Putative kinesin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin - putative

Species:

Leishmania infantum

UniProt:

A4I4V2_LEIIN

TriTrypDb:

LINF_290031500

Length:

590

Annotations

Annotations by Jardim et al.

Structural Proteins, kinesin

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	2
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4I4V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4V2

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	14
GO:0007018	microtubule-based movement	3	14
GO:0009987	cellular process	1	14

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003774	cytoskeletal motor activity	1	14
GO:0003777	microtubule motor activity	2	14
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	14
GO:0005515	protein binding	2	14
GO:0005524	ATP binding	5	14
GO:0008017	microtubule binding	5	14
GO:0008092	cytoskeletal protein binding	3	14
GO:0015631	tubulin binding	4	14
GO:0016787	hydrolase activity	2	7
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140657	ATP-dependent activity	1	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.504
CLV_C14_Caspase3-7	415	419	PF00656	0.403
CLV_NRD_NRD_1	173	175	PF00675	0.368
CLV_NRD_NRD_1	283	285	PF00675	0.310
CLV_NRD_NRD_1	556	558	PF00675	0.475
CLV_PCSK_FUR_1	47	51	PF00082	0.377
CLV_PCSK_KEX2_1	173	175	PF00082	0.368
CLV_PCSK_KEX2_1	49	51	PF00082	0.382
CLV_PCSK_KEX2_1	556	558	PF00082	0.475
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.397
CLV_PCSK_SKI1_1	117	121	PF00082	0.445
CLV_PCSK_SKI1_1	150	154	PF00082	0.322
CLV_PCSK_SKI1_1	396	400	PF00082	0.519
CLV_PCSK_SKI1_1	417	421	PF00082	0.564
CLV_PCSK_SKI1_1	525	529	PF00082	0.514
CLV_PCSK_SKI1_1	556	560	PF00082	0.458
CLV_PCSK_SKI1_1	71	75	PF00082	0.301
DEG_SCF_FBW7_1	526	532	PF00400	0.558
DOC_CKS1_1	526	531	PF01111	0.491
DOC_CYCLIN_RxL_1	114	122	PF00134	0.455
DOC_CYCLIN_RxL_1	393	403	PF00134	0.505
DOC_CYCLIN_yClb5_NLxxxL_5	477	486	PF00134	0.538
DOC_MAPK_MEF2A_6	10	17	PF00069	0.407
DOC_MAPK_MEF2A_6	215	224	PF00069	0.321
DOC_PP2B_LxvP_1	152	155	PF13499	0.334
DOC_PP2B_LxvP_1	464	467	PF13499	0.482
DOC_USP7_MATH_1	277	281	PF00917	0.315
DOC_USP7_MATH_1	419	423	PF00917	0.564
DOC_USP7_MATH_1	455	459	PF00917	0.522
DOC_USP7_MATH_1	529	533	PF00917	0.542
DOC_USP7_MATH_1	575	579	PF00917	0.632
DOC_USP7_UBL2_3	539	543	PF12436	0.547
DOC_WW_Pin1_4	316	321	PF00397	0.334
DOC_WW_Pin1_4	525	530	PF00397	0.472
LIG_14-3-3_CanoR_1	10	16	PF00244	0.427
LIG_14-3-3_CanoR_1	178	183	PF00244	0.455
LIG_14-3-3_CanoR_1	202	209	PF00244	0.423
LIG_14-3-3_CanoR_1	276	282	PF00244	0.316
LIG_14-3-3_CanoR_1	556	566	PF00244	0.491
LIG_14-3-3_CterR_2	587	590	PF00244	0.638
LIG_Actin_WH2_2	62	77	PF00022	0.308
LIG_APCC_ABBA_1	142	147	PF00400	0.320
LIG_APCC_ABBA_1	165	170	PF00400	0.325
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_BRCT_BRCA1_1	224	228	PF00533	0.455
LIG_BRCT_BRCA1_1	286	290	PF00533	0.410
LIG_BRCT_BRCA1_1	302	306	PF00533	0.244
LIG_BRCT_BRCA1_1	514	518	PF00533	0.483
LIG_EH1_1	458	466	PF00400	0.526
LIG_eIF4E_1	459	465	PF01652	0.531
LIG_FHA_1	132	138	PF00498	0.455
LIG_FHA_1	297	303	PF00498	0.308
LIG_FHA_1	310	316	PF00498	0.320
LIG_FHA_1	324	330	PF00498	0.320
LIG_FHA_1	46	52	PF00498	0.328
LIG_FHA_1	461	467	PF00498	0.410
LIG_FHA_1	507	513	PF00498	0.475
LIG_FHA_1	526	532	PF00498	0.494
LIG_FHA_1	550	556	PF00498	0.447
LIG_FHA_1	6	12	PF00498	0.536
LIG_FHA_1	94	100	PF00498	0.325
LIG_FHA_2	250	256	PF00498	0.429
LIG_FHA_2	398	404	PF00498	0.504
LIG_FHA_2	413	419	PF00498	0.403
LIG_LIR_Gen_1	225	236	PF02991	0.417
LIG_LIR_Gen_1	287	298	PF02991	0.352
LIG_LIR_Gen_1	353	362	PF02991	0.537
LIG_LIR_Gen_1	562	571	PF02991	0.461
LIG_LIR_Gen_1	64	74	PF02991	0.297
LIG_LIR_Gen_1	96	103	PF02991	0.390
LIG_LIR_LC3C_4	463	466	PF02991	0.518
LIG_LIR_Nem_3	225	231	PF02991	0.368
LIG_LIR_Nem_3	287	293	PF02991	0.352
LIG_LIR_Nem_3	353	359	PF02991	0.544
LIG_LIR_Nem_3	562	568	PF02991	0.481
LIG_LIR_Nem_3	64	69	PF02991	0.299
LIG_LIR_Nem_3	76	81	PF02991	0.304
LIG_LIR_Nem_3	96	100	PF02991	0.340
LIG_NRBOX	297	303	PF00104	0.368
LIG_NRBOX	481	487	PF00104	0.441
LIG_Pex14_2	54	58	PF04695	0.315
LIG_PTB_Apo_2	534	541	PF02174	0.530
LIG_Rb_pABgroove_1	114	122	PF01858	0.455
LIG_Rb_pABgroove_1	463	471	PF01858	0.552
LIG_SH2_CRK	469	473	PF00017	0.566
LIG_SH2_CRK	97	101	PF00017	0.455
LIG_SH2_NCK_1	469	473	PF00017	0.600
LIG_SH2_SRC	365	368	PF00017	0.549
LIG_SH2_STAP1	334	338	PF00017	0.326
LIG_SH2_STAP1	356	360	PF00017	0.601
LIG_SH2_STAP1	380	384	PF00017	0.495
LIG_SH2_STAT3	380	383	PF00017	0.576
LIG_SH2_STAT5	176	179	PF00017	0.320
LIG_SH2_STAT5	365	368	PF00017	0.567
LIG_SH2_STAT5	546	549	PF00017	0.432
LIG_SH2_STAT5	565	568	PF00017	0.172
LIG_SH3_3	1	7	PF00018	0.737
LIG_SH3_3	469	475	PF00018	0.608
LIG_SH3_3	523	529	PF00018	0.513
LIG_SUMO_SIM_anti_2	491	497	PF11976	0.497
LIG_SUMO_SIM_par_1	237	244	PF11976	0.368
LIG_SUMO_SIM_par_1	397	404	PF11976	0.561
LIG_SUMO_SIM_par_1	491	497	PF11976	0.503
LIG_TYR_ITIM	354	359	PF00017	0.564
LIG_TYR_ITIM	563	568	PF00017	0.477
LIG_UBA3_1	191	197	PF00899	0.368
LIG_WRC_WIRS_1	278	283	PF05994	0.334
MOD_CK1_1	213	219	PF00069	0.306
MOD_CK1_1	296	302	PF00069	0.320
MOD_CK1_1	328	334	PF00069	0.421
MOD_CK1_1	379	385	PF00069	0.567
MOD_CK1_1	450	456	PF00069	0.451
MOD_CK1_1	93	99	PF00069	0.349
MOD_CK2_1	137	143	PF00069	0.320
MOD_CK2_1	249	255	PF00069	0.303
MOD_CK2_1	289	295	PF00069	0.478
MOD_CK2_1	401	407	PF00069	0.553
MOD_DYRK1A_RPxSP_1	525	529	PF00069	0.552
MOD_GlcNHglycan	186	189	PF01048	0.455
MOD_GlcNHglycan	255	259	PF01048	0.416
MOD_GlcNHglycan	26	29	PF01048	0.524
MOD_GlcNHglycan	559	562	PF01048	0.564
MOD_GlcNHglycan	572	575	PF01048	0.560
MOD_GlcNHglycan	58	61	PF01048	0.400
MOD_GlcNHglycan	92	95	PF01048	0.336
MOD_GSK3_1	131	138	PF00069	0.417
MOD_GSK3_1	209	216	PF00069	0.334
MOD_GSK3_1	245	252	PF00069	0.310
MOD_GSK3_1	289	296	PF00069	0.334
MOD_GSK3_1	314	321	PF00069	0.322
MOD_GSK3_1	323	330	PF00069	0.309
MOD_GSK3_1	397	404	PF00069	0.546
MOD_GSK3_1	419	426	PF00069	0.577
MOD_GSK3_1	443	450	PF00069	0.464
MOD_GSK3_1	521	528	PF00069	0.463
MOD_N-GLC_1	209	214	PF02516	0.321
MOD_N-GLC_1	267	272	PF02516	0.320
MOD_N-GLC_1	323	328	PF02516	0.334
MOD_N-GLC_1	347	352	PF02516	0.501
MOD_N-GLC_1	401	406	PF02516	0.597
MOD_N-GLC_2	82	84	PF02516	0.319
MOD_NEK2_1	209	214	PF00069	0.327
MOD_NEK2_1	220	225	PF00069	0.306
MOD_NEK2_1	293	298	PF00069	0.326
MOD_NEK2_1	302	307	PF00069	0.310
MOD_NEK2_1	314	319	PF00069	0.321
MOD_NEK2_1	325	330	PF00069	0.322
MOD_NEK2_1	339	344	PF00069	0.438
MOD_NEK2_1	366	371	PF00069	0.550
MOD_NEK2_1	401	406	PF00069	0.509
MOD_NEK2_1	443	448	PF00069	0.473
MOD_NEK2_2	131	136	PF00069	0.455
MOD_NEK2_2	289	294	PF00069	0.308
MOD_OFUCOSY	442	447	PF10250	0.468
MOD_PIKK_1	222	228	PF00454	0.334
MOD_PIKK_1	379	385	PF00454	0.597
MOD_PIKK_1	401	407	PF00454	0.599
MOD_PK_1	178	184	PF00069	0.455
MOD_PKA_1	284	290	PF00069	0.445
MOD_PKA_2	201	207	PF00069	0.338
MOD_PKA_2	249	255	PF00069	0.322
MOD_PKA_2	293	299	PF00069	0.317
MOD_PKA_2	512	518	PF00069	0.487
MOD_Plk_1	131	137	PF00069	0.455
MOD_Plk_1	267	273	PF00069	0.320
MOD_Plk_1	401	407	PF00069	0.597
MOD_Plk_1	575	581	PF00069	0.701
MOD_Plk_2-3	161	167	PF00069	0.368
MOD_Plk_2-3	397	403	PF00069	0.503
MOD_Plk_2-3	412	418	PF00069	0.405
MOD_Plk_4	137	143	PF00069	0.320
MOD_Plk_4	238	244	PF00069	0.393
MOD_Plk_4	267	273	PF00069	0.321
MOD_Plk_4	309	315	PF00069	0.309
MOD_Plk_4	460	466	PF00069	0.431
MOD_Plk_4	512	518	PF00069	0.426
MOD_Plk_4	95	101	PF00069	0.320
MOD_ProDKin_1	316	322	PF00069	0.334
MOD_ProDKin_1	525	531	PF00069	0.470
MOD_SUMO_rev_2	257	267	PF00179	0.330
MOD_SUMO_rev_2	280	287	PF00179	0.463
MOD_SUMO_rev_2	292	299	PF00179	0.472
TRG_DiLeu_BaEn_1	355	360	PF01217	0.585
TRG_DiLeu_BaEn_1	416	421	PF01217	0.529
TRG_DiLeu_BaEn_1	460	465	PF01217	0.525
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.368
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.461
TRG_ENDOCYTIC_2	356	359	PF00928	0.553
TRG_ENDOCYTIC_2	469	472	PF00928	0.554
TRG_ENDOCYTIC_2	565	568	PF00928	0.479
TRG_ENDOCYTIC_2	78	81	PF00928	0.455
TRG_ENDOCYTIC_2	97	100	PF00928	0.390
TRG_ER_diArg_1	15	18	PF00400	0.522
TRG_ER_diArg_1	155	158	PF00400	0.327
TRG_ER_diArg_1	173	175	PF00400	0.334
TRG_ER_diArg_1	360	363	PF00400	0.570
TRG_ER_diArg_1	555	557	PF00400	0.467
TRG_NES_CRM1_1	235	249	PF08389	0.380
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	28%	67%
A0A0N1PDD6	Leptomonas seymouri	31%	78%
A0A0S4IP49	Bodo saltans	27%	73%
A0A0S4J0Q2	Bodo saltans	34%	71%
A0A0S4JFN9	Bodo saltans	35%	69%
A0A0S4JJ54	Bodo saltans	32%	84%
A0A0S4JXY6	Bodo saltans	31%	69%
A0A0S4KL43	Bodo saltans	29%	100%
A0A1X0NQ03	Trypanosomatidae	28%	71%
A0A1X0NWZ8	Trypanosomatidae	30%	79%
A0A1X0P0C2	Trypanosomatidae	32%	72%
A0A1X0P2B6	Trypanosomatidae	30%	96%
A0A1X0P728	Trypanosomatidae	28%	67%
A0A1X0P9E3	Trypanosomatidae	60%	99%
A0A1X0P9H3	Trypanosomatidae	33%	68%
A0A1X0P9T0	Trypanosomatidae	33%	100%
A0A1X0PAG9	Trypanosomatidae	50%	99%
A0A3Q8IHG6	Leishmania donovani	100%	100%
A0A3R7LY66	Trypanosoma rangeli	32%	73%
A0A3R7MDH9	Trypanosoma rangeli	28%	83%
A0A3R7R330	Trypanosoma rangeli	62%	100%
A0A3R7RD86	Trypanosoma rangeli	33%	74%
A0A3S7WPL3	Leishmania donovani	29%	66%
A0A3S7WU64	Leishmania donovani	32%	68%
A0A3S7X2P9	Leishmania donovani	98%	100%
A0A3S7X9Y1	Leishmania donovani	31%	100%
A0A422MZ05	Trypanosoma rangeli	28%	87%
A0A422NE49	Trypanosoma rangeli	32%	66%
A0A422NEQ8	Trypanosoma rangeli	30%	78%
A4H4R6	Leishmania braziliensis	29%	67%
A4HAQ7	Leishmania braziliensis	27%	100%
A4HHN7	Leishmania braziliensis	88%	100%
A4HHY2	Leishmania braziliensis	29%	100%
A4HND6	Leishmania braziliensis	30%	100%
A4HSA6	Leishmania infantum	33%	100%
A4HSZ5	Leishmania infantum	29%	66%
A4HX45	Leishmania infantum	32%	74%
A4IC09	Leishmania infantum	31%	100%
B9G2X9	Oryza sativa subsp. japonica	34%	98%
C9ZI82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	67%
C9ZK93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	79%
C9ZL08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZL09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
C9ZTV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	66%
C9ZU98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	73%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	79%
E9AEA0	Leishmania major	97%	100%
E9AFU7	Leishmania major	31%	100%
E9AKY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	66%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
F4K4C5	Arabidopsis thaliana	32%	77%
P46870	Chlamydomonas reinhardtii	30%	76%
Q10E64	Oryza sativa subsp. japonica	35%	80%
Q1MTQ7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	93%
Q29DY1	Drosophila pseudoobscura pseudoobscura	35%	74%
Q2R2P7	Oryza sativa subsp. japonica	33%	92%
Q4QEL8	Leishmania major	32%	73%
Q4QIX3	Leishmania major	29%	67%
Q4QJ61	Leishmania major	26%	100%
Q4R918	Macaca fascicularis	27%	100%
Q5E913	Arabidopsis thaliana	28%	94%
Q5VQ09	Oryza sativa subsp. japonica	32%	66%
Q5XI51	Rattus norvegicus	30%	89%
Q651Z7	Oryza sativa subsp. japonica	30%	68%
Q6H638	Oryza sativa subsp. japonica	31%	67%
Q6L512	Oryza sativa subsp. japonica	31%	100%
Q7ZYL5	Xenopus laevis	28%	91%
Q8VWI7	Arabidopsis thaliana	28%	68%
Q8W5R6	Arabidopsis thaliana	30%	66%
Q965T6	Caenorhabditis elegans	35%	91%
Q9I869	Xenopus laevis	29%	91%
Q9SCJ4	Arabidopsis thaliana	33%	73%
Q9V877	Drosophila melanogaster	29%	94%
V5B8M1	Trypanosoma cruzi	37%	96%
V5B8X9	Trypanosoma cruzi	28%	84%
V5BAA8	Trypanosoma cruzi	32%	72%
V5BIC1	Trypanosoma cruzi	32%	93%
V5BK25	Trypanosoma cruzi	29%	82%
V5BMP0	Trypanosoma cruzi	33%	76%
V5D4P5	Trypanosoma cruzi	30%	96%
V5D733	Trypanosoma cruzi	30%	79%
V5DTU1	Trypanosoma cruzi	49%	100%