Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I4T1_LEIIN

TriTrypDb:

LINF_290029900

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I4T1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4T1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.718
CLV_C14_Caspase3-7	5	9	PF00656	0.596
CLV_NRD_NRD_1	130	132	PF00675	0.494
CLV_NRD_NRD_1	17	19	PF00675	0.550
CLV_NRD_NRD_1	318	320	PF00675	0.734
CLV_NRD_NRD_1	328	330	PF00675	0.629
CLV_NRD_NRD_1	357	359	PF00675	0.546
CLV_PCSK_FUR_1	70	74	PF00082	0.547
CLV_PCSK_KEX2_1	130	132	PF00082	0.494
CLV_PCSK_KEX2_1	318	320	PF00082	0.692
CLV_PCSK_KEX2_1	357	359	PF00082	0.546
CLV_PCSK_KEX2_1	72	74	PF00082	0.471
CLV_PCSK_KEX2_1	87	89	PF00082	0.506
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.471
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.506
CLV_PCSK_SKI1_1	173	177	PF00082	0.525
CLV_PCSK_SKI1_1	284	288	PF00082	0.769
CLV_PCSK_SKI1_1	54	58	PF00082	0.403
CLV_PCSK_SKI1_1	73	77	PF00082	0.539
CLV_PCSK_SKI1_1	93	97	PF00082	0.552
DEG_COP1_1	255	263	PF00400	0.573
DEG_SPOP_SBC_1	332	336	PF00917	0.734
DOC_CYCLIN_yClb1_LxF_4	155	161	PF00134	0.464
DOC_MAPK_gen_1	70	77	PF00069	0.480
DOC_PP1_RVXF_1	52	58	PF00149	0.553
DOC_PP1_RVXF_1	70	77	PF00149	0.396
DOC_USP7_MATH_1	145	149	PF00917	0.356
DOC_USP7_MATH_1	189	193	PF00917	0.609
DOC_USP7_MATH_1	219	223	PF00917	0.706
DOC_USP7_MATH_1	243	247	PF00917	0.707
DOC_USP7_MATH_1	254	258	PF00917	0.715
DOC_USP7_MATH_1	271	275	PF00917	0.694
DOC_USP7_MATH_1	332	336	PF00917	0.740
DOC_USP7_MATH_1	356	360	PF00917	0.669
DOC_USP7_UBL2_3	326	330	PF12436	0.703
DOC_WW_Pin1_4	19	24	PF00397	0.768
DOC_WW_Pin1_4	273	278	PF00397	0.718
DOC_WW_Pin1_4	287	292	PF00397	0.690
DOC_WW_Pin1_4	294	299	PF00397	0.647
DOC_WW_Pin1_4	3	8	PF00397	0.740
LIG_14-3-3_CanoR_1	249	254	PF00244	0.696
LIG_14-3-3_CanoR_1	26	32	PF00244	0.480
LIG_14-3-3_CanoR_1	264	270	PF00244	0.602
LIG_14-3-3_CanoR_1	357	361	PF00244	0.661
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_BRCT_BRCA1_1	117	121	PF00533	0.623
LIG_BRCT_BRCA1_1	271	275	PF00533	0.726
LIG_BRCT_BRCA1_1	43	47	PF00533	0.562
LIG_Clathr_ClatBox_1	55	59	PF01394	0.438
LIG_FHA_1	297	303	PF00498	0.748
LIG_FHA_1	79	85	PF00498	0.453
LIG_FHA_2	283	289	PF00498	0.737
LIG_LIR_Gen_1	148	158	PF02991	0.386
LIG_LIR_Nem_3	148	154	PF02991	0.392
LIG_LIR_Nem_3	44	50	PF02991	0.441
LIG_SH2_CRK	201	205	PF00017	0.643
LIG_SH2_NCK_1	43	47	PF00017	0.562
LIG_SH2_SRC	201	204	PF00017	0.646
LIG_SH2_STAP1	151	155	PF00017	0.557
LIG_SH2_STAP1	43	47	PF00017	0.562
LIG_SH2_STAT5	49	52	PF00017	0.453
LIG_SH2_STAT5	80	83	PF00017	0.418
LIG_SH3_1	201	207	PF00018	0.677
LIG_SH3_3	183	189	PF00018	0.594
LIG_SH3_3	201	207	PF00018	0.679
LIG_SH3_3	229	235	PF00018	0.666
LIG_SH3_3	295	301	PF00018	0.696
LIG_SH3_3	307	313	PF00018	0.769
LIG_SUMO_SIM_par_1	308	315	PF11976	0.719
LIG_SUMO_SIM_par_1	35	41	PF11976	0.366
LIG_TRFH_1	292	296	PF08558	0.686
LIG_UBA3_1	36	42	PF00899	0.591
LIG_WRC_WIRS_1	157	162	PF05994	0.459
LIG_WW_3	354	358	PF00397	0.543
MOD_CDK_SPxxK_3	19	26	PF00069	0.664
MOD_CK1_1	2	8	PF00069	0.650
MOD_CK1_1	208	214	PF00069	0.749
MOD_CK1_1	22	28	PF00069	0.652
MOD_CK1_1	222	228	PF00069	0.642
MOD_CK1_1	248	254	PF00069	0.700
MOD_CK1_1	273	279	PF00069	0.683
MOD_CK1_1	290	296	PF00069	0.723
MOD_CK2_1	162	168	PF00069	0.462
MOD_CK2_1	27	33	PF00069	0.485
MOD_CK2_1	282	288	PF00069	0.735
MOD_GlcNHglycan	147	150	PF01048	0.470
MOD_GlcNHglycan	217	220	PF01048	0.710
MOD_GlcNHglycan	224	228	PF01048	0.699
MOD_GlcNHglycan	241	244	PF01048	0.671
MOD_GlcNHglycan	245	248	PF01048	0.699
MOD_GlcNHglycan	251	254	PF01048	0.648
MOD_GlcNHglycan	255	259	PF01048	0.605
MOD_GlcNHglycan	277	280	PF01048	0.789
MOD_GlcNHglycan	314	317	PF01048	0.690
MOD_GlcNHglycan	44	47	PF01048	0.442
MOD_GSK3_1	177	184	PF00069	0.557
MOD_GSK3_1	205	212	PF00069	0.756
MOD_GSK3_1	213	220	PF00069	0.745
MOD_GSK3_1	239	246	PF00069	0.664
MOD_GSK3_1	265	272	PF00069	0.716
MOD_GSK3_1	290	297	PF00069	0.756
MOD_GSK3_1	308	315	PF00069	0.669
MOD_N-GLC_1	332	337	PF02516	0.705
MOD_NEK2_1	1	6	PF00069	0.674
MOD_NEK2_1	143	148	PF00069	0.539
MOD_NEK2_1	171	176	PF00069	0.584
MOD_NEK2_1	217	222	PF00069	0.765
MOD_NEK2_1	269	274	PF00069	0.680
MOD_NEK2_2	356	361	PF00069	0.543
MOD_PIKK_1	219	225	PF00454	0.787
MOD_PKA_2	248	254	PF00069	0.737
MOD_PKA_2	356	362	PF00069	0.570
MOD_PKA_2	89	95	PF00069	0.450
MOD_Plk_1	78	84	PF00069	0.444
MOD_Plk_4	156	162	PF00069	0.521
MOD_Plk_4	181	187	PF00069	0.572
MOD_Plk_4	225	231	PF00069	0.631
MOD_Plk_4	27	33	PF00069	0.479
MOD_ProDKin_1	19	25	PF00069	0.762
MOD_ProDKin_1	273	279	PF00069	0.716
MOD_ProDKin_1	287	293	PF00069	0.690
MOD_ProDKin_1	294	300	PF00069	0.644
MOD_ProDKin_1	3	9	PF00069	0.740
MOD_SUMO_for_1	95	98	PF00179	0.531
MOD_SUMO_rev_2	11	21	PF00179	0.692
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.679
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.539
TRG_ENDOCYTIC_2	151	154	PF00928	0.559
TRG_ENDOCYTIC_2	200	203	PF00928	0.655
TRG_ER_diArg_1	114	117	PF00400	0.587
TRG_ER_diArg_1	129	131	PF00400	0.475
TRG_ER_diArg_1	356	358	PF00400	0.544
TRG_ER_diArg_1	360	363	PF00400	0.507
TRG_ER_diArg_1	88	91	PF00400	0.390
TRG_NLS_Bipartite_1	72	91	PF00514	0.343
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W2	Leptomonas seymouri	43%	66%
A0A3Q8IFH8	Leishmania donovani	99%	100%
A4HHU4	Leishmania braziliensis	57%	100%
E9AE84	Leishmania major	90%	100%
E9ALK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%