DNA replication complex GINS protein SLD5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication complex GINS protein SLD5 - putative

Species:

Leishmania infantum

UniProt:

A4I4U0_LEIIN

TriTrypDb:

LINF_290030300

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0000811	GINS complex	4	1
GO:0031261	DNA replication preinitiation complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4I4U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4U0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	12
GO:0006261	DNA-templated DNA replication	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.383
CLV_PCSK_KEX2_1	123	125	PF00082	0.528
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.583
CLV_PCSK_SKI1_1	129	133	PF00082	0.575
CLV_PCSK_SKI1_1	225	229	PF00082	0.432
CLV_Separin_Metazoa	153	157	PF03568	0.346
DEG_APCC_DBOX_1	155	163	PF00400	0.355
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DOC_CKS1_1	301	306	PF01111	0.519
DOC_MAPK_MEF2A_6	135	144	PF00069	0.451
DOC_PP1_RVXF_1	144	150	PF00149	0.450
DOC_PP4_FxxP_1	301	304	PF00568	0.453
DOC_USP7_MATH_1	127	131	PF00917	0.554
DOC_USP7_MATH_1	194	198	PF00917	0.642
DOC_USP7_MATH_1	251	255	PF00917	0.616
DOC_USP7_MATH_1	40	44	PF00917	0.665
DOC_USP7_MATH_1	58	62	PF00917	0.630
DOC_WW_Pin1_4	300	305	PF00397	0.519
DOC_WW_Pin1_4	87	92	PF00397	0.503
LIG_14-3-3_CanoR_1	212	218	PF00244	0.422
LIG_14-3-3_CanoR_1	225	235	PF00244	0.455
LIG_Actin_WH2_2	144	162	PF00022	0.466
LIG_BRCT_BRCA1_1	45	49	PF00533	0.709
LIG_FHA_1	46	52	PF00498	0.728
LIG_FHA_2	82	88	PF00498	0.400
LIG_LIR_Apic_2	299	304	PF02991	0.453
LIG_LIR_Gen_1	10	19	PF02991	0.632
LIG_LIR_Gen_1	303	313	PF02991	0.530
LIG_LIR_Nem_3	10	16	PF02991	0.703
LIG_LIR_Nem_3	168	174	PF02991	0.514
LIG_LIR_Nem_3	303	308	PF02991	0.539
LIG_NRBOX	150	156	PF00104	0.366
LIG_PCNA_yPIPBox_3	110	119	PF02747	0.566
LIG_SH2_GRB2like	305	308	PF00017	0.530
LIG_SH2_STAP1	13	17	PF00017	0.635
LIG_SH2_STAT5	248	251	PF00017	0.587
LIG_SH2_STAT5	270	273	PF00017	0.453
LIG_SH2_STAT5	311	314	PF00017	0.464
LIG_SH3_3	130	136	PF00018	0.482
LIG_SH3_3	20	26	PF00018	0.653
LIG_SH3_3	204	210	PF00018	0.593
LIG_SH3_3	247	253	PF00018	0.416
LIG_SH3_3	52	58	PF00018	0.725
LIG_TYR_ITIM	169	174	PF00017	0.518
LIG_WRPW_2	308	311	PF00400	0.464
MOD_CK1_1	179	185	PF00069	0.508
MOD_CK1_1	28	34	PF00069	0.709
MOD_CK1_1	43	49	PF00069	0.727
MOD_CK1_1	71	77	PF00069	0.351
MOD_CK2_1	213	219	PF00069	0.394
MOD_CK2_1	251	257	PF00069	0.627
MOD_CK2_1	81	87	PF00069	0.400
MOD_GlcNHglycan	196	199	PF01048	0.677
MOD_GlcNHglycan	228	231	PF01048	0.488
MOD_GlcNHglycan	236	239	PF01048	0.415
MOD_GlcNHglycan	313	316	PF01048	0.339
MOD_GlcNHglycan	36	39	PF01048	0.640
MOD_GlcNHglycan	42	45	PF01048	0.616
MOD_GlcNHglycan	60	63	PF01048	0.665
MOD_GlcNHglycan	70	73	PF01048	0.446
MOD_GSK3_1	177	184	PF00069	0.546
MOD_GSK3_1	234	241	PF00069	0.497
MOD_GSK3_1	34	41	PF00069	0.691
MOD_GSK3_1	66	73	PF00069	0.510
MOD_GSK3_1	96	103	PF00069	0.530
MOD_N-GLC_1	213	218	PF02516	0.521
MOD_N-GLC_1	7	12	PF02516	0.687
MOD_NEK2_1	165	170	PF00069	0.368
MOD_NEK2_1	181	186	PF00069	0.507
MOD_NEK2_1	226	231	PF00069	0.538
MOD_NEK2_1	234	239	PF00069	0.422
MOD_PIKK_1	108	114	PF00454	0.522
MOD_PIKK_1	179	185	PF00454	0.499
MOD_PIKK_1	25	31	PF00454	0.708
MOD_PIKK_1	66	72	PF00454	0.608
MOD_PKA_2	134	140	PF00069	0.462
MOD_Plk_1	127	133	PF00069	0.435
MOD_Plk_1	213	219	PF00069	0.463
MOD_Plk_4	100	106	PF00069	0.472
MOD_Plk_4	12	18	PF00069	0.675
MOD_Plk_4	165	171	PF00069	0.407
MOD_ProDKin_1	300	306	PF00069	0.519
MOD_ProDKin_1	87	93	PF00069	0.501
TRG_DiLeu_BaEn_1	12	17	PF01217	0.672
TRG_ENDOCYTIC_2	13	16	PF00928	0.714
TRG_ENDOCYTIC_2	171	174	PF00928	0.526
TRG_ENDOCYTIC_2	305	308	PF00928	0.453
TRG_ER_diArg_1	155	158	PF00400	0.346
TRG_NES_CRM1_1	266	278	PF08389	0.493
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I580	Leptomonas seymouri	61%	100%
A0A0S4IV76	Bodo saltans	39%	100%
A0A1X0PA08	Trypanosomatidae	41%	100%
A0A3R7MDL7	Trypanosoma rangeli	43%	100%
A0A3S7X2T6	Leishmania donovani	100%	100%
A4HHM6	Leishmania braziliensis	79%	100%
C9ZLI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AE88	Leishmania major	96%	100%
E9ALJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q6CKF3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	28%	100%
Q9BRT9	Homo sapiens	23%	100%
V5DTT2	Trypanosoma cruzi	45%	100%