LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
SAM domain (Sterile alpha motif) - putative
Species:
Leishmania infantum
UniProt:
A4I4T9_LEIIN
TriTrypDb:
LINF_290034100
Length:
1237

Annotations

Annotations by Jardim et al.

Mitochondrial protein, outer mitochondrial membrane proteome 24 (POMP24)Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 4
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 4

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I4T9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4T9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1106 1110 PF00656 0.658
CLV_C14_Caspase3-7 1186 1190 PF00656 0.773
CLV_C14_Caspase3-7 248 252 PF00656 0.478
CLV_C14_Caspase3-7 423 427 PF00656 0.744
CLV_C14_Caspase3-7 509 513 PF00656 0.708
CLV_C14_Caspase3-7 551 555 PF00656 0.599
CLV_C14_Caspase3-7 797 801 PF00656 0.692
CLV_NRD_NRD_1 1056 1058 PF00675 0.409
CLV_NRD_NRD_1 1095 1097 PF00675 0.462
CLV_NRD_NRD_1 127 129 PF00675 0.557
CLV_NRD_NRD_1 300 302 PF00675 0.357
CLV_NRD_NRD_1 35 37 PF00675 0.404
CLV_NRD_NRD_1 579 581 PF00675 0.395
CLV_NRD_NRD_1 643 645 PF00675 0.406
CLV_NRD_NRD_1 882 884 PF00675 0.417
CLV_NRD_NRD_1 919 921 PF00675 0.427
CLV_PCSK_KEX2_1 1056 1058 PF00082 0.434
CLV_PCSK_KEX2_1 1094 1096 PF00082 0.454
CLV_PCSK_KEX2_1 127 129 PF00082 0.559
CLV_PCSK_KEX2_1 282 284 PF00082 0.370
CLV_PCSK_KEX2_1 300 302 PF00082 0.281
CLV_PCSK_KEX2_1 35 37 PF00082 0.402
CLV_PCSK_KEX2_1 364 366 PF00082 0.408
CLV_PCSK_KEX2_1 543 545 PF00082 0.522
CLV_PCSK_KEX2_1 643 645 PF00082 0.388
CLV_PCSK_KEX2_1 882 884 PF00082 0.444
CLV_PCSK_KEX2_1 919 921 PF00082 0.427
CLV_PCSK_PC1ET2_1 1094 1096 PF00082 0.454
CLV_PCSK_PC1ET2_1 282 284 PF00082 0.404
CLV_PCSK_PC1ET2_1 364 366 PF00082 0.363
CLV_PCSK_PC1ET2_1 543 545 PF00082 0.522
CLV_PCSK_PC7_1 123 129 PF00082 0.551
CLV_PCSK_SKI1_1 101 105 PF00082 0.378
CLV_PCSK_SKI1_1 282 286 PF00082 0.429
CLV_PCSK_SKI1_1 315 319 PF00082 0.419
CLV_PCSK_SKI1_1 336 340 PF00082 0.342
CLV_PCSK_SKI1_1 489 493 PF00082 0.422
CLV_PCSK_SKI1_1 496 500 PF00082 0.387
CLV_PCSK_SKI1_1 630 634 PF00082 0.455
CLV_PCSK_SKI1_1 643 647 PF00082 0.265
CLV_PCSK_SKI1_1 840 844 PF00082 0.483
CLV_Separin_Metazoa 690 694 PF03568 0.620
DEG_APCC_DBOX_1 100 108 PF00400 0.513
DEG_APCC_DBOX_1 335 343 PF00400 0.638
DEG_APCC_DBOX_1 495 503 PF00400 0.474
DEG_APCC_DBOX_1 775 783 PF00400 0.654
DEG_APCC_DBOX_1 918 926 PF00400 0.574
DEG_MDM2_SWIB_1 148 155 PF02201 0.586
DOC_ANK_TNKS_1 73 80 PF00023 0.614
DOC_ANK_TNKS_1 881 888 PF00023 0.620
DOC_CYCLIN_RxL_1 1021 1032 PF00134 0.624
DOC_CYCLIN_RxL_1 1036 1046 PF00134 0.617
DOC_MAPK_gen_1 580 587 PF00069 0.614
DOC_MAPK_MEF2A_6 580 587 PF00069 0.582
DOC_MAPK_MEF2A_6 693 702 PF00069 0.580
DOC_MAPK_MEF2A_6 919 926 PF00069 0.564
DOC_PP1_RVXF_1 956 962 PF00149 0.582
DOC_PP2B_LxvP_1 1085 1088 PF13499 0.642
DOC_PP2B_LxvP_1 611 614 PF13499 0.587
DOC_PP4_MxPP_1 1 4 PF00568 0.490
DOC_USP7_MATH_1 1029 1033 PF00917 0.598
DOC_USP7_MATH_1 1165 1169 PF00917 0.787
DOC_USP7_MATH_1 334 338 PF00917 0.587
DOC_USP7_MATH_1 358 362 PF00917 0.589
DOC_USP7_MATH_1 373 377 PF00917 0.496
DOC_USP7_MATH_1 4 8 PF00917 0.487
DOC_USP7_MATH_1 709 713 PF00917 0.677
DOC_USP7_MATH_1 801 805 PF00917 0.716
DOC_USP7_MATH_1 864 868 PF00917 0.709
DOC_USP7_UBL2_3 992 996 PF12436 0.653
DOC_WW_Pin1_4 1176 1181 PF00397 0.749
DOC_WW_Pin1_4 118 123 PF00397 0.696
DOC_WW_Pin1_4 130 135 PF00397 0.686
DOC_WW_Pin1_4 164 169 PF00397 0.626
DOC_WW_Pin1_4 256 261 PF00397 0.604
DOC_WW_Pin1_4 42 47 PF00397 0.694
DOC_WW_Pin1_4 479 484 PF00397 0.546
DOC_WW_Pin1_4 733 738 PF00397 0.588
DOC_WW_Pin1_4 840 845 PF00397 0.654
LIG_14-3-3_CanoR_1 127 133 PF00244 0.752
LIG_14-3-3_CanoR_1 336 345 PF00244 0.575
LIG_14-3-3_CanoR_1 643 651 PF00244 0.640
LIG_14-3-3_CanoR_1 774 783 PF00244 0.593
LIG_14-3-3_CanoR_1 84 92 PF00244 0.623
LIG_14-3-3_CanoR_1 919 923 PF00244 0.538
LIG_14-3-3_CanoR_1 972 981 PF00244 0.593
LIG_Actin_WH2_2 270 288 PF00022 0.619
LIG_Actin_WH2_2 380 397 PF00022 0.585
LIG_Actin_WH2_2 967 984 PF00022 0.647
LIG_BRCT_BRCA1_1 447 451 PF00533 0.609
LIG_BRCT_BRCA1_1 628 632 PF00533 0.627
LIG_BRCT_BRCA1_1 647 651 PF00533 0.419
LIG_CORNRBOX 393 401 PF00104 0.545
LIG_FHA_1 134 140 PF00498 0.724
LIG_FHA_1 156 162 PF00498 0.642
LIG_FHA_1 177 183 PF00498 0.592
LIG_FHA_1 25 31 PF00498 0.371
LIG_FHA_1 462 468 PF00498 0.617
LIG_FHA_1 47 53 PF00498 0.610
LIG_FHA_1 493 499 PF00498 0.580
LIG_FHA_1 607 613 PF00498 0.599
LIG_FHA_1 634 640 PF00498 0.601
LIG_FHA_1 819 825 PF00498 0.618
LIG_FHA_1 866 872 PF00498 0.505
LIG_FHA_1 910 916 PF00498 0.613
LIG_FHA_1 945 951 PF00498 0.582
LIG_FHA_1 966 972 PF00498 0.552
LIG_FHA_2 1012 1018 PF00498 0.622
LIG_FHA_2 1035 1041 PF00498 0.584
LIG_FHA_2 1067 1073 PF00498 0.782
LIG_FHA_2 1123 1129 PF00498 0.625
LIG_FHA_2 179 185 PF00498 0.626
LIG_FHA_2 188 194 PF00498 0.526
LIG_FHA_2 339 345 PF00498 0.585
LIG_FHA_2 436 442 PF00498 0.632
LIG_FHA_2 537 543 PF00498 0.721
LIG_FHA_2 549 555 PF00498 0.688
LIG_FHA_2 574 580 PF00498 0.670
LIG_FHA_2 684 690 PF00498 0.593
LIG_FHA_2 745 751 PF00498 0.598
LIG_FHA_2 84 90 PF00498 0.596
LIG_FHA_2 934 940 PF00498 0.650
LIG_LIR_Gen_1 1020 1029 PF02991 0.610
LIG_LIR_Gen_1 184 191 PF02991 0.605
LIG_LIR_Gen_1 251 260 PF02991 0.515
LIG_LIR_Gen_1 269 278 PF02991 0.517
LIG_LIR_Gen_1 304 311 PF02991 0.488
LIG_LIR_Gen_1 561 572 PF02991 0.534
LIG_LIR_Gen_1 629 639 PF02991 0.548
LIG_LIR_Gen_1 648 657 PF02991 0.554
LIG_LIR_Gen_1 674 684 PF02991 0.650
LIG_LIR_Nem_3 1017 1022 PF02991 0.621
LIG_LIR_Nem_3 149 155 PF02991 0.565
LIG_LIR_Nem_3 184 189 PF02991 0.601
LIG_LIR_Nem_3 251 256 PF02991 0.513
LIG_LIR_Nem_3 269 273 PF02991 0.526
LIG_LIR_Nem_3 27 31 PF02991 0.329
LIG_LIR_Nem_3 304 310 PF02991 0.585
LIG_LIR_Nem_3 561 567 PF02991 0.523
LIG_LIR_Nem_3 629 635 PF02991 0.559
LIG_LIR_Nem_3 648 654 PF02991 0.552
LIG_LIR_Nem_3 674 680 PF02991 0.646
LIG_LIR_Nem_3 89 95 PF02991 0.454
LIG_NRBOX 1114 1120 PF00104 0.652
LIG_PCNA_yPIPBox_3 485 496 PF02747 0.608
LIG_PCNA_yPIPBox_3 693 703 PF02747 0.583
LIG_PCNA_yPIPBox_3 996 1009 PF02747 0.635
LIG_PDZ_Class_1 1232 1237 PF00595 0.713
LIG_Pex14_2 148 152 PF04695 0.586
LIG_Pex14_2 307 311 PF04695 0.466
LIG_SH2_CRK 92 96 PF00017 0.454
LIG_SH2_STAP1 1220 1224 PF00017 0.698
LIG_SH2_STAT3 556 559 PF00017 0.502
LIG_SH2_STAT5 1022 1025 PF00017 0.584
LIG_SH2_STAT5 178 181 PF00017 0.622
LIG_SH2_STAT5 556 559 PF00017 0.533
LIG_SH3_1 1056 1062 PF00018 0.642
LIG_SH3_2 844 849 PF14604 0.625
LIG_SH3_3 1056 1062 PF00018 0.698
LIG_SH3_3 1179 1185 PF00018 0.717
LIG_SH3_3 136 142 PF00018 0.680
LIG_SH3_3 206 212 PF00018 0.686
LIG_SH3_3 339 345 PF00018 0.641
LIG_SH3_3 477 483 PF00018 0.610
LIG_SH3_3 841 847 PF00018 0.631
LIG_SH3_3 868 874 PF00018 0.493
LIG_SUMO_SIM_anti_2 1040 1046 PF11976 0.597
LIG_SUMO_SIM_anti_2 113 119 PF11976 0.643
LIG_SUMO_SIM_anti_2 383 388 PF11976 0.548
LIG_SUMO_SIM_anti_2 938 945 PF11976 0.627
LIG_SUMO_SIM_par_1 113 119 PF11976 0.698
LIG_SUMO_SIM_par_1 432 438 PF11976 0.625
LIG_SUMO_SIM_par_1 497 503 PF11976 0.423
LIG_TRAF2_1 1046 1049 PF00917 0.624
LIG_TRAF2_1 1101 1104 PF00917 0.623
LIG_TRAF2_1 238 241 PF00917 0.661
LIG_TRAF2_1 576 579 PF00917 0.671
LIG_TRAF2_1 687 690 PF00917 0.580
LIG_TRAF2_1 712 715 PF00917 0.666
LIG_TYR_ITIM 90 95 PF00017 0.310
LIG_UBA3_1 1041 1045 PF00899 0.565
LIG_WRC_WIRS_1 183 188 PF05994 0.557
MOD_CDK_SPK_2 118 123 PF00069 0.662
MOD_CDK_SPK_2 130 135 PF00069 0.669
MOD_CDK_SPxxK_3 733 740 PF00069 0.500
MOD_CK1_1 118 124 PF00069 0.690
MOD_CK1_1 1208 1214 PF00069 0.719
MOD_CK1_1 130 136 PF00069 0.672
MOD_CK1_1 164 170 PF00069 0.561
MOD_CK1_1 337 343 PF00069 0.392
MOD_CK1_1 548 554 PF00069 0.631
MOD_CK1_1 65 71 PF00069 0.468
MOD_CK1_1 675 681 PF00069 0.543
MOD_CK1_1 683 689 PF00069 0.505
MOD_CK1_1 777 783 PF00069 0.487
MOD_CK1_1 965 971 PF00069 0.497
MOD_CK2_1 1011 1017 PF00069 0.420
MOD_CK2_1 1034 1040 PF00069 0.558
MOD_CK2_1 1043 1049 PF00069 0.528
MOD_CK2_1 1066 1072 PF00069 0.785
MOD_CK2_1 1097 1103 PF00069 0.671
MOD_CK2_1 1165 1171 PF00069 0.754
MOD_CK2_1 140 146 PF00069 0.587
MOD_CK2_1 164 170 PF00069 0.552
MOD_CK2_1 178 184 PF00069 0.523
MOD_CK2_1 187 193 PF00069 0.504
MOD_CK2_1 318 324 PF00069 0.575
MOD_CK2_1 337 343 PF00069 0.561
MOD_CK2_1 401 407 PF00069 0.463
MOD_CK2_1 536 542 PF00069 0.684
MOD_CK2_1 573 579 PF00069 0.614
MOD_CK2_1 678 684 PF00069 0.532
MOD_CK2_1 709 715 PF00069 0.570
MOD_CK2_1 733 739 PF00069 0.590
MOD_CK2_1 933 939 PF00069 0.544
MOD_CK2_1 942 948 PF00069 0.420
MOD_CK2_1 970 976 PF00069 0.490
MOD_CK2_1 992 998 PF00069 0.537
MOD_DYRK1A_RPxSP_1 840 844 PF00069 0.477
MOD_GlcNHglycan 1031 1034 PF01048 0.527
MOD_GlcNHglycan 1078 1082 PF01048 0.686
MOD_GlcNHglycan 1100 1103 PF01048 0.634
MOD_GlcNHglycan 118 121 PF01048 0.613
MOD_GlcNHglycan 1186 1189 PF01048 0.634
MOD_GlcNHglycan 1201 1204 PF01048 0.718
MOD_GlcNHglycan 1207 1210 PF01048 0.690
MOD_GlcNHglycan 1211 1214 PF01048 0.696
MOD_GlcNHglycan 1234 1237 PF01048 0.711
MOD_GlcNHglycan 142 145 PF01048 0.602
MOD_GlcNHglycan 163 166 PF01048 0.583
MOD_GlcNHglycan 320 323 PF01048 0.594
MOD_GlcNHglycan 377 380 PF01048 0.509
MOD_GlcNHglycan 455 458 PF01048 0.584
MOD_GlcNHglycan 711 714 PF01048 0.562
MOD_GlcNHglycan 739 743 PF01048 0.512
MOD_GlcNHglycan 779 782 PF01048 0.544
MOD_GlcNHglycan 796 800 PF01048 0.638
MOD_GlcNHglycan 802 806 PF01048 0.761
MOD_GlcNHglycan 897 900 PF01048 0.665
MOD_GlcNHglycan 952 955 PF01048 0.497
MOD_GlcNHglycan 983 986 PF01048 0.691
MOD_GSK3_1 1043 1050 PF00069 0.475
MOD_GSK3_1 1066 1073 PF00069 0.728
MOD_GSK3_1 1205 1212 PF00069 0.698
MOD_GSK3_1 1227 1234 PF00069 0.695
MOD_GSK3_1 123 130 PF00069 0.622
MOD_GSK3_1 133 140 PF00069 0.649
MOD_GSK3_1 178 185 PF00069 0.558
MOD_GSK3_1 309 316 PF00069 0.471
MOD_GSK3_1 334 341 PF00069 0.402
MOD_GSK3_1 40 47 PF00069 0.580
MOD_GSK3_1 617 624 PF00069 0.500
MOD_GSK3_1 633 640 PF00069 0.522
MOD_GSK3_1 671 678 PF00069 0.495
MOD_GSK3_1 731 738 PF00069 0.527
MOD_GSK3_1 938 945 PF00069 0.518
MOD_NEK2_1 1001 1006 PF00069 0.460
MOD_NEK2_1 1043 1048 PF00069 0.467
MOD_NEK2_1 116 121 PF00069 0.511
MOD_NEK2_1 155 160 PF00069 0.560
MOD_NEK2_1 182 187 PF00069 0.526
MOD_NEK2_1 318 323 PF00069 0.637
MOD_NEK2_1 389 394 PF00069 0.335
MOD_NEK2_1 462 467 PF00069 0.491
MOD_NEK2_1 492 497 PF00069 0.443
MOD_NEK2_1 633 638 PF00069 0.433
MOD_NEK2_1 673 678 PF00069 0.528
MOD_NEK2_1 83 88 PF00069 0.522
MOD_NEK2_1 918 923 PF00069 0.455
MOD_NEK2_1 981 986 PF00069 0.651
MOD_NEK2_2 967 972 PF00069 0.428
MOD_PIKK_1 1165 1171 PF00454 0.684
MOD_PIKK_1 543 549 PF00454 0.652
MOD_PIKK_1 774 780 PF00454 0.528
MOD_PK_1 128 134 PF00069 0.525
MOD_PKA_1 127 133 PF00069 0.739
MOD_PKA_1 543 549 PF00069 0.674
MOD_PKA_2 127 133 PF00069 0.706
MOD_PKA_2 401 407 PF00069 0.544
MOD_PKA_2 543 549 PF00069 0.700
MOD_PKA_2 83 89 PF00069 0.550
MOD_PKA_2 918 924 PF00069 0.452
MOD_PKA_2 981 987 PF00069 0.634
MOD_PKB_1 1068 1076 PF00069 0.686
MOD_Plk_1 230 236 PF00069 0.700
MOD_Plk_1 730 736 PF00069 0.610
MOD_Plk_1 738 744 PF00069 0.458
MOD_Plk_1 938 944 PF00069 0.527
MOD_Plk_2-3 1122 1128 PF00069 0.561
MOD_Plk_2-3 573 579 PF00069 0.620
MOD_Plk_4 1047 1053 PF00069 0.458
MOD_Plk_4 110 116 PF00069 0.578
MOD_Plk_4 178 184 PF00069 0.542
MOD_Plk_4 196 202 PF00069 0.383
MOD_Plk_4 389 395 PF00069 0.434
MOD_Plk_4 462 468 PF00069 0.541
MOD_Plk_4 603 609 PF00069 0.610
MOD_Plk_4 78 84 PF00069 0.400
MOD_Plk_4 876 882 PF00069 0.507
MOD_Plk_4 938 944 PF00069 0.551
MOD_ProDKin_1 1176 1182 PF00069 0.722
MOD_ProDKin_1 118 124 PF00069 0.651
MOD_ProDKin_1 130 136 PF00069 0.637
MOD_ProDKin_1 164 170 PF00069 0.550
MOD_ProDKin_1 256 262 PF00069 0.518
MOD_ProDKin_1 42 48 PF00069 0.644
MOD_ProDKin_1 479 485 PF00069 0.435
MOD_ProDKin_1 733 739 PF00069 0.501
MOD_ProDKin_1 840 846 PF00069 0.592
MOD_SUMO_for_1 458 461 PF00179 0.557
MOD_SUMO_rev_2 108 113 PF00179 0.566
MOD_SUMO_rev_2 1221 1230 PF00179 0.662
MOD_SUMO_rev_2 515 524 PF00179 0.734
MOD_SUMO_rev_2 573 583 PF00179 0.525
TRG_DiLeu_BaEn_1 764 769 PF01217 0.500
TRG_DiLeu_BaLyEn_6 1021 1026 PF01217 0.490
TRG_DiLeu_BaLyEn_6 1114 1119 PF01217 0.516
TRG_DiLeu_BaLyEn_6 641 646 PF01217 0.440
TRG_ENDOCYTIC_2 1022 1025 PF00928 0.495
TRG_ENDOCYTIC_2 92 95 PF00928 0.310
TRG_ER_diArg_1 1055 1057 PF00400 0.524
TRG_ER_diArg_1 299 301 PF00400 0.491
TRG_ER_diArg_1 585 588 PF00400 0.526
TRG_ER_diArg_1 642 644 PF00400 0.522
TRG_ER_diArg_1 703 706 PF00400 0.421
TRG_ER_diArg_1 881 883 PF00400 0.568
TRG_ER_diArg_1 918 920 PF00400 0.540
TRG_NES_CRM1_1 385 399 PF08389 0.427
TRG_Pf-PMV_PEXEL_1 1045 1049 PF00026 0.517
TRG_Pf-PMV_PEXEL_1 1056 1060 PF00026 0.641
TRG_Pf-PMV_PEXEL_1 1117 1122 PF00026 0.609
TRG_Pf-PMV_PEXEL_1 244 248 PF00026 0.449
TRG_Pf-PMV_PEXEL_1 395 399 PF00026 0.500
TRG_Pf-PMV_PEXEL_1 644 649 PF00026 0.511
TRG_Pf-PMV_PEXEL_1 693 697 PF00026 0.485
TRG_Pf-PMV_PEXEL_1 972 976 PF00026 0.563

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6J6 Leptomonas seymouri 43% 99%
A0A1X0P9W2 Trypanosomatidae 25% 76%
A0A3Q8IBP4 Leishmania donovani 99% 100%
A0A3R7MCK0 Trypanosoma rangeli 24% 77%
A4HHR1 Leishmania braziliensis 65% 100%
C9ZKY2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 75%
E9AEC5 Leishmania major 90% 100%
E9ALG1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
V5C230 Trypanosoma cruzi 24% 78%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS