LeishMANIAdb
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ThiF family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ThiF family protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I4T2_LEIIN
TriTrypDb:
LINF_290030000
Length:
582

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0009331 glycerol-3-phosphate dehydrogenase complex 4 1
GO:0032991 protein-containing complex 1 1
GO:1902494 catalytic complex 2 1
GO:1990204 oxidoreductase complex 3 1

Expansion

Sequence features

A4I4T2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4T2

Function

Biological processes
Term Name Level Count
GO:0006072 glycerol-3-phosphate metabolic process 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009987 cellular process 1 1
GO:0019637 organophosphate metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0046168 glycerol-3-phosphate catabolic process 5 1
GO:0046434 organophosphate catabolic process 4 1
GO:0052646 alditol phosphate metabolic process 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901135 carbohydrate derivative metabolic process 3 1
GO:1901136 carbohydrate derivative catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 1
GO:0003824 catalytic activity 1 1
GO:0005488 binding 1 1
GO:0016491 oxidoreductase activity 2 1
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 1
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 1
GO:0036094 small molecule binding 2 1
GO:0047952 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity 5 1
GO:0051287 NAD binding 4 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 375 379 PF00656 0.569
CLV_NRD_NRD_1 153 155 PF00675 0.497
CLV_NRD_NRD_1 462 464 PF00675 0.618
CLV_NRD_NRD_1 469 471 PF00675 0.593
CLV_PCSK_KEX2_1 155 157 PF00082 0.578
CLV_PCSK_KEX2_1 43 45 PF00082 0.702
CLV_PCSK_PC1ET2_1 155 157 PF00082 0.578
CLV_PCSK_PC1ET2_1 43 45 PF00082 0.617
CLV_PCSK_SKI1_1 179 183 PF00082 0.550
CLV_PCSK_SKI1_1 319 323 PF00082 0.718
CLV_PCSK_SKI1_1 363 367 PF00082 0.489
CLV_PCSK_SKI1_1 38 42 PF00082 0.446
CLV_PCSK_SKI1_1 50 54 PF00082 0.560
CLV_PCSK_SKI1_1 549 553 PF00082 0.449
CLV_PCSK_SKI1_1 572 576 PF00082 0.565
CLV_Separin_Metazoa 546 550 PF03568 0.512
DEG_Nend_Nbox_1 1 3 PF02207 0.473
DEG_SCF_FBW7_1 127 134 PF00400 0.585
DEG_SCF_FBW7_1 163 169 PF00400 0.549
DEG_SCF_FBW7_1 277 284 PF00400 0.673
DOC_CKS1_1 163 168 PF01111 0.515
DOC_CKS1_1 259 264 PF01111 0.580
DOC_CKS1_1 278 283 PF01111 0.479
DOC_CYCLIN_yCln2_LP_2 32 35 PF00134 0.450
DOC_MAPK_gen_1 154 163 PF00069 0.487
DOC_PP1_RVXF_1 361 367 PF00149 0.556
DOC_PP1_RVXF_1 461 468 PF00149 0.653
DOC_PP2B_LxvP_1 32 35 PF13499 0.450
DOC_PP2B_LxvP_1 374 377 PF13499 0.572
DOC_PP2B_LxvP_1 439 442 PF13499 0.543
DOC_PP4_FxxP_1 2 5 PF00568 0.471
DOC_USP7_MATH_1 110 114 PF00917 0.744
DOC_USP7_MATH_1 122 126 PF00917 0.637
DOC_USP7_MATH_1 131 135 PF00917 0.548
DOC_USP7_MATH_1 166 170 PF00917 0.488
DOC_USP7_MATH_1 203 207 PF00917 0.668
DOC_USP7_MATH_1 211 215 PF00917 0.515
DOC_USP7_MATH_1 24 28 PF00917 0.616
DOC_USP7_MATH_1 281 285 PF00917 0.590
DOC_USP7_MATH_1 321 325 PF00917 0.725
DOC_USP7_MATH_1 367 371 PF00917 0.553
DOC_USP7_MATH_1 391 395 PF00917 0.460
DOC_USP7_MATH_1 442 446 PF00917 0.494
DOC_USP7_MATH_1 70 74 PF00917 0.567
DOC_WW_Pin1_4 117 122 PF00397 0.725
DOC_WW_Pin1_4 127 132 PF00397 0.634
DOC_WW_Pin1_4 162 167 PF00397 0.505
DOC_WW_Pin1_4 197 202 PF00397 0.622
DOC_WW_Pin1_4 20 25 PF00397 0.455
DOC_WW_Pin1_4 258 263 PF00397 0.614
DOC_WW_Pin1_4 277 282 PF00397 0.364
DOC_WW_Pin1_4 342 347 PF00397 0.463
DOC_WW_Pin1_4 434 439 PF00397 0.468
DOC_WW_Pin1_4 502 507 PF00397 0.450
LIG_14-3-3_CanoR_1 196 201 PF00244 0.555
LIG_14-3-3_CanoR_1 497 506 PF00244 0.356
LIG_14-3-3_CanoR_1 50 55 PF00244 0.426
LIG_14-3-3_CanoR_1 565 573 PF00244 0.534
LIG_BRCT_BRCA1_1 213 217 PF00533 0.601
LIG_BRCT_BRCA1_1 35 39 PF00533 0.443
LIG_BRCT_BRCA1_1 455 459 PF00533 0.491
LIG_CSL_BTD_1 343 346 PF09270 0.463
LIG_CtBP_PxDLS_1 34 38 PF00389 0.484
LIG_CtBP_PxDLS_1 46 50 PF00389 0.475
LIG_deltaCOP1_diTrp_1 175 182 PF00928 0.559
LIG_FHA_1 188 194 PF00498 0.450
LIG_FHA_1 259 265 PF00498 0.570
LIG_FHA_1 343 349 PF00498 0.465
LIG_FHA_1 421 427 PF00498 0.387
LIG_FHA_1 450 456 PF00498 0.537
LIG_FHA_1 49 55 PF00498 0.516
LIG_FHA_1 498 504 PF00498 0.339
LIG_FHA_2 373 379 PF00498 0.555
LIG_FHA_2 537 543 PF00498 0.639
LIG_FHA_2 550 556 PF00498 0.526
LIG_LIR_Gen_1 214 225 PF02991 0.451
LIG_LIR_Gen_1 505 515 PF02991 0.433
LIG_LIR_Nem_3 130 135 PF02991 0.558
LIG_LIR_Nem_3 214 220 PF02991 0.550
LIG_LIR_Nem_3 505 511 PF02991 0.419
LIG_LIR_Nem_3 531 536 PF02991 0.629
LIG_PDZ_Class_1 577 582 PF00595 0.651
LIG_Pex14_2 217 221 PF04695 0.510
LIG_REV1ctd_RIR_1 37 45 PF16727 0.450
LIG_SH2_SRC 170 173 PF00017 0.453
LIG_SH2_SRC 9 12 PF00017 0.450
LIG_SH2_STAP1 415 419 PF00017 0.504
LIG_SH2_STAP1 508 512 PF00017 0.401
LIG_SH2_STAT5 170 173 PF00017 0.559
LIG_SH2_STAT5 373 376 PF00017 0.510
LIG_SH2_STAT5 404 407 PF00017 0.654
LIG_SH2_STAT5 468 471 PF00017 0.621
LIG_SH2_STAT5 9 12 PF00017 0.450
LIG_SH3_3 118 124 PF00018 0.711
LIG_SH3_3 2 8 PF00018 0.463
LIG_SH3_3 500 506 PF00018 0.540
LIG_SUMO_SIM_anti_2 75 81 PF11976 0.531
LIG_SUMO_SIM_par_1 260 267 PF11976 0.513
LIG_TRAF2_2 232 237 PF00917 0.466
LIG_WRC_WIRS_1 392 397 PF05994 0.504
MOD_CK1_1 125 131 PF00069 0.610
MOD_CK1_1 206 212 PF00069 0.729
MOD_CK1_1 276 282 PF00069 0.613
MOD_CK1_1 285 291 PF00069 0.599
MOD_CK1_1 293 299 PF00069 0.630
MOD_CK1_1 323 329 PF00069 0.593
MOD_CK1_1 402 408 PF00069 0.556
MOD_CK1_1 73 79 PF00069 0.498
MOD_CK1_1 98 104 PF00069 0.733
MOD_CK2_1 105 111 PF00069 0.670
MOD_CK2_1 252 258 PF00069 0.747
MOD_CK2_1 323 329 PF00069 0.666
MOD_CK2_1 536 542 PF00069 0.593
MOD_CK2_1 557 563 PF00069 0.543
MOD_Cter_Amidation 461 464 PF01082 0.631
MOD_GlcNHglycan 100 103 PF01048 0.736
MOD_GlcNHglycan 107 110 PF01048 0.765
MOD_GlcNHglycan 149 152 PF01048 0.623
MOD_GlcNHglycan 249 252 PF01048 0.704
MOD_GlcNHglycan 26 29 PF01048 0.450
MOD_GlcNHglycan 266 269 PF01048 0.461
MOD_GlcNHglycan 284 287 PF01048 0.546
MOD_GlcNHglycan 300 303 PF01048 0.750
MOD_GlcNHglycan 323 326 PF01048 0.716
MOD_GlcNHglycan 334 337 PF01048 0.471
MOD_GlcNHglycan 500 503 PF01048 0.489
MOD_GlcNHglycan 542 546 PF01048 0.638
MOD_GlcNHglycan 559 562 PF01048 0.494
MOD_GSK3_1 111 118 PF00069 0.779
MOD_GSK3_1 123 130 PF00069 0.663
MOD_GSK3_1 162 169 PF00069 0.499
MOD_GSK3_1 192 199 PF00069 0.617
MOD_GSK3_1 20 27 PF00069 0.454
MOD_GSK3_1 254 261 PF00069 0.691
MOD_GSK3_1 273 280 PF00069 0.337
MOD_GSK3_1 281 288 PF00069 0.607
MOD_GSK3_1 289 296 PF00069 0.530
MOD_GSK3_1 398 405 PF00069 0.491
MOD_GSK3_1 449 456 PF00069 0.450
MOD_GSK3_1 498 505 PF00069 0.475
MOD_GSK3_1 92 99 PF00069 0.748
MOD_LATS_1 495 501 PF00433 0.335
MOD_N-GLC_1 105 110 PF02516 0.610
MOD_N-GLC_1 70 75 PF02516 0.571
MOD_N-GLC_1 92 97 PF02516 0.565
MOD_N-GLC_2 387 389 PF02516 0.390
MOD_NEK2_1 264 269 PF00069 0.529
MOD_NEK2_1 282 287 PF00069 0.527
MOD_NEK2_1 294 299 PF00069 0.546
MOD_NEK2_1 39 44 PF00069 0.452
MOD_NEK2_1 399 404 PF00069 0.547
MOD_NEK2_1 498 503 PF00069 0.485
MOD_NEK2_1 511 516 PF00069 0.463
MOD_NEK2_1 577 582 PF00069 0.643
MOD_NEK2_1 96 101 PF00069 0.561
MOD_PKA_2 3 9 PF00069 0.602
MOD_PKA_2 367 373 PF00069 0.437
MOD_PKA_2 519 525 PF00069 0.538
MOD_PKA_2 536 542 PF00069 0.698
MOD_PKA_2 564 570 PF00069 0.520
MOD_Plk_1 273 279 PF00069 0.548
MOD_Plk_1 70 76 PF00069 0.584
MOD_Plk_1 92 98 PF00069 0.681
MOD_Plk_2-3 254 260 PF00069 0.515
MOD_Plk_4 131 137 PF00069 0.543
MOD_Plk_4 166 172 PF00069 0.469
MOD_Plk_4 290 296 PF00069 0.675
MOD_Plk_4 369 375 PF00069 0.504
MOD_Plk_4 399 405 PF00069 0.581
MOD_Plk_4 443 449 PF00069 0.473
MOD_Plk_4 50 56 PF00069 0.492
MOD_Plk_4 514 520 PF00069 0.466
MOD_Plk_4 75 81 PF00069 0.493
MOD_ProDKin_1 117 123 PF00069 0.724
MOD_ProDKin_1 127 133 PF00069 0.619
MOD_ProDKin_1 162 168 PF00069 0.504
MOD_ProDKin_1 197 203 PF00069 0.629
MOD_ProDKin_1 20 26 PF00069 0.455
MOD_ProDKin_1 258 264 PF00069 0.609
MOD_ProDKin_1 277 283 PF00069 0.372
MOD_ProDKin_1 342 348 PF00069 0.462
MOD_ProDKin_1 434 440 PF00069 0.461
MOD_ProDKin_1 502 508 PF00069 0.443
MOD_SUMO_rev_2 134 144 PF00179 0.555
TRG_DiLeu_BaEn_1 260 265 PF01217 0.531
TRG_ENDOCYTIC_2 508 511 PF00928 0.407
TRG_ENDOCYTIC_2 515 518 PF00928 0.437

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P658 Leptomonas seymouri 55% 100%
A0A0S4ITH1 Bodo saltans 23% 100%
A0A1X0P970 Trypanosomatidae 33% 100%
A0A3Q8IFB4 Leishmania donovani 100% 100%
A0A422NEK6 Trypanosoma rangeli 32% 100%
A4HHM3 Leishmania braziliensis 80% 100%
E9AE85 Leishmania major 93% 100%
E9ALK0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS