LeishMANIAdb
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Putative GTP-binding protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative GTP-binding protein
Gene product:
dynamin-1-like protein
Species:
Leishmania infantum
UniProt:
A4I4S9_LEIIN
TriTrypDb:
LINF_290029700
Length:
700

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, GTP-binding

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005874 microtubule 6 1
GO:0016020 membrane 2 1
GO:0099080 supramolecular complex 2 1
GO:0099081 supramolecular polymer 3 1
GO:0099512 supramolecular fiber 4 1
GO:0099513 polymeric cytoskeletal fiber 5 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 510

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I4S9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I4S9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003824 catalytic activity 1 13
GO:0003924 GTPase activity 7 13
GO:0005488 binding 1 13
GO:0005525 GTP binding 5 13
GO:0016462 pyrophosphatase activity 5 13
GO:0016787 hydrolase activity 2 13
GO:0016817 hydrolase activity, acting on acid anhydrides 3 13
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 13
GO:0017076 purine nucleotide binding 4 13
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 13
GO:0019001 guanyl nucleotide binding 5 13
GO:0032553 ribonucleotide binding 3 13
GO:0032555 purine ribonucleotide binding 4 13
GO:0032561 guanyl ribonucleotide binding 5 13
GO:0035639 purine ribonucleoside triphosphate binding 4 13
GO:0036094 small molecule binding 2 13
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0097159 organic cyclic compound binding 2 13
GO:0097367 carbohydrate derivative binding 2 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13
GO:0005515 protein binding 2 1
GO:0008017 microtubule binding 5 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0015631 tubulin binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 504 508 PF00656 0.549
CLV_NRD_NRD_1 102 104 PF00675 0.417
CLV_NRD_NRD_1 242 244 PF00675 0.430
CLV_NRD_NRD_1 250 252 PF00675 0.448
CLV_NRD_NRD_1 541 543 PF00675 0.686
CLV_NRD_NRD_1 662 664 PF00675 0.344
CLV_PCSK_KEX2_1 102 104 PF00082 0.417
CLV_PCSK_KEX2_1 250 252 PF00082 0.386
CLV_PCSK_KEX2_1 295 297 PF00082 0.388
CLV_PCSK_KEX2_1 538 540 PF00082 0.800
CLV_PCSK_KEX2_1 546 548 PF00082 0.766
CLV_PCSK_KEX2_1 553 555 PF00082 0.759
CLV_PCSK_PC1ET2_1 295 297 PF00082 0.388
CLV_PCSK_PC1ET2_1 538 540 PF00082 0.643
CLV_PCSK_PC1ET2_1 546 548 PF00082 0.657
CLV_PCSK_PC1ET2_1 553 555 PF00082 0.590
CLV_PCSK_PC7_1 542 548 PF00082 0.599
CLV_PCSK_SKI1_1 152 156 PF00082 0.315
CLV_PCSK_SKI1_1 186 190 PF00082 0.362
CLV_PCSK_SKI1_1 350 354 PF00082 0.362
CLV_PCSK_SKI1_1 377 381 PF00082 0.362
CLV_PCSK_SKI1_1 422 426 PF00082 0.398
CLV_PCSK_SKI1_1 457 461 PF00082 0.312
CLV_PCSK_SKI1_1 49 53 PF00082 0.315
CLV_PCSK_SKI1_1 535 539 PF00082 0.778
CLV_PCSK_SKI1_1 582 586 PF00082 0.641
CLV_PCSK_SKI1_1 587 591 PF00082 0.622
CLV_PCSK_SKI1_1 621 625 PF00082 0.328
CLV_PCSK_SKI1_1 647 651 PF00082 0.442
CLV_PCSK_SKI1_1 664 668 PF00082 0.331
DEG_Nend_UBRbox_2 1 3 PF02207 0.462
DOC_ANK_TNKS_1 600 607 PF00023 0.315
DOC_CDC14_PxL_1 132 140 PF14671 0.328
DOC_CYCLIN_RxL_1 274 285 PF00134 0.386
DOC_CYCLIN_RxL_1 455 462 PF00134 0.373
DOC_CYCLIN_RxL_1 647 655 PF00134 0.431
DOC_MAPK_DCC_7 23 31 PF00069 0.389
DOC_MAPK_gen_1 277 284 PF00069 0.362
DOC_MAPK_gen_1 476 484 PF00069 0.347
DOC_MAPK_JIP1_4 116 122 PF00069 0.315
DOC_MAPK_MEF2A_6 165 172 PF00069 0.442
DOC_MAPK_MEF2A_6 19 26 PF00069 0.465
DOC_MAPK_MEF2A_6 61 68 PF00069 0.315
DOC_MAPK_NFAT4_5 165 173 PF00069 0.442
DOC_MAPK_NFAT4_5 19 27 PF00069 0.454
DOC_PP1_RVXF_1 275 282 PF00149 0.386
DOC_PP1_RVXF_1 420 427 PF00149 0.315
DOC_PP2B_LxvP_1 24 27 PF13499 0.399
DOC_PP2B_LxvP_1 83 86 PF13499 0.410
DOC_PP2B_PxIxI_1 26 32 PF00149 0.315
DOC_USP7_MATH_1 108 112 PF00917 0.297
DOC_USP7_MATH_1 249 253 PF00917 0.437
DOC_USP7_MATH_1 512 516 PF00917 0.758
DOC_USP7_MATH_1 518 522 PF00917 0.777
DOC_USP7_MATH_1 53 57 PF00917 0.328
DOC_USP7_MATH_1 530 534 PF00917 0.466
DOC_USP7_MATH_1 555 559 PF00917 0.665
DOC_USP7_MATH_1 679 683 PF00917 0.362
DOC_USP7_MATH_1 692 696 PF00917 0.644
DOC_USP7_UBL2_3 19 23 PF12436 0.498
DOC_USP7_UBL2_3 307 311 PF12436 0.356
DOC_USP7_UBL2_3 553 557 PF12436 0.654
DOC_WW_Pin1_4 160 165 PF00397 0.314
DOC_WW_Pin1_4 170 175 PF00397 0.315
DOC_WW_Pin1_4 257 262 PF00397 0.422
DOC_WW_Pin1_4 507 512 PF00397 0.717
DOC_WW_Pin1_4 566 571 PF00397 0.714
LIG_14-3-3_CanoR_1 243 247 PF00244 0.438
LIG_14-3-3_CanoR_1 250 257 PF00244 0.447
LIG_14-3-3_CanoR_1 464 474 PF00244 0.392
LIG_14-3-3_CanoR_1 513 518 PF00244 0.589
LIG_Actin_WH2_2 211 228 PF00022 0.344
LIG_APCC_ABBA_1 330 335 PF00400 0.360
LIG_CORNRBOX 283 291 PF00104 0.315
LIG_deltaCOP1_diTrp_1 76 82 PF00928 0.315
LIG_FHA_1 157 163 PF00498 0.305
LIG_FHA_1 165 171 PF00498 0.309
LIG_FHA_1 196 202 PF00498 0.313
LIG_FHA_1 270 276 PF00498 0.308
LIG_FHA_1 321 327 PF00498 0.461
LIG_FHA_1 347 353 PF00498 0.366
LIG_FHA_1 374 380 PF00498 0.386
LIG_FHA_1 430 436 PF00498 0.250
LIG_FHA_2 129 135 PF00498 0.315
LIG_FHA_2 201 207 PF00498 0.315
LIG_FHA_2 412 418 PF00498 0.370
LIG_FHA_2 502 508 PF00498 0.661
LIG_FHA_2 524 530 PF00498 0.771
LIG_FHA_2 588 594 PF00498 0.621
LIG_IRF3_LxIS_1 168 173 PF10401 0.328
LIG_LIR_Apic_2 159 164 PF02991 0.304
LIG_LIR_Apic_2 462 466 PF02991 0.315
LIG_LIR_Gen_1 212 223 PF02991 0.346
LIG_LIR_Gen_1 252 262 PF02991 0.430
LIG_LIR_Gen_1 380 391 PF02991 0.314
LIG_LIR_Gen_1 402 413 PF02991 0.315
LIG_LIR_Gen_1 425 435 PF02991 0.388
LIG_LIR_Gen_1 478 489 PF02991 0.315
LIG_LIR_Gen_1 605 616 PF02991 0.344
LIG_LIR_Gen_1 633 644 PF02991 0.328
LIG_LIR_Gen_1 81 90 PF02991 0.442
LIG_LIR_Gen_1 92 100 PF02991 0.329
LIG_LIR_Nem_3 13 18 PF02991 0.425
LIG_LIR_Nem_3 212 218 PF02991 0.346
LIG_LIR_Nem_3 252 257 PF02991 0.411
LIG_LIR_Nem_3 260 266 PF02991 0.322
LIG_LIR_Nem_3 364 369 PF02991 0.306
LIG_LIR_Nem_3 380 386 PF02991 0.315
LIG_LIR_Nem_3 402 408 PF02991 0.315
LIG_LIR_Nem_3 425 431 PF02991 0.379
LIG_LIR_Nem_3 443 448 PF02991 0.183
LIG_LIR_Nem_3 478 484 PF02991 0.315
LIG_LIR_Nem_3 605 611 PF02991 0.315
LIG_LIR_Nem_3 633 639 PF02991 0.304
LIG_LIR_Nem_3 76 82 PF02991 0.316
LIG_LIR_Nem_3 92 96 PF02991 0.319
LIG_LYPXL_yS_3 445 448 PF13949 0.410
LIG_NRBOX 278 284 PF00104 0.315
LIG_Pex14_2 362 366 PF04695 0.315
LIG_PTB_Apo_2 84 91 PF02174 0.412
LIG_SH2_CRK 263 267 PF00017 0.315
LIG_SH2_CRK 463 467 PF00017 0.344
LIG_SH2_CRK 636 640 PF00017 0.315
LIG_SH2_GRB2like 123 126 PF00017 0.328
LIG_SH2_GRB2like 595 598 PF00017 0.357
LIG_SH2_NCK_1 263 267 PF00017 0.315
LIG_SH2_PTP2 161 164 PF00017 0.315
LIG_SH2_PTP2 383 386 PF00017 0.314
LIG_SH2_STAP1 123 127 PF00017 0.384
LIG_SH2_STAP1 254 258 PF00017 0.377
LIG_SH2_STAP1 636 640 PF00017 0.328
LIG_SH2_STAT5 161 164 PF00017 0.315
LIG_SH2_STAT5 274 277 PF00017 0.328
LIG_SH2_STAT5 328 331 PF00017 0.480
LIG_SH2_STAT5 360 363 PF00017 0.315
LIG_SH2_STAT5 369 372 PF00017 0.308
LIG_SH2_STAT5 383 386 PF00017 0.281
LIG_SH2_STAT5 607 610 PF00017 0.317
LIG_SH3_3 130 136 PF00018 0.340
LIG_SH3_3 481 487 PF00018 0.314
LIG_SH3_3 564 570 PF00018 0.737
LIG_SH3_3 66 72 PF00018 0.328
LIG_SUMO_SIM_anti_2 203 209 PF11976 0.398
LIG_SUMO_SIM_par_1 167 173 PF11976 0.314
LIG_SUMO_SIM_par_1 624 629 PF11976 0.317
LIG_TRAF2_1 74 77 PF00917 0.347
LIG_UBA3_1 283 288 PF00899 0.328
LIG_UBA3_1 326 331 PF00899 0.292
LIG_UBA3_1 452 458 PF00899 0.473
LIG_UBA3_1 669 675 PF00899 0.315
LIG_WW_3 510 514 PF00397 0.683
MOD_CDC14_SPxK_1 510 513 PF00782 0.681
MOD_CDK_SPK_2 160 165 PF00069 0.428
MOD_CDK_SPxK_1 507 513 PF00069 0.674
MOD_CDK_SPxxK_3 566 573 PF00069 0.731
MOD_CK1_1 111 117 PF00069 0.305
MOD_CK1_1 569 575 PF00069 0.608
MOD_CK1_1 645 651 PF00069 0.343
MOD_CK2_1 249 255 PF00069 0.386
MOD_CK2_1 38 44 PF00069 0.315
MOD_CK2_1 411 417 PF00069 0.332
MOD_CK2_1 587 593 PF00069 0.484
MOD_CK2_1 71 77 PF00069 0.345
MOD_GlcNHglycan 110 113 PF01048 0.305
MOD_GlcNHglycan 373 376 PF01048 0.362
MOD_GlcNHglycan 520 523 PF01048 0.757
MOD_GlcNHglycan 532 535 PF01048 0.764
MOD_GlcNHglycan 55 58 PF01048 0.435
MOD_GlcNHglycan 597 600 PF01048 0.441
MOD_GSK3_1 156 163 PF00069 0.307
MOD_GSK3_1 170 177 PF00069 0.282
MOD_GSK3_1 257 264 PF00069 0.419
MOD_GSK3_1 269 276 PF00069 0.288
MOD_GSK3_1 33 40 PF00069 0.313
MOD_GSK3_1 333 340 PF00069 0.325
MOD_GSK3_1 365 372 PF00069 0.413
MOD_GSK3_1 373 380 PF00069 0.401
MOD_GSK3_1 394 401 PF00069 0.332
MOD_GSK3_1 466 473 PF00069 0.431
MOD_GSK3_1 53 60 PF00069 0.133
MOD_GSK3_1 638 645 PF00069 0.480
MOD_GSK3_1 686 693 PF00069 0.623
MOD_N-GLC_1 128 133 PF02516 0.328
MOD_N-GLC_1 337 342 PF02516 0.362
MOD_N-GLC_1 513 518 PF02516 0.791
MOD_N-GLC_1 587 592 PF02516 0.540
MOD_NEK2_1 128 133 PF00069 0.303
MOD_NEK2_1 179 184 PF00069 0.310
MOD_NEK2_1 302 307 PF00069 0.328
MOD_NEK2_1 333 338 PF00069 0.365
MOD_NEK2_1 394 399 PF00069 0.336
MOD_NEK2_1 626 631 PF00069 0.315
MOD_NEK2_2 679 684 PF00069 0.362
MOD_PIKK_1 179 185 PF00454 0.410
MOD_PIKK_1 233 239 PF00454 0.315
MOD_PIKK_1 31 37 PF00454 0.312
MOD_PIKK_1 523 529 PF00454 0.825
MOD_PIKK_1 658 664 PF00454 0.364
MOD_PKA_2 101 107 PF00069 0.361
MOD_PKA_2 242 248 PF00069 0.438
MOD_PKA_2 249 255 PF00069 0.447
MOD_PKA_2 512 518 PF00069 0.686
MOD_PKA_2 53 59 PF00069 0.315
MOD_Plk_1 128 134 PF00069 0.328
MOD_Plk_1 337 343 PF00069 0.362
MOD_Plk_1 587 593 PF00069 0.492
MOD_Plk_2-3 242 248 PF00069 0.442
MOD_Plk_4 123 129 PF00069 0.348
MOD_Plk_4 164 170 PF00069 0.338
MOD_Plk_4 365 371 PF00069 0.344
MOD_Plk_4 38 44 PF00069 0.308
MOD_Plk_4 394 400 PF00069 0.344
MOD_Plk_4 422 428 PF00069 0.442
MOD_ProDKin_1 160 166 PF00069 0.314
MOD_ProDKin_1 170 176 PF00069 0.315
MOD_ProDKin_1 257 263 PF00069 0.422
MOD_ProDKin_1 507 513 PF00069 0.723
MOD_ProDKin_1 566 572 PF00069 0.710
MOD_SUMO_for_1 475 478 PF00179 0.347
MOD_SUMO_rev_2 236 246 PF00179 0.336
MOD_SUMO_rev_2 545 555 PF00179 0.789
TRG_DiLeu_BaEn_3 429 435 PF01217 0.328
TRG_DiLeu_BaEn_3 77 83 PF01217 0.344
TRG_ENDOCYTIC_2 254 257 PF00928 0.358
TRG_ENDOCYTIC_2 263 266 PF00928 0.253
TRG_ENDOCYTIC_2 383 386 PF00928 0.315
TRG_ENDOCYTIC_2 428 431 PF00928 0.341
TRG_ENDOCYTIC_2 445 448 PF00928 0.271
TRG_ENDOCYTIC_2 607 610 PF00928 0.315
TRG_ENDOCYTIC_2 636 639 PF00928 0.303
TRG_NES_CRM1_1 450 462 PF08389 0.366
TRG_Pf-PMV_PEXEL_1 152 156 PF00026 0.362

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD95 Leptomonas seymouri 82% 100%
A0A0S4IST4 Bodo saltans 54% 84%
A0A1X0P9B2 Trypanosomatidae 71% 100%
A0A3Q8IRJ0 Leishmania donovani 100% 100%
A0A422NEK1 Trypanosoma rangeli 66% 100%
A1E2I5 Macaca mulatta 33% 98%
A4HHM0 Leishmania braziliensis 85% 100%
A6H7I5 Bos taurus 44% 81%
C9ZLH7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 65% 100%
C9ZLI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
E9AE82 Leishmania major 94% 100%
E9ALK3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 99%
O00429 Homo sapiens 37% 95%
O35303 Rattus norvegicus 36% 93%
P20592 Homo sapiens 33% 98%
P21575 Rattus norvegicus 44% 81%
P21576 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 99%
P27619 Drosophila melanogaster 44% 80%
P33238 Anas platyrhynchos 32% 97%
P39052 Rattus norvegicus 44% 80%
P39053 Mus musculus 44% 81%
P39054 Mus musculus 44% 80%
P39055 Caenorhabditis elegans 41% 84%
P50570 Homo sapiens 44% 80%
P54861 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 92%
Q05193 Homo sapiens 44% 81%
Q08877 Rattus norvegicus 43% 81%
Q08DF4 Bos taurus 45% 82%
Q09748 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 90%
Q2KIA5 Bos taurus 36% 93%
Q2KTC2 Dicentrarchus labrax 30% 100%
Q39828 Glycine max 37% 100%
Q5U752 Solea senegalensis 32% 100%
Q6DKF0 Danio rerio 31% 100%
Q7SXN5 Danio rerio 39% 100%
Q7T2P0 Ictalurus punctatus 34% 100%
Q84XF3 Arabidopsis thaliana 37% 100%
Q8BZ98 Mus musculus 43% 81%
Q8JH68 Danio rerio 34% 100%
Q8K1M6 Mus musculus 37% 94%
Q8LF21 Arabidopsis thaliana 37% 100%
Q8LFT2 Arabidopsis thaliana 36% 90%
Q8S3C9 Arabidopsis thaliana 36% 100%
Q8S944 Arabidopsis thaliana 35% 87%
Q94464 Dictyostelium discoideum 49% 82%
Q9FNX5 Arabidopsis thaliana 36% 100%
Q9LQ55 Arabidopsis thaliana 23% 76%
Q9SE83 Arabidopsis thaliana 24% 77%
Q9U1M9 Dictyostelium discoideum 40% 76%
Q9UQ16 Homo sapiens 43% 81%
Q9URZ5 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 37% 100%
Q9ZP55 Arabidopsis thaliana 27% 100%
V5DTS8 Trypanosoma cruzi 68% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS