LeishMANIAdb
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Phosphodiesterase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphodiesterase
Gene product:
3'5'-cyclic nucleotide phosphodiesterase - putative
Species:
Leishmania infantum
UniProt:
A4I4V8_LEIIN
TriTrypDb:
LINF_290032100
Length:
724

Annotations

LeishMANIAdb annotations

Phosphodiesterase, with probable N-terminal lipidation signal. Not embedded in membrane, like its homologs.

Annotations by Jardim et al.

Phosphodiesterase, 3'5'-cyclic nucleotide phosphodiesterase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0020016 ciliary pocket 2 1
GO:0110165 cellular anatomical entity 1 4
GO:0016020 membrane 2 3

Expansion

Sequence features

A4I4V8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4V8

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 13
GO:0009987 cellular process 1 13
GO:0050789 regulation of biological process 2 13
GO:0050794 regulation of cellular process 3 13
GO:0065007 biological regulation 1 13
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 13
GO:0004112 cyclic-nucleotide phosphodiesterase activity 6 13
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 7 13
GO:0005488 binding 1 13
GO:0008081 phosphoric diester hydrolase activity 5 13
GO:0016787 hydrolase activity 2 13
GO:0016788 hydrolase activity, acting on ester bonds 3 13
GO:0042578 phosphoric ester hydrolase activity 4 13
GO:0043167 ion binding 2 13
GO:0043169 cation binding 3 13
GO:0046872 metal ion binding 4 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 184 188 PF00656 0.580
CLV_NRD_NRD_1 184 186 PF00675 0.563
CLV_NRD_NRD_1 304 306 PF00675 0.535
CLV_NRD_NRD_1 379 381 PF00675 0.592
CLV_NRD_NRD_1 446 448 PF00675 0.533
CLV_NRD_NRD_1 706 708 PF00675 0.634
CLV_PCSK_KEX2_1 304 306 PF00082 0.550
CLV_PCSK_KEX2_1 446 448 PF00082 0.533
CLV_PCSK_KEX2_1 706 708 PF00082 0.612
CLV_PCSK_PC7_1 300 306 PF00082 0.638
CLV_PCSK_SKI1_1 107 111 PF00082 0.494
CLV_PCSK_SKI1_1 220 224 PF00082 0.504
CLV_PCSK_SKI1_1 304 308 PF00082 0.597
CLV_PCSK_SKI1_1 356 360 PF00082 0.441
CLV_PCSK_SKI1_1 446 450 PF00082 0.409
CLV_PCSK_SKI1_1 530 534 PF00082 0.348
CLV_PCSK_SKI1_1 582 586 PF00082 0.385
CLV_PCSK_SKI1_1 605 609 PF00082 0.395
CLV_PCSK_SKI1_1 92 96 PF00082 0.509
CLV_Separin_Metazoa 543 547 PF03568 0.416
DEG_APCC_DBOX_1 445 453 PF00400 0.471
DEG_SCF_FBW7_1 13 20 PF00400 0.711
DEG_SPOP_SBC_1 76 80 PF00917 0.691
DOC_CYCLIN_RxL_1 643 653 PF00134 0.461
DOC_MAPK_gen_1 446 452 PF00069 0.527
DOC_MAPK_gen_1 600 608 PF00069 0.416
DOC_MAPK_gen_1 646 652 PF00069 0.470
DOC_MAPK_MEF2A_6 600 608 PF00069 0.350
DOC_PP4_FxxP_1 117 120 PF00568 0.522
DOC_PP4_FxxP_1 204 207 PF00568 0.576
DOC_PP4_FxxP_1 506 509 PF00568 0.377
DOC_SPAK_OSR1_1 224 228 PF12202 0.497
DOC_SPAK_OSR1_1 447 451 PF12202 0.528
DOC_USP7_MATH_1 286 290 PF00917 0.556
DOC_USP7_MATH_1 451 455 PF00917 0.496
DOC_USP7_MATH_2 347 353 PF00917 0.562
DOC_USP7_UBL2_3 632 636 PF12436 0.497
DOC_USP7_UBL2_3 86 90 PF12436 0.574
DOC_WW_Pin1_4 11 16 PF00397 0.758
DOC_WW_Pin1_4 213 218 PF00397 0.570
DOC_WW_Pin1_4 334 339 PF00397 0.707
DOC_WW_Pin1_4 359 364 PF00397 0.546
DOC_WW_Pin1_4 65 70 PF00397 0.749
DOC_WW_Pin1_4 650 655 PF00397 0.348
LIG_14-3-3_CanoR_1 140 147 PF00244 0.479
LIG_14-3-3_CanoR_1 590 597 PF00244 0.429
LIG_14-3-3_CanoR_1 605 611 PF00244 0.395
LIG_APCC_ABBA_1 114 119 PF00400 0.537
LIG_APCC_ABBA_1 652 657 PF00400 0.377
LIG_BRCT_BRCA1_1 634 638 PF00533 0.395
LIG_CSL_BTD_1 335 338 PF09270 0.703
LIG_CtBP_PxDLS_1 207 211 PF00389 0.590
LIG_eIF4E_1 423 429 PF01652 0.411
LIG_FHA_1 111 117 PF00498 0.432
LIG_FHA_1 132 138 PF00498 0.547
LIG_FHA_1 167 173 PF00498 0.487
LIG_FHA_1 229 235 PF00498 0.522
LIG_FHA_1 266 272 PF00498 0.622
LIG_FHA_1 407 413 PF00498 0.445
LIG_FHA_1 422 428 PF00498 0.294
LIG_FHA_1 539 545 PF00498 0.475
LIG_FHA_1 690 696 PF00498 0.503
LIG_FHA_1 71 77 PF00498 0.776
LIG_FHA_1 8 14 PF00498 0.770
LIG_FHA_2 141 147 PF00498 0.467
LIG_FHA_2 177 183 PF00498 0.582
LIG_FHA_2 553 559 PF00498 0.407
LIG_FHA_2 565 571 PF00498 0.326
LIG_IBAR_NPY_1 459 461 PF08397 0.427
LIG_IRF3_LxIS_1 648 653 PF10401 0.446
LIG_LIR_Apic_2 201 207 PF02991 0.588
LIG_LIR_Apic_2 505 509 PF02991 0.348
LIG_LIR_Gen_1 187 198 PF02991 0.514
LIG_LIR_Gen_1 394 402 PF02991 0.452
LIG_LIR_Gen_1 406 415 PF02991 0.412
LIG_LIR_Gen_1 424 434 PF02991 0.262
LIG_LIR_Gen_1 541 550 PF02991 0.419
LIG_LIR_Nem_3 159 163 PF02991 0.418
LIG_LIR_Nem_3 187 193 PF02991 0.498
LIG_LIR_Nem_3 199 205 PF02991 0.536
LIG_LIR_Nem_3 221 226 PF02991 0.523
LIG_LIR_Nem_3 394 399 PF02991 0.418
LIG_LIR_Nem_3 406 410 PF02991 0.407
LIG_LIR_Nem_3 424 429 PF02991 0.260
LIG_LIR_Nem_3 492 498 PF02991 0.443
LIG_LIR_Nem_3 541 545 PF02991 0.419
LIG_LIR_Nem_3 671 675 PF02991 0.348
LIG_LIR_Nem_3 96 100 PF02991 0.568
LIG_LYPXL_yS_3 202 205 PF13949 0.515
LIG_Pex14_1 160 164 PF04695 0.400
LIG_PTB_Apo_2 544 551 PF02174 0.443
LIG_PTB_Apo_2 698 705 PF02174 0.560
LIG_PTB_Phospho_1 544 550 PF10480 0.443
LIG_PTB_Phospho_1 698 704 PF10480 0.560
LIG_Rb_pABgroove_1 317 325 PF01858 0.665
LIG_REV1ctd_RIR_1 161 169 PF16727 0.398
LIG_SH2_CRK 407 411 PF00017 0.428
LIG_SH2_CRK 97 101 PF00017 0.564
LIG_SH2_GRB2like 437 440 PF00017 0.520
LIG_SH2_GRB2like 461 464 PF00017 0.361
LIG_SH2_NCK_1 236 240 PF00017 0.587
LIG_SH2_NCK_1 407 411 PF00017 0.429
LIG_SH2_SRC 323 326 PF00017 0.615
LIG_SH2_STAP1 138 142 PF00017 0.488
LIG_SH2_STAP1 423 427 PF00017 0.361
LIG_SH2_STAP1 627 631 PF00017 0.416
LIG_SH2_STAT3 675 678 PF00017 0.443
LIG_SH2_STAT5 142 145 PF00017 0.613
LIG_SH2_STAT5 270 273 PF00017 0.629
LIG_SH2_STAT5 423 426 PF00017 0.397
LIG_SH2_STAT5 437 440 PF00017 0.444
LIG_SH2_STAT5 476 479 PF00017 0.349
LIG_SH2_STAT5 522 525 PF00017 0.348
LIG_SH2_STAT5 639 642 PF00017 0.431
LIG_SH2_STAT5 675 678 PF00017 0.348
LIG_SH2_STAT5 93 96 PF00017 0.448
LIG_SH3_3 12 18 PF00018 0.745
LIG_SH3_3 223 229 PF00018 0.560
LIG_SH3_3 357 363 PF00018 0.451
LIG_SH3_3 54 60 PF00018 0.771
LIG_SH3_3 63 69 PF00018 0.741
LIG_SH3_3 683 689 PF00018 0.421
LIG_SUMO_SIM_anti_2 682 688 PF11976 0.283
LIG_SUMO_SIM_par_1 448 454 PF11976 0.512
LIG_TRAF2_1 143 146 PF00917 0.541
LIG_TRAF2_1 342 345 PF00917 0.556
LIG_TRAF2_1 490 493 PF00917 0.395
LIG_TRFH_1 359 363 PF08558 0.449
LIG_TYR_ITIM 435 440 PF00017 0.524
LIG_TYR_ITSM 422 429 PF00017 0.423
LIG_WRC_WIRS_1 350 355 PF05994 0.455
LIG_WRC_WIRS_1 690 695 PF05994 0.419
MOD_CDK_SPxxK_3 213 220 PF00069 0.546
MOD_CDK_SPxxK_3 359 366 PF00069 0.550
MOD_CK1_1 133 139 PF00069 0.541
MOD_CK1_1 166 172 PF00069 0.391
MOD_CK1_1 174 180 PF00069 0.447
MOD_CK1_1 212 218 PF00069 0.531
MOD_CK1_1 241 247 PF00069 0.588
MOD_CK1_1 3 9 PF00069 0.724
MOD_CK1_1 368 374 PF00069 0.547
MOD_CK1_1 592 598 PF00069 0.458
MOD_CK1_1 68 74 PF00069 0.753
MOD_CK2_1 125 131 PF00069 0.420
MOD_CK2_1 140 146 PF00069 0.536
MOD_CK2_1 16 22 PF00069 0.837
MOD_CK2_1 241 247 PF00069 0.668
MOD_CK2_1 487 493 PF00069 0.395
MOD_CK2_1 528 534 PF00069 0.348
MOD_CK2_1 564 570 PF00069 0.384
MOD_CK2_1 596 602 PF00069 0.423
MOD_GlcNHglycan 2 5 PF01048 0.756
MOD_GlcNHglycan 240 243 PF01048 0.583
MOD_GlcNHglycan 26 29 PF01048 0.708
MOD_GlcNHglycan 283 287 PF01048 0.605
MOD_GlcNHglycan 369 373 PF01048 0.505
MOD_GlcNHglycan 37 40 PF01048 0.690
MOD_GlcNHglycan 453 456 PF01048 0.465
MOD_GlcNHglycan 80 83 PF01048 0.714
MOD_GSK3_1 121 128 PF00069 0.484
MOD_GSK3_1 13 20 PF00069 0.697
MOD_GSK3_1 177 184 PF00069 0.518
MOD_GSK3_1 188 195 PF00069 0.508
MOD_GSK3_1 209 216 PF00069 0.592
MOD_GSK3_1 261 268 PF00069 0.586
MOD_GSK3_1 282 289 PF00069 0.540
MOD_GSK3_1 3 10 PF00069 0.783
MOD_GSK3_1 327 334 PF00069 0.725
MOD_GSK3_1 592 599 PF00069 0.397
MOD_N-GLC_1 188 193 PF02516 0.480
MOD_N-GLC_1 632 637 PF02516 0.412
MOD_N-GLC_1 648 653 PF02516 0.336
MOD_N-GLC_1 76 81 PF02516 0.814
MOD_N-GLC_2 696 698 PF02516 0.545
MOD_NEK2_1 110 115 PF00069 0.511
MOD_NEK2_1 163 168 PF00069 0.375
MOD_NEK2_1 331 336 PF00069 0.690
MOD_NEK2_1 421 426 PF00069 0.353
MOD_NEK2_1 606 611 PF00069 0.349
MOD_NEK2_1 648 653 PF00069 0.443
MOD_NEK2_2 188 193 PF00069 0.579
MOD_NEK2_2 255 260 PF00069 0.540
MOD_NEK2_2 522 527 PF00069 0.348
MOD_NMyristoyl 1 7 PF02799 0.678
MOD_PIKK_1 196 202 PF00454 0.498
MOD_PIKK_1 468 474 PF00454 0.395
MOD_PIKK_1 68 74 PF00454 0.806
MOD_PK_1 714 720 PF00069 0.482
MOD_PKA_1 706 712 PF00069 0.617
MOD_PKA_2 564 570 PF00069 0.364
MOD_PKA_2 589 595 PF00069 0.443
MOD_PKA_2 706 712 PF00069 0.609
MOD_Plk_1 122 128 PF00069 0.488
MOD_Plk_1 188 194 PF00069 0.481
MOD_Plk_1 255 261 PF00069 0.550
MOD_Plk_1 282 288 PF00069 0.534
MOD_Plk_1 468 474 PF00069 0.348
MOD_Plk_1 528 534 PF00069 0.348
MOD_Plk_1 648 654 PF00069 0.443
MOD_Plk_2-3 298 304 PF00069 0.580
MOD_Plk_4 110 116 PF00069 0.471
MOD_Plk_4 122 128 PF00069 0.451
MOD_Plk_4 133 139 PF00069 0.435
MOD_Plk_4 266 272 PF00069 0.556
MOD_Plk_4 331 337 PF00069 0.694
MOD_Plk_4 422 428 PF00069 0.356
MOD_Plk_4 522 528 PF00069 0.348
MOD_Plk_4 564 570 PF00069 0.361
MOD_Plk_4 668 674 PF00069 0.408
MOD_ProDKin_1 11 17 PF00069 0.756
MOD_ProDKin_1 213 219 PF00069 0.573
MOD_ProDKin_1 334 340 PF00069 0.702
MOD_ProDKin_1 359 365 PF00069 0.547
MOD_ProDKin_1 65 71 PF00069 0.748
MOD_ProDKin_1 650 656 PF00069 0.348
MOD_SUMO_rev_2 643 648 PF00179 0.475
TRG_DiLeu_BaEn_1 559 564 PF01217 0.497
TRG_DiLeu_BaEn_2 220 226 PF01217 0.472
TRG_DiLeu_BaLyEn_6 558 563 PF01217 0.458
TRG_ENDOCYTIC_2 202 205 PF00928 0.539
TRG_ENDOCYTIC_2 407 410 PF00928 0.392
TRG_ENDOCYTIC_2 426 429 PF00928 0.248
TRG_ENDOCYTIC_2 437 440 PF00928 0.392
TRG_ENDOCYTIC_2 475 478 PF00928 0.348
TRG_ENDOCYTIC_2 550 553 PF00928 0.353
TRG_ENDOCYTIC_2 97 100 PF00928 0.558
TRG_ER_diArg_1 304 306 PF00400 0.569
TRG_ER_diArg_1 445 447 PF00400 0.530
TRG_ER_diArg_1 705 707 PF00400 0.609
TRG_Pf-PMV_PEXEL_1 279 283 PF00026 0.539
TRG_Pf-PMV_PEXEL_1 530 534 PF00026 0.348
TRG_Pf-PMV_PEXEL_1 561 566 PF00026 0.497

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1Y4 Leptomonas seymouri 68% 100%
A0A0S4IPG9 Bodo saltans 43% 97%
A0A0S4IRJ2 Bodo saltans 46% 100%
A0A1X0P936 Trypanosomatidae 54% 100%
A0A3R7KV25 Trypanosoma rangeli 55% 100%
A0A3S7X2R6 Leishmania donovani 100% 100%
A4HHP3 Leishmania braziliensis 82% 100%
C9ZL03 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9AEA6 Leishmania major 94% 100%
E9ALI0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
V5DTU5 Trypanosoma cruzi 54% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS