Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SAM domain (Sterile alpha motif) - putative

Species:

Leishmania infantum

UniProt:

A4I4T9_LEIIN

TriTrypDb:

LINF_290034100

Length:

1237

Annotations

Annotations by Jardim et al.

Mitochondrial protein, outer mitochondrial membrane proteome 24 (POMP24)Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	4
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	4

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I4T9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4T9

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1106	1110	PF00656	0.658
CLV_C14_Caspase3-7	1186	1190	PF00656	0.773
CLV_C14_Caspase3-7	248	252	PF00656	0.478
CLV_C14_Caspase3-7	423	427	PF00656	0.744
CLV_C14_Caspase3-7	509	513	PF00656	0.708
CLV_C14_Caspase3-7	551	555	PF00656	0.599
CLV_C14_Caspase3-7	797	801	PF00656	0.692
CLV_NRD_NRD_1	1056	1058	PF00675	0.409
CLV_NRD_NRD_1	1095	1097	PF00675	0.462
CLV_NRD_NRD_1	127	129	PF00675	0.557

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Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J6	Leptomonas seymouri	43%	99%
A0A1X0P9W2	Trypanosomatidae	25%	76%
A0A3Q8IBP4	Leishmania donovani	99%	100%
A0A3R7MCK0	Trypanosoma rangeli	24%	77%
A4HHR1	Leishmania braziliensis	65%	100%
C9ZKY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	75%
E9AEC5	Leishmania major	90%	100%
E9ALG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5C230	Trypanosoma cruzi	24%	78%

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