Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acyltransferase - putative

Species:

Leishmania infantum

UniProt:

A4I4U1_LEIIN

TriTrypDb:

LINF_290030400

Length:

324

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 45

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	26
GO:0110165	cellular anatomical entity	1	26

Expansion

Sequence features

A4I4U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4U1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	5
GO:0006644	phospholipid metabolic process	4	5
GO:0006650	glycerophospholipid metabolic process	5	5
GO:0006654	phosphatidic acid biosynthetic process	6	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0008610	lipid biosynthetic process	4	5
GO:0008654	phospholipid biosynthetic process	5	5
GO:0009058	biosynthetic process	2	5
GO:0009987	cellular process	1	5
GO:0019637	organophosphate metabolic process	3	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044255	cellular lipid metabolic process	3	5
GO:0045017	glycerolipid biosynthetic process	4	5
GO:0046473	phosphatidic acid metabolic process	6	5
GO:0046474	glycerophospholipid biosynthetic process	5	5
GO:0046486	glycerolipid metabolic process	4	5
GO:0071704	organic substance metabolic process	2	5
GO:0090407	organophosphate biosynthetic process	4	5
GO:1901576	organic substance biosynthetic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	34
GO:0016740	transferase activity	2	34
GO:0016746	acyltransferase activity	3	34
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	7	9
GO:0008374	O-acyltransferase activity	5	9
GO:0016411	acylglycerol O-acyltransferase activity	6	9
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	9
GO:0042171	lysophosphatidic acid acyltransferase activity	6	9
GO:0071617	lysophospholipid acyltransferase activity	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	313	315	PF00675	0.755
CLV_PCSK_FUR_1	311	315	PF00082	0.616
CLV_PCSK_KEX2_1	292	294	PF00082	0.604
CLV_PCSK_KEX2_1	313	315	PF00082	0.794
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.606
CLV_PCSK_SKI1_1	135	139	PF00082	0.500
CLV_PCSK_SKI1_1	218	222	PF00082	0.493
DOC_ANK_TNKS_1	313	320	PF00023	0.381
DOC_CYCLIN_RxL_1	189	199	PF00134	0.220
DOC_MAPK_gen_1	189	196	PF00069	0.299
DOC_MAPK_HePTP_8	28	40	PF00069	0.453
DOC_MAPK_MEF2A_6	139	147	PF00069	0.301
DOC_MAPK_MEF2A_6	31	40	PF00069	0.444
DOC_PP1_RVXF_1	190	197	PF00149	0.332
DOC_PP1_RVXF_1	29	35	PF00149	0.476
DOC_PP1_RVXF_1	48	55	PF00149	0.208
DOC_PP1_RVXF_1	73	80	PF00149	0.312
DOC_PP2B_LxvP_1	143	146	PF13499	0.329
DOC_USP7_MATH_1	108	112	PF00917	0.301
DOC_WW_Pin1_4	202	207	PF00397	0.265
LIG_14-3-3_CanoR_1	23	28	PF00244	0.532
LIG_14-3-3_CanoR_1	31	37	PF00244	0.474
LIG_14-3-3_CanoR_1	50	55	PF00244	0.260
LIG_Actin_WH2_2	123	141	PF00022	0.363
LIG_AP2alpha_2	118	120	PF02296	0.327
LIG_BRCT_BRCA1_1	166	170	PF00533	0.309
LIG_BRCT_BRCA1_1	192	196	PF00533	0.332
LIG_CSL_BTD_1	238	241	PF09270	0.366
LIG_DCNL_PONY_1	1	4	PF03556	0.322
LIG_FHA_1	203	209	PF00498	0.309
LIG_FHA_1	56	62	PF00498	0.335
LIG_GBD_Chelix_1	272	280	PF00786	0.556
LIG_Integrin_isoDGR_2	133	135	PF01839	0.388
LIG_LIR_Gen_1	252	262	PF02991	0.371
LIG_LIR_Gen_1	98	109	PF02991	0.308
LIG_LIR_Nem_3	115	120	PF02991	0.286
LIG_LIR_Nem_3	216	220	PF02991	0.272
LIG_LIR_Nem_3	252	257	PF02991	0.350
LIG_LIR_Nem_3	53	57	PF02991	0.412
LIG_LIR_Nem_3	7	12	PF02991	0.464
LIG_NRBOX	24	30	PF00104	0.625
LIG_Pex14_2	117	121	PF04695	0.252
LIG_Pex14_2	158	162	PF04695	0.287
LIG_Pex14_2	79	83	PF04695	0.342
LIG_SH2_PTP2	254	257	PF00017	0.384
LIG_SH2_SRC	254	257	PF00017	0.348
LIG_SH2_STAP1	128	132	PF00017	0.301
LIG_SH2_STAP1	57	61	PF00017	0.367
LIG_SH2_STAT5	157	160	PF00017	0.254
LIG_SH2_STAT5	161	164	PF00017	0.255
LIG_SH2_STAT5	229	232	PF00017	0.293
LIG_SH2_STAT5	254	257	PF00017	0.327
LIG_SH2_STAT5	57	60	PF00017	0.371
LIG_SH2_STAT5	82	85	PF00017	0.332
LIG_SH3_1	244	250	PF00018	0.338
LIG_SH3_3	235	241	PF00018	0.298
LIG_SH3_3	244	250	PF00018	0.313
LIG_SH3_3	5	11	PF00018	0.480
LIG_SH3_3	90	96	PF00018	0.391
LIG_SUMO_SIM_anti_2	26	31	PF11976	0.522
LIG_TRAF2_1	264	267	PF00917	0.423
LIG_TYR_ITIM	126	131	PF00017	0.315
LIG_WRC_WIRS_1	214	219	PF05994	0.279
LIG_WRC_WIRS_1	51	56	PF05994	0.318
MOD_CK1_1	163	169	PF00069	0.306
MOD_CK1_1	216	222	PF00069	0.301
MOD_CK1_1	271	277	PF00069	0.395
MOD_Cter_Amidation	290	293	PF01082	0.604
MOD_Cter_Amidation	311	314	PF01082	0.793
MOD_GlcNHglycan	164	169	PF01048	0.570
MOD_GlcNHglycan	83	86	PF01048	0.569
MOD_GSK3_1	108	115	PF00069	0.282
MOD_GSK3_1	133	140	PF00069	0.301
MOD_GSK3_1	160	167	PF00069	0.269
MOD_GSK3_1	95	102	PF00069	0.355
MOD_LATS_1	21	27	PF00433	0.430
MOD_N-GLC_1	202	207	PF02516	0.465
MOD_NEK2_1	121	126	PF00069	0.263
MOD_NEK2_1	137	142	PF00069	0.304
MOD_NEK2_1	4	9	PF00069	0.387
MOD_NEK2_1	55	60	PF00069	0.408
MOD_NEK2_2	108	113	PF00069	0.282
MOD_PK_1	23	29	PF00069	0.431
MOD_Plk_4	112	118	PF00069	0.268
MOD_Plk_4	121	127	PF00069	0.275
MOD_Plk_4	138	144	PF00069	0.252
MOD_Plk_4	216	222	PF00069	0.313
MOD_Plk_4	23	29	PF00069	0.566
MOD_Plk_4	99	105	PF00069	0.339
MOD_ProDKin_1	202	208	PF00069	0.265
TRG_ENDOCYTIC_2	101	104	PF00928	0.328
TRG_ENDOCYTIC_2	128	131	PF00928	0.337
TRG_ENDOCYTIC_2	13	16	PF00928	0.363
TRG_ENDOCYTIC_2	157	160	PF00928	0.222
TRG_ENDOCYTIC_2	228	231	PF00928	0.276
TRG_ENDOCYTIC_2	254	257	PF00928	0.341
TRG_ER_diArg_1	311	314	PF00400	0.582
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.777

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P455	Leptomonas seymouri	35%	95%
A0A0N0P6B0	Leptomonas seymouri	26%	100%
A0A0N1HTP4	Leptomonas seymouri	31%	100%
A0A0N1I6V1	Leptomonas seymouri	59%	100%
A0A0N1IKX5	Leptomonas seymouri	51%	100%
A0A0S4IQ05	Bodo saltans	37%	96%
A0A0S4IR22	Bodo saltans	35%	100%
A0A0S4JRB2	Bodo saltans	33%	100%
A0A0S4JRP7	Bodo saltans	21%	100%
A0A1X0P9F0	Trypanosomatidae	41%	100%
A0A3Q8IFY7	Leishmania donovani	24%	100%
A0A3R7NKA0	Trypanosoma rangeli	41%	100%
A0A3S5H5E4	Leishmania donovani	30%	75%
A0A3S5H7L8	Leishmania donovani	65%	100%
A0A3S7WNW6	Leishmania donovani	32%	91%
A4H418	Leishmania braziliensis	36%	100%
A4H419	Leishmania braziliensis	32%	100%
A4HHM7	Leishmania braziliensis	48%	100%
A4HKI5	Leishmania braziliensis	23%	100%
A4HSA1	Leishmania infantum	30%	100%
A4HSA2	Leishmania infantum	31%	100%
A4I4U2	Leishmania infantum	58%	100%
A4I816	Leishmania infantum	24%	100%
C9ZLI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AE89	Leishmania major	92%	100%
E9AE90	Leishmania major	58%	100%
E9ALJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9B2X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q582	Leishmania major	23%	100%
Q9NF90	Leishmania major	33%	100%
Q9NF91	Leishmania major	30%	100%
V5C201	Trypanosoma cruzi	39%	100%