LeishMANIAdb
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Aminopeptidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Aminopeptidase
Gene product:
metallo-peptidase - Clan MA(E) Family M1
Species:
Leishmania infantum
UniProt:
A4I4T3_LEIIN
TriTrypDb:
LINF_290030100
Length:
868

Annotations

Annotations by Jardim et al.

Proteases, aminopeptidase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. yes yes: 1
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I4T3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4T3

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0019538 protein metabolic process 3 13
GO:0043170 macromolecule metabolic process 3 13
GO:0044238 primary metabolic process 2 13
GO:0071704 organic substance metabolic process 2 13
GO:1901564 organonitrogen compound metabolic process 3 13
GO:0006518 peptide metabolic process 4 1
GO:0009056 catabolic process 2 1
GO:0009987 cellular process 1 1
GO:0043171 peptide catabolic process 4 1
GO:0043603 amide metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 13
GO:0004177 aminopeptidase activity 5 13
GO:0005488 binding 1 13
GO:0008233 peptidase activity 3 13
GO:0008237 metallopeptidase activity 4 13
GO:0008238 exopeptidase activity 4 13
GO:0008270 zinc ion binding 6 13
GO:0016787 hydrolase activity 2 13
GO:0043167 ion binding 2 13
GO:0043169 cation binding 3 13
GO:0046872 metal ion binding 4 13
GO:0046914 transition metal ion binding 5 13
GO:0140096 catalytic activity, acting on a protein 2 13
GO:0008235 metalloexopeptidase activity 5 1
GO:0033218 amide binding 2 1
GO:0042277 peptide binding 3 1
GO:0070006 metalloaminopeptidase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 527 529 PF00675 0.388
CLV_NRD_NRD_1 556 558 PF00675 0.341
CLV_NRD_NRD_1 645 647 PF00675 0.420
CLV_NRD_NRD_1 71 73 PF00675 0.468
CLV_PCSK_KEX2_1 291 293 PF00082 0.389
CLV_PCSK_KEX2_1 527 529 PF00082 0.398
CLV_PCSK_KEX2_1 556 558 PF00082 0.341
CLV_PCSK_KEX2_1 645 647 PF00082 0.420
CLV_PCSK_KEX2_1 71 73 PF00082 0.468
CLV_PCSK_PC1ET2_1 291 293 PF00082 0.389
CLV_PCSK_SKI1_1 174 178 PF00082 0.280
CLV_PCSK_SKI1_1 470 474 PF00082 0.489
CLV_PCSK_SKI1_1 5 9 PF00082 0.599
CLV_PCSK_SKI1_1 518 522 PF00082 0.462
CLV_PCSK_SKI1_1 557 561 PF00082 0.400
CLV_PCSK_SKI1_1 579 583 PF00082 0.396
CLV_PCSK_SKI1_1 615 619 PF00082 0.466
CLV_PCSK_SKI1_1 65 69 PF00082 0.451
DEG_SPOP_SBC_1 230 234 PF00917 0.280
DOC_CDC14_PxL_1 571 579 PF14671 0.378
DOC_CYCLIN_RxL_1 728 739 PF00134 0.280
DOC_CYCLIN_yCln2_LP_2 9 15 PF00134 0.419
DOC_MAPK_DCC_7 248 256 PF00069 0.345
DOC_MAPK_gen_1 105 115 PF00069 0.468
DOC_MAPK_gen_1 477 486 PF00069 0.534
DOC_MAPK_MEF2A_6 147 156 PF00069 0.313
DOC_MAPK_MEF2A_6 248 256 PF00069 0.341
DOC_MAPK_MEF2A_6 480 488 PF00069 0.508
DOC_MAPK_MEF2A_6 503 512 PF00069 0.577
DOC_MAPK_RevD_3 278 292 PF00069 0.443
DOC_PP2B_PxIxI_1 449 455 PF00149 0.411
DOC_PP2B_PxIxI_1 56 62 PF00149 0.378
DOC_PP4_FxxP_1 624 627 PF00568 0.468
DOC_USP7_MATH_1 170 174 PF00917 0.456
DOC_USP7_MATH_1 283 287 PF00917 0.398
DOC_USP7_MATH_1 439 443 PF00917 0.342
DOC_USP7_MATH_1 55 59 PF00917 0.506
DOC_USP7_MATH_1 664 668 PF00917 0.461
DOC_USP7_MATH_1 736 740 PF00917 0.418
DOC_USP7_UBL2_3 116 120 PF12436 0.378
DOC_USP7_UBL2_3 615 619 PF12436 0.451
DOC_WW_Pin1_4 496 501 PF00397 0.546
DOC_WW_Pin1_4 549 554 PF00397 0.468
DOC_WW_Pin1_4 633 638 PF00397 0.410
LIG_14-3-3_CanoR_1 123 132 PF00244 0.335
LIG_14-3-3_CanoR_1 470 479 PF00244 0.456
LIG_14-3-3_CanoR_1 556 560 PF00244 0.363
LIG_14-3-3_CanoR_1 848 853 PF00244 0.399
LIG_Actin_WH2_2 306 324 PF00022 0.326
LIG_APCC_ABBAyCdc20_2 556 562 PF00400 0.468
LIG_BIR_II_1 1 5 PF00653 0.632
LIG_BRCT_BRCA1_1 125 129 PF00533 0.420
LIG_BRCT_BRCA1_1 741 745 PF00533 0.378
LIG_deltaCOP1_diTrp_1 317 325 PF00928 0.332
LIG_deltaCOP1_diTrp_1 781 790 PF00928 0.404
LIG_EH1_1 801 809 PF00400 0.326
LIG_FHA_1 149 155 PF00498 0.354
LIG_FHA_1 194 200 PF00498 0.422
LIG_FHA_1 2 8 PF00498 0.588
LIG_FHA_1 292 298 PF00498 0.381
LIG_FHA_1 34 40 PF00498 0.374
LIG_FHA_1 417 423 PF00498 0.315
LIG_FHA_1 435 441 PF00498 0.306
LIG_FHA_1 459 465 PF00498 0.462
LIG_FHA_1 479 485 PF00498 0.475
LIG_FHA_1 48 54 PF00498 0.287
LIG_FHA_1 497 503 PF00498 0.316
LIG_FHA_1 612 618 PF00498 0.516
LIG_FHA_1 76 82 PF00498 0.353
LIG_FHA_1 828 834 PF00498 0.420
LIG_FHA_1 85 91 PF00498 0.321
LIG_FHA_1 98 104 PF00498 0.300
LIG_FHA_2 125 131 PF00498 0.330
LIG_FHA_2 272 278 PF00498 0.412
LIG_FXI_DFP_1 259 263 PF00024 0.324
LIG_GBD_Chelix_1 391 399 PF00786 0.326
LIG_GBD_Chelix_1 807 815 PF00786 0.378
LIG_IBAR_NPY_1 11 13 PF08397 0.517
LIG_LIR_Apic_2 361 365 PF02991 0.236
LIG_LIR_Apic_2 481 485 PF02991 0.350
LIG_LIR_Gen_1 160 171 PF02991 0.363
LIG_LIR_Gen_1 184 193 PF02991 0.319
LIG_LIR_Gen_1 216 224 PF02991 0.501
LIG_LIR_Gen_1 239 249 PF02991 0.319
LIG_LIR_Gen_1 28 39 PF02991 0.496
LIG_LIR_Gen_1 377 385 PF02991 0.313
LIG_LIR_Gen_1 781 790 PF02991 0.416
LIG_LIR_Gen_1 822 832 PF02991 0.345
LIG_LIR_Gen_1 98 107 PF02991 0.334
LIG_LIR_Nem_3 126 132 PF02991 0.386
LIG_LIR_Nem_3 160 166 PF02991 0.363
LIG_LIR_Nem_3 184 188 PF02991 0.319
LIG_LIR_Nem_3 216 221 PF02991 0.491
LIG_LIR_Nem_3 239 244 PF02991 0.319
LIG_LIR_Nem_3 268 273 PF02991 0.343
LIG_LIR_Nem_3 28 34 PF02991 0.506
LIG_LIR_Nem_3 327 331 PF02991 0.339
LIG_LIR_Nem_3 377 383 PF02991 0.313
LIG_LIR_Nem_3 630 635 PF02991 0.447
LIG_LIR_Nem_3 781 786 PF02991 0.423
LIG_LIR_Nem_3 822 827 PF02991 0.331
LIG_LIR_Nem_3 98 102 PF02991 0.404
LIG_LYPXL_yS_3 449 452 PF13949 0.381
LIG_PALB2_WD40_1 302 310 PF16756 0.313
LIG_PCNA_PIPBox_1 104 113 PF02747 0.334
LIG_PCNA_PIPBox_1 598 607 PF02747 0.312
LIG_PCNA_yPIPBox_3 104 116 PF02747 0.467
LIG_Pex14_1 544 548 PF04695 0.468
LIG_Pex14_2 236 240 PF04695 0.345
LIG_Pex14_2 241 245 PF04695 0.309
LIG_Pex14_2 604 608 PF04695 0.468
LIG_Pex14_2 786 790 PF04695 0.341
LIG_Pex14_2 824 828 PF04695 0.326
LIG_PTB_Apo_2 535 542 PF02174 0.468
LIG_Rb_LxCxE_1 268 289 PF01857 0.341
LIG_REV1ctd_RIR_1 238 247 PF16727 0.377
LIG_SH2_CRK 218 222 PF00017 0.379
LIG_SH2_CRK 548 552 PF00017 0.335
LIG_SH2_CRK 717 721 PF00017 0.371
LIG_SH2_GRB2like 536 539 PF00017 0.468
LIG_SH2_NCK_1 31 35 PF00017 0.372
LIG_SH2_NCK_1 571 575 PF00017 0.420
LIG_SH2_PTP2 163 166 PF00017 0.378
LIG_SH2_SRC 13 16 PF00017 0.516
LIG_SH2_SRC 360 363 PF00017 0.319
LIG_SH2_SRC 536 539 PF00017 0.468
LIG_SH2_SRC 571 574 PF00017 0.420
LIG_SH2_SRC 649 652 PF00017 0.383
LIG_SH2_STAP1 536 540 PF00017 0.306
LIG_SH2_STAT3 337 340 PF00017 0.334
LIG_SH2_STAT3 763 766 PF00017 0.439
LIG_SH2_STAT5 13 16 PF00017 0.469
LIG_SH2_STAT5 138 141 PF00017 0.356
LIG_SH2_STAT5 163 166 PF00017 0.361
LIG_SH2_STAT5 194 197 PF00017 0.330
LIG_SH2_STAT5 410 413 PF00017 0.313
LIG_SH2_STAT5 592 595 PF00017 0.422
LIG_SH2_STAT5 649 652 PF00017 0.386
LIG_SH3_3 151 157 PF00018 0.375
LIG_SH3_3 186 192 PF00018 0.341
LIG_SH3_3 254 260 PF00018 0.326
LIG_SH3_3 363 369 PF00018 0.305
LIG_SH3_3 40 46 PF00018 0.434
LIG_SH3_3 507 513 PF00018 0.408
LIG_SH3_3 9 15 PF00018 0.402
LIG_SUMO_SIM_par_1 149 155 PF11976 0.474
LIG_SUMO_SIM_par_1 255 261 PF11976 0.313
LIG_SUMO_SIM_par_1 458 465 PF11976 0.411
LIG_SUMO_SIM_par_1 484 489 PF11976 0.420
LIG_TRAF2_1 427 430 PF00917 0.341
LIG_TRAF2_1 843 846 PF00917 0.334
LIG_TRAF2_2 144 149 PF00917 0.468
LIG_UBA3_1 379 387 PF00899 0.326
LIG_WRC_WIRS_1 182 187 PF05994 0.446
LIG_WRC_WIRS_1 440 445 PF05994 0.387
LIG_WRC_WIRS_1 601 606 PF05994 0.369
MOD_CDK_SPxxK_3 496 503 PF00069 0.545
MOD_CDK_SPxxK_3 549 556 PF00069 0.468
MOD_CK1_1 27 33 PF00069 0.523
MOD_CK1_1 442 448 PF00069 0.383
MOD_CK1_1 475 481 PF00069 0.576
MOD_CK1_1 549 555 PF00069 0.349
MOD_CK1_1 558 564 PF00069 0.369
MOD_CK1_1 653 659 PF00069 0.334
MOD_CK1_1 739 745 PF00069 0.490
MOD_CK1_1 770 776 PF00069 0.404
MOD_CK2_1 124 130 PF00069 0.313
MOD_CK2_1 271 277 PF00069 0.420
MOD_CK2_1 283 289 PF00069 0.451
MOD_CK2_1 582 588 PF00069 0.345
MOD_CK2_1 775 781 PF00069 0.378
MOD_GlcNHglycan 132 135 PF01048 0.383
MOD_GlcNHglycan 15 18 PF01048 0.567
MOD_GlcNHglycan 352 355 PF01048 0.319
MOD_GlcNHglycan 404 407 PF01048 0.334
MOD_GlcNHglycan 474 477 PF01048 0.437
MOD_GlcNHglycan 584 587 PF01048 0.341
MOD_GlcNHglycan 639 643 PF01048 0.506
MOD_GlcNHglycan 665 669 PF01048 0.420
MOD_GlcNHglycan 683 686 PF01048 0.317
MOD_GlcNHglycan 738 741 PF01048 0.473
MOD_GlcNHglycan 777 780 PF01048 0.497
MOD_GlcNHglycan 815 818 PF01048 0.375
MOD_GSK3_1 148 155 PF00069 0.343
MOD_GSK3_1 177 184 PF00069 0.365
MOD_GSK3_1 213 220 PF00069 0.432
MOD_GSK3_1 434 441 PF00069 0.428
MOD_GSK3_1 458 465 PF00069 0.505
MOD_GSK3_1 504 511 PF00069 0.445
MOD_GSK3_1 55 62 PF00069 0.386
MOD_GSK3_1 600 607 PF00069 0.520
MOD_GSK3_1 609 616 PF00069 0.444
MOD_GSK3_1 653 660 PF00069 0.471
MOD_GSK3_1 735 742 PF00069 0.524
MOD_N-GLC_1 546 551 PF02516 0.336
MOD_NEK2_1 1 6 PF00069 0.610
MOD_NEK2_1 124 129 PF00069 0.369
MOD_NEK2_1 150 155 PF00069 0.344
MOD_NEK2_1 229 234 PF00069 0.393
MOD_NEK2_1 416 421 PF00069 0.432
MOD_NEK2_1 428 433 PF00069 0.312
MOD_NEK2_1 508 513 PF00069 0.527
MOD_NEK2_1 560 565 PF00069 0.468
MOD_NEK2_1 613 618 PF00069 0.410
MOD_NEK2_1 650 655 PF00069 0.504
MOD_NEK2_1 729 734 PF00069 0.414
MOD_NEK2_1 735 740 PF00069 0.397
MOD_NEK2_1 827 832 PF00069 0.405
MOD_NEK2_1 97 102 PF00069 0.458
MOD_NEK2_2 33 38 PF00069 0.555
MOD_PIKK_1 374 380 PF00454 0.326
MOD_PIKK_1 442 448 PF00454 0.350
MOD_PIKK_1 462 468 PF00454 0.529
MOD_PIKK_1 546 552 PF00454 0.312
MOD_PIKK_1 758 764 PF00454 0.356
MOD_PKA_1 291 297 PF00069 0.402
MOD_PKA_2 291 297 PF00069 0.474
MOD_PKA_2 526 532 PF00069 0.451
MOD_PKA_2 555 561 PF00069 0.420
MOD_Plk_1 148 154 PF00069 0.323
MOD_Plk_1 24 30 PF00069 0.462
MOD_Plk_1 374 380 PF00069 0.341
MOD_Plk_1 458 464 PF00069 0.595
MOD_Plk_1 504 510 PF00069 0.617
MOD_Plk_1 546 552 PF00069 0.485
MOD_Plk_1 59 65 PF00069 0.458
MOD_Plk_1 609 615 PF00069 0.353
MOD_Plk_1 650 656 PF00069 0.288
MOD_Plk_1 97 103 PF00069 0.398
MOD_Plk_4 177 183 PF00069 0.449
MOD_Plk_4 205 211 PF00069 0.513
MOD_Plk_4 213 219 PF00069 0.466
MOD_Plk_4 231 237 PF00069 0.289
MOD_Plk_4 458 464 PF00069 0.537
MOD_Plk_4 600 606 PF00069 0.438
MOD_Plk_4 628 634 PF00069 0.468
MOD_Plk_4 65 71 PF00069 0.339
MOD_Plk_4 653 659 PF00069 0.457
MOD_Plk_4 75 81 PF00069 0.441
MOD_ProDKin_1 496 502 PF00069 0.541
MOD_ProDKin_1 549 555 PF00069 0.468
MOD_ProDKin_1 633 639 PF00069 0.410
MOD_SUMO_for_1 157 160 PF00179 0.468
MOD_SUMO_for_1 7 10 PF00179 0.481
TRG_DiLeu_BaEn_2 466 472 PF01217 0.411
TRG_DiLeu_BaEn_2 619 625 PF01217 0.468
TRG_DiLeu_BaEn_4 429 435 PF01217 0.420
TRG_ENDOCYTIC_2 163 166 PF00928 0.361
TRG_ENDOCYTIC_2 218 221 PF00928 0.386
TRG_ENDOCYTIC_2 31 34 PF00928 0.573
TRG_ENDOCYTIC_2 449 452 PF00928 0.381
TRG_ENDOCYTIC_2 548 551 PF00928 0.339
TRG_ENDOCYTIC_2 571 574 PF00928 0.398
TRG_ENDOCYTIC_2 717 720 PF00928 0.483
TRG_ER_diArg_1 526 528 PF00400 0.352
TRG_ER_diArg_1 532 535 PF00400 0.330
TRG_ER_diArg_1 644 646 PF00400 0.422
TRG_ER_diArg_1 70 72 PF00400 0.418
TRG_ER_diArg_1 847 850 PF00400 0.366
TRG_Pf-PMV_PEXEL_1 557 562 PF00026 0.361

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5R5 Leptomonas seymouri 72% 100%
A0A0S4IPD6 Bodo saltans 41% 97%
A0A0S4JBK9 Bodo saltans 33% 100%
A0A1X0P9F6 Trypanosomatidae 51% 100%
A0A3S7X2P7 Leishmania donovani 99% 100%
A0A422NEK9 Trypanosoma rangeli 52% 100%
A4HHM4 Leishmania braziliensis 83% 100%
A5HUI5 Gloydius brevicaudus 30% 91%
A6QPT7 Bos taurus 25% 91%
C9ZLI0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
D0A6I7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
D3UW23 Bitis rhinoceros 30% 91%
E9AE86 Leishmania major 96% 100%
E9AIS1 Leishmania braziliensis 28% 100%
E9ALJ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
P15541 Oryctolagus cuniculus 26% 90%
P15684 Rattus norvegicus 25% 90%
P16406 Mus musculus 31% 92%
P40462 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 92%
P55786 Homo sapiens 28% 94%
P97629 Rattus norvegicus 30% 85%
Q0J2B5 Oryza sativa subsp. japonica 29% 99%
Q0J5V5 Oryza sativa subsp. japonica 30% 99%
Q11000 Heliothis virescens 27% 86%
Q11001 Manduca sexta 26% 88%
Q11011 Mus musculus 28% 94%
Q4TT88 Caenorhabditis elegans 29% 92%
Q59KZ1 Candida albicans (strain SC5314 / ATCC MYA-2876) 30% 94%
Q5RFP3 Pongo abelii 24% 90%
Q6K4E7 Oryza sativa subsp. japonica 30% 99%
Q6P179 Homo sapiens 24% 90%
Q6Z6L4 Oryza sativa subsp. japonica 30% 99%
Q8C129 Mus musculus 30% 85%
Q8VZH2 Arabidopsis thaliana 30% 99%
Q9JJ22 Rattus norvegicus 24% 93%
Q9NZ08 Homo sapiens 24% 92%
Q9USX1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 98%
V5BSI2 Trypanosoma cruzi 51% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS