Putative heat shock protein 20

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein 20 - putative

Species:

Leishmania infantum

UniProt:

A4I4V9_LEIIN

TriTrypDb:

LINF_290032200

Length:

155

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, heat shock 20

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I4V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4V9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.303
CLV_NRD_NRD_1	68	70	PF00675	0.191
CLV_NRD_NRD_1	88	90	PF00675	0.273
CLV_PCSK_KEX2_1	7	9	PF00082	0.532
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.532
CLV_PCSK_SKI1_1	31	35	PF00082	0.487
CLV_PCSK_SKI1_1	90	94	PF00082	0.284
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DOC_MAPK_DCC_7	43	52	PF00069	0.437
DOC_MAPK_gen_1	69	75	PF00069	0.391
DOC_MAPK_MEF2A_6	43	52	PF00069	0.437
DOC_PP4_FxxP_1	114	117	PF00568	0.405
DOC_USP7_UBL2_3	90	94	PF12436	0.342
LIG_14-3-3_CanoR_1	74	83	PF00244	0.391
LIG_APCC_ABBA_1	73	78	PF00400	0.391
LIG_BRCT_BRCA1_1	34	38	PF00533	0.608
LIG_CSL_BTD_1	1	4	PF09270	0.580
LIG_FHA_1	149	155	PF00498	0.191
LIG_FHA_2	116	122	PF00498	0.329
LIG_LIR_Apic_2	111	117	PF02991	0.391
LIG_LIR_Gen_1	56	66	PF02991	0.394
LIG_LIR_Nem_3	16	22	PF02991	0.581
LIG_LIR_Nem_3	56	62	PF02991	0.265
LIG_MLH1_MIPbox_1	34	38	PF16413	0.591
LIG_MYND_1	26	30	PF01753	0.432
LIG_Pex14_2	110	114	PF04695	0.391
LIG_Pex14_2	21	25	PF04695	0.520
LIG_Pex14_2	34	38	PF04695	0.394
LIG_REV1ctd_RIR_1	35	45	PF16727	0.548
LIG_SH2_CRK	59	63	PF00017	0.221
LIG_SH2_NCK_1	59	63	PF00017	0.368
LIG_SH2_STAP1	59	63	PF00017	0.266
LIG_SH2_STAT5	59	62	PF00017	0.391
LIG_SH2_STAT5	76	79	PF00017	0.329
LIG_SH3_3	133	139	PF00018	0.390
LIG_SUMO_SIM_par_1	148	155	PF11976	0.292
LIG_UBA3_1	82	90	PF00899	0.329
LIG_WRC_WIRS_1	34	39	PF05994	0.556
MOD_CK1_1	119	125	PF00069	0.289
MOD_CK1_1	146	152	PF00069	0.358
MOD_CK1_1	36	42	PF00069	0.466
MOD_GlcNHglycan	145	148	PF01048	0.324
MOD_GlcNHglycan	85	88	PF01048	0.308
MOD_GSK3_1	115	122	PF00069	0.338
MOD_GSK3_1	141	148	PF00069	0.247
MOD_GSK3_1	32	39	PF00069	0.547
MOD_GSK3_1	7	14	PF00069	0.620
MOD_GSK3_1	74	81	PF00069	0.413
MOD_N-GLC_1	134	139	PF02516	0.396
MOD_NEK2_1	134	139	PF00069	0.288
MOD_NEK2_1	141	146	PF00069	0.347
MOD_NEK2_1	33	38	PF00069	0.534
MOD_PKA_1	7	13	PF00069	0.521
MOD_PKA_2	141	147	PF00069	0.428
MOD_PKA_2	42	48	PF00069	0.377
MOD_PKA_2	7	13	PF00069	0.521
MOD_Plk_1	134	140	PF00069	0.373
MOD_Plk_1	77	83	PF00069	0.358
MOD_Plk_4	33	39	PF00069	0.497
MOD_Plk_4	42	48	PF00069	0.392
MOD_Plk_4	57	63	PF00069	0.296
MOD_Plk_4	7	13	PF00069	0.521
MOD_Plk_4	78	84	PF00069	0.404
TRG_DiLeu_BaEn_1	97	102	PF01217	0.329
TRG_ENDOCYTIC_2	59	62	PF00928	0.248

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHY2	Leptomonas seymouri	63%	100%
A0A0S4ITJ1	Bodo saltans	39%	100%
A0A1X0P9Y3	Trypanosomatidae	40%	100%
A0A3Q8IBN6	Leishmania donovani	100%	100%
A0A3R7N2L9	Trypanosoma rangeli	43%	100%
A4HHP4	Leishmania braziliensis	81%	100%
C9ZL02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AEA7	Leishmania major	92%	100%
E9ALH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O14368	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
O30851	Streptococcus thermophilus	34%	100%
O74984	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
O82011	Solanum peruvianum	30%	100%
O82013	Solanum peruvianum	27%	100%
P02519	Glycine max	30%	100%
P04794	Glycine max	31%	100%
P04795	Glycine max	30%	100%
P05478	Glycine max	33%	96%
P15992	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	72%
P19244	Pisum sativum	29%	79%
P27879	Medicago sativa	33%	100%
P27880	Medicago sativa	34%	98%
P29830	Arabidopsis thaliana	29%	100%
P30236	Glycine max	29%	81%
P46516	Helianthus annuus	26%	97%
Q01545	Ipomoea nil	28%	93%
Q06823	Stigmatella aurantiaca (strain DW4/3-1)	29%	92%
Q38806	Arabidopsis thaliana	30%	79%
Q4UJB1	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	30%	95%
Q4UKR8	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	29%	100%
Q53M11	Oryza sativa subsp. japonica	32%	75%
V5BXI2	Trypanosoma cruzi	45%	100%