Enoyl-CoA hydratase/isomerase-like protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

enoyl-CoA hydratase/isomerase-like protein

Species:

Leishmania infantum

UniProt:

A4I4U5_LEIIN

TriTrypDb:

LINF_290030800

Length:

267

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, Enoyl-CoA hydratase/isomerase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I4U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4U5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006635	fatty acid beta-oxidation	6	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009062	fatty acid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016042	lipid catabolic process	4	1
GO:0016054	organic acid catabolic process	4	1
GO:0019395	fatty acid oxidation	5	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030258	lipid modification	4	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0034440	lipid oxidation	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072329	monocarboxylic acid catabolic process	6	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	7
GO:0004300	enoyl-CoA hydratase activity	5	3
GO:0016829	lyase activity	2	3
GO:0016835	carbon-oxygen lyase activity	3	3
GO:0016836	hydro-lyase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	248	250	PF00675	0.392
CLV_PCSK_KEX2_1	259	261	PF00082	0.276
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.276
CLV_PCSK_SKI1_1	143	147	PF00082	0.360
CLV_PCSK_SKI1_1	188	192	PF00082	0.322
CLV_PCSK_SKI1_1	215	219	PF00082	0.386
CLV_PCSK_SKI1_1	78	82	PF00082	0.413
DEG_Nend_Nbox_1	1	3	PF02207	0.532
DOC_CDC14_PxL_1	144	152	PF14671	0.367
DOC_MAPK_gen_1	162	171	PF00069	0.413
DOC_MAPK_MEF2A_6	136	144	PF00069	0.408
DOC_PP4_FxxP_1	137	140	PF00568	0.286
DOC_USP7_MATH_1	234	238	PF00917	0.413
DOC_USP7_MATH_1	57	61	PF00917	0.245
LIG_14-3-3_CanoR_1	40	47	PF00244	0.455
LIG_14-3-3_CanoR_1	83	90	PF00244	0.343
LIG_BRCT_BRCA1_1	236	240	PF00533	0.419
LIG_BRCT_BRCA1_1	90	94	PF00533	0.383
LIG_CaM_IQ_9	150	166	PF13499	0.336
LIG_FHA_1	151	157	PF00498	0.284
LIG_FHA_1	24	30	PF00498	0.319
LIG_FHA_1	252	258	PF00498	0.408
LIG_FHA_2	174	180	PF00498	0.292
LIG_FHA_2	82	88	PF00498	0.367
LIG_LIR_Apic_2	134	140	PF02991	0.407
LIG_LIR_Gen_1	167	175	PF02991	0.413
LIG_LIR_Gen_1	208	217	PF02991	0.408
LIG_LIR_Gen_1	91	100	PF02991	0.316
LIG_LIR_Nem_3	167	171	PF02991	0.413
LIG_LIR_Nem_3	208	212	PF02991	0.408
LIG_LIR_Nem_3	91	97	PF02991	0.316
LIG_Pex14_2	240	244	PF04695	0.276
LIG_PTB_Apo_2	238	245	PF02174	0.413
LIG_SH2_CRK	209	213	PF00017	0.367
LIG_SH2_NCK_1	175	179	PF00017	0.367
LIG_SH2_NCK_1	209	213	PF00017	0.367
LIG_SH2_STAP1	209	213	PF00017	0.413
LIG_SH2_STAP1	235	239	PF00017	0.367
LIG_SH2_STAP1	4	8	PF00017	0.618
LIG_SH2_STAT5	175	178	PF00017	0.292
LIG_SUMO_SIM_par_1	23	28	PF11976	0.311
LIG_TRAF2_1	131	134	PF00917	0.343
LIG_UBA3_1	46	55	PF00899	0.367
MOD_CK1_1	224	230	PF00069	0.414
MOD_CK1_1	242	248	PF00069	0.374
MOD_CK2_1	173	179	PF00069	0.276
MOD_CK2_1	42	48	PF00069	0.446
MOD_CK2_1	81	87	PF00069	0.408
MOD_GlcNHglycan	59	62	PF01048	0.378
MOD_GSK3_1	150	157	PF00069	0.338
MOD_GSK3_1	239	246	PF00069	0.352
MOD_GSK3_1	95	102	PF00069	0.327
MOD_N-GLC_1	221	226	PF02516	0.355
MOD_N-GLC_1	240	245	PF02516	0.336
MOD_NEK2_1	150	155	PF00069	0.342
MOD_NEK2_1	171	176	PF00069	0.425
MOD_NEK2_1	2	7	PF00069	0.514
MOD_NEK2_1	240	245	PF00069	0.400
MOD_OFUCOSY	120	126	PF10250	0.311
MOD_PIKK_1	150	156	PF00454	0.278
MOD_PIKK_1	207	213	PF00454	0.337
MOD_PIKK_1	221	227	PF00454	0.358
MOD_PIKK_1	30	36	PF00454	0.400
MOD_PKA_2	154	160	PF00069	0.336
MOD_PKA_2	2	8	PF00069	0.549
MOD_PKA_2	30	36	PF00069	0.408
MOD_Plk_1	240	246	PF00069	0.393
MOD_Plk_1	81	87	PF00069	0.408
MOD_Plk_2-3	76	82	PF00069	0.413
MOD_Plk_4	224	230	PF00069	0.378
MOD_Plk_4	234	240	PF00069	0.299
MOD_Plk_4	42	48	PF00069	0.382
MOD_SUMO_for_1	190	193	PF00179	0.292
MOD_SUMO_rev_2	132	137	PF00179	0.343
TRG_DiLeu_BaEn_2	66	72	PF01217	0.262
TRG_ENDOCYTIC_2	209	212	PF00928	0.367
TRG_ENDOCYTIC_2	235	238	PF00928	0.413
TRG_ENDOCYTIC_2	4	7	PF00928	0.618
TRG_NES_CRM1_1	211	223	PF08389	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z0	Leptomonas seymouri	77%	100%
A0A0N0P500	Leptomonas seymouri	22%	74%
A0A0N1HVP1	Leptomonas seymouri	31%	86%
A0A0N1I4C8	Leptomonas seymouri	24%	76%
A0A0N1PCQ9	Leptomonas seymouri	31%	91%
A0A0S4IKH3	Bodo saltans	28%	77%
A0A0S4IPV6	Bodo saltans	62%	94%
A0A0S4J4R9	Bodo saltans	30%	80%
A0A0S4JA19	Bodo saltans	26%	80%
A0A0S4JCT1	Bodo saltans	26%	97%
A0A0S4JJN1	Bodo saltans	28%	100%
A0A0S4JRT1	Bodo saltans	30%	96%
A0A0S4JWH0	Bodo saltans	35%	100%
A0A1X0NJ83	Trypanosomatidae	38%	96%
A0A1X0NRI1	Trypanosomatidae	30%	73%
A0A1X0P9A2	Trypanosomatidae	66%	100%
A0A3Q8IE71	Leishmania donovani	27%	90%
A0A3Q8IIZ5	Leishmania donovani	100%	100%
A0A3Q8IV04	Leishmania donovani	37%	90%
A0A3R7KI60	Trypanosoma rangeli	34%	97%
A0A3R7N7B2	Trypanosoma rangeli	64%	100%
A0A3S7WUX8	Leishmania donovani	31%	83%
A0A3S7X4R5	Leishmania donovani	25%	78%
A0A3S7X4T7	Leishmania donovani	26%	78%
A0A422N418	Trypanosoma rangeli	29%	77%
A0A422NUW6	Trypanosoma rangeli	26%	95%
A0PJR5	Danio rerio	30%	92%
A0QJH8	Mycobacterium avium (strain 104)	28%	100%
A0QRD3	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	26%	86%
A0R4Q3	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	34%	100%
A1KN36	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	28%	100%
A2VDC2	Xenopus laevis	32%	69%
A4H9G6	Leishmania braziliensis	29%	83%
A4HHN0	Leishmania braziliensis	90%	100%
A4HJK5	Leishmania braziliensis	27%	100%
A4HM74	Leishmania braziliensis	36%	100%
A4HXT3	Leishmania infantum	31%	83%
A4I438	Leishmania infantum	27%	100%
A4I708	Leishmania infantum	25%	78%
A4I738	Leishmania infantum	26%	77%
A4YI89	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	45%	100%
A5JTM5	Pseudomonas sp. (strain CBS-3)	28%	99%
A5U753	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	28%	100%
A8ALR7	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	35%	100%
A9JS71	Xenopus laevis	29%	91%
A9MR28	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	34%	100%
A9MYJ5	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	36%	100%
B1IRE0	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	35%	100%
B1LFW9	Escherichia coli (strain SMS-3-5 / SECEC)	35%	100%
B4EY26	Proteus mirabilis (strain HI4320)	35%	100%
B4T6J5	Salmonella newport (strain SL254)	37%	100%
B4TIG9	Salmonella heidelberg (strain SL476)	36%	100%
B4TWR3	Salmonella schwarzengrund (strain CVM19633)	36%	100%
B5BL54	Salmonella paratyphi A (strain AKU_12601)	37%	100%
B5F749	Salmonella agona (strain SL483)	37%	100%
B5FHG4	Salmonella dublin (strain CT_02021853)	36%	100%
B5R1Q9	Salmonella enteritidis PT4 (strain P125109)	36%	100%
B5RGA4	Salmonella gallinarum (strain 287/91 / NCTC 13346)	36%	100%
C0Q4L2	Salmonella paratyphi C (strain RKS4594)	37%	100%
C9ZLJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
C9ZWP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	75%
D0A2C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	96%
E9ADK3	Leishmania major	26%	100%
E9AE93	Leishmania major	98%	100%
E9AEL3	Leishmania major	36%	100%
E9AHU0	Leishmania infantum	37%	90%
E9ALJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AM78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ARJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	83%
E9B226	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	78%
E9B233	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	79%
E9B5S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
F1LU71	Rattus norvegicus	37%	85%
F1NB38	Gallus gallus	27%	90%
F1R6N4	Danio rerio	25%	88%
F4JML5	Arabidopsis thaliana	37%	89%
F9XMX6	Zymoseptoria tritici (strain CBS 115943 / IPO323)	34%	87%
G4V4T7	Amycolatopsis orientalis	34%	100%
I6Y3U6	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	33%	100%
O07137	Mycobacterium leprae (strain TN)	51%	100%
O07533	Bacillus subtilis (strain 168)	29%	100%
O34893	Bacillus subtilis (strain 168)	43%	100%
O35459	Mus musculus	30%	82%
O53561	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	34%	100%
O69762	Pseudomonas fluorescens	23%	97%
O75521	Homo sapiens	24%	68%
O85078	Arthrobacter sp.	30%	97%
O87873	Thauera aromatica	27%	100%
P0ABU0	Escherichia coli (strain K12)	31%	94%
P0ABU1	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	31%	94%
P14604	Rattus norvegicus	52%	92%
P23965	Rattus norvegicus	24%	92%
P23966	Bacillus subtilis (strain 168)	31%	99%
P24162	Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)	32%	100%
P30084	Homo sapiens	49%	92%
P31551	Escherichia coli (strain K12)	35%	100%
P34559	Caenorhabditis elegans	52%	93%
P40802	Bacillus subtilis (strain 168)	25%	100%
P41942	Caenorhabditis elegans	26%	100%
P42125	Mus musculus	25%	92%
P42126	Homo sapiens	24%	88%
P44960	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	33%	94%
P52045	Escherichia coli (strain K12)	28%	100%
P52046	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	46%	100%
P53526	Mycobacterium leprae (strain TN)	34%	91%
P59395	Shigella flexneri	35%	100%
P64015	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	29%	100%
P64017	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	51%	100%
P76082	Escherichia coli (strain K12)	45%	100%
P77467	Escherichia coli (strain K12)	36%	100%
P94549	Bacillus subtilis (strain 168)	41%	100%
P95279	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	84%
P9WNN2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	28%	100%
P9WNN3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
P9WNN6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	33%	94%
P9WNN7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	33%	94%
P9WNN8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	51%	100%
P9WNN9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	51%	100%
P9WNP0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	100%
P9WNP1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
P9WNP4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	85%
P9WNP5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	85%
Q0AVM1	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	44%	100%
Q0S7P8	Rhodococcus jostii (strain RHA1)	32%	100%
Q0TLV3	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	35%	100%
Q13011	Homo sapiens	29%	81%
Q13825	Homo sapiens	37%	79%
Q1ZXF1	Dictyostelium discoideum	57%	96%
Q2HJ73	Bos taurus	31%	69%
Q2HJD5	Bos taurus	26%	87%
Q2TBT3	Bos taurus	36%	90%
Q3MIE0	Rattus norvegicus	32%	89%
Q3TLP5	Mus musculus	34%	90%
Q49WG8	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	33%	98%
Q4L549	Staphylococcus haemolyticus (strain JCSC1435)	34%	98%
Q4PEN0	Ustilago maydis (strain 521 / FGSC 9021)	33%	97%
Q4Q628	Leishmania major	27%	77%
Q4Q636	Leishmania major	24%	70%
Q4QDY4	Leishmania major	30%	83%
Q4WF54	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	37%	99%
Q50130	Mycobacterium leprae (strain TN)	28%	100%
Q52995	Rhizobium meliloti (strain 1021)	52%	100%
Q54HG7	Dictyostelium discoideum	33%	88%
Q54SS0	Dictyostelium discoideum	30%	91%
Q55GS6	Dictyostelium discoideum	30%	70%
Q57TJ1	Salmonella choleraesuis (strain SC-B67)	37%	100%
Q589W8	Alternaria alternata	29%	90%
Q58DM8	Bos taurus	51%	92%
Q58EB4	Danio rerio	32%	70%
Q5HH38	Staphylococcus aureus (strain COL)	34%	98%
Q5HQC3	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	33%	98%
Q5LLW6	Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)	32%	100%
Q5PIL1	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	37%	100%
Q5R646	Pongo abelii	50%	92%
Q5RFG0	Pongo abelii	29%	81%
Q5XIC0	Rattus norvegicus	23%	68%
Q62651	Rattus norvegicus	30%	82%
Q6GAG7	Staphylococcus aureus (strain MSSA476)	34%	98%
Q6GI37	Staphylococcus aureus (strain MRSA252)	34%	98%
Q6NL24	Arabidopsis thaliana	33%	100%
Q6NVY1	Homo sapiens	30%	69%
Q73VC7	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	29%	100%
Q78JN3	Mus musculus	27%	84%
Q7A6A9	Staphylococcus aureus (strain N315)	33%	98%
Q7CQ56	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	32%	94%
Q7TXE1	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	28%	100%
Q7U004	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	33%	94%
Q869N6	Dictyostelium discoideum	32%	89%
Q86YB7	Homo sapiens	37%	91%
Q8BH95	Mus musculus	52%	92%
Q8CPQ4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	33%	98%
Q8DR19	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	30%	100%
Q8DSN0	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	28%	100%
Q8FLA6	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	35%	100%
Q8GB17	Proteus sp. (strain LE138)	35%	100%
Q8GYN9	Arabidopsis thaliana	31%	79%
Q8NXA0	Staphylococcus aureus (strain MW2)	34%	98%
Q8QZS1	Mus musculus	30%	69%
Q8XA35	Escherichia coli O157:H7	35%	100%
Q8Z9L5	Salmonella typhi	37%	100%
Q8ZRX5	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	36%	100%
Q93TU6	Rhodococcus sp.	28%	100%
Q96DC8	Homo sapiens	31%	88%
Q96VB3	Alternaria alternata	29%	90%
Q99V48	Staphylococcus aureus (strain Mu50 / ATCC 700699)	33%	98%
Q9CLV5	Pasteurella multocida (strain Pm70)	32%	94%
Q9D7J9	Mus musculus	31%	89%
Q9D9V3	Mus musculus	28%	83%
Q9FHR8	Arabidopsis thaliana	34%	96%
Q9JLZ3	Mus musculus	37%	85%
Q9LCU3	Arthrobacter sp.	30%	97%
Q9P4U7	Alternaria alternata	29%	90%
Q9P4U9	Alternaria alternata	29%	90%
Q9SHJ8	Arabidopsis thaliana	27%	69%
Q9TM10	Cyanidium caldarium	33%	100%
Q9WUR2	Mus musculus	26%	68%
Q9XB60	Pectobacterium carotovorum subsp. carotovorum	27%	100%
V5B2L9	Trypanosoma cruzi	28%	68%
V5BK92	Trypanosoma cruzi	27%	92%
V5BNA5	Trypanosoma cruzi	35%	97%
V5BWB9	Trypanosoma cruzi	27%	73%
V5DTT7	Trypanosoma cruzi	64%	100%