Ubiquitin carboxyl-terminal hydrolase

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin hydrolase - putative

Species:

Leishmania infantum

UniProt:

A4I4U4_LEIIN

TriTrypDb:

LINF_290030700

Length:

748

Annotations

Annotations by Jardim et al.

Protein modification, ubiquitin hydrolase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 140, 590

Expansion

Sequence features

A4I4U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4U4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0016579	protein deubiquitination	6	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0070646	protein modification by small protein removal	5	12
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004843	cysteine-type deubiquitinase activity	5	12
GO:0005488	binding	1	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0008270	zinc ion binding	6	12
GO:0016787	hydrolase activity	2	12
GO:0019783	ubiquitin-like protein peptidase activity	4	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0101005	deubiquitinase activity	5	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.713
CLV_C14_Caspase3-7	425	429	PF00656	0.397
CLV_NRD_NRD_1	542	544	PF00675	0.309
CLV_PCSK_KEX2_1	542	544	PF00082	0.309
CLV_PCSK_SKI1_1	266	270	PF00082	0.460
CLV_PCSK_SKI1_1	329	333	PF00082	0.343
CLV_PCSK_SKI1_1	381	385	PF00082	0.309
CLV_PCSK_SKI1_1	565	569	PF00082	0.403
CLV_PCSK_SKI1_1	626	630	PF00082	0.326
CLV_PCSK_SKI1_1	681	685	PF00082	0.449
CLV_PCSK_SKI1_1	719	723	PF00082	0.343
DOC_CDC14_PxL_1	115	123	PF14671	0.517
DOC_CDC14_PxL_1	653	661	PF14671	0.316
DOC_CKS1_1	19	24	PF01111	0.433
DOC_CYCLIN_RxL_1	713	726	PF00134	0.350
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	466	472	PF00134	0.318
DOC_MAPK_DCC_7	114	123	PF00069	0.330
DOC_MAPK_FxFP_2	330	333	PF00069	0.303
DOC_MAPK_gen_1	38	48	PF00069	0.380
DOC_MAPK_gen_1	554	562	PF00069	0.343
DOC_MAPK_MEF2A_6	114	123	PF00069	0.383
DOC_MAPK_MEF2A_6	41	50	PF00069	0.380
DOC_MAPK_MEF2A_6	464	472	PF00069	0.440
DOC_PP1_RVXF_1	717	724	PF00149	0.352
DOC_PP2B_LxvP_1	466	469	PF13499	0.330
DOC_PP4_FxxP_1	330	333	PF00568	0.303
DOC_PP4_FxxP_1	644	647	PF00568	0.402
DOC_USP7_MATH_1	137	141	PF00917	0.749
DOC_USP7_MATH_1	290	294	PF00917	0.615
DOC_USP7_MATH_1	333	337	PF00917	0.422
DOC_USP7_MATH_1	476	480	PF00917	0.510
DOC_USP7_MATH_1	482	486	PF00917	0.478
DOC_USP7_MATH_1	494	498	PF00917	0.229
DOC_USP7_MATH_1	584	588	PF00917	0.430
DOC_USP7_MATH_1	611	615	PF00917	0.450
DOC_USP7_MATH_1	670	674	PF00917	0.378
DOC_USP7_UBL2_3	265	269	PF12436	0.473
DOC_USP7_UBL2_3	79	83	PF12436	0.579
DOC_WW_Pin1_4	162	167	PF00397	0.403
DOC_WW_Pin1_4	18	23	PF00397	0.537
DOC_WW_Pin1_4	292	297	PF00397	0.464
DOC_WW_Pin1_4	334	339	PF00397	0.444
DOC_WW_Pin1_4	504	509	PF00397	0.433
LIG_14-3-3_CanoR_1	455	461	PF00244	0.405
LIG_14-3-3_CanoR_1	493	499	PF00244	0.317
LIG_14-3-3_CanoR_1	529	534	PF00244	0.387
LIG_14-3-3_CanoR_1	542	546	PF00244	0.380
LIG_APCC_ABBAyCdc20_2	719	725	PF00400	0.343
LIG_BRCT_BRCA1_1	278	282	PF00533	0.490
LIG_BRCT_BRCA1_1	363	367	PF00533	0.324
LIG_BRCT_BRCA1_1	739	743	PF00533	0.332
LIG_Clathr_ClatBox_1	157	161	PF01394	0.404
LIG_FHA_1	353	359	PF00498	0.343
LIG_FHA_1	373	379	PF00498	0.368
LIG_FHA_1	691	697	PF00498	0.426
LIG_FHA_1	83	89	PF00498	0.638
LIG_FHA_2	171	177	PF00498	0.536
LIG_FHA_2	268	274	PF00498	0.457
LIG_FHA_2	301	307	PF00498	0.392
LIG_FHA_2	423	429	PF00498	0.309
LIG_FHA_2	542	548	PF00498	0.378
LIG_IBAR_NPY_1	346	348	PF08397	0.281
LIG_LIR_Apic_2	641	647	PF02991	0.402
LIG_LIR_Gen_1	283	292	PF02991	0.445
LIG_LIR_Gen_1	44	51	PF02991	0.402
LIG_LIR_Gen_1	557	567	PF02991	0.343
LIG_LIR_Gen_1	717	728	PF02991	0.312
LIG_LIR_Nem_3	124	129	PF02991	0.371
LIG_LIR_Nem_3	235	239	PF02991	0.484
LIG_LIR_Nem_3	283	287	PF02991	0.416
LIG_LIR_Nem_3	404	408	PF02991	0.311
LIG_LIR_Nem_3	521	527	PF02991	0.378
LIG_LIR_Nem_3	532	536	PF02991	0.250
LIG_LIR_Nem_3	557	562	PF02991	0.329
LIG_LIR_Nem_3	717	723	PF02991	0.319
LIG_LIR_Nem_3	90	96	PF02991	0.703
LIG_MLH1_MIPbox_1	739	743	PF16413	0.356
LIG_NRBOX	405	411	PF00104	0.402
LIG_Pex14_2	327	331	PF04695	0.309
LIG_PTB_Apo_2	307	314	PF02174	0.309
LIG_PTB_Apo_2	730	737	PF02174	0.402
LIG_PTB_Phospho_1	307	313	PF10480	0.309
LIG_REV1ctd_RIR_1	741	748	PF16727	0.507
LIG_SH2_CRK	126	130	PF00017	0.405
LIG_SH2_CRK	627	631	PF00017	0.368
LIG_SH2_CRK	74	78	PF00017	0.450
LIG_SH2_PTP2	559	562	PF00017	0.450
LIG_SH2_SRC	276	279	PF00017	0.499
LIG_SH2_SRC	559	562	PF00017	0.450
LIG_SH2_STAP1	102	106	PF00017	0.353
LIG_SH2_STAP1	278	282	PF00017	0.490
LIG_SH2_STAP1	690	694	PF00017	0.394
LIG_SH2_STAT3	278	281	PF00017	0.479
LIG_SH2_STAT3	387	390	PF00017	0.342
LIG_SH2_STAT3	742	745	PF00017	0.485
LIG_SH2_STAT5	237	240	PF00017	0.470
LIG_SH2_STAT5	313	316	PF00017	0.432
LIG_SH2_STAT5	35	38	PF00017	0.309
LIG_SH2_STAT5	405	408	PF00017	0.326
LIG_SH2_STAT5	458	461	PF00017	0.343
LIG_SH2_STAT5	47	50	PF00017	0.309
LIG_SH2_STAT5	525	528	PF00017	0.385
LIG_SH2_STAT5	540	543	PF00017	0.347
LIG_SH2_STAT5	545	548	PF00017	0.333
LIG_SH2_STAT5	559	562	PF00017	0.287
LIG_SH2_STAT5	642	645	PF00017	0.324
LIG_SH2_STAT5	708	711	PF00017	0.309
LIG_SH2_STAT5	74	77	PF00017	0.343
LIG_SH2_STAT5	742	745	PF00017	0.343
LIG_SH2_STAT5	93	96	PF00017	0.702
LIG_SH3_3	149	155	PF00018	0.468
LIG_SH3_3	166	172	PF00018	0.373
LIG_SH3_3	468	474	PF00018	0.328
LIG_SH3_3	557	563	PF00018	0.358
LIG_SH3_3	578	584	PF00018	0.348
LIG_SH3_3	597	603	PF00018	0.464
LIG_SH3_3	674	680	PF00018	0.466
LIG_SH3_3	93	99	PF00018	0.544
LIG_SUMO_SIM_anti_2	608	614	PF11976	0.402
LIG_SUMO_SIM_par_1	611	617	PF11976	0.450
LIG_TRAF2_1	603	606	PF00917	0.450
LIG_TRAF2_2	603	608	PF00917	0.394
LIG_TYR_ITIM	91	96	PF00017	0.704
MOD_CK1_1	421	427	PF00069	0.437
MOD_CK1_1	586	592	PF00069	0.397
MOD_CK1_1	614	620	PF00069	0.413
MOD_CK1_1	673	679	PF00069	0.397
MOD_CK1_1	702	708	PF00069	0.324
MOD_CK1_1	737	743	PF00069	0.444
MOD_CK2_1	267	273	PF00069	0.455
MOD_CK2_1	300	306	PF00069	0.342
MOD_CK2_1	482	488	PF00069	0.334
MOD_CK2_1	506	512	PF00069	0.370
MOD_GlcNHglycan	126	129	PF01048	0.498
MOD_GlcNHglycan	139	142	PF01048	0.636
MOD_GlcNHglycan	16	19	PF01048	0.476
MOD_GlcNHglycan	363	366	PF01048	0.310
MOD_GlcNHglycan	421	424	PF01048	0.449
MOD_GlcNHglycan	425	428	PF01048	0.452
MOD_GlcNHglycan	508	511	PF01048	0.347
MOD_GlcNHglycan	520	523	PF01048	0.325
MOD_GlcNHglycan	586	589	PF01048	0.411
MOD_GlcNHglycan	672	675	PF01048	0.299
MOD_GlcNHglycan	677	680	PF01048	0.307
MOD_GlcNHglycan	701	704	PF01048	0.329
MOD_GSK3_1	14	21	PF00069	0.547
MOD_GSK3_1	260	267	PF00069	0.451
MOD_GSK3_1	290	297	PF00069	0.624
MOD_GSK3_1	361	368	PF00069	0.320
MOD_GSK3_1	418	425	PF00069	0.460
MOD_GSK3_1	525	532	PF00069	0.359
MOD_GSK3_1	546	553	PF00069	0.441
MOD_GSK3_1	583	590	PF00069	0.324
MOD_GSK3_1	668	675	PF00069	0.433
MOD_GSK3_1	686	693	PF00069	0.426
MOD_N-GLC_1	419	424	PF02516	0.388
MOD_N-GLC_2	310	312	PF02516	0.309
MOD_NEK2_1	191	196	PF00069	0.470
MOD_NEK2_1	419	424	PF00069	0.342
MOD_NEK2_1	448	453	PF00069	0.517
MOD_NEK2_1	546	551	PF00069	0.462
MOD_NEK2_1	629	634	PF00069	0.362
MOD_NEK2_1	699	704	PF00069	0.376
MOD_NEK2_2	24	29	PF00069	0.410
MOD_NEK2_2	36	41	PF00069	0.309
MOD_OFUCOSY	33	40	PF10250	0.324
MOD_PIKK_1	277	283	PF00454	0.447
MOD_PIKK_1	3	9	PF00454	0.476
MOD_PIKK_1	668	674	PF00454	0.488
MOD_PIKK_1	728	734	PF00454	0.450
MOD_PKA_2	456	462	PF00069	0.366
MOD_PKA_2	494	500	PF00069	0.368
MOD_PKA_2	541	547	PF00069	0.455
MOD_PKA_2	571	577	PF00069	0.380
MOD_Plk_1	690	696	PF00069	0.312
MOD_Plk_2-3	176	182	PF00069	0.525
MOD_Plk_4	313	319	PF00069	0.343
MOD_Plk_4	611	617	PF00069	0.375
MOD_Plk_4	737	743	PF00069	0.406
MOD_ProDKin_1	162	168	PF00069	0.414
MOD_ProDKin_1	18	24	PF00069	0.450
MOD_ProDKin_1	292	298	PF00069	0.459
MOD_ProDKin_1	334	340	PF00069	0.444
MOD_ProDKin_1	504	510	PF00069	0.433
MOD_SUMO_rev_2	651	656	PF00179	0.394
MOD_SUMO_rev_2	84	91	PF00179	0.649
TRG_ENDOCYTIC_2	126	129	PF00928	0.370
TRG_ENDOCYTIC_2	47	50	PF00928	0.450
TRG_ENDOCYTIC_2	524	527	PF00928	0.394
TRG_ENDOCYTIC_2	545	548	PF00928	0.450
TRG_ENDOCYTIC_2	559	562	PF00928	0.450
TRG_ENDOCYTIC_2	627	630	PF00928	0.369
TRG_ENDOCYTIC_2	74	77	PF00928	0.343
TRG_ENDOCYTIC_2	93	96	PF00928	0.702
TRG_ER_diArg_1	455	458	PF00400	0.468
TRG_ER_diArg_1	492	495	PF00400	0.428
TRG_ER_diArg_1	541	543	PF00400	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2C0	Leptomonas seymouri	74%	100%
A0A0S4IPD1	Bodo saltans	46%	100%
A0A1X0PA40	Trypanosomatidae	55%	100%
A0A3Q8IDW9	Leishmania donovani	100%	100%
A0A422NEJ9	Trypanosoma rangeli	55%	100%
A4HHM9	Leishmania braziliensis	84%	100%
C9ZLJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E1BMF7	Bos taurus	30%	87%
E1BY77	Gallus gallus	29%	87%
E9AE92	Leishmania major	95%	100%
E9ALJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
F1QFS9	Danio rerio	29%	87%
F6V6I0	Xenopus tropicalis	29%	88%
P0C8Z3	Bos taurus	21%	100%
P38237	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	96%
P45974	Homo sapiens	32%	87%
P54201	Dictyostelium discoideum	28%	89%
P56399	Mus musculus	32%	87%
Q11119	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	97%
Q5BKP2	Mus musculus	29%	87%
Q5R407	Pongo abelii	32%	87%
Q6DCJ1	Xenopus laevis	22%	100%
Q8L6Y1	Arabidopsis thaliana	30%	94%
Q92995	Homo sapiens	29%	87%
V5BC27	Trypanosoma cruzi	55%	100%