LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I4V7_LEIIN
TriTrypDb:
LINF_290032000
Length:
788

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 522, 571, 575
Promastigote/Amastigote: 520

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I4V7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4V7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 118 122 PF00656 0.674
CLV_C14_Caspase3-7 250 254 PF00656 0.639
CLV_C14_Caspase3-7 263 267 PF00656 0.525
CLV_C14_Caspase3-7 510 514 PF00656 0.543
CLV_C14_Caspase3-7 56 60 PF00656 0.510
CLV_NRD_NRD_1 113 115 PF00675 0.616
CLV_NRD_NRD_1 186 188 PF00675 0.554
CLV_NRD_NRD_1 282 284 PF00675 0.647
CLV_NRD_NRD_1 312 314 PF00675 0.616
CLV_NRD_NRD_1 394 396 PF00675 0.635
CLV_NRD_NRD_1 413 415 PF00675 0.614
CLV_NRD_NRD_1 503 505 PF00675 0.587
CLV_NRD_NRD_1 543 545 PF00675 0.577
CLV_NRD_NRD_1 729 731 PF00675 0.660
CLV_NRD_NRD_1 734 736 PF00675 0.597
CLV_NRD_NRD_1 86 88 PF00675 0.549
CLV_PCSK_FUR_1 501 505 PF00082 0.525
CLV_PCSK_KEX2_1 113 115 PF00082 0.616
CLV_PCSK_KEX2_1 141 143 PF00082 0.472
CLV_PCSK_KEX2_1 282 284 PF00082 0.595
CLV_PCSK_KEX2_1 312 314 PF00082 0.610
CLV_PCSK_KEX2_1 363 365 PF00082 0.523
CLV_PCSK_KEX2_1 394 396 PF00082 0.635
CLV_PCSK_KEX2_1 413 415 PF00082 0.614
CLV_PCSK_KEX2_1 503 505 PF00082 0.587
CLV_PCSK_KEX2_1 542 544 PF00082 0.579
CLV_PCSK_KEX2_1 590 592 PF00082 0.730
CLV_PCSK_KEX2_1 614 616 PF00082 0.504
CLV_PCSK_KEX2_1 639 641 PF00082 0.655
CLV_PCSK_PC1ET2_1 141 143 PF00082 0.514
CLV_PCSK_PC1ET2_1 363 365 PF00082 0.523
CLV_PCSK_PC1ET2_1 590 592 PF00082 0.637
CLV_PCSK_PC1ET2_1 614 616 PF00082 0.518
CLV_PCSK_PC1ET2_1 639 641 PF00082 0.655
CLV_PCSK_SKI1_1 322 326 PF00082 0.497
CLV_PCSK_SKI1_1 523 527 PF00082 0.653
CLV_PCSK_SKI1_1 631 635 PF00082 0.515
CLV_PCSK_SKI1_1 687 691 PF00082 0.533
CLV_PCSK_SKI1_1 730 734 PF00082 0.651
CLV_PCSK_SKI1_1 79 83 PF00082 0.582
CLV_Separin_Metazoa 743 747 PF03568 0.541
DEG_SCF_FBW7_1 376 382 PF00400 0.567
DEG_SCF_FBW7_1 718 724 PF00400 0.588
DEG_SCF_FBW7_2 196 202 PF00400 0.581
DEG_SIAH_1 349 357 PF03145 0.501
DOC_CDC14_PxL_1 589 597 PF14671 0.485
DOC_CKS1_1 128 133 PF01111 0.544
DOC_CKS1_1 196 201 PF01111 0.566
DOC_CKS1_1 323 328 PF01111 0.470
DOC_CKS1_1 376 381 PF01111 0.567
DOC_CKS1_1 573 578 PF01111 0.594
DOC_CKS1_1 718 723 PF01111 0.589
DOC_CYCLIN_RxL_1 164 175 PF00134 0.528
DOC_MAPK_DCC_7 578 586 PF00069 0.625
DOC_MAPK_DCC_7 591 601 PF00069 0.483
DOC_MAPK_RevD_3 754 768 PF00069 0.495
DOC_PP1_RVXF_1 165 172 PF00149 0.536
DOC_PP2B_LxvP_1 240 243 PF13499 0.487
DOC_PP2B_LxvP_1 292 295 PF13499 0.633
DOC_PP2B_LxvP_1 324 327 PF13499 0.466
DOC_PP2B_LxvP_1 358 361 PF13499 0.535
DOC_PP2B_LxvP_1 384 387 PF13499 0.614
DOC_PP2B_LxvP_1 46 49 PF13499 0.615
DOC_PP2B_LxvP_1 657 660 PF13499 0.507
DOC_PP4_FxxP_1 422 425 PF00568 0.467
DOC_USP7_MATH_1 15 19 PF00917 0.589
DOC_USP7_MATH_1 153 157 PF00917 0.636
DOC_USP7_MATH_1 206 210 PF00917 0.641
DOC_USP7_MATH_1 247 251 PF00917 0.541
DOC_USP7_MATH_1 400 404 PF00917 0.535
DOC_USP7_MATH_1 406 410 PF00917 0.538
DOC_USP7_MATH_1 517 521 PF00917 0.491
DOC_USP7_MATH_1 55 59 PF00917 0.549
DOC_USP7_MATH_1 652 656 PF00917 0.539
DOC_USP7_MATH_1 673 677 PF00917 0.581
DOC_USP7_MATH_1 682 686 PF00917 0.503
DOC_USP7_MATH_1 707 711 PF00917 0.662
DOC_USP7_MATH_1 96 100 PF00917 0.614
DOC_USP7_UBL2_3 562 566 PF12436 0.608
DOC_USP7_UBL2_3 727 731 PF12436 0.599
DOC_USP7_UBL2_3 774 778 PF12436 0.532
DOC_WW_Pin1_4 121 126 PF00397 0.742
DOC_WW_Pin1_4 127 132 PF00397 0.653
DOC_WW_Pin1_4 186 191 PF00397 0.497
DOC_WW_Pin1_4 192 197 PF00397 0.572
DOC_WW_Pin1_4 266 271 PF00397 0.638
DOC_WW_Pin1_4 322 327 PF00397 0.580
DOC_WW_Pin1_4 372 377 PF00397 0.626
DOC_WW_Pin1_4 385 390 PF00397 0.501
DOC_WW_Pin1_4 526 531 PF00397 0.602
DOC_WW_Pin1_4 554 559 PF00397 0.707
DOC_WW_Pin1_4 568 573 PF00397 0.640
DOC_WW_Pin1_4 623 628 PF00397 0.596
DOC_WW_Pin1_4 639 644 PF00397 0.564
DOC_WW_Pin1_4 671 676 PF00397 0.566
DOC_WW_Pin1_4 689 694 PF00397 0.602
DOC_WW_Pin1_4 717 722 PF00397 0.706
DOC_WW_Pin1_4 778 783 PF00397 0.558
LIG_14-3-3_CanoR_1 129 139 PF00244 0.581
LIG_14-3-3_CanoR_1 260 270 PF00244 0.520
LIG_14-3-3_CanoR_1 312 320 PF00244 0.579
LIG_14-3-3_CanoR_1 342 350 PF00244 0.604
LIG_14-3-3_CanoR_1 542 551 PF00244 0.573
LIG_14-3-3_CanoR_1 631 636 PF00244 0.513
LIG_14-3-3_CanoR_1 730 737 PF00244 0.594
LIG_14-3-3_CanoR_1 87 95 PF00244 0.614
LIG_BRCT_BRCA1_1 285 289 PF00533 0.548
LIG_FHA_1 134 140 PF00498 0.627
LIG_FHA_1 196 202 PF00498 0.558
LIG_FHA_1 367 373 PF00498 0.557
LIG_FHA_1 41 47 PF00498 0.492
LIG_FHA_1 437 443 PF00498 0.512
LIG_FHA_1 555 561 PF00498 0.552
LIG_FHA_1 611 617 PF00498 0.577
LIG_FHA_2 170 176 PF00498 0.488
LIG_FHA_2 54 60 PF00498 0.707
LIG_FHA_2 569 575 PF00498 0.656
LIG_FHA_2 75 81 PF00498 0.557
LIG_LIR_Apic_2 420 425 PF02991 0.509
LIG_LIR_Apic_2 439 443 PF02991 0.467
LIG_LIR_Apic_2 502 508 PF02991 0.618
LIG_LIR_Gen_1 286 295 PF02991 0.537
LIG_LIR_Gen_1 318 327 PF02991 0.542
LIG_LIR_Gen_1 401 411 PF02991 0.533
LIG_LIR_Nem_3 162 168 PF02991 0.534
LIG_LIR_Nem_3 286 292 PF02991 0.545
LIG_LIR_Nem_3 318 323 PF02991 0.576
LIG_LIR_Nem_3 401 407 PF02991 0.536
LIG_LIR_Nem_3 80 86 PF02991 0.569
LIG_MYND_1 593 597 PF01753 0.479
LIG_SH2_CRK 165 169 PF00017 0.496
LIG_SH2_CRK 320 324 PF00017 0.560
LIG_SH2_CRK 440 444 PF00017 0.546
LIG_SH2_NCK_1 440 444 PF00017 0.494
LIG_SH2_PTP2 505 508 PF00017 0.605
LIG_SH2_SRC 505 508 PF00017 0.605
LIG_SH2_STAP1 237 241 PF00017 0.498
LIG_SH2_STAP1 320 324 PF00017 0.560
LIG_SH2_STAT5 332 335 PF00017 0.483
LIG_SH2_STAT5 440 443 PF00017 0.521
LIG_SH2_STAT5 505 508 PF00017 0.520
LIG_SH2_STAT5 770 773 PF00017 0.525
LIG_SH3_1 193 199 PF00018 0.508
LIG_SH3_1 210 216 PF00018 0.519
LIG_SH3_1 440 446 PF00018 0.497
LIG_SH3_1 591 597 PF00018 0.506
LIG_SH3_1 614 620 PF00018 0.489
LIG_SH3_2 573 578 PF14604 0.516
LIG_SH3_3 122 128 PF00018 0.553
LIG_SH3_3 154 160 PF00018 0.563
LIG_SH3_3 193 199 PF00018 0.652
LIG_SH3_3 210 216 PF00018 0.609
LIG_SH3_3 224 230 PF00018 0.435
LIG_SH3_3 292 298 PF00018 0.665
LIG_SH3_3 304 310 PF00018 0.503
LIG_SH3_3 320 326 PF00018 0.516
LIG_SH3_3 347 353 PF00018 0.601
LIG_SH3_3 373 379 PF00018 0.625
LIG_SH3_3 440 446 PF00018 0.477
LIG_SH3_3 463 469 PF00018 0.667
LIG_SH3_3 527 533 PF00018 0.578
LIG_SH3_3 545 551 PF00018 0.752
LIG_SH3_3 570 576 PF00018 0.548
LIG_SH3_3 591 597 PF00018 0.540
LIG_SH3_3 600 606 PF00018 0.563
LIG_SH3_3 614 620 PF00018 0.554
LIG_SH3_3 626 632 PF00018 0.567
LIG_SH3_3 646 652 PF00018 0.641
LIG_SH3_3 657 663 PF00018 0.519
LIG_SH3_3 716 722 PF00018 0.560
LIG_SH3_4 774 781 PF00018 0.512
LIG_SUMO_SIM_anti_2 56 68 PF11976 0.494
LIG_SUMO_SIM_par_1 369 375 PF11976 0.483
LIG_SUMO_SIM_par_1 496 502 PF11976 0.530
LIG_SUMO_SIM_par_1 598 604 PF11976 0.461
LIG_SUMO_SIM_par_1 631 638 PF11976 0.590
LIG_TRAF2_1 172 175 PF00917 0.470
LIG_TRAF2_1 508 511 PF00917 0.516
LIG_TRAF2_1 525 528 PF00917 0.590
MOD_CDK_SPK_2 186 191 PF00069 0.481
MOD_CDK_SPK_2 778 783 PF00069 0.558
MOD_CDK_SPxK_1 572 578 PF00069 0.566
MOD_CDK_SPxxK_3 186 193 PF00069 0.518
MOD_CDK_SPxxK_3 778 785 PF00069 0.496
MOD_CK1_1 115 121 PF00069 0.656
MOD_CK1_1 189 195 PF00069 0.531
MOD_CK1_1 259 265 PF00069 0.573
MOD_CK1_1 272 278 PF00069 0.534
MOD_CK1_1 285 291 PF00069 0.491
MOD_CK1_1 343 349 PF00069 0.591
MOD_CK1_1 375 381 PF00069 0.633
MOD_CK1_1 417 423 PF00069 0.533
MOD_CK1_1 444 450 PF00069 0.564
MOD_CK1_1 674 680 PF00069 0.630
MOD_CK1_1 74 80 PF00069 0.683
MOD_CK1_1 781 787 PF00069 0.502
MOD_CK1_1 89 95 PF00069 0.529
MOD_CK2_1 169 175 PF00069 0.497
MOD_CK2_1 211 217 PF00069 0.595
MOD_CK2_1 406 412 PF00069 0.645
MOD_CK2_1 424 430 PF00069 0.471
MOD_CK2_1 568 574 PF00069 0.656
MOD_CK2_1 64 70 PF00069 0.588
MOD_CK2_1 652 658 PF00069 0.609
MOD_CK2_1 707 713 PF00069 0.554
MOD_CK2_1 74 80 PF00069 0.532
MOD_Cter_Amidation 392 395 PF01082 0.586
MOD_DYRK1A_RPxSP_1 322 326 PF00069 0.497
MOD_GlcNHglycan 115 118 PF01048 0.545
MOD_GlcNHglycan 249 252 PF01048 0.582
MOD_GlcNHglycan 342 345 PF01048 0.552
MOD_GlcNHglycan 400 403 PF01048 0.589
MOD_GlcNHglycan 449 452 PF01048 0.534
MOD_GlcNHglycan 485 488 PF01048 0.566
MOD_GlcNHglycan 519 522 PF01048 0.503
MOD_GlcNHglycan 602 606 PF01048 0.463
MOD_GlcNHglycan 646 649 PF01048 0.620
MOD_GlcNHglycan 667 670 PF01048 0.571
MOD_GlcNHglycan 680 683 PF01048 0.508
MOD_GlcNHglycan 707 710 PF01048 0.648
MOD_GlcNHglycan 738 741 PF01048 0.490
MOD_GlcNHglycan 98 101 PF01048 0.704
MOD_GSK3_1 105 112 PF00069 0.747
MOD_GSK3_1 130 137 PF00069 0.528
MOD_GSK3_1 197 204 PF00069 0.580
MOD_GSK3_1 211 218 PF00069 0.675
MOD_GSK3_1 256 263 PF00069 0.587
MOD_GSK3_1 269 276 PF00069 0.514
MOD_GSK3_1 366 373 PF00069 0.552
MOD_GSK3_1 375 382 PF00069 0.563
MOD_GSK3_1 394 401 PF00069 0.446
MOD_GSK3_1 413 420 PF00069 0.643
MOD_GSK3_1 5 12 PF00069 0.464
MOD_GSK3_1 53 60 PF00069 0.577
MOD_GSK3_1 542 549 PF00069 0.622
MOD_GSK3_1 568 575 PF00069 0.586
MOD_GSK3_1 631 638 PF00069 0.643
MOD_GSK3_1 674 681 PF00069 0.546
MOD_GSK3_1 717 724 PF00069 0.653
MOD_GSK3_1 86 93 PF00069 0.728
MOD_GSK3_1 96 103 PF00069 0.616
MOD_LATS_1 734 740 PF00433 0.547
MOD_N-GLC_1 169 174 PF02516 0.576
MOD_N-GLC_1 340 345 PF02516 0.545
MOD_N-GLC_1 700 705 PF02516 0.591
MOD_N-GLC_1 74 79 PF02516 0.636
MOD_N-GLC_1 96 101 PF02516 0.558
MOD_NEK2_1 201 206 PF00069 0.587
MOD_NEK2_1 273 278 PF00069 0.758
MOD_NEK2_1 5 10 PF00069 0.513
MOD_NEK2_1 567 572 PF00069 0.583
MOD_NEK2_1 635 640 PF00069 0.733
MOD_NEK2_1 86 91 PF00069 0.596
MOD_OFUCOSY 421 428 PF10250 0.483
MOD_PIKK_1 201 207 PF00454 0.608
MOD_PIKK_1 229 235 PF00454 0.444
MOD_PIKK_1 441 447 PF00454 0.640
MOD_PIKK_1 9 15 PF00454 0.452
MOD_PIKK_1 90 96 PF00454 0.686
MOD_PKA_1 113 119 PF00069 0.621
MOD_PKA_1 282 288 PF00069 0.646
MOD_PKA_1 394 400 PF00069 0.554
MOD_PKA_1 413 419 PF00069 0.555
MOD_PKA_1 542 548 PF00069 0.575
MOD_PKA_1 730 736 PF00069 0.651
MOD_PKA_1 87 93 PF00069 0.587
MOD_PKA_2 112 118 PF00069 0.629
MOD_PKA_2 259 265 PF00069 0.512
MOD_PKA_2 282 288 PF00069 0.586
MOD_PKA_2 394 400 PF00069 0.581
MOD_PKA_2 413 419 PF00069 0.587
MOD_PKA_2 542 548 PF00069 0.575
MOD_PKA_2 86 92 PF00069 0.546
MOD_PKB_1 313 321 PF00069 0.577
MOD_Plk_1 79 85 PF00069 0.539
MOD_Plk_2-3 700 706 PF00069 0.566
MOD_Plk_4 15 21 PF00069 0.586
MOD_Plk_4 153 159 PF00069 0.619
MOD_Plk_4 315 321 PF00069 0.578
MOD_Plk_4 367 373 PF00069 0.531
MOD_Plk_4 59 65 PF00069 0.485
MOD_Plk_4 79 85 PF00069 0.580
MOD_ProDKin_1 121 127 PF00069 0.737
MOD_ProDKin_1 186 192 PF00069 0.500
MOD_ProDKin_1 195 201 PF00069 0.745
MOD_ProDKin_1 266 272 PF00069 0.640
MOD_ProDKin_1 322 328 PF00069 0.573
MOD_ProDKin_1 372 378 PF00069 0.627
MOD_ProDKin_1 385 391 PF00069 0.501
MOD_ProDKin_1 526 532 PF00069 0.602
MOD_ProDKin_1 554 560 PF00069 0.707
MOD_ProDKin_1 568 574 PF00069 0.641
MOD_ProDKin_1 623 629 PF00069 0.595
MOD_ProDKin_1 639 645 PF00069 0.566
MOD_ProDKin_1 671 677 PF00069 0.566
MOD_ProDKin_1 689 695 PF00069 0.605
MOD_ProDKin_1 717 723 PF00069 0.704
MOD_ProDKin_1 778 784 PF00069 0.494
MOD_SUMO_for_1 525 528 PF00179 0.656
MOD_SUMO_for_1 740 743 PF00179 0.535
MOD_SUMO_rev_2 66 74 PF00179 0.505
MOD_SUMO_rev_2 723 729 PF00179 0.588
TRG_DiLeu_BaEn_4 304 310 PF01217 0.552
TRG_DiLeu_BaLyEn_6 164 169 PF01217 0.585
TRG_DiLeu_BaLyEn_6 591 596 PF01217 0.459
TRG_ENDOCYTIC_2 165 168 PF00928 0.532
TRG_ENDOCYTIC_2 237 240 PF00928 0.545
TRG_ENDOCYTIC_2 320 323 PF00928 0.573
TRG_ER_diArg_1 190 193 PF00400 0.513
TRG_ER_diArg_1 281 283 PF00400 0.594
TRG_ER_diArg_1 312 315 PF00400 0.609
TRG_ER_diArg_1 413 415 PF00400 0.562
TRG_ER_diArg_1 500 503 PF00400 0.537
TRG_ER_diArg_1 541 544 PF00400 0.576
TRG_NLS_MonoExtC_3 726 731 PF00514 0.508
TRG_NLS_MonoExtN_4 726 731 PF00514 0.508

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0L3 Leptomonas seymouri 37% 91%
A0A3S7X2R9 Leishmania donovani 96% 100%
A4HHP2 Leishmania braziliensis 53% 98%
E9AEA5 Leishmania major 82% 97%
E9ALI1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS