LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Acyltransferase - putative
Species:
Leishmania infantum
UniProt:
A4I4V5_LEIIN
TriTrypDb:
LINF_290031800
Length:
415

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, acyl transferase lysophosphatidylglycerol acyl transferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 3, no: 7
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4I4V5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4V5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0008374 O-acyltransferase activity 5 11
GO:0016740 transferase activity 2 11
GO:0016746 acyltransferase activity 3 11
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 11
GO:0005488 binding 1 2
GO:0005509 calcium ion binding 5 2
GO:0043167 ion binding 2 2
GO:0043169 cation binding 3 2
GO:0046872 metal ion binding 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 238 240 PF00675 0.485
CLV_NRD_NRD_1 277 279 PF00675 0.515
CLV_NRD_NRD_1 371 373 PF00675 0.522
CLV_PCSK_KEX2_1 277 279 PF00082 0.492
CLV_PCSK_KEX2_1 371 373 PF00082 0.592
CLV_PCSK_SKI1_1 146 150 PF00082 0.364
CLV_PCSK_SKI1_1 306 310 PF00082 0.468
CLV_PCSK_SKI1_1 402 406 PF00082 0.624
CLV_PCSK_SKI1_1 5 9 PF00082 0.500
DEG_APCC_KENBOX_2 239 243 PF00400 0.333
DOC_CKS1_1 12 17 PF01111 0.669
DOC_CKS1_1 122 127 PF01111 0.493
DOC_MAPK_gen_1 239 245 PF00069 0.305
DOC_PP1_RVXF_1 62 69 PF00149 0.358
DOC_PP2B_LxvP_1 26 29 PF13499 0.550
DOC_PP2B_LxvP_1 92 95 PF13499 0.613
DOC_USP7_MATH_1 206 210 PF00917 0.531
DOC_USP7_MATH_1 216 220 PF00917 0.351
DOC_USP7_MATH_1 264 268 PF00917 0.261
DOC_USP7_MATH_1 6 10 PF00917 0.630
DOC_WW_Pin1_4 11 16 PF00397 0.661
DOC_WW_Pin1_4 121 126 PF00397 0.498
LIG_14-3-3_CanoR_1 146 155 PF00244 0.412
LIG_14-3-3_CanoR_1 181 189 PF00244 0.449
LIG_14-3-3_CanoR_1 253 260 PF00244 0.289
LIG_14-3-3_CanoR_1 347 355 PF00244 0.272
LIG_14-3-3_CanoR_1 383 389 PF00244 0.368
LIG_14-3-3_CanoR_1 98 103 PF00244 0.580
LIG_APCC_ABBA_1 287 292 PF00400 0.253
LIG_BIR_II_1 1 5 PF00653 0.704
LIG_BRCT_BRCA1_1 243 247 PF00533 0.357
LIG_BRCT_BRCA1_1 348 352 PF00533 0.321
LIG_BRCT_BRCA1_1 56 60 PF00533 0.395
LIG_CaM_NSCaTE_8 35 42 PF13499 0.451
LIG_Clathr_ClatBox_1 83 87 PF01394 0.285
LIG_deltaCOP1_diTrp_1 223 233 PF00928 0.451
LIG_eIF4E_1 355 361 PF01652 0.379
LIG_FHA_1 12 18 PF00498 0.677
LIG_FHA_1 149 155 PF00498 0.416
LIG_FHA_1 158 164 PF00498 0.306
LIG_FHA_1 181 187 PF00498 0.395
LIG_FHA_1 271 277 PF00498 0.271
LIG_FHA_1 80 86 PF00498 0.350
LIG_FHA_2 110 116 PF00498 0.538
LIG_FHA_2 122 128 PF00498 0.550
LIG_FHA_2 205 211 PF00498 0.550
LIG_FHA_2 264 270 PF00498 0.287
LIG_FHA_2 365 371 PF00498 0.335
LIG_FHA_2 47 53 PF00498 0.385
LIG_LIR_Apic_2 121 125 PF02991 0.519
LIG_LIR_Apic_2 168 173 PF02991 0.383
LIG_LIR_Gen_1 127 137 PF02991 0.505
LIG_LIR_Gen_1 183 193 PF02991 0.392
LIG_LIR_Gen_1 223 234 PF02991 0.427
LIG_LIR_Gen_1 23 33 PF02991 0.505
LIG_LIR_Nem_3 127 132 PF02991 0.506
LIG_LIR_Nem_3 152 158 PF02991 0.352
LIG_LIR_Nem_3 183 188 PF02991 0.355
LIG_LIR_Nem_3 223 229 PF02991 0.416
LIG_LIR_Nem_3 23 28 PF02991 0.570
LIG_LIR_Nem_3 244 248 PF02991 0.331
LIG_LIR_Nem_3 349 355 PF02991 0.324
LIG_LIR_Nem_3 395 401 PF02991 0.302
LIG_LIR_Nem_3 403 408 PF02991 0.315
LIG_MLH1_MIPbox_1 243 247 PF16413 0.329
LIG_NRP_CendR_1 412 415 PF00754 0.608
LIG_PCNA_yPIPBox_3 375 389 PF02747 0.319
LIG_Pex14_1 174 178 PF04695 0.345
LIG_Pex14_1 68 72 PF04695 0.294
LIG_Pex14_2 144 148 PF04695 0.347
LIG_Pex14_2 155 159 PF04695 0.349
LIG_Pex14_2 327 331 PF04695 0.277
LIG_PTAP_UEV_1 281 286 PF05743 0.329
LIG_SH2_CRK 122 126 PF00017 0.530
LIG_SH2_CRK 36 40 PF00017 0.334
LIG_SH2_CRK 4 8 PF00017 0.566
LIG_SH2_NCK_1 122 126 PF00017 0.596
LIG_SH2_SRC 106 109 PF00017 0.558
LIG_SH2_SRC 170 173 PF00017 0.370
LIG_SH2_SRC 355 358 PF00017 0.354
LIG_SH2_STAT3 197 200 PF00017 0.401
LIG_SH2_STAT5 16 19 PF00017 0.631
LIG_SH2_STAT5 166 169 PF00017 0.373
LIG_SH2_STAT5 228 231 PF00017 0.451
LIG_SH2_STAT5 25 28 PF00017 0.509
LIG_SH2_STAT5 72 75 PF00017 0.338
LIG_SH3_3 279 285 PF00018 0.264
LIG_SH3_3 360 366 PF00018 0.316
LIG_SH3_3 9 15 PF00018 0.642
LIG_TRAF2_1 366 369 PF00917 0.361
LIG_TYR_ITIM 34 39 PF00017 0.373
LIG_TYR_ITIM 353 358 PF00017 0.354
LIG_WRC_WIRS_1 233 238 PF05994 0.253
MOD_CK1_1 180 186 PF00069 0.309
MOD_CK1_1 235 241 PF00069 0.267
MOD_CK1_1 394 400 PF00069 0.299
MOD_CK2_1 204 210 PF00069 0.563
MOD_CK2_1 235 241 PF00069 0.253
MOD_CK2_1 263 269 PF00069 0.327
MOD_CK2_1 364 370 PF00069 0.330
MOD_CK2_1 46 52 PF00069 0.402
MOD_GlcNHglycan 39 42 PF01048 0.434
MOD_GSK3_1 180 187 PF00069 0.356
MOD_GSK3_1 7 14 PF00069 0.695
MOD_N-GLC_1 216 221 PF02516 0.326
MOD_N-GLC_1 241 246 PF02516 0.533
MOD_N-GLC_1 391 396 PF02516 0.522
MOD_NEK2_1 137 142 PF00069 0.294
MOD_NEK2_1 148 153 PF00069 0.121
MOD_NEK2_1 159 164 PF00069 0.311
MOD_NEK2_1 376 381 PF00069 0.370
MOD_NEK2_1 384 389 PF00069 0.306
MOD_NEK2_1 79 84 PF00069 0.313
MOD_PKA_2 180 186 PF00069 0.325
MOD_PKA_2 252 258 PF00069 0.305
MOD_PKA_2 346 352 PF00069 0.321
MOD_Plk_1 216 222 PF00069 0.326
MOD_Plk_1 241 247 PF00069 0.333
MOD_Plk_1 394 400 PF00069 0.292
MOD_Plk_1 51 57 PF00069 0.343
MOD_Plk_4 232 238 PF00069 0.249
MOD_Plk_4 241 247 PF00069 0.253
MOD_Plk_4 254 260 PF00069 0.186
MOD_Plk_4 271 277 PF00069 0.305
MOD_Plk_4 384 390 PF00069 0.324
MOD_Plk_4 79 85 PF00069 0.362
MOD_ProDKin_1 11 17 PF00069 0.661
MOD_ProDKin_1 121 127 PF00069 0.498
MOD_SUMO_rev_2 209 214 PF00179 0.470
MOD_SUMO_rev_2 368 376 PF00179 0.413
MOD_SUMO_rev_2 394 404 PF00179 0.382
TRG_DiLeu_BaEn_1 210 215 PF01217 0.467
TRG_DiLeu_BaLyEn_6 356 361 PF01217 0.376
TRG_ENDOCYTIC_2 129 132 PF00928 0.495
TRG_ENDOCYTIC_2 202 205 PF00928 0.566
TRG_ENDOCYTIC_2 25 28 PF00928 0.560
TRG_ENDOCYTIC_2 324 327 PF00928 0.296
TRG_ENDOCYTIC_2 355 358 PF00928 0.354
TRG_ENDOCYTIC_2 36 39 PF00928 0.368
TRG_ENDOCYTIC_2 4 7 PF00928 0.663
TRG_ER_diArg_1 276 278 PF00400 0.342
TRG_ER_diLys_1 412 415 PF00400 0.429

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3C8 Leptomonas seymouri 61% 99%
A0A0S4IPK1 Bodo saltans 45% 86%
A0A1X0P927 Trypanosomatidae 48% 88%
A0A3R7NZP9 Trypanosoma rangeli 49% 91%
A0A3S7X2X4 Leishmania donovani 100% 100%
A4HHP0 Leishmania braziliensis 82% 100%
C9ZL05 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 89%
E9AEA3 Leishmania major 94% 100%
E9ALI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q8BYI6 Mus musculus 31% 76%
Q8S8S2 Arabidopsis thaliana 29% 77%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS