LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I4W2_LEIIN
TriTrypDb:
LINF_290032500
Length:
846

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4W2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4W2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 136 140 PF00656 0.632
CLV_C14_Caspase3-7 224 228 PF00656 0.585
CLV_C14_Caspase3-7 292 296 PF00656 0.579
CLV_C14_Caspase3-7 301 305 PF00656 0.562
CLV_C14_Caspase3-7 561 565 PF00656 0.499
CLV_NRD_NRD_1 196 198 PF00675 0.516
CLV_NRD_NRD_1 366 368 PF00675 0.620
CLV_NRD_NRD_1 504 506 PF00675 0.656
CLV_NRD_NRD_1 551 553 PF00675 0.492
CLV_NRD_NRD_1 562 564 PF00675 0.416
CLV_NRD_NRD_1 630 632 PF00675 0.750
CLV_NRD_NRD_1 640 642 PF00675 0.656
CLV_NRD_NRD_1 705 707 PF00675 0.775
CLV_NRD_NRD_1 716 718 PF00675 0.503
CLV_NRD_NRD_1 727 729 PF00675 0.524
CLV_NRD_NRD_1 744 746 PF00675 0.544
CLV_NRD_NRD_1 757 759 PF00675 0.463
CLV_NRD_NRD_1 780 782 PF00675 0.743
CLV_NRD_NRD_1 834 836 PF00675 0.657
CLV_PCSK_FUR_1 364 368 PF00082 0.620
CLV_PCSK_FUR_1 560 564 PF00082 0.499
CLV_PCSK_FUR_1 628 632 PF00082 0.734
CLV_PCSK_FUR_1 755 759 PF00082 0.518
CLV_PCSK_KEX2_1 181 183 PF00082 0.521
CLV_PCSK_KEX2_1 196 198 PF00082 0.462
CLV_PCSK_KEX2_1 357 359 PF00082 0.625
CLV_PCSK_KEX2_1 364 366 PF00082 0.582
CLV_PCSK_KEX2_1 503 505 PF00082 0.657
CLV_PCSK_KEX2_1 527 529 PF00082 0.607
CLV_PCSK_KEX2_1 550 552 PF00082 0.492
CLV_PCSK_KEX2_1 562 564 PF00082 0.408
CLV_PCSK_KEX2_1 630 632 PF00082 0.768
CLV_PCSK_KEX2_1 640 642 PF00082 0.638
CLV_PCSK_KEX2_1 704 706 PF00082 0.766
CLV_PCSK_KEX2_1 716 718 PF00082 0.493
CLV_PCSK_KEX2_1 727 729 PF00082 0.473
CLV_PCSK_KEX2_1 744 746 PF00082 0.544
CLV_PCSK_KEX2_1 757 759 PF00082 0.463
CLV_PCSK_KEX2_1 780 782 PF00082 0.600
CLV_PCSK_KEX2_1 834 836 PF00082 0.657
CLV_PCSK_PC1ET2_1 181 183 PF00082 0.521
CLV_PCSK_PC1ET2_1 196 198 PF00082 0.462
CLV_PCSK_PC1ET2_1 357 359 PF00082 0.625
CLV_PCSK_PC1ET2_1 527 529 PF00082 0.607
CLV_PCSK_PC7_1 558 564 PF00082 0.495
CLV_PCSK_PC7_1 626 632 PF00082 0.552
CLV_PCSK_PC7_1 740 746 PF00082 0.547
CLV_PCSK_SKI1_1 348 352 PF00082 0.653
CLV_PCSK_SKI1_1 354 358 PF00082 0.626
CLV_PCSK_SKI1_1 403 407 PF00082 0.609
CLV_PCSK_SKI1_1 551 555 PF00082 0.490
CLV_PCSK_SKI1_1 573 577 PF00082 0.552
CLV_PCSK_SKI1_1 717 721 PF00082 0.709
DEG_APCC_DBOX_1 550 558 PF00400 0.491
DEG_Nend_UBRbox_3 1 3 PF02207 0.586
DEG_SPOP_SBC_1 676 680 PF00917 0.597
DEG_SPOP_SBC_1 84 88 PF00917 0.587
DOC_CYCLIN_RxL_1 549 556 PF00134 0.492
DOC_MAPK_DCC_7 758 768 PF00069 0.457
DOC_MAPK_gen_1 550 557 PF00069 0.493
DOC_MAPK_MEF2A_6 406 415 PF00069 0.565
DOC_MAPK_MEF2A_6 550 557 PF00069 0.493
DOC_MAPK_MEF2A_6 660 669 PF00069 0.507
DOC_PP1_RVXF_1 571 578 PF00149 0.553
DOC_PP2B_LxvP_1 246 249 PF13499 0.651
DOC_PP2B_LxvP_1 317 320 PF13499 0.621
DOC_PP2B_LxvP_1 544 547 PF13499 0.467
DOC_PP4_FxxP_1 619 622 PF00568 0.595
DOC_USP7_MATH_1 120 124 PF00917 0.621
DOC_USP7_MATH_1 142 146 PF00917 0.625
DOC_USP7_MATH_1 213 217 PF00917 0.597
DOC_USP7_MATH_1 257 261 PF00917 0.620
DOC_USP7_MATH_1 262 266 PF00917 0.629
DOC_USP7_MATH_1 298 302 PF00917 0.671
DOC_USP7_MATH_1 31 35 PF00917 0.636
DOC_USP7_MATH_1 320 324 PF00917 0.618
DOC_USP7_MATH_1 340 344 PF00917 0.630
DOC_USP7_MATH_1 405 409 PF00917 0.624
DOC_USP7_MATH_1 424 428 PF00917 0.511
DOC_USP7_MATH_1 476 480 PF00917 0.620
DOC_USP7_MATH_1 486 490 PF00917 0.577
DOC_USP7_MATH_1 496 500 PF00917 0.523
DOC_USP7_MATH_1 507 511 PF00917 0.573
DOC_USP7_MATH_1 659 663 PF00917 0.504
DOC_USP7_MATH_1 676 680 PF00917 0.520
DOC_USP7_MATH_1 715 719 PF00917 0.565
DOC_USP7_MATH_1 738 742 PF00917 0.611
DOC_USP7_MATH_1 826 830 PF00917 0.631
DOC_USP7_UBL2_3 348 352 PF12436 0.657
DOC_WW_Pin1_4 225 230 PF00397 0.633
DOC_WW_Pin1_4 253 258 PF00397 0.627
DOC_WW_Pin1_4 407 412 PF00397 0.564
DOC_WW_Pin1_4 422 427 PF00397 0.539
DOC_WW_Pin1_4 434 439 PF00397 0.581
DOC_WW_Pin1_4 446 451 PF00397 0.575
DOC_WW_Pin1_4 526 531 PF00397 0.543
DOC_WW_Pin1_4 589 594 PF00397 0.644
DOC_WW_Pin1_4 599 604 PF00397 0.567
DOC_WW_Pin1_4 620 625 PF00397 0.579
DOC_WW_Pin1_4 630 635 PF00397 0.519
DOC_WW_Pin1_4 677 682 PF00397 0.743
DOC_WW_Pin1_4 710 715 PF00397 0.605
DOC_WW_Pin1_4 726 731 PF00397 0.479
DOC_WW_Pin1_4 734 739 PF00397 0.579
DOC_WW_Pin1_4 775 780 PF00397 0.615
DOC_WW_Pin1_4 782 787 PF00397 0.605
DOC_WW_Pin1_4 85 90 PF00397 0.622
DOC_WW_Pin1_4 93 98 PF00397 0.644
LIG_14-3-3_CanoR_1 175 180 PF00244 0.508
LIG_14-3-3_CanoR_1 197 205 PF00244 0.574
LIG_14-3-3_CanoR_1 289 297 PF00244 0.596
LIG_14-3-3_CanoR_1 3 9 PF00244 0.592
LIG_14-3-3_CanoR_1 395 404 PF00244 0.670
LIG_14-3-3_CanoR_1 677 681 PF00244 0.598
LIG_14-3-3_CanoR_1 716 720 PF00244 0.613
LIG_14-3-3_CanoR_1 728 734 PF00244 0.511
LIG_14-3-3_CanoR_1 757 766 PF00244 0.588
LIG_14-3-3_CanoR_1 774 778 PF00244 0.526
LIG_14-3-3_CanoR_1 811 820 PF00244 0.594
LIG_14-3-3_CanoR_1 823 832 PF00244 0.542
LIG_14-3-3_CanoR_1 834 843 PF00244 0.588
LIG_APCC_ABBA_1 154 159 PF00400 0.611
LIG_BIR_III_2 711 715 PF00653 0.580
LIG_BRCT_BRCA1_1 606 610 PF00533 0.602
LIG_deltaCOP1_diTrp_1 571 577 PF00928 0.547
LIG_eIF4E_1 549 555 PF01652 0.492
LIG_FHA_1 108 114 PF00498 0.583
LIG_FHA_1 200 206 PF00498 0.544
LIG_FHA_1 218 224 PF00498 0.546
LIG_FHA_1 314 320 PF00498 0.621
LIG_FHA_1 408 414 PF00498 0.565
LIG_FHA_1 531 537 PF00498 0.588
LIG_FHA_1 797 803 PF00498 0.606
LIG_FHA_2 219 225 PF00498 0.570
LIG_FHA_2 828 834 PF00498 0.614
LIG_FHA_2 840 846 PF00498 0.584
LIG_FHA_2 93 99 PF00498 0.639
LIG_GSK3_LRP6_1 93 98 PF00069 0.641
LIG_IBAR_NPY_1 583 585 PF08397 0.538
LIG_Integrin_RGD_1 794 796 PF01839 0.595
LIG_LIR_Apic_2 617 622 PF02991 0.595
LIG_LIR_Gen_1 718 726 PF02991 0.581
LIG_LIR_Nem_3 571 575 PF02991 0.538
LIG_LIR_Nem_3 607 613 PF02991 0.556
LIG_LIR_Nem_3 718 723 PF02991 0.580
LIG_SH2_NCK_1 613 617 PF00017 0.580
LIG_SH2_STAP1 464 468 PF00017 0.570
LIG_SH2_STAP1 470 474 PF00017 0.553
LIG_SH2_STAT3 321 324 PF00017 0.566
LIG_SH2_STAT5 321 324 PF00017 0.566
LIG_SH2_STAT5 702 705 PF00017 0.581
LIG_SH3_1 432 438 PF00018 0.564
LIG_SH3_1 640 646 PF00018 0.624
LIG_SH3_3 158 164 PF00018 0.622
LIG_SH3_3 21 27 PF00018 0.578
LIG_SH3_3 330 336 PF00018 0.629
LIG_SH3_3 408 414 PF00018 0.580
LIG_SH3_3 432 438 PF00018 0.607
LIG_SH3_3 441 447 PF00018 0.617
LIG_SH3_3 63 69 PF00018 0.636
LIG_SH3_3 640 646 PF00018 0.669
LIG_SH3_3 647 653 PF00018 0.640
LIG_SH3_3 678 684 PF00018 0.587
LIG_SH3_3 686 692 PF00018 0.548
LIG_SH3_3 761 767 PF00018 0.514
LIG_SH3_3 88 94 PF00018 0.633
LIG_SH3_4 348 355 PF00018 0.671
LIG_TRAF2_1 216 219 PF00917 0.614
LIG_TRAF2_1 272 275 PF00917 0.631
LIG_TRAF2_1 842 845 PF00917 0.594
LIG_UBA3_1 191 199 PF00899 0.518
LIG_WRC_WIRS_1 176 181 PF05994 0.491
LIG_WW_3 713 717 PF00397 0.587
MOD_CDC14_SPxK_1 228 231 PF00782 0.562
MOD_CDC14_SPxK_1 623 626 PF00782 0.565
MOD_CDC14_SPxK_1 733 736 PF00782 0.645
MOD_CDC14_SPxK_1 737 740 PF00782 0.616
MOD_CDC14_SPxK_1 778 781 PF00782 0.591
MOD_CDC14_SPxK_1 785 788 PF00782 0.566
MOD_CDK_SPK_2 630 635 PF00069 0.615
MOD_CDK_SPK_2 775 780 PF00069 0.587
MOD_CDK_SPxK_1 225 231 PF00069 0.559
MOD_CDK_SPxK_1 620 626 PF00069 0.563
MOD_CDK_SPxK_1 710 716 PF00069 0.605
MOD_CDK_SPxK_1 730 736 PF00069 0.644
MOD_CDK_SPxK_1 775 781 PF00069 0.588
MOD_CDK_SPxK_1 782 788 PF00069 0.564
MOD_CDK_SPxxK_3 710 717 PF00069 0.631
MOD_CK1_1 145 151 PF00069 0.654
MOD_CK1_1 261 267 PF00069 0.650
MOD_CK1_1 35 41 PF00069 0.613
MOD_CK1_1 377 383 PF00069 0.614
MOD_CK1_1 387 393 PF00069 0.587
MOD_CK1_1 396 402 PF00069 0.592
MOD_CK1_1 422 428 PF00069 0.636
MOD_CK1_1 437 443 PF00069 0.579
MOD_CK1_1 45 51 PF00069 0.582
MOD_CK1_1 472 478 PF00069 0.617
MOD_CK1_1 489 495 PF00069 0.531
MOD_CK1_1 511 517 PF00069 0.619
MOD_CK1_1 523 529 PF00069 0.576
MOD_CK1_1 602 608 PF00069 0.632
MOD_CK1_1 614 620 PF00069 0.547
MOD_CK1_1 729 735 PF00069 0.640
MOD_CK1_1 813 819 PF00069 0.617
MOD_CK2_1 213 219 PF00069 0.599
MOD_CK2_1 269 275 PF00069 0.599
MOD_CK2_1 387 393 PF00069 0.632
MOD_CK2_1 839 845 PF00069 0.592
MOD_DYRK1A_RPxSP_1 599 603 PF00069 0.640
MOD_DYRK1A_RPxSP_1 677 681 PF00069 0.581
MOD_GlcNHglycan 103 107 PF01048 0.621
MOD_GlcNHglycan 120 123 PF01048 0.647
MOD_GlcNHglycan 170 173 PF01048 0.567
MOD_GlcNHglycan 211 214 PF01048 0.621
MOD_GlcNHglycan 215 218 PF01048 0.604
MOD_GlcNHglycan 260 263 PF01048 0.613
MOD_GlcNHglycan 292 295 PF01048 0.642
MOD_GlcNHglycan 300 303 PF01048 0.621
MOD_GlcNHglycan 342 345 PF01048 0.662
MOD_GlcNHglycan 37 40 PF01048 0.644
MOD_GlcNHglycan 376 379 PF01048 0.645
MOD_GlcNHglycan 395 398 PF01048 0.582
MOD_GlcNHglycan 407 410 PF01048 0.568
MOD_GlcNHglycan 421 424 PF01048 0.544
MOD_GlcNHglycan 426 429 PF01048 0.519
MOD_GlcNHglycan 454 457 PF01048 0.632
MOD_GlcNHglycan 460 463 PF01048 0.559
MOD_GlcNHglycan 474 477 PF01048 0.480
MOD_GlcNHglycan 491 494 PF01048 0.532
MOD_GlcNHglycan 505 508 PF01048 0.586
MOD_GlcNHglycan 510 513 PF01048 0.539
MOD_GlcNHglycan 517 520 PF01048 0.549
MOD_GlcNHglycan 523 526 PF01048 0.517
MOD_GlcNHglycan 614 617 PF01048 0.616
MOD_GlcNHglycan 740 743 PF01048 0.673
MOD_GlcNHglycan 759 762 PF01048 0.546
MOD_GSK3_1 108 115 PF00069 0.628
MOD_GSK3_1 145 152 PF00069 0.609
MOD_GSK3_1 209 216 PF00069 0.610
MOD_GSK3_1 235 242 PF00069 0.613
MOD_GSK3_1 253 260 PF00069 0.545
MOD_GSK3_1 281 288 PF00069 0.633
MOD_GSK3_1 309 316 PF00069 0.628
MOD_GSK3_1 31 38 PF00069 0.668
MOD_GSK3_1 380 387 PF00069 0.648
MOD_GSK3_1 405 412 PF00069 0.626
MOD_GSK3_1 422 429 PF00069 0.528
MOD_GSK3_1 446 453 PF00069 0.626
MOD_GSK3_1 454 461 PF00069 0.542
MOD_GSK3_1 464 471 PF00069 0.527
MOD_GSK3_1 472 479 PF00069 0.497
MOD_GSK3_1 480 487 PF00069 0.520
MOD_GSK3_1 503 510 PF00069 0.609
MOD_GSK3_1 511 518 PF00069 0.573
MOD_GSK3_1 526 533 PF00069 0.541
MOD_GSK3_1 589 596 PF00069 0.610
MOD_GSK3_1 700 707 PF00069 0.525
MOD_GSK3_1 726 733 PF00069 0.649
MOD_GSK3_1 734 741 PF00069 0.671
MOD_GSK3_1 801 808 PF00069 0.624
MOD_GSK3_1 812 819 PF00069 0.552
MOD_GSK3_1 822 829 PF00069 0.530
MOD_N-GLC_1 313 318 PF02516 0.561
MOD_N-GLC_1 45 50 PF02516 0.622
MOD_N-GLC_1 782 787 PF02516 0.629
MOD_N-GLC_2 586 588 PF02516 0.574
MOD_NEK2_1 102 107 PF00069 0.623
MOD_NEK2_1 285 290 PF00069 0.606
MOD_NEK2_1 480 485 PF00069 0.580
MOD_NEK2_1 604 609 PF00069 0.599
MOD_NEK2_1 636 641 PF00069 0.595
MOD_NEK2_1 836 841 PF00069 0.612
MOD_NEK2_2 142 147 PF00069 0.606
MOD_NEK2_2 659 664 PF00069 0.487
MOD_NEK2_2 715 720 PF00069 0.566
MOD_PIKK_1 129 135 PF00454 0.632
MOD_PIKK_1 163 169 PF00454 0.597
MOD_PIKK_1 320 326 PF00454 0.615
MOD_PIKK_1 61 67 PF00454 0.643
MOD_PIKK_1 813 819 PF00454 0.567
MOD_PIKK_1 834 840 PF00454 0.647
MOD_PK_1 190 196 PF00069 0.518
MOD_PK_1 244 250 PF00069 0.572
MOD_PKA_1 168 174 PF00069 0.589
MOD_PKA_1 197 203 PF00069 0.555
MOD_PKA_1 365 371 PF00069 0.620
MOD_PKA_1 503 509 PF00069 0.622
MOD_PKA_1 704 710 PF00069 0.558
MOD_PKA_1 744 750 PF00069 0.529
MOD_PKA_1 757 763 PF00069 0.467
MOD_PKA_1 834 840 PF00069 0.650
MOD_PKA_2 2 8 PF00069 0.589
MOD_PKA_2 235 241 PF00069 0.606
MOD_PKA_2 365 371 PF00069 0.620
MOD_PKA_2 503 509 PF00069 0.656
MOD_PKA_2 676 682 PF00069 0.601
MOD_PKA_2 704 710 PF00069 0.561
MOD_PKA_2 715 721 PF00069 0.530
MOD_PKA_2 744 750 PF00069 0.563
MOD_PKA_2 757 763 PF00069 0.467
MOD_PKA_2 773 779 PF00069 0.585
MOD_PKA_2 810 816 PF00069 0.595
MOD_PKA_2 822 828 PF00069 0.541
MOD_PKA_2 834 840 PF00069 0.582
MOD_PKB_1 287 295 PF00069 0.620
MOD_PKB_1 755 763 PF00069 0.519
MOD_Plk_1 218 224 PF00069 0.590
MOD_Plk_1 281 287 PF00069 0.633
MOD_Plk_1 313 319 PF00069 0.603
MOD_Plk_1 45 51 PF00069 0.604
MOD_Plk_1 573 579 PF00069 0.561
MOD_Plk_1 75 81 PF00069 0.643
MOD_Plk_2-3 219 225 PF00069 0.588
MOD_Plk_4 108 114 PF00069 0.614
MOD_Plk_4 531 537 PF00069 0.588
MOD_ProDKin_1 225 231 PF00069 0.636
MOD_ProDKin_1 253 259 PF00069 0.625
MOD_ProDKin_1 407 413 PF00069 0.565
MOD_ProDKin_1 422 428 PF00069 0.541
MOD_ProDKin_1 434 440 PF00069 0.580
MOD_ProDKin_1 446 452 PF00069 0.575
MOD_ProDKin_1 526 532 PF00069 0.542
MOD_ProDKin_1 589 595 PF00069 0.644
MOD_ProDKin_1 599 605 PF00069 0.564
MOD_ProDKin_1 620 626 PF00069 0.582
MOD_ProDKin_1 630 636 PF00069 0.518
MOD_ProDKin_1 677 683 PF00069 0.745
MOD_ProDKin_1 710 716 PF00069 0.605
MOD_ProDKin_1 726 732 PF00069 0.483
MOD_ProDKin_1 734 740 PF00069 0.580
MOD_ProDKin_1 775 781 PF00069 0.616
MOD_ProDKin_1 782 788 PF00069 0.607
MOD_ProDKin_1 85 91 PF00069 0.622
MOD_ProDKin_1 93 99 PF00069 0.642
MOD_SUMO_for_1 278 281 PF00179 0.558
TRG_DiLeu_BaEn_4 539 545 PF01217 0.458
TRG_DiLeu_BaLyEn_6 632 637 PF01217 0.789
TRG_ER_diArg_1 363 366 PF00400 0.617
TRG_ER_diArg_1 502 505 PF00400 0.654
TRG_ER_diArg_1 549 552 PF00400 0.493
TRG_ER_diArg_1 557 560 PF00400 0.437
TRG_ER_diArg_1 627 630 PF00400 0.747
TRG_ER_diArg_1 704 706 PF00400 0.646
TRG_ER_diArg_1 715 717 PF00400 0.511
TRG_ER_diArg_1 726 728 PF00400 0.502
TRG_ER_diArg_1 743 745 PF00400 0.659
TRG_ER_diArg_1 755 758 PF00400 0.472
TRG_ER_diArg_1 779 781 PF00400 0.597
TRG_ER_diArg_1 787 790 PF00400 0.567
TRG_ER_diArg_1 834 836 PF00400 0.623
TRG_NLS_Bipartite_1 168 185 PF00514 0.566
TRG_NLS_MonoCore_2 195 200 PF00514 0.515
TRG_NLS_MonoExtN_4 196 201 PF00514 0.559
TRG_NLS_MonoExtN_4 354 361 PF00514 0.624
TRG_Pf-PMV_PEXEL_1 552 556 PF00026 0.496
TRG_Pf-PMV_PEXEL_1 834 838 PF00026 0.577

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H7L9 Leishmania donovani 99% 100%
A4HHP7 Leishmania braziliensis 52% 100%
E9AEB0 Leishmania major 88% 100%
E9ALH6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS