | 276 | PF11976 | 0.295 |
LIG_UBA3_1 | 147 | 151 | PF00899 | 0.530 |
LIG_UBA3_1 | 404 | 412 | PF00899 | 0.440 |
MOD_CK1_1 | 115 | 121 | PF00069 | 0.481 |
MOD_CK1_1 | 193 | 199 | PF00069 | 0.343 |
MOD_CK1_1 | 238 | 244 | PF00069 | 0.295 |
MOD_CK1_1 | 283 | 289 | PF00069 | 0.389 |
MOD_CK1_1 | 422 | 428 | PF00069 | 0.384 |
MOD_CK1_1 | 58 | 64 | PF00069 | 0.483 |
MOD_CK1_1 | 88 | 94 | PF00069 | 0.668 |
MOD_CK2_1 | 15 | 21 | PF00069 | 0.399 |
MOD_CK2_1 | 210 | 216 | PF00069 | 0.426 |
MOD_CK2_1 | 241 | 247 | PF00069 | 0.295 |
MOD_CK2_1 | 336 | 342 | PF00069 | 0.509 |
MOD_CK2_1 | 392 | 398 | PF00069 | 0.341 |
MOD_CK2_1 | 48 | 54 | PF00069 | 0.354 |
MOD_Cter_Amidation | 157 | 160 | PF01082 | 0.571 |
MOD_Cter_Amidation | 329 | 332 | PF01082 | 0.360 |
MOD_GlcNHglycan | 117 | 120 | PF01048 | 0.620 |
MOD_GlcNHglycan | 240 | 243 | PF01048 | 0.400 |
MOD_GlcNHglycan | 285 | 288 | PF01048 | 0.317 |
MOD_GlcNHglycan | 336 | 339 | PF01048 | 0.295 |
MOD_GlcNHglycan | 394 | 397 | PF01048 | 0.360 |
MOD_GlcNHglycan | 87 | 90 | PF01048 | 0.696 |
MOD_GlcNHglycan | 96 | 99 | PF01048 | 0.599 |
MOD_GSK3_1 | 111 | 118 | PF00069 | 0.704 |
MOD_GSK3_1 | 190 | 197 | PF00069 | 0.451 |
MOD_GSK3_1 | 330 | 337 | PF00069 | 0.295 |
MOD_GSK3_1 | 418 | 425 | PF00069 | 0.301 |
MOD_GSK3_1 | 81 | 88 | PF00069 | 0.632 |
MOD_GSK3_1 | 92 | 99 | PF00069 | 0.654 |
MOD_NEK2_1 | 112 | 117 | PF00069 | 0.498 |
MOD_NEK2_1 | 142 | 147 | PF00069 | 0.510 |
MOD_NEK2_1 | 192 | 197 | PF00069 | 0.295 |
MOD_NEK2_1 | 210 | 215 | PF00069 | 0.295 |
MOD_NEK2_1 | 275 | 280 | PF00069 | 0.339 |
MOD_NEK2_1 | 419 | 424 | PF00069 | 0.429 |
MOD_PIKK_1 | 81 | 87 | PF00454 | 0.732 |
MOD_PKA_2 | 112 | 118 | PF00069 | 0.605 |
MOD_PKA_2 | 330 | 336 | PF00069 | 0.411 |
MOD_PKA_2 | 419 | 425 | PF00069 | 0.313 |
MOD_Plk_4 | 142 | 148 | PF00069 | 0.515 |
MOD_Plk_4 | 174 | 180 | PF00069 | 0.301 |
MOD_Plk_4 | 187 | 193 | PF00069 | 0.325 |
MOD_Plk_4 | 226 | 232 | PF00069 | 0.389 |
MOD_Plk_4 | 235 | 241 | PF00069 | 0.389 |
MOD_Plk_4 | 317 | 323 | PF00069 | 0.526 |
MOD_ProDKin_1 | 314 | 320 | PF00069 | 0.430 |
MOD_ProDKin_1 | 382 | 388 | PF00069 | 0.295 |
MOD_SUMO_for_1 | 254 | 257 | PF00179 | 0.295 |
MOD_SUMO_for_1 | 43 | 46 | PF00179 | 0.295 |
TRG_DiLeu_BaEn_1 | 235 | 240 | PF01217 | 0.440 |
TRG_DiLeu_BaEn_1 | 401 | 406 | PF01217 | 0.329 |
TRG_DiLeu_BaLyEn_6 | 377 | 382 | PF01217 | 0.423 |
TRG_ENDOCYTIC_2 | 297 | 300 | PF00928 | 0.298 |
TRG_ER_diArg_1 | 252 | 254 | PF00400 | 0.296 |
TRG_ER_diArg_1 | 288 | 291 | PF00400 | 0.341 |
TRG_ER_diArg_1 | 294 | 296 | PF00400 | 0.346 |
TRG_Pf-PMV_PEXEL_1 | 202 | 206 | PF00026 | 0.295 |
TRG_Pf-PMV_PEXEL_1 | 212 | 216 | PF00026 | 0.295 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A0N0P897 | Leptomonas seymouri | 43% | 77% |
A0A0N1HRH8 | Leptomonas seymouri | 44% | 82% |
A0A0N1P9H6 | Leptomonas seymouri | 87% | 100% |
A0A0S4IM94 | Bodo saltans | 44% | 96% |
A0A0S4IPV5 | Bodo saltans | 73% | 100% |
A0A0S4IUM1 | Bodo saltans | 41% | 75% |
A0A0S4JAU3 | Bodo saltans | 33% | 67% |
A0A1X0NYV7 | Trypanosomatidae | 44% | 79% |
A0A1X0P8T7 | Trypanosomatidae | 34% | 100% |
A0A1X0P983 | Trypanosomatidae | 75% | 100% |
A0A1X0P9Z1 | Trypanosomatidae | 42% | 94% |
A0A3Q8IHU1 | Leishmania donovani | 34% | 100% |
A0A3R7KPY1 | Trypanosoma rangeli | 73% | 98% |
A0A3S7X163 | Leishmania donovani | 42% | 84% |
A0A3S7X2R4 | Leishmania donovani | 100% | 100% |
A0A422MWE3 | Trypanosoma rangeli | 32% | 69% |
A0A422NNS9 | Trypanosoma rangeli | 43% | 100% |
A0A422P1K0 | Trypanosoma rangeli | 43% | 80% |
A2VDN5 | Bos taurus | 39% | 72% |
A4HG81 | Leishmania braziliensis | 40% | 100% |
A4HHP9 | Leishmania braziliensis | 94% | 100% |
A4I3C0 | Leishmania infantum | 42% | 74% |
A4IB20 | Leishmania infantum | 34% | 100% |
A4IHT0 | Xenopus tropicalis | 38% | 68% |
A8QFF6 | Brugia malayi | 40% | 98% |
A8XV40 | Caenorhabditis briggsae | 38% | 82% |
A9RA82 | Papio anubis | 44% | 91% |
B2RYN7 | Rattus norvegicus | 40% | 77% |
B3EX35 | Sorex araneus | 44% | 91% |
B4USW8 | Otolemur garnettii | 44% | 91% |
B5X3X5 | Salmo salar | 46% | 92% |
B7NZ88 | Oryctolagus cuniculus | 44% | 91% |
C9ZKZ7 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 73% | 100% |
C9ZLZ3 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 41% | 97% |
C9ZQC1 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 31% | 100% |
D0A3J7 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 33% | 68% |
D0A833 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 43% | 80% |
D0FH76 | Bombyx mori | 54% | 100% |
E9AEB2 | Leishmania major | 99% | 100% |
E9AEU9 | Leishmania major | 34% | 100% |
E9ALH4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 98% | 100% |
E9AZ07 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 67% |
E9AZK1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 42% | 82% |
E9B605 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 34% | 100% |
F2Z6D2 | Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) | 37% | 100% |
O43078 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 40% | 67% |
O61577 | Strongylocentrotus purpuratus | 44% | 86% |
O75351 | Homo sapiens | 54% | 100% |
O75449 | Homo sapiens | 45% | 91% |
P34123 | Dictyostelium discoideum | 33% | 100% |
P46467 | Mus musculus | 54% | 100% |
P52917 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 55% | 100% |
P85200 | Helianthus annuus | 31% | 100% |
Q05AS3 | Xenopus tropicalis | 39% | 74% |
Q09803 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 53% | 100% |
Q0IIR9 | Xenopus tropicalis | 44% | 90% |
Q0VD48 | Bos taurus | 54% | 100% |
Q1AV13 | Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1) | 35% | 68% |
Q1HGK7 | Gallus gallus | 43% | 90% |
Q4Q8N0 | Leishmania major | 42% | 81% |
Q4R407 | Macaca fascicularis | 45% | 91% |
Q54KQ7 | Dictyostelium discoideum | 39% | 68% |
Q54PT2 | Dictyostelium discoideum | 52% | 100% |
Q5AG40 | Candida albicans (strain SC5314 / ATCC MYA-2876) | 53% | 100% |
Q5R658 | Pongo abelii | 54% | 100% |
Q5RII9 | Danio rerio | 46% | 92% |
Q5U3S1 | Danio rerio | 43% | 91% |
Q5XIK7 | Rattus norvegicus | 43% | 91% |
Q5ZK92 | Gallus gallus | 41% | 73% |
Q6AZT2 | Xenopus laevis | 37% | 74% |
Q6DDU8 | Xenopus laevis | 37% | 68% |
Q6E0V2 | Rattus norvegicus | 44% | 91% |
Q6NW58 | Danio rerio | 40% | 78% |
Q6PIW4 | Homo sapiens | 36% | 66% |
Q719N1 | Sus scrofa | 40% | 72% |
Q793F9 | Rattus norvegicus | 53% | 100% |
Q8K0T4 | Mus musculus | 43% | 91% |
Q8SQK0 | Encephalitozoon cuniculi (strain GB-M1) | 32% | 100% |
Q8VEJ9 | Mus musculus | 53% | 100% |
Q975U2 | Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) | 35% | 100% |
Q9BW62 | Homo sapiens | 41% | 91% |
Q9PUL2 | Xenopus laevis | 44% | 92% |
Q9QYY8 | Mus musculus | 42% | 72% |
Q9SEX2 | Arabidopsis thaliana | 41% | 85% |
Q9UBP0 | Homo sapiens | 39% | 72% |
Q9UN37 | Homo sapiens | 53% | 100% |
Q9VQN8 | Drosophila melanogaster | 38% | 85% |
Q9WV86 | Mus musculus | 43% | 91% |
Q9ZNT0 | Arabidopsis thaliana | 50% | 100% |
V5B0U7 | Trypanosoma cruzi | 43% | 80% |
V5B5D2 | Trypanosoma cruzi | 38% | 90% |
V5BC41 | Trypanosoma cruzi | 75% | 100% |
V5BD45 | Trypanosoma cruzi | 31% | 67% |